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Gene: Asb4 (ankyrin repeat and SOCS box-containing 4) Rattus norvegicus

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Symbol:

Asb4

Name:

ankyrin repeat and SOCS box-containing 4

RGD ID:

1563114

Description:

Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of vasculogenesis and protein autoubiquitination. Predicted to be part of Cul2-RING ubiquitin ligase complex and Cul5-RING ubiquitin ligase complex. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ankyrin repeat and SOCS box protein 4; ankyrin repeat and SOCS box-containing protein 4; Asb-4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	34,473,527 - 34,511,163 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	34,473,408 - 34,512,888 (+)	Ensembl				GRCr8
mRatBN7.2	4	33,506,992 - 33,544,630 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	33,506,992 - 33,544,630 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	38,466,026 - 38,503,652 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	34,392,177 - 34,429,805 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	32,801,950 - 32,839,584 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	30,461,673 - 30,501,340 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	30,313,102 - 30,501,329 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	30,369,302 - 30,408,933 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	30,150,502 - 30,188,132 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	29,034,019 - 29,071,609 (+)	NCBI		Celera
Cytogenetic Map	4	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pre-eclampsia (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

entinostat (ISO)

epoxiconazole (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

L-methionine (ISO)

methapyrilene (ISO)

methylarsonic acid (ISO)

N,N-diethyl-m-toluamide (EXP)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

permethrin (EXP)

phenylephrine (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tetrachloromethane (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

positive regulation of vasculogenesis (ISO)

protein autoubiquitination (ISO)

protein ubiquitination (IEA)

Cellular Component

Cul2-RING ubiquitin ligase complex (ISO)

Cul5-RING ubiquitin ligase complex (ISO)

Molecular Function

enzyme binding (ISO)

ubiquitin protein ligase activity (ISO)

ubiquitin protein ligase binding (ISO)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15929745	PMID:17636018	PMID:21955513

Genomics

Comparative Map Data

Asb4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	34,473,527 - 34,511,163 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	34,473,408 - 34,512,888 (+)	Ensembl				GRCr8
mRatBN7.2	4	33,506,992 - 33,544,630 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	33,506,992 - 33,544,630 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	38,466,026 - 38,503,652 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	34,392,177 - 34,429,805 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	32,801,950 - 32,839,584 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	30,461,673 - 30,501,340 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	30,313,102 - 30,501,329 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	30,369,302 - 30,408,933 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	30,150,502 - 30,188,132 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	29,034,019 - 29,071,609 (+)	NCBI		Celera
Cytogenetic Map	4	q21	NCBI

ASB4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	95,470,656 - 95,551,317 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	95,478,444 - 95,540,233 (+)	Ensembl			hg38	GRCh38
GRCh37	7	95,115,255 - 95,169,545 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	94,953,220 - 95,005,007 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	94,759,934 - 94,802,763	NCBI
Celera	7	89,814,002 - 89,865,786 (+)	NCBI		Celera
Cytogenetic Map	7	q21.3	NCBI
HuRef	7	89,722,265 - 89,776,678 (+)	NCBI		HuRef
CHM1_1	7	95,045,258 - 95,099,588 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	96,722,134 - 96,790,011 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	94,444,224 - 94,498,555 (+)	NCBI

Asb4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	5,383,386 - 5,433,022 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	5,383,386 - 5,433,022 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	5,383,386 - 5,433,022 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	5,383,386 - 5,433,022 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	5,333,386 - 5,383,022 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	5,333,386 - 5,383,022 (+)	NCBI		MGSCv36	mm8
Celera	6	5,532,909 - 5,582,551 (+)	NCBI		Celera
Cytogenetic Map	6	A1	NCBI
cM Map	6	1.99	NCBI

Asb4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	12,078,090 - 12,139,264 (+)	Ensembl
ChiLan1.0	NW_004955432	12,078,104 - 12,137,988 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASB4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	113,328,179 - 113,382,397 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	161,592,818 - 161,646,986 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	87,443,445 - 87,497,640 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	101,031,050 - 101,085,009 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	101,030,584 - 101,085,009 (+)	Ensembl			panPan2	panpan1.1

ASB4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	20,733,592 - 20,794,394 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	20,733,436 - 20,792,082 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	20,292,553 - 20,353,066 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	20,555,776 - 20,616,422 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	20,555,504 - 20,614,456 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	20,700,599 - 20,760,938 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	20,435,515 - 20,496,059 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	20,692,985 - 20,753,784 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Asb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	34,049,708 - 34,107,135 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936585	4,755,071 - 4,813,555 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936585	4,754,989 - 4,813,431 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASB4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	75,018,067 - 75,203,447 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	75,110,367 - 75,337,619 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	82,483,124 - 82,581,580 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ASB4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	53,497,078 - 53,551,149 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	53,496,860 - 53,550,837 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	50,795,269 - 50,849,160 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Asb4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624813	2,150,750 - 2,226,528 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624813	2,150,800 - 2,226,481 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Asb4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	133,186,502 - 133,226,206 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Asb4
82 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	139
Count of miRNA genes:	105
Interacting mature miRNAs:	118
Transcripts:	ENSRNOT00000012657
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	13080146	58080146	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	15644309	60644309	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
70222	Eae2	Experimental allergic encephalomyelitis QTL 2	4.3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	4	22288453	40471598	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	18900697	63900697	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	22288453	63245191	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	18900697	63900697	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	40471598	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	18913151	63913151	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	27862204	62997402	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21925151	66925151	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
11530004	Niddm71	Non-insulin dependent diabetes mellitus QTL 71		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	33538816	53719714	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	22288453	45429897	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10758701	40490708	Rat

Markers in Region

Asb4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	33,515,057 - 33,515,188 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	30,470,040 - 30,470,170	NCBI	Rnor6.0
Rnor_5.0	4	30,377,633 - 30,377,763	UniSTS	Rnor5.0
RGSC_v3.4	4	30,158,564 - 30,158,694	UniSTS	RGSC3.4
Celera	4	29,042,079 - 29,042,209	UniSTS
Cytogenetic Map	4	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	66	124	85	84	53	24	53	6	231	122	9	96	39	92	31	2	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY577765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012657 ⟹ ENSRNOP00000012656

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	34,473,471 - 34,512,888 (+)	Ensembl
mRatBN7.2 Ensembl	4	33,506,992 - 33,544,630 (+)	Ensembl
Rnor_6.0 Ensembl	4	30,313,102 - 30,501,329 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148647 ⟹ ENSRNOP00000106172

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	34,473,408 - 34,512,888 (+)	Ensembl

RefSeq Acc Id:

NM_001024318 ⟹ NP_001019489

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	34,473,527 - 34,511,163 (+)	NCBI
mRatBN7.2	4	33,506,992 - 33,544,630 (+)	NCBI
Rnor_6.0	4	30,461,978 - 30,499,608 (+)	NCBI
Rnor_5.0	4	30,369,302 - 30,408,933 (+)	NCBI
RGSC_v3.4	4	30,150,502 - 30,188,132 (+)	RGD
Celera	4	29,034,019 - 29,071,609 (+)	RGD

Sequence:

show sequence

AGGGCTCGGAGGATGGACGGCATCACTGCCTCTATGAGCAGAGCTGGGGCTGCCAAGTTAGTTA
AGAAAGAGTTCCTGGAGGCTCTAAAAACAAATGACTTCGAAAAGCTGAAGGCTATTTTAATCGA
AAGGCAAATAGATGTGGACACAGTGTTTGAAGTGGAAGATGAGAACATGATTTTGGCATCATAC
AAACAAGGCTATTGGCTGCCCAGTTATAAGCTGAAGTCTTCCTGGGCAACAGGCCTGCACCTCT
CAGTTTTGCTCGGTCACGTGGAGTGCCTGATGGTACTGCTGGACCACAATGCGACCATCAACTG
TCGGCCCAACGGGAAGACCCCTCTGCACGTGGCTTGTGAGATAGCTAACCTCGAATGCGTGAAG
ATTCTCTGTGACCGTGGCGCAAAGCTCAACTGCTACTCCCTCAGCGGCCACACTGCTTTGCACT
TCTGTACCACACCCAGCTCCATCGTCTGTGCCAAGCAGTTGGTGTCGAGAGGTGCAAACGTGAA
CATGAAAACCAACAACCAGGATGAGGAGACACCCCTGCACACGGCGGCCCACTTCGGCCTCTCT
GAGCTGGTGGCCTTCTATGTGGAGAACGGGGCCATCGTGGATAGCATGAACGCCCACATGGAGA
CCCCACTGGCCATCGCCACCTACTGGGCCCTGCGCTTCAAGGAGCAGGAGTACAGCAGGGAACA
CCACCTCATCTGCCGTATGCTTCTAGACAACAACGCTGAGGTCAACGCTCGGGATGACGACTTC
AAGTCCCCTCTGCACAAGGCTGCCTGGAATTGCGACCACGTGCTCATGCACATGATGCTGGAGG
CGGGTGCGGAGGCCAACCTCATGGATATCAATGGCTGTGCAGCCATCCAGTACGTGCTGAAGGT
CACCTCCGTGCGTCCTGCTGCGCAGCCCGAGATCTGCTACCAGCTGCTGCTGAATCACGGGGCT
GCGCGCATCTACCCCCCACAGTTCCACAAGGTGATCCAGGCTTGCCACTCTTGTCCCAAGGCAA
TTGAAGTTGTGGTCAATGCCTACGAGCACATCAGATGGAACATAAAGTGGAGGAGAGCCATTCC
TGATGACGACCTGGAGAAACACTGGGATTTCTACCACTCTCTCTTCAAGGTGTGCTGTAACACT
CCCAGGACCCTCATGCACCTGTCAAGATGTGCCATTCGAAAAGCGTTACACAACAGATGCCACA
AAGCAATTCCTATGCTGTCCCTCCCACTGTCATTGAAGAAGTACTTGCTTTTGGAGCCAGAGGG
AATCATTTATTAAGTCTTAGGAGACAACAGTTCCCAACCCTAGATTTCTAAGTGGACTCACTGG
GTAGACGCAGTTTGCATGGATAAAACGGTACTTGGGTTGGTTATCACACTTTAGGGATTTCAAA
ATGCTTTACATTCACCAAGCCATTAATCCTAGAGTAGCATGCTGAGGGAAAATAAGCCGGTAAA
GTTAAAGAATTTTGAGACAATGGCCACATTTAGAAGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001019489	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAT39522	(Get FASTA)	NCBI Sequence Viewer
	EDM15024	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012656
	ENSRNOP00000012656.4
	ENSRNOP00000106172.1

RefSeq Acc Id:

NP_001019489 ⟸ NM_001024318

- UniProtKB:

Q6J757 (UniProtKB/TrEMBL), F7EPG5 (UniProtKB/TrEMBL), A6IDT7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDGITASMSRAGAAKLVKKEFLEALKTNDFEKLKAILIERQIDVDTVFEVEDENMILASYKQGY
WLPSYKLKSSWATGLHLSVLLGHVECLMVLLDHNATINCRPNGKTPLHVACEIANLECVKILCD
RGAKLNCYSLSGHTALHFCTTPSSIVCAKQLVSRGANVNMKTNNQDEETPLHTAAHFGLSELVA
FYVENGAIVDSMNAHMETPLAIATYWALRFKEQEYSREHHLICRMLLDNNAEVNARDDDFKSPL
HKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIY
PPQFHKVIQACHSCPKAIEVVVNAYEHIRWNIKWRRAIPDDDLEKHWDFYHSLFKVCCNTPRTL
MHLSRCAIRKALHNRCHKAIPMLSLPLSLKKYLLLEPEGIIY

hide sequence

Ensembl Acc Id:

ENSRNOP00000012656 ⟸ ENSRNOT00000012657

Ensembl Acc Id:

ENSRNOP00000106172 ⟸ ENSRNOT00000148647

Protein Domains

SOCS box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7EPG5-F1-model_v2	AlphaFold	F7EPG5	1-455	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563114	AgrOrtholog
BioCyc Gene	G2FUF-45709	BioCyc
Ensembl Genes	ENSRNOG00000009197	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000012657	ENTREZGENE
	ENSRNOT00000012657.6	UniProtKB/TrEMBL
	ENSRNOT00000148647.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	SOCS box	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	SOCS_box_dom_like	UniProtKB/TrEMBL
	SOCS_C	UniProtKB/TrEMBL
KEGG Report	rno:500017	UniProtKB/TrEMBL
NCBI Gene	500017	ENTREZGENE
PANTHER	ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE	UniProtKB/TrEMBL
	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED	UniProtKB/TrEMBL
	ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	Ank_4	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
PhenoGen	Asb4	PhenoGen
PRINTS	ANKYRIN	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009197	RatGTEx
SMART	ANK	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
Superfamily-SCOP	ANK	UniProtKB/TrEMBL
	SSF158235	UniProtKB/TrEMBL
UniProt	A0ABK0LWN7_RAT	UniProtKB/TrEMBL
	A6IDT7	ENTREZGENE, UniProtKB/TrEMBL
	F7EPG5	ENTREZGENE
	Q6J757	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7EPG5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-25	Asb4	ankyrin repeat and SOCS box-containing 4	Asb4	ankyrin repeat and SOCS box-containing protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-03	Asb4	ankyrin repeat and SOCS box-containing protein 4	Asb-4	ankyrin repeat and SOCS box-containing protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Asb-4	ankyrin repeat and SOCS box-containing protein 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI