Defb15 (defensin beta 15) - Rat Genome Database

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Gene: Defb15 (defensin beta 15) Rattus norvegicus
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Symbol: Defb15
Name: defensin beta 15
RGD ID: 1563061
Description: Predicted to enable CCR2 chemokine receptor binding activity; heparin binding activity; and lipopolysaccharide binding activity. Predicted to be involved in innate immune response. Predicted to be located in membrane; microvesicle; and nucleus. Orthologous to several human genes including DEFB106B (defensin beta 106B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog); aflatoxin B1 (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-15; beta-defensin 15; beta-defensin 15-like; defensin, beta 15; LOC100362655
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,843,661 - 76,846,359 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,843,661 - 76,846,359 (+)EnsemblGRCr8
mRatBN7.21670,141,193 - 70,143,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,141,193 - 70,143,834 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,414,882 - 75,417,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,459,938 - 79,462,579 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,709,360 - 74,712,001 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,105,290 - 75,107,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,105,290 - 75,107,931 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1675,122,996 - 75,125,627 (+)Ensemblrn6Rnor6.0
Rnor_5.01674,663,812 - 74,666,453 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41674,818,206 - 74,820,847 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,585,304 - 68,587,938 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865   PMID:20694738   PMID:23938203   PMID:24189797  


Genomics

Comparative Map Data
Defb15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,843,661 - 76,846,359 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,843,661 - 76,846,359 (+)EnsemblGRCr8
mRatBN7.21670,141,193 - 70,143,891 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,141,193 - 70,143,834 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,414,882 - 75,417,523 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,459,938 - 79,462,579 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,709,360 - 74,712,001 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,105,290 - 75,107,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,105,290 - 75,107,931 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1675,122,996 - 75,125,627 (+)Ensemblrn6Rnor6.0
Rnor_5.01674,663,812 - 74,666,453 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41674,818,206 - 74,820,847 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,585,304 - 68,587,938 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
DEFB106B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3887,482,504 - 7,486,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl87,482,504 - 7,486,400 (-)Ensemblhg38GRCh38
GRCh38.p14 Ensembl87,825,139 - 7,829,053 (+)Ensemblhg38GRCh38
GRCh3787,340,026 - 7,343,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3687,327,436 - 7,331,319 (-)NCBIBuild 36Build 36hg18NCBI36
Cytogenetic Map8p23.1NCBI
HuRef86,965,939 - 6,967,992 (+)NCBIHuRef
CHM1_187,283,884 - 7,287,767 (+)NCBICHM1_1
T2T-CHM13v2.087,211,498 - 7,215,418 (-)NCBIT2T-CHM13v2.0
Defb15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,419,813 - 22,422,728 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,419,815 - 22,422,726 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38821,929,813 - 21,932,710 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,929,799 - 21,932,710 (-)Ensemblmm10GRCm38
MGSCv37823,040,285 - 23,043,182 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36823,395,344 - 23,398,256 (-)NCBIMGSCv36mm8
Celera823,420,631 - 23,423,529 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.64NCBI
LOC110257188
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11537,989,086 - 37,996,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Defb15
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000018375, ENSRNOT00000058066
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)167523528581732231Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat


Expression

RNA-SEQ Expression

endoderm
mesenchyme
renal system
reproductive system
respiratory system
1 9 9 13 1

Sequence


Ensembl Acc Id: ENSRNOT00000018375   ⟹   ENSRNOP00000018375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1675,122,996 - 75,125,627 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000058066   ⟹   ENSRNOP00000054874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1676,843,661 - 76,846,359 (+)Ensembl
mRatBN7.2 Ensembl1670,141,193 - 70,143,834 (+)Ensembl
Rnor_6.0 Ensembl1675,105,290 - 75,107,931 (-)Ensembl
RefSeq Acc Id: NM_001037520   ⟹   NP_001032609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,843,661 - 76,846,359 (+)NCBI
mRatBN7.21670,141,193 - 70,143,891 (+)NCBI
Rnor_6.01675,105,290 - 75,107,931 (-)NCBI
Rnor_5.01674,663,812 - 74,666,453 (+)NCBI
RGSC_v3.41674,818,206 - 74,820,847 (+)RGD
Celera1668,585,304 - 68,587,938 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032609 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51886 (Get FASTA)   NCBI Sequence Viewer  
  EDM08965 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054874
GenBank Protein Q32ZH6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032609   ⟸   NM_001037520
- Peptide Label: precursor
- UniProtKB: Q32ZH6 (UniProtKB/Swiss-Prot),   A0A0G2JSN0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018375   ⟸   ENSRNOT00000018375
Ensembl Acc Id: ENSRNOP00000054874   ⟸   ENSRNOT00000058066
Protein Domains
Beta-defensin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZH6-F1-model_v2 AlphaFold Q32ZH6 1-79 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563061 AgrOrtholog
BioCyc Gene G2FUF-10846 BioCyc
Ensembl Genes ENSRNOG00000045897 Ensembl
  ENSRNOG00000048359 Ensembl
  ENSRNOG00000065276 Ensembl
  ENSRNOG00000072020 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000058066 ENTREZGENE
Gene3D-CATH Antimicrobial Peptide, Beta-defensin 2, Chain A UniProtKB/Swiss-Prot
InterPro Beta_defensin UniProtKB/Swiss-Prot
KEGG Report rno:641645 UniProtKB/Swiss-Prot
NCBI Gene 641645 ENTREZGENE
Pfam Defensin_beta_2 UniProtKB/Swiss-Prot
PhenoGen Defb15 PhenoGen
RatGTEx ENSRNOG00000045897 RatGTEx
  ENSRNOG00000048359 RatGTEx
  ENSRNOG00000065276 RatGTEx
  ENSRNOG00000072020 RatGTEx
UniProt A0A0G2JSN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JSX4_RAT UniProtKB/TrEMBL
  A6IWA7_RAT UniProtKB/TrEMBL
  DFB15_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Defb15  defensin beta 15  LOC100362655  beta-defensin 15-like  Data merged from RGD:2324303 737654 PROVISIONAL
2010-05-06 LOC100362655  beta-defensin 15-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-07 Defb15  defensin beta 15    beta-defensin 15  Name updated 1299863 APPROVED
2006-02-09 Defb15  beta-defensin 15      Symbol and Name status set to provisional 70820 PROVISIONAL