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Gene: Lefty1 (left right determination factor 1) Rattus norvegicus

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Symbol:

Lefty1

Name:

left right determination factor 1

RGD ID:

1561867

Description:

Predicted to enable cytokine activity and nodal binding activity. Predicted to be involved in several processes, including BMP signaling pathway; negative regulation of nodal receptor complex assembly; and regionalization. Predicted to act upstream of or within cell migration involved in gastrulation; negative regulation of cell population proliferation; and response to retinoic acid. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including LEFTY1 (left-right determination factor 1); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH amphetamine; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

left-right determination factor 1; LOC498299; RGD1561867; similar to Stra3 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LEFTY1 (left-right determination factor 1)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lefty1 (left right determination factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100969502 (left-right determination factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LEFTY1 (left-right determination factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100524517 (left-right determination factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LEFTY2 (left-right determination factor 2)	HGNC	EggNOG, Ensembl, Inparanoid, OrthoDB, Panther, PhylomeDB, Treefam
Homo sapiens (human):	PKP1 (plakophilin 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	LEFTY2 (left-right determination factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LEFTY1 (left-right determination factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lefty1 (left right determination factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lft2 (lefty2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lft2 (lefty2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	lft1 (lefty1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lefty	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lefty	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	95,188,091 - 95,191,488 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	95,188,091 - 95,191,488 (+)	Ensembl				GRCr8
mRatBN7.2	13	92,649,226 - 92,659,722 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,656,323 - 92,659,720 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	95,161,640 - 95,165,037 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,561,569 - 96,564,966 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	93,736,266 - 93,739,663 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	99,212,778 - 99,217,786 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	99,214,389 - 99,217,786 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	104,212,236 - 104,215,633 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	96,664,408 - 96,667,805 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	92,199,283 - 92,202,680 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

myocardial infarction (ISO)

Tubulointerstitial Fibrosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

acetaldehyde (ISO)

acetic acid (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromochloroacetic acid (ISO)

butanal (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chrysene (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyproconazole (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

doxorubicin (ISO)

ethanol (ISO)

flusilazole (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

hexaconazole (ISO)

mifepristone (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

permethrin (EXP)

progesterone (ISO)

propanal (ISO)

rifampicin (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior axis specification (IBA,ISO)

BMP signaling pathway (IBA)

cell migration involved in gastrulation (ISO)

determination of left/right symmetry (IEA,ISO)

heart morphogenesis (IEA,ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of nodal receptor complex assembly (IEA,ISO)

negative regulation of nodal signaling pathway (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

response to retinoic acid (ISO)

Cellular Component

extracellular region (IEA,ISO)

extracellular space (IBA,IEA)

Molecular Function

cytokine activity (IBA,IEA)

growth factor activity (IEA)

nodal binding (IEA,ISO)

transforming growth factor beta receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

transforming growth factor-beta superfamily mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.	Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.	Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.

Additional References at PubMed

PMID:9708732	PMID:10500184	PMID:15004567	PMID:15062104	PMID:29286065

Genomics

Comparative Map Data

Lefty1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	95,188,091 - 95,191,488 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	95,188,091 - 95,191,488 (+)	Ensembl				GRCr8
mRatBN7.2	13	92,649,226 - 92,659,722 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,656,323 - 92,659,720 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	95,161,640 - 95,165,037 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,561,569 - 96,564,966 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	93,736,266 - 93,739,663 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	99,212,778 - 99,217,786 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	99,214,389 - 99,217,786 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	104,212,236 - 104,215,633 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	96,664,408 - 96,667,805 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	92,199,283 - 92,202,680 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

LEFTY1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	225,886,282 - 225,889,146 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	225,886,279 - 225,911,382 (-)	Ensembl			hg38	GRCh38
GRCh37	1	226,073,982 - 226,076,846 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	224,140,605 - 224,143,459 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	222,380,717 - 222,383,571	NCBI
Celera	1	199,265,024 - 199,267,877 (-)	NCBI		Celera
Cytogenetic Map	1	q42.12	NCBI
HuRef	1	196,591,667 - 196,594,530 (-)	NCBI		HuRef
CHM1_1	1	227,346,296 - 227,349,159 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	225,074,031 - 225,076,895 (-)	NCBI		T2T-CHM13v2.0

Lefty1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,762,587 - 180,765,966 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	180,762,587 - 180,765,965 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	180,935,022 - 180,938,401 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,935,022 - 180,938,400 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	182,865,170 - 182,868,532 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	182,771,734 - 182,775,075 (+)	NCBI		MGSCv36	mm8
Celera	1	187,999,497 - 188,003,975 (+)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.46	NCBI

LOC100969502
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	23,638,440 - 23,651,563 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	23,586,789 - 23,599,910 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	201,347,411 - 201,351,295 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	206,347,974 - 206,351,201 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	206,348,419 - 206,350,787 (-)	Ensembl			panPan2	panpan1.1

LEFTY1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	38,932,668 - 38,934,989 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	38,414,884 - 38,417,205 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	38,766,526 - 38,768,964 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	38,766,707 - 38,768,939 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	38,606,312 - 38,608,748 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	38,614,462 - 38,616,899 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	38,884,233 - 38,886,670 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC100524517
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	10	13,815,157 - 13,819,249 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	15,951,740 - 15,974,455 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in Lefty1
53 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	52
Count of miRNA genes:	47
Interacting mature miRNAs:	51
Transcripts:	ENSRNOT00000004354
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

AU048458

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	95,187,040 - 95,187,265 (+)	Marker Load Pipeline
mRatBN7.2	13	92,655,271 - 92,655,497 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	99,213,339 - 99,213,563	NCBI	Rnor6.0
Rnor_5.0	13	104,211,186 - 104,211,410	UniSTS	Rnor5.0
RGSC_v3.4	13	96,663,358 - 96,663,582	UniSTS	RGSC3.4
Cytogenetic Map	13	q26	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	3	23	70	49	49	25	47	25	6	169	93	10	47	37	63	24	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004354 ⟹ ENSRNOP00000004354

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	95,188,091 - 95,191,488 (+)	Ensembl
mRatBN7.2 Ensembl	13	92,656,323 - 92,659,720 (+)	Ensembl
Rnor_6.0 Ensembl	13	99,214,389 - 99,217,786 (+)	Ensembl

RefSeq Acc Id:

NM_001109080 ⟹ NP_001102550

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	95,188,091 - 95,191,488 (+)	NCBI
mRatBN7.2	13	92,656,323 - 92,659,720 (+)	NCBI
Rnor_6.0	13	99,214,389 - 99,217,786 (+)	NCBI
Rnor_5.0	13	104,212,236 - 104,215,633 (+)	NCBI
RGSC_v3.4	13	96,664,408 - 96,667,805 (+)	RGD
Celera	13	92,199,283 - 92,202,680 (+)	RGD

Sequence:

show sequence

GTACCAGCCCTCAGCAGACTCAAGACCCTTTCAAGACACCTGAGGGACACAAGAGCTACAGGTT
CTCTTCCTGGGCAGCACCATGCGGTTCCTATGGCTCTGTTGGGCACTCTGGGCACTATTCCAGG
TTAGCCCTGGAGAAGCCCTGACTGGAGAGCAGGTCCTGGGCAGCCTTCTGCAACAGCTGCGGCT
TGATCGACCGCCAGTCTTGGACAAGGCTGATGTGGAGGGAATGGTCATCCCCTCGCATGTGAGG
GCCCAGTATGTGGCCCTGCTCCAGCACAGCCATGACAGCCGCTCCCGAGGCAAGAGGTTTAGCC
AGAACTTTCGAGAGGTGGCAGGCAGGTTCCTGGTGTCAGAGACCTCCAGTCACCTGCTGGTGTT
CGGCATGGAGCAGCGGCTGCCGCCTAACAGTGAGCTGGTGCAGGCTGTGCTGCGGCTGTTCCAG
GAGCCTGTGCCCAGAACAGCTCTCCGGAGGCAAAAGAGGCTGTCCCCACACAGCGCCCGGGCTC
GGGTCACCATTGAATGGCTGCGCTTCCGCGAGGATGGCTCCAACCGTACCGCCCTTATCGATTC
TAGGCTCGTGTCCATCCACGAGAGCGGCTGGAAGGTCTTCGATGTGACCGAGGCCGTGAACTTC
TGGCAGCAGCTGAGCCGGCCGAGGCAGCCGCTGCTGCTCCAGGTGTCGGTGCAGAGGGAGCATC
TGGGACCGGGGACCTGGAGCGCACACAAGTTGGTCCGGTTCGCGGCGCAGGGGACGCCGGACGG
CAAGGGGCTGGGCGAGCCACAGCTGGAGCTGCACACGCTGGACCTCAAGGACTATGGGGCTCAA
GGCAATTGTGACCCCGAGACACCAGTGACTGAAGGCACCCGATGCTGTCGCCAAGAGATGTACC
TGGACCTGCAGGGGATGAAGTGGGCTGAGAACTGGATCCTAGAACCCCCAGGATTCCTGACTTA
CGAATGTGTGGGCAGCTGCCTGCAGCCACCAGAGTCCCTGACCATCAGGTGGCCATTTCTGGGG
CCTCGGCAGTGTGTGGCCTCAGAGATGACTTCCTTGCCCCTGATTGTCAGCATAAAGGAGGACG
GCAGGACCAGGCCTCAAGTGGTCAGCCTGCCCAACATGAGGGTGCAGAGGTGTAGCTGTGCCTC
GGATGGGGCGCTCATACCCAGGAGGCTGGAGCCATAGGCACAGGGCGTGGCCTCCCCAAGGACG
TGACGGTAATATACGGGGAGAGATGGGGATTCTAAATCCCTAAGGGGCGAATGCTCTGCGTGGT
CCTCTGAACCAGCCCCATCCCTAAATTTTACCTTCAAGGAATGTGACTCGCTGGCCACTGGAGG
CGCCACCTAGTGGTCTCTGTCCTTCATATTGTTTACTGCACTGTATACGAAGCACTTACCTGTA
TAGAAACCGTAAACTAAGGACAGAATCCCGAACTGCCATTGCTCCCTTAATCTGTCCCTGTATC
TGGGCTGAGCCCCAGTCTTGTCTCTGGACCTAAGACCCAAGTGTATCAAACTAGGTAATACCAG
CTTTGCTAGATGGGAATAAAATATGTTTTGCTTTGT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102550	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94838	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004354
	ENSRNOP00000004354.3

RefSeq Acc Id:	NP_001102550 ⟸ NM_001109080
- Peptide Label:	precursor
- UniProtKB:	D4A670 (UniProtKB/TrEMBL), A6JGI2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRFLWLCWALWALFQVSPGEALTGEQVLGSLLQQLRLDRPPVLDKADVEGMVIPSHVRAQYVAL LQHSHDSRSRGKRFSQNFREVAGRFLVSETSSHLLVFGMEQRLPPNSELVQAVLRLFQEPVPRT ALRRQKRLSPHSARARVTIEWLRFREDGSNRTALIDSRLVSIHESGWKVFDVTEAVNFWQQLSR PRQPLLLQVSVQREHLGPGTWSAHKLVRFAAQGTPDGKGLGEPQLELHTLDLKDYGAQGNCDPE TPVTEGTRCCRQEMYLDLQGMKWAENWILEPPGFLTYECVGSCLQPPESLTIRWPFLGPRQCVA SEMTSLPLIVSIKEDGRTRPQVVSLPNMRVQRCSCASDGALIPRRLEP hide sequence

Ensembl Acc Id:

ENSRNOP00000004354 ⟸ ENSRNOT00000004354

Protein Domains

TGF-beta family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A670-F1-model_v2	AlphaFold	D4A670	1-368	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561867	AgrOrtholog
BioCyc Gene	G2FUF-17108	BioCyc
Ensembl Genes	ENSRNOG00000003263	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004354	ENTREZGENE
	ENSRNOT00000004354.7	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	LRDF	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_N	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
KEGG Report	rno:498299	UniProtKB/TrEMBL
NCBI Gene	498299	ENTREZGENE
PANTHER	LEFT-RIGHT DETERMINATION FACTOR 1	UniProtKB/TrEMBL
	TGFbeta	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PhenoGen	Lefty1	PhenoGen
PIRSF	TGFb4	UniProtKB/TrEMBL
PRINTS	TGFBETA4	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003263	RatGTEx
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A6JGI2	ENTREZGENE, UniProtKB/TrEMBL
	D4A670	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-29	Lefty1	left right determination factor 1	RGD1561867_predicted	similar to Stra3 protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561867_predicted	similar to Stra3 protein (predicted)	LOC498299	similar to Stra3 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498299	similar to Stra3 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)