Rab17 (RAB17, member RAS oncogene family) - Rat Genome Database

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Gene: Rab17 (RAB17, member RAS oncogene family) Rattus norvegicus
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Symbol: Rab17
Name: RAB17, member RAS oncogene family
RGD ID: 1562478
Description: Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; plasma membrane bounded cell projection assembly; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynapse. Orthologous to human RAB17 (RAB17, member RAS oncogene family); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC503269; ras-related protein Rab-17; RGD1562478; similar to RAB17, member RAS oncogene family
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,001,044 - 99,014,340 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,001,045 - 99,014,032 (-)EnsemblGRCr8
mRatBN7.2991,552,924 - 91,566,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,553,464 - 91,566,451 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx999,980,262 - 99,993,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,116,022 - 105,129,014 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,481,328 - 103,494,316 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,118,907 - 98,131,883 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,118,908 - 98,131,883 (-)Ensemblrn6Rnor6.0
Rnor_5.0997,800,064 - 97,813,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,159,592 - 90,198,282 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,097,774 - 89,109,527 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8486736   PMID:9490718   PMID:9624171   PMID:12477932   PMID:17646400   PMID:19056867   PMID:20937701   PMID:21291502   PMID:22291024   PMID:24895134   PMID:30256711  


Genomics

Comparative Map Data
Rab17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,001,044 - 99,014,340 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl999,001,045 - 99,014,032 (-)EnsemblGRCr8
mRatBN7.2991,552,924 - 91,566,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,553,464 - 91,566,451 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx999,980,262 - 99,993,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,116,022 - 105,129,014 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,481,328 - 103,494,316 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,118,907 - 98,131,883 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,118,908 - 98,131,883 (-)Ensemblrn6Rnor6.0
Rnor_5.0997,800,064 - 97,813,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4990,159,592 - 90,198,282 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera989,097,774 - 89,109,527 (-)NCBICelera
Cytogenetic Map9q36NCBI
RAB17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,574,326 - 237,590,734 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,574,322 - 237,601,623 (-)Ensemblhg38GRCh38
GRCh372238,482,969 - 238,499,377 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,147,704 - 238,177,653 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342238,264,964 - 238,281,736NCBI
Celera2232,196,815 - 232,213,528 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,273,094 - 230,289,898 (-)NCBIHuRef
CHM1_12238,488,032 - 238,504,837 (-)NCBICHM1_1
T2T-CHM13v2.02238,064,233 - 238,091,618 (-)NCBIT2T-CHM13v2.0
Rab17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39190,885,855 - 90,897,395 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl190,885,855 - 90,897,383 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38190,958,133 - 90,969,673 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,958,133 - 90,969,661 (-)Ensemblmm10GRCm38
MGSCv37192,854,710 - 92,866,197 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36192,788,541 - 92,800,026 (-)NCBIMGSCv36mm8
Celera193,903,499 - 93,914,395 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.84NCBI
Rab17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555422,751,953 - 2,759,661 (+)NCBIChiLan1.0ChiLan1.0
RAB17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,202,994 - 140,229,285 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,216,354 - 140,242,919 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B124,802,789 - 124,820,775 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B243,654,176 - 243,671,003 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B243,654,176 - 243,671,003 (-)EnsemblpanPan2panpan1.1
RAB17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,181,557 - 48,220,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,188,085 - 48,203,149 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2548,678,331 - 48,717,616 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02548,566,563 - 48,606,048 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2548,573,948 - 48,588,458 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,442,454 - 48,482,046 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,230,979 - 48,270,251 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,462,757 - 48,502,042 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,174,049 - 190,221,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525748,600 - 765,642 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936525748,851 - 765,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,235,936 - 137,261,057 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115137,232,781 - 137,255,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215151,631,277 - 151,635,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110123,579,771 - 123,603,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10123,580,621 - 123,594,374 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604075,803,128 - 75,824,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab17
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14162,964,689 - 162,971,699 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rab17
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:385
Count of miRNA genes:221
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000026918
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH132977  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,553,531 - 91,553,719 (+)MAPPERmRatBN7.2
Rnor_6.0998,118,976 - 98,119,163NCBIRnor6.0
Rnor_5.0997,800,133 - 97,800,320UniSTSRnor5.0
RGSC_v3.4990,159,661 - 90,159,848UniSTSRGSC3.4
Celera989,097,843 - 89,098,030UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 4 26 37 85 89 59 23 59 6 224 64 2 20 81 84 30 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000079446   ⟹   ENSRNOP00000068669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl999,001,045 - 99,014,032 (-)Ensembl
mRatBN7.2 Ensembl991,553,464 - 91,566,451 (-)Ensembl
Rnor_6.0 Ensembl998,118,908 - 98,131,883 (-)Ensembl
RefSeq Acc Id: NM_001109363   ⟹   NP_001102833
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,001,044 - 99,014,032 (-)NCBI
mRatBN7.2991,553,463 - 91,566,451 (-)NCBI
Rnor_6.0998,118,907 - 98,131,883 (-)NCBI
Rnor_5.0997,800,064 - 97,813,040 (-)NCBI
RGSC_v3.4990,159,592 - 90,198,282 (-)RGD
Celera989,097,774 - 89,109,527 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084134   ⟹   XP_038940062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,001,044 - 99,014,340 (-)NCBI
mRatBN7.2991,552,924 - 91,566,759 (-)NCBI
RefSeq Acc Id: XM_039084135   ⟹   XP_038940063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,001,044 - 99,014,340 (-)NCBI
mRatBN7.2991,552,924 - 91,566,759 (-)NCBI
RefSeq Acc Id: NP_001102833   ⟸   NM_001109363
- UniProtKB: B2RZ46 (UniProtKB/TrEMBL),   A0A0G2JTD9 (UniProtKB/TrEMBL),   A0A9K3Y7P9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068669   ⟸   ENSRNOT00000079446
RefSeq Acc Id: XP_038940062   ⟸   XM_039084134
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTD9 (UniProtKB/TrEMBL),   B2RZ46 (UniProtKB/TrEMBL),   A0A9K3Y7P9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940063   ⟸   XM_039084135
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTD9 (UniProtKB/TrEMBL),   B2RZ46 (UniProtKB/TrEMBL),   A0A9K3Y7P9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTD9-F1-model_v2 AlphaFold A0A0G2JTD9 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696852
Promoter ID:EPDNEW_R7377
Type:single initiation site
Name:Rab17_1
Description:RAB17, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,131,866 - 98,131,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562478 AgrOrtholog
BioCyc Gene G2FUF-26731 BioCyc
Ensembl Genes ENSRNOG00000052979 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079446 ENTREZGENE
  ENSRNOT00000079446.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126868 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Rab_GTPases_membrane_traffic UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:503269 UniProtKB/TrEMBL
MGC_CLONE MGC:189241 IMAGE-MGC_LOAD
NCBI Gene 503269 ENTREZGENE
PANTHER DRAB11-RELATED UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rab17 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052979 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JTD9 ENTREZGENE
  A0A9K3Y7P9 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ46 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JTD9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Rab17  RAB17, member RAS oncogene family  RGD1562478_predicted  similar to RAB17, member RAS oncogene family (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562478_predicted  similar to RAB17, member RAS oncogene family (predicted)  LOC503269  similar to RAB17, member RAS oncogene family  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503269  similar to RAB17, member RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL