Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tmem117 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TMEM117 mRNA | CTD | PMID:22079256 | Tmem117 | Rat | 1,1-dichloroethene | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of TMEM117 mRNA | CTD | PMID:26682919 | Tmem117 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Tmem117 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TMEM117 mRNA | CTD | PMID:22206623 | Tmem117 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of TMEM117 mRNA | CTD | PMID:22206623 | Tmem117 | Rat | 17beta-estradiol | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of TMEM117 mRNA | CTD | PMID:31614463 | Tmem117 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TMEM117 mRNA | CTD | PMID:32109520 | Tmem117 | Rat | 3,4-dichloroaniline | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | 3,4-dichloroaniline results in increased expression of TMEM117 mRNA | CTD | PMID:24172598 | Tmem117 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TMEM117 mRNA | CTD | PMID:26251327 | Tmem117 | Rat | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Tmem117 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of TMEM117 promoter | CTD | PMID:26251327 | Tmem117 | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | TMEM117 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of TMEM117 gene | CTD | PMID:31601247 | Tmem117 | Rat | aflatoxin B1 | affects expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of TMEM117 protein | CTD | PMID:20106945 | Tmem117 | Rat | aflatoxin B1 | increases methylation | ISO | TMEM117 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TMEM117 intron | CTD | PMID:30157460 | Tmem117 | Rat | aflatoxin B1 | decreases methylation | ISO | TMEM117 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of TMEM117 gene | CTD | PMID:27153756 | Tmem117 | Rat | aflatoxin B1 | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of TMEM117 mRNA | CTD | PMID:21632981|PMID:21641981|PMID:22100608|PMID:27153756 | Tmem117 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | TMEM117 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of TMEM117 intron | CTD | PMID:30157460 | Tmem117 | Rat | all-trans-retinoic acid | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of TMEM117 mRNA | CTD | PMID:21934132|PMID:23724009 | Tmem117 | Rat | all-trans-retinoic acid | multiple interactions | ISO | Tmem117 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of TMEM117 mRNA | CTD | PMID:36189433 | Tmem117 | Rat | all-trans-retinoic acid | increases expression | ISO | Tmem117 (Mus musculus) | 6480464 | Tretinoin results in increased expression of TMEM117 mRNA | CTD | PMID:36189433 | Tmem117 | Rat | all-trans-retinoic acid | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TMEM117 mRNA | CTD | PMID:33167477 | Tmem117 | Rat | antirheumatic drug | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of TMEM117 mRNA | CTD | PMID:24449571 | Tmem117 | Rat | aristolochic acid A | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of TMEM117 mRNA | CTD | PMID:33212167 | Tmem117 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of TMEM117 gene | CTD | PMID:35440735 | Tmem117 | Rat | benzo[a]pyrene | increases mutagenesis | ISO | TMEM117 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of TMEM117 gene | CTD | PMID:25435355 | Tmem117 | Rat | benzo[a]pyrene | increases methylation | ISO | TMEM117 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of TMEM117 3' UTR | CTD | PMID:27901495 | Tmem117 | Rat | benzo[a]pyrene | affects methylation | ISO | TMEM117 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TMEM117 intron | CTD | PMID:30157460 | Tmem117 | Rat | benzo[a]pyrene | increases methylation | ISO | Tmem117 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of TMEM117 intron | CTD | PMID:27901495 | Tmem117 | Rat | benzo[a]pyrene | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of TMEM117 mRNA | CTD | PMID:20064835|PMID:20106945|PMID:21632981|PMID:22316170|PMID:26238291 | Tmem117 | Rat | benzo[a]pyrene | affects expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the expression of TMEM117 mRNA | CTD | PMID:21714911 | Tmem117 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEM117 mRNA | CTD | PMID:19150397|PMID:26238291 | Tmem117 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of TMEM117 mRNA | CTD | PMID:31163220 | Tmem117 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of TMEM117 mRNA | CTD | PMID:25181051 | Tmem117 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TMEM117 mRNA | CTD | PMID:34947998 | Tmem117 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of TMEM117 gene | CTD | PMID:28505145 | Tmem117 | Rat | butanal | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of TMEM117 mRNA | CTD | PMID:26079696 | Tmem117 | Rat | Butylbenzyl phthalate | increases methylation | ISO | Tmem117 (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of TMEM117 intron | CTD | PMID:28392331 | Tmem117 | Rat | cadmium dichloride | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of TMEM117 mRNA | CTD | PMID:38174414 | Tmem117 | Rat | calcitriol | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of TMEM117 mRNA | CTD | PMID:16002434 | Tmem117 | Rat | carbon nanotube | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | Nanotubes, Carbon results in decreased expression of TMEM117 mRNA | CTD | PMID:25554681 | Tmem117 | Rat | cisplatin | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of TMEM117 mRNA | CTD | PMID:27392435 | Tmem117 | Rat | copper atom | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TMEM117 mRNA | CTD | PMID:20971185 | Tmem117 | Rat | copper(0) | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TMEM117 mRNA | CTD | PMID:20971185 | Tmem117 | Rat | copper(II) sulfate | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TMEM117 mRNA | CTD | PMID:19549813 | Tmem117 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of TMEM117 mRNA | CTD | PMID:27523638 | Tmem117 | Rat | cyclosporin A | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TMEM117 mRNA | CTD | PMID:25562108 | Tmem117 | Rat | dicrotophos | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of TMEM117 mRNA | CTD | PMID:28302478 | Tmem117 | Rat | diuron | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Diuron metabolite results in increased expression of TMEM117 mRNA | CTD | PMID:24172598 | Tmem117 | Rat | dorsomorphin | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Tmem117 | Rat | fenvalerate | decreases expression | EXP | | 6480464 | fenvalerate results in decreased expression of TMEM117 mRNA | CTD | PMID:30307764 | Tmem117 | Rat | folic acid | multiple interactions | ISO | Tmem117 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TMEM117 mRNA | CTD | PMID:22206623 | Tmem117 | Rat | genistein | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | Genistein results in decreased expression of TMEM117 mRNA | CTD | PMID:32186404 | Tmem117 | Rat | glyphosate | decreases methylation | EXP | | 6480464 | Glyphosate results in decreased methylation of TMEM117 gene | CTD | PMID:31011160 | Tmem117 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of TMEM117 gene | CTD | PMID:35440735 | Tmem117 | Rat | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Tmem117 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of TMEM117 mRNA | CTD | PMID:36189433 | Tmem117 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of TMEM117 gene | CTD | PMID:33148267 | Tmem117 | Rat | nickel sulfate | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of TMEM117 mRNA | CTD | PMID:22714537 | Tmem117 | Rat | O-methyleugenol | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of TMEM117 mRNA | CTD | PMID:32234424 | Tmem117 | Rat | paracetamol | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TMEM117 mRNA | CTD | PMID:26690555 | Tmem117 | Rat | perfluorohexanesulfonic acid | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | perfluorohexanesulfonic acid results in increased expression of TMEM117 mRNA | CTD | PMID:25812627 | Tmem117 | Rat | perfluorooctane-1-sulfonic acid | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in increased expression of TMEM117 mRNA | CTD | PMID:25812627 | Tmem117 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of TMEM117 gene | CTD | PMID:33148267 | Tmem117 | Rat | phenylmercury acetate | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of TMEM117 mRNA | CTD | PMID:26272509 | Tmem117 | Rat | phenylmercury acetate | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Tmem117 | Rat | pirinixic acid | multiple interactions | ISO | Tmem117 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Tmem117 | Rat | potassium chromate | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TMEM117 mRNA | CTD | PMID:22079256 | Tmem117 | Rat | potassium chromate | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of TMEM117 mRNA | CTD | PMID:22079256 | Tmem117 | Rat | quercetin | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of TMEM117 mRNA | CTD | PMID:21632981 | Tmem117 | Rat | SB 431542 | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Tmem117 | Rat | silicon dioxide | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of TMEM117 mRNA | CTD | PMID:25895662 | Tmem117 | Rat | silicon dioxide | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of TMEM117 mRNA | CTD | PMID:29341224 | Tmem117 | Rat | sodium arsenite | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of TMEM117 mRNA | CTD | PMID:22714537 | Tmem117 | Rat | sodium arsenite | decreases expression | ISO | Tmem117 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of TMEM117 mRNA | CTD | PMID:37682722 | Tmem117 | Rat | sodium arsenite | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TMEM117 mRNA | CTD | PMID:38568856 | Tmem117 | Rat | sotorasib | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM117 mRNA | CTD | PMID:36139627 | Tmem117 | Rat | sunitinib | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of TMEM117 mRNA | CTD | PMID:31533062 | Tmem117 | Rat | titanium dioxide | increases methylation | ISO | Tmem117 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of TMEM117 promoter | CTD | PMID:35295148 | Tmem117 | Rat | trametinib | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of TMEM117 mRNA | CTD | PMID:36139627 | Tmem117 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of TMEM117 mRNA | CTD | PMID:33387578 | Tmem117 | Rat | trichostatin A | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of TMEM117 mRNA | CTD | PMID:24935251 | Tmem117 | Rat | triphenyl phosphate | affects expression | ISO | TMEM117 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of TMEM117 mRNA | CTD | PMID:37042841 | Tmem117 | Rat | urethane | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Urethane results in decreased expression of TMEM117 mRNA | CTD | PMID:28818685 | Tmem117 | Rat | valproic acid | decreases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TMEM117 mRNA | CTD | PMID:23179753 | Tmem117 | Rat | valproic acid | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Tmem117 | Rat | valproic acid | increases expression | ISO | TMEM117 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TMEM117 mRNA | CTD | PMID:24383497|PMID:26272509 | Tmem117 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of TMEM117 gene | CTD | PMID:31079544|PMID:31682807 | Tmem117 | Rat | zinc atom | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TMEM117 mRNA | CTD | PMID:18593933 | Tmem117 | Rat | zinc(0) | multiple interactions | ISO | TMEM117 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TMEM117 mRNA | CTD | PMID:18593933 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















