Muc5b (mucin 5B, oligomeric mucus/gel-forming) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Muc5b (mucin 5B, oligomeric mucus/gel-forming) Rattus norvegicus
Analyze
Symbol: Muc5b
Name: mucin 5B, oligomeric mucus/gel-forming
RGD ID: 1561983
Description: Predicted to be an extracellular matrix structural constituent. Predicted to act upstream of or within defense response to bacterium and regulation of macrophage activation. Predicted to be located in mucus layer. Predicted to be active in extracellular matrix and extracellular space. Biomarker of nasopharynx carcinoma. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; interstitial lung disease 2; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming); INTERACTS WITH astragaloside IV; atrazine; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309114; mucin-5B; RGD1561983; similar to Muc5b protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,346,400 - 206,378,367 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1206,346,400 - 206,378,367 (+)EnsemblGRCr8
mRatBN7.21196,916,861 - 196,948,830 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,916,825 - 196,949,250 (+)EnsemblmRatBN7.2
Rnor_6.01214,778,459 - 214,811,237 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,778,496 - 214,810,720 (+)Ensemblrn6Rnor6.0
Rnor_5.01221,691,881 - 221,724,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,962,340 - 201,997,147 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,545,288 - 194,577,247 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astragaloside IV  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxynivalenol  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
icariin  (EXP)
leflunomide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
Nivalenol  (ISO)
nobiletin  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
Paeonol  (EXP)
paraquat  (EXP)
permethrin  (EXP)
pioglitazone  (ISO)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium lactate  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Variants of MUC5B minisatellites and the susceptibility of bladder cancer. Ahn EK, etal., DNA Cell Biol. 2009 Apr;28(4):169-76. doi: 10.1089/dna.2008.0827.
2. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Balague C, etal., Gastroenterology. 1995 Sep;109(3):953-64.
3. In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Chen Y, etal., Am J Respir Crit Care Med. 2001 Sep 15;164(6):1059-66.
4. Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion. Elsheikh MN and Mahfouz ME, Laryngoscope. 2006 Mar;116(3):365-9.
5. Mucin deficiency causes functional and structural changes of the ocular surface. Floyd AM, etal., PLoS One. 2012;7(12):e50704. doi: 10.1371/journal.pone.0050704. Epub 2012 Dec 18.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Regulation of MUC5 and MUC1 gene expression: correlation with airway mucous differentiation. Guzman K, etal., Am J Physiol 1996 May;270(5 Pt 1):L846-53.
8. Epidermal growth factor regulates expression of the mucous phenotype of rat tracheal epithelial cells. Guzman K, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):412-8.
9. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation. Henke MO, etal., Am J Respir Crit Care Med. 2007 Apr 15;175(8):816-21. Epub 2007 Jan 25.
10. Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis. Kamio K, etal., Am J Respir Crit Care Med. 2005 May 1;171(9):949-57. Epub 2005 Feb 11.
11. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Kirkham S, etal., Am J Respir Crit Care Med. 2008 Nov 15;178(10):1033-9. Epub 2008 Sep 5.
12. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Kirkham S, etal., Biochem J. 2002 Feb 1;361(Pt 3):537-46.
13. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
14. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
15. Expression of mucins in mucoid otitis media. Lin J, etal., J Assoc Res Otolaryngol. 2003 Sep;4(3):384-93.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Altered sialyl- and fucosyl-linkage on mucins in cystic fibrosis patients promotes formation of the sialyl-Lewis X determinant on salivary MUC-5B and MUC-7. Shori DK, etal., Pflugers Arch. 2001;443 Suppl 1:S55-61. Epub 2001 Sep 28.
21. HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis. Tang FQ, etal., Cancer Sci. 2008 Dec 4.
22. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. Tian C, etal., PLoS One. 2012;7(4):e34944. doi: 10.1371/journal.pone.0034944. Epub 2012 Apr 23.
23. MUC5B secretion is up-regulated in sinusitis compared with controls. Viswanathan H, etal., Am J Rhinol. 2006 Sep-Oct;20(5):554-7.
Additional References at PubMed
PMID:16502470   PMID:23533145   PMID:24317696   PMID:31170201  


Genomics

Comparative Map Data
Muc5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,346,400 - 206,378,367 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1206,346,400 - 206,378,367 (+)EnsemblGRCr8
mRatBN7.21196,916,861 - 196,948,830 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,916,825 - 196,949,250 (+)EnsemblmRatBN7.2
Rnor_6.01214,778,459 - 214,811,237 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,778,496 - 214,810,720 (+)Ensemblrn6Rnor6.0
Rnor_5.01221,691,881 - 221,724,641 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41201,962,340 - 201,997,147 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1194,545,288 - 194,577,247 (+)NCBICelera
Cytogenetic Map1q41NCBI
MUC5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,223,066 - 1,262,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,223,066 - 1,262,172 (+)Ensemblhg38GRCh38
GRCh37111,244,296 - 1,283,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,200,872 - 1,239,982 (+)NCBIBuild 36Build 36hg18NCBI36
Celera111,282,436 - 1,319,815 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,037,643 - 1,074,965 (+)NCBIHuRef
CHM1_1111,243,203 - 1,282,327 (+)NCBICHM1_1
T2T-CHM13v2.0111,294,310 - 1,333,348 (+)NCBIT2T-CHM13v2.0
Muc5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,392,796 - 141,426,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,392,807 - 141,426,821 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387141,839,059 - 141,873,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,839,070 - 141,873,084 (+)Ensemblmm10GRCm38
MGSCv377149,024,977 - 149,058,990 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367141,648,460 - 141,682,474 (+)NCBIMGSCv36mm8
Celera7141,593,709 - 141,626,780 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.29NCBI
Muc5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547611,021,665 - 11,049,239 (-)NCBIChiLan1.0ChiLan1.0
MUC5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,636,561 - 3,678,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,848,247 - 2,890,386 (+)NCBINHGRI_mPanPan1
MUC5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,517,479 - 45,545,765 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,517,474 - 45,545,184 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,126,169 - 44,157,219 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01846,196,222 - 46,227,346 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11845,644,488 - 45,675,326 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,224,935 - 45,256,112 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,962,705 - 45,994,038 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Muc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947920,929 - 940,708 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936816174,943 - 209,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12807,685 - 842,096 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MUC5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,040,756 - 1,083,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,042,110 - 1,081,240 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603898,170,452 - 98,213,879 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,398,595 - 21,425,755 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Muc5b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v127,656,743 - 7,687,845 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Muc5b
288 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:97
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000028967, ENSRNOT00000073645
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
AA945883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,948,475 - 196,948,686 (+)MAPPERmRatBN7.2
Rnor_6.01214,810,883 - 214,811,093NCBIRnor6.0
Rnor_5.01221,724,287 - 221,724,497UniSTSRnor5.0
Celera1194,576,893 - 194,577,103UniSTS
RH 3.4 Map11438.9UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 12 30 23 30 5 9 5 3 76 34 5 16 21 67 25

Sequence


Ensembl Acc Id: ENSRNOT00000028967   ⟹   ENSRNOP00000036806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1206,346,400 - 206,378,367 (+)Ensembl
mRatBN7.2 Ensembl1196,916,825 - 196,948,847 (+)Ensembl
Rnor_6.0 Ensembl1214,778,496 - 214,810,720 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095664   ⟹   ENSRNOP00000093192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,919,544 - 196,948,847 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110437   ⟹   ENSRNOP00000083565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,916,825 - 196,949,250 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113273   ⟹   ENSRNOP00000086793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,916,825 - 196,948,313 (+)Ensembl
RefSeq Acc Id: NM_001427156   ⟹   NP_001414085
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81206,346,400 - 206,378,367 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414085 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM12106 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036806
  ENSRNOP00000036806.7
Ensembl Acc Id: ENSRNOP00000036806   ⟸   ENSRNOT00000028967
Ensembl Acc Id: ENSRNOP00000083565   ⟸   ENSRNOT00000110437
Ensembl Acc Id: ENSRNOP00000086793   ⟸   ENSRNOT00000113273
Ensembl Acc Id: ENSRNOP00000093192   ⟸   ENSRNOT00000095664
RefSeq Acc Id: NP_001414085   ⟸   NM_001427156
- Peptide Label: precursor
- UniProtKB: D3ZAU0 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690557
Promoter ID:EPDNEW_R1079
Type:single initiation site
Name:Muc5b_1
Description:mucin 5B, oligomeric mucus/gel-forming
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01214,778,451 - 214,778,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561983 AgrOrtholog
BioCyc Gene G2FUF-56932 BioCyc
Ensembl Genes ENSRNOG00000019846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028967 ENTREZGENE
  ENSRNOT00000028967.8 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  WxxW_domain UniProtKB/TrEMBL
NCBI Gene 309114 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  MUCIN-5B UniProtKB/TrEMBL
Pfam Mucin2_WxxW UniProtKB/TrEMBL
  PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Muc5b PhenoGen
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019846 RatGTEx
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
UniProt D3ZAU0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-19 Muc5b  mucin 5B, oligomeric mucus/gel-forming  RGD1561983  similar to Muc5b protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561983  similar to Muc5b protein   RGD1561983_predicted  similar to Muc5b protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561983_predicted  similar to Muc5b protein (predicted)  LOC309114  similar to Muc5b protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309114  similar to Muc5b protein      Symbol and Name status set to provisional 70820 PROVISIONAL