Eola1 (endothelium and lymphocyte associated ASCH domain 1) - Rat Genome Database

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Gene: Eola1 (endothelium and lymphocyte associated ASCH domain 1) Rattus norvegicus
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Symbol: Eola1 (Ensembl: Eola2)
Name: endothelium and lymphocyte associated ASCH domain 1 (Ensembl:endothelium and lymphocyte associated ASCH domain 2)
RGD ID: 1562747
Description: Orthologous to several human genes including EOLA2 (endothelium and lymphocyte associated ASCH domain 2); INTERACTS WITH bisphenol A; dibutyl phthalate; furan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC292328; LOC292328; RGD1562747; similar to RIKEN cDNA 1110012L19; uncharacterized protein LOC292328
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,108,628 - 154,113,426 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2X149,064,015 - 149,068,627 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX151,258,277 - 151,261,793 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X154,792,460 - 154,795,976 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X152,334,022 - 152,337,538 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
RGSC_v3.4X156,620,142 - 156,623,658 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic MapX Ensembl
Cytogenetic MapXq37NCBI
Cytogenetic MapX Ensembl
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18534126   PMID:34800366  


Genomics

Comparative Map Data
Eola1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,108,628 - 154,113,426 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2X149,064,015 - 149,068,627 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX151,258,277 - 151,261,793 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X154,792,460 - 154,795,976 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X152,334,022 - 152,337,538 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
RGSC_v3.4X156,620,142 - 156,623,658 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Cytogenetic MapX Ensembl
Cytogenetic MapXq37NCBI
Cytogenetic MapX Ensembl
EOLA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X149,540,601 - 149,555,345 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX149,536,605 - 149,550,510 (+)Ensemblhg38GRCh38
GRCh37X148,622,146 - 148,636,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X148,430,463 - 148,436,760 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X148,328,316 - 148,334,613NCBI
CeleraX148,971,238 - 148,980,804 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX137,575,573 - 137,585,411 (+)NCBIHuRef
CHM1_1X148,583,532 - 148,593,099 (+)NCBICHM1_1
T2T-CHM13v2.0X147,806,368 - 147,821,110 (+)NCBIT2T-CHM13v2.0
Eola1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X69,429,519 - 69,433,022 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX69,429,483 - 69,433,023 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X70,385,913 - 70,389,416 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX70,385,877 - 70,389,417 (+)Ensemblmm10GRCm38
MGSCv37X67,639,088 - 67,642,591 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X66,646,469 - 66,649,972 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.2NCBI
cM MapX36.02NCBI
Eola1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554981,911,103 - 1,916,645 (+)NCBIChiLan1.0ChiLan1.0
EOLA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X150,060,911 - 150,074,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X150,069,781 - 150,078,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X139,577,979 - 139,587,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X149,508,737 - 149,523,459 (-)NCBIPanPan1.1PanPan1.1panPan2
EOLA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X117,536,100 - 117,559,404 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X119,594,974 - 119,617,352 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX119,594,984 - 119,617,349 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X116,706,963 - 116,729,273 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X118,918,298 - 118,940,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X119,549,239 - 119,571,605 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100515119
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X121,769,595 - 121,777,428 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X139,227,098 - 139,231,267 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EOLA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X124,529,014 - 124,543,153 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606562,220,348 - 62,234,690 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:112
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000056518
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat

Markers in Region
RH128792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X149,067,413 - 149,067,563 (+)MAPPERmRatBN7.2
Rnor_6.0869,487,785 - 69,487,934NCBIRnor6.0
Rnor_5.0869,196,485 - 69,196,634UniSTSRnor5.0
RGSC_v3.4X156,620,159 - 156,620,308UniSTSRGSC3.4
Celera1132,341,875 - 132,342,024UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056518   ⟹   ENSRNOP00000053358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl869,484,323 - 69,487,951 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077290   ⟹   ENSRNOP00000071593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl869,484,174 - 69,489,891 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095412   ⟹   ENSRNOP00000093972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX154,108,836 - 154,113,436 (+)Ensembl
mRatBN7.2 EnsemblX149,064,041 - 149,068,627 (+)Ensembl
RefSeq Acc Id: NM_001106212   ⟹   NP_001099682
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,108,863 - 154,112,379 (+)NCBI
mRatBN7.2X149,064,064 - 149,067,580 (+)NCBI
Rnor_6.0869,484,323 - 69,487,951 (+)NCBI
Rnor_5.0869,192,972 - 69,197,698 (+)NCBI
RGSC_v3.4X156,620,142 - 156,623,658 (-)RGD
Celera1132,341,858 - 132,345,374 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243225   ⟹   XP_006243287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,108,628 - 154,113,426 (+)NCBI
mRatBN7.2X149,064,015 - 149,068,627 (+)NCBI
Rnor_6.0869,484,134 - 69,488,998 (+)NCBI
Rnor_5.0869,192,972 - 69,197,698 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099682 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84454 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093972
  ENSRNOP00000093972.1
RefSeq Acc Id: NP_001099682   ⟸   NM_001106212
- UniProtKB: D3ZPT1 (UniProtKB/TrEMBL),   A6KQ84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243287   ⟸   XM_006243225
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0V2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071593   ⟸   ENSRNOT00000077290
Ensembl Acc Id: ENSRNOP00000053358   ⟸   ENSRNOT00000056518
Ensembl Acc Id: ENSRNOP00000093972   ⟸   ENSRNOT00000095412
Protein Domains
ASCH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPT1-F1-model_v2 AlphaFold D3ZPT1 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562747 AgrOrtholog
BioCyc Gene G2FUF-730 BioCyc
Ensembl Genes ENSRNOG00000037352 Ensembl
  ENSRNOG00000063254 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095412 ENTREZGENE
  ENSRNOT00000095412.2 UniProtKB/TrEMBL
Gene3D-CATH Hypothetical protein UniProtKB/TrEMBL
InterPro ASCH_domain UniProtKB/TrEMBL
  CXorf40 UniProtKB/TrEMBL
  PUA-like UniProtKB/TrEMBL
KEGG Report rno:292328 UniProtKB/TrEMBL
NCBI Gene 292328 ENTREZGENE
PANTHER PROTEIN EOLA1-RELATED UniProtKB/TrEMBL
  PTHR31666 UniProtKB/TrEMBL
PhenoGen Eola1 PhenoGen
RatGTEx ENSRNOG00000037352 RatGTEx
  ENSRNOG00000063254 RatGTEx
SMART ASCH UniProtKB/TrEMBL
Superfamily-SCOP PUA-like UniProtKB/TrEMBL
UniProt A0A0G2K0V2 ENTREZGENE
  A6KQ84 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-12-09 Eola1  endothelium and lymphocyte associated ASCH domain 1  Eola2  endothelium and lymphocyte associated ASCH domain 2  Name and Symbol changed 629549 APPROVED
2019-11-11 Eola2  endothelium and lymphocyte associated ASCH domain 2  RGD1562747  similar to RIKEN cDNA 1110012L19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562747  similar to RIKEN cDNA 1110012L19   RGD1562747_predicted  similar to RIKEN cDNA 1110012L19 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562747_predicted  similar to RIKEN cDNA 1110012L19 (predicted)  LOC292328  similar to RIKEN cDNA 1110012L19  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC292328  similar to RIKEN cDNA 1110012L19      Symbol and Name status set to provisional 70820 PROVISIONAL