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Gene: Egfl6 (EGF-like-domain, multiple 6) Rattus norvegicus

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Symbol:

Egfl6

Name:

EGF-like-domain, multiple 6

RGD ID:

1563321

Description:

Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion and cell differentiation. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in basement membrane. Orthologous to human EGFL6 (EGF like domain multiple 6); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

epidermal growth factor-like protein 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EGFL6 (EGF like domain multiple 6)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Egfl6 (EGF-like-domain, multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Egfl6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EGFL6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EGFL6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Egfl6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EGFL6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EGFL6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Egfl6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Egfl6 (EGF like domain multiple 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EGFL6 (EGF like domain multiple 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Egfl6 (EGF-like-domain, multiple 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	egfl6 (EGF-like-domain, multiple 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	egfl6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	31,515,752 - 31,573,699 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	31,515,767 - 31,574,632 (+)	Ensembl				GRCr8
mRatBN7.2	X	27,884,087 - 27,942,044 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	27,884,125 - 27,942,044 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	28,918,085 - 28,976,353 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	32,353,819 - 32,411,722 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	28,532,727 - 28,590,990 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	29,430,789 - 29,488,737 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	29,430,831 - 29,488,739 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	29,823,750 - 29,881,382 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	48,568,644 - 48,626,802 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	28,256,591 - 28,314,648 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bladder exstrophy-epispadias-cloacal exstrophy complex (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amiodarone (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cytarabine (ISO)

diarsenic trioxide (ISO)

dioxygen (EXP)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

fulvestrant (ISO)

gentamycin (EXP)

indometacin (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

methotrexate (ISO)

nitrofen (EXP)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP)

paraquat (EXP)

perfluorooctanoic acid (EXP)

progesterone (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

sulforaphane (ISO)

topotecan (EXP,ISO)

trichostatin A (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vincristine (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

cell differentiation (IEA)

extracellular matrix organization (IEA,ISO)

positive regulation of cell-substrate adhesion (IEA,ISO)

Cellular Component

basement membrane (IEA,ISO)

extracellular matrix (IEA,ISO)

membrane (IEA)

Molecular Function

calcium ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:18757743

Genomics

Comparative Map Data

Egfl6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	31,515,752 - 31,573,699 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	31,515,767 - 31,574,632 (+)	Ensembl				GRCr8
mRatBN7.2	X	27,884,087 - 27,942,044 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	27,884,125 - 27,942,044 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	28,918,085 - 28,976,353 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	32,353,819 - 32,411,722 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	28,532,727 - 28,590,990 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	29,430,789 - 29,488,737 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	29,430,831 - 29,488,739 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	29,823,750 - 29,881,382 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	48,568,644 - 48,626,802 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	28,256,591 - 28,314,648 (+)	NCBI		Celera
Cytogenetic Map	X	q13	NCBI

EGFL6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	13,569,601 - 13,633,575 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	13,569,601 - 13,633,575 (+)	Ensembl			hg38	GRCh38
GRCh37	X	13,587,720 - 13,651,694 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	13,497,662 - 13,561,615 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	13,347,397 - 13,411,350	NCBI
Celera	X	17,704,800 - 17,768,780 (+)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	11,346,706 - 11,404,147 (+)	NCBI		HuRef
CHM1_1	X	13,618,522 - 13,682,553 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	13,151,011 - 13,214,962 (+)	NCBI		T2T-CHM13v2.0

Egfl6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	165,306,003 - 165,368,712 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	165,306,003 - 165,368,716 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	166,523,007 - 166,585,716 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	166,523,007 - 166,585,720 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	162,960,939 - 163,023,648 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	161,867,112 - 161,929,821 (-)	NCBI		MGSCv36	mm8
Celera	X	149,703,700 - 149,765,223 (-)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI
cM Map	X	77.66	NCBI

Egfl6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955519	4,556,610 - 4,616,296 (-)	Ensembl
ChiLan1.0	NW_004955519	4,557,007 - 4,616,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

EGFL6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	15,348,589 - 15,413,279 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	15,352,255 - 15,416,854 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	6,177,141 - 6,240,969 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	13,465,614 - 13,529,394 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	13,465,605 - 13,529,474 (+)	Ensembl			panPan2	panpan1.1

EGFL6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	9,944,648 - 10,062,699 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	9,995,846 - 10,062,266 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	9,816,026 - 10,037,235 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	9,811,918 - 10,020,620 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	9,955,601 - 10,020,150 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	9,802,862 - 10,089,431 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	9,836,276 - 10,080,587 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	10,020,615 - 10,106,745 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Egfl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	3,156,546 - 3,214,971 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	3,156,518 - 3,215,990 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	3,156,593 - 3,215,039 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EGFL6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	10,217,924 - 10,283,810 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	10,218,108 - 10,284,152 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	11,171,935 - 11,237,889 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EGFL6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	12,051,172 - 12,116,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	12,052,518 - 12,116,845 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666056	13,881,736 - 13,946,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Egfl6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624882	513,227 - 575,126 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624882	513,105 - 575,126 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Egfl6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	30,659,353 - 30,716,800 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Egfl6
246 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	135
Interacting mature miRNAs:	155
Transcripts:	ENSRNOT00000068337
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	24470360	44931007	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	24470360	45082063	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	8111486	53111486	Rat

Markers in Region

RH131444

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	27,941,793 - 27,941,974 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	29,488,487 - 29,488,667	NCBI	Rnor6.0
Rnor_5.0	X	29,881,132 - 29,881,312	UniSTS	Rnor5.0
RGSC_v3.4	X	48,626,552 - 48,626,732	UniSTS	RGSC3.4
Celera	X	28,314,398 - 28,314,578	UniSTS
RH 3.4 Map	X	357.2	UniSTS
Cytogenetic Map	X	q21	UniSTS

RH143432

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	27,893,846 - 27,893,965 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	29,440,551 - 29,440,669	NCBI	Rnor6.0
Rnor_5.0	X	29,833,470 - 29,833,588	UniSTS	Rnor5.0
RGSC_v3.4	X	48,578,364 - 48,578,482	UniSTS	RGSC3.4
Celera	X	28,266,311 - 28,266,429	UniSTS
RH 3.4 Map	X	375.0	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	12	63	146	91	90	59	52	59	6	307	147	11	123	81	90	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC130009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000068337 ⟹ ENSRNOP00000062411

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	31,515,789 - 31,573,699 (+)	Ensembl
mRatBN7.2 Ensembl	X	27,884,125 - 27,942,044 (+)	Ensembl
Rnor_6.0 Ensembl	X	29,430,831 - 29,488,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087621 ⟹ ENSRNOP00000075650

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	31,515,767 - 31,574,632 (+)	Ensembl
mRatBN7.2 Ensembl	X	27,884,154 - 27,942,001 (+)	Ensembl
Rnor_6.0 Ensembl	X	29,430,837 - 29,488,739 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139027 ⟹ ENSRNOP00000108918

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	31,515,767 - 31,574,632 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000156241 ⟹ ENSRNOP00000103187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	31,515,767 - 31,574,632 (+)	Ensembl

RefSeq Acc Id:

NM_001108254 ⟹ NP_001101724

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	31,515,789 - 31,573,699 (+)	NCBI
mRatBN7.2	X	27,884,125 - 27,942,044 (+)	NCBI
Rnor_6.0	X	29,430,831 - 29,488,737 (+)	NCBI
Rnor_5.0	X	29,823,750 - 29,881,382 (+)	NCBI
RGSC_v3.4	X	48,568,644 - 48,626,802 (+)	RGD
Celera	X	28,256,591 - 28,314,648 (+)	RGD

Sequence:

show sequence

TCGCCAGGGCGCCCCCAGCCACTCACAGCTCCAAACGTTCCCCAGCTCTCCAACCCCGCTGTCC
CCTCTGCGCCCGCTGCCACAGAGCCTGCCAGCTGCGCGCAAAACCAAGGTCCTGACCAGCGAAG
CAGAGACGAGGCGGTGGCTCCTCTGTGTCCCACGTCCTGAGGGGCTCAGGACAAGAAAGGAGCC
CACCCCCAGCCAGTATGCAGCCGCCCTGGGGCCTGGCGCTCCCTCTGCTGCTCCCCTGGGTGGC
AGGTGGAGTAGGGACCAGCCCACGGGATTATTGGTTGCCAGCACTGGCACACCAGCCTGGGGTC
TGTCACTACGGAACTAAGACGGCCTGCTGCTATGGCTGGAAAAGGAACAGCAAAGGAGTATGTG
AAGCTGTGTGTGAGCCCAGATGCAAGTTTGGTGAGTGTGTGGGACCGAATAAATGTAGATGCTT
TCCAGGATACACCGGGAAGACCTGCAGTCAAGACGTGAATGAGTGTGCATTCAAACCCCGGCCA
TGCCAGCACAGATGTGTGAATACACACGGTAGCTACAAATGCTTTTGCCTCAGCGGCCACATGC
TTCTACCAGACGCCACATGTTCAAACTCCAGGACATGTGCCAGAATAAACTGCCAGTACAGTTG
TGAAGACACAGCAGAAGGGCCACGATGTGTGTGTCCATCCTCTGGCCTCCGCCTGGGTCCAAAT
GGAAGAGTGTGCCTAGATATCGATGAATGTGCTTCTAGCAAAGCAGTCTGTCCTTCCAATAGAA
GATGTGTGAACACATTTGGAAGCTACTACTGCAAATGTCACATTGGTTTTGAACTGAAATATAT
CAGTCGCCGATATGATTGTGTAGATATAAATGAGTGCACTCTGAATACCCGTACGTGCAGCCCC
CATGCCAATTGCCTCAATACCCAAGGATCCTTCAAGTGCAAATGCAAGCAGGGATACAGGGGGA
ATGGACTGCAGTGTTCTGTGATTCCTGAACATTCTGTGAAGGAAATACTCACAGCACCTGGGAC
CATCAAAGACCGAATCAAGAAGTTACTGGCTCACAAGCACACCATGAAGAAAAAGGTGAAGCTT
AAAAACGTCACCCCAAGACCCACCAGTACACGAGCCCCTAAGGTCAACTTGCCTTACAGCTCTG
AGGAGGGTGTTTCCAGAGGCAGAAACTCTGGTGGGGAACAGAAAAGGAAGGAAGAGAGAAAGAG
AAAGAGGCTTGAAGAAGAGAAAAGTGAGAAAGCCCTGAGGAATGAGGTGGAACAGGAGCGACCC
CTCCGAGGGGATGTGTTCTCCCCTAAGGTAAATGAAGCAGAGGATTTGGATCTGGTCTACATCC
AAAGAAAAGAGCTAAATTCCAAACAGGAGCACAAAGATGTGGGTTACTATATGGCAGTCCCTGC
ACTGGCAGGGCACAAGAAGAATATTGGCCGATTGAAACTTCTCCTTCCCAACTTGACACCCCAA
AGCAACTTCTGTTTGCTCTTTGATTACCGGCTTGCTGGGGACAAAGTAGGAAAACTTCGAGTGT
TCGTGAAAAATAGCAACAACGCCCTGGCATGGGAGGAGACTAAAACTGAGGATGGAAAGTGGAA
GACAGGAAAAGTCCCTTTGTACCAAGGAATCGACACTACCAAAAGTGTCATTTTTGAAGCAGAG
CGTGGCAAAGGCAAAACTGGAGAAATTGCAGTGGATGGTGTCTTACTGGTGTCAGGCTTGTGTC
CAGATGACTTTTTATCTGAGGAGGGTTGAATGTCACTGTCCTTCTTTATAGCTTCATATGTGGC
TTTTTAAATGTCATTTCTCTGTGGTATCTTTGTATATCATATCCTAGGACTCTTCCATTTTATA
GATACAAGCTGACAATGTGTAATGTTCCAACAGAAATACTATCATAAGATGCCTTTTTTTTATC
AAATGCACTAAGACTTGCCTTATATATAGTACCACTGTGCCTTCTCATTTGTTTCTGAATTTCC
CACATTATATCACAAAATGGGGAAATGCCAGTCCATCTCCTCCTGCCCAGTATGTCTGCTCTTC
CTACACGAGTTGGTGAACTTTTCTATATAACATTTGTAGAATAACAGCAACAGAAAAAGATAAG
TACAGATAAATGGTTAATTGTTGGGGCTGGGGCAATGGCCTAGCGGTTAAGTGTTCATTTCTCC
AGGATCAATTTCCAGCATCCACATGGTGGGTTGCAACCACCTGGAACTCCAATTCCAGAGAATT
CAATGCCCTTCTGGCTTCTGTGGACATTTTCATATGTGTGATATACATGCATAAACTACATACA
CACACACACACCAATGAAGTAAATCATTTTTTTAGATTGCTTAACTTGTAAGGTGCTTCTTGGA
AACAATGATATTAAACATAGATTTGCGCCTATGTGGCTCAGCCTGCTCCTTCACAGTCAAGCTT
GCACATTTAATTTTTTATAATCATATCCAATAAACCACCTTGTGTCATAGTACAATAAAAGGGT
ATCTTTACTGACTCTGTTTACTTCTGTATATAATTCTGCATATTTTATTCTTC

hide sequence

RefSeq Acc Id:

XM_039099835 ⟹ XP_038955763

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	31,515,752 - 31,572,927 (+)	NCBI
mRatBN7.2	X	27,884,088 - 27,941,306 (+)	NCBI

RefSeq Acc Id:

XM_039099836 ⟹ XP_038955764

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	31,515,752 - 31,572,927 (+)	NCBI
mRatBN7.2	X	27,884,087 - 27,941,267 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101724	(Get FASTA)	NCBI Sequence Viewer
	XP_038955763	(Get FASTA)	NCBI Sequence Viewer
	XP_038955764	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90557	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062411
	ENSRNOP00000062411.3
	ENSRNOP00000075650.1
	ENSRNOP00000103187.1
	ENSRNOP00000108918.1

RefSeq Acc Id:	NP_001101724 ⟸ NM_001108254
- Peptide Label:	precursor
- UniProtKB:	D3Z8B8 (UniProtKB/TrEMBL), A6K2H3 (UniProtKB/TrEMBL), A0A0G2KB47 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQPPWGLALPLLLPWVAGGVGTSPRDYWLPALAHQPGVCHYGTKTACCYGWKRNSKGVCEAVCE PRCKFGECVGPNKCRCFPGYTGKTCSQDVNECAFKPRPCQHRCVNTHGSYKCFCLSGHMLLPDA TCSNSRTCARINCQYSCEDTAEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNT FGSYYCKCHIGFELKYISRRYDCVDINECTLNTRTCSPHANCLNTQGSFKCKCKQGYRGNGLQC SVIPEHSVKEILTAPGTIKDRIKKLLAHKHTMKKKVKLKNVTPRPTSTRAPKVNLPYSSEEGVS RGRNSGGEQKRKEERKRKRLEEEKSEKALRNEVEQERPLRGDVFSPKVNEAEDLDLVYIQRKEL NSKQEHKDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNS NNALAWEETKTEDGKWKTGKVPLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFL SEEG hide sequence

Ensembl Acc Id:

ENSRNOP00000075650 ⟸ ENSRNOT00000087621

Ensembl Acc Id:

ENSRNOP00000062411 ⟸ ENSRNOT00000068337

RefSeq Acc Id:	XP_038955764 ⟸ XM_039099836
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038955763 ⟸ XM_039099835
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000103187 ⟸ ENSRNOT00000156241

Ensembl Acc Id:

ENSRNOP00000108918 ⟸ ENSRNOT00000139027

Protein Domains

EGF-like MAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2KB47-F1-model_v2	AlphaFold	A0A0G2KB47	1-551	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701791

Promoter ID:

EPDNEW_R12311

Type:

initiation region

Name:

Egfl6_1

Description:

EGF-like-domain, multiple 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	29,430,914 - 29,430,974	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563321	AgrOrtholog
BioCyc Gene	G2FUF-2613	BioCyc
Ensembl Genes	ENSRNOG00000004275	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000068337	ENTREZGENE
	ENSRNOT00000068337.5	UniProtKB/TrEMBL
	ENSRNOT00000087621.3	UniProtKB/TrEMBL
	ENSRNOT00000139027.1	UniProtKB/TrEMBL
	ENSRNOT00000156241.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ConA-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_Ca-bd	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	EGF_dom	UniProtKB/TrEMBL
	Growth_fac_rcpt_N_dom	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
	Nephronectin_domain	UniProtKB/TrEMBL
	NOTCH1_EGF-like	UniProtKB/TrEMBL
KEGG Report	rno:317470	UniProtKB/TrEMBL
NCBI Gene	317470	ENTREZGENE
PANTHER	PA14 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	PTHR24050:SF24	UniProtKB/TrEMBL
Pfam	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
PhenoGen	Egfl6	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004275	RatGTEx
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
Superfamily-SCOP	ConA_like_lec_gl	UniProtKB/TrEMBL
	EGF/Laminin	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A0G2KB47	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LCF8_RAT	UniProtKB/TrEMBL
	A0ABK0LS36_RAT	UniProtKB/TrEMBL
	A6K2H3	ENTREZGENE, UniProtKB/TrEMBL
	D3Z8B8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Egfl6	EGF-like-domain, multiple 6	Egfl6	epidermal growth factor-like protein 6	Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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