Fscb (fibrous sheath CABYR binding protein) - Rat Genome Database

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Gene: Fscb (fibrous sheath CABYR binding protein) Rattus norvegicus
Analyze
Symbol: Fscb
Name: fibrous sheath CABYR binding protein
RGD ID: 1561721
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Predicted to be located in motile cilium. Predicted to be active in sperm fibrous sheath and sperm principal piece. Orthologous to human FSCB (fibrous sheath CABYR binding protein); INTERACTS WITH bisphenol A; benzo[a]pyrene (ortholog); bis(2-ethylhexyl) phthalate (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibrous sheath CABYR-binding protein; LOC500659; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8688,264,133 - 88,266,925 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl688,109,663 - 88,266,941 (-)EnsemblGRCr8
mRatBN7.2682,527,849 - 82,530,641 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx682,853,462 - 82,856,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0683,152,822 - 83,155,614 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0682,602,830 - 82,605,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0686,220,260 - 86,223,052 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,220,260 - 86,223,052 (-)Ensemblrn6Rnor6.0
Rnor_5.0695,722,718 - 95,725,510 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4685,795,682 - 85,798,474 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera681,098,527 - 81,101,319 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
calcium ion binding  (IBA,IEA,ISO)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17855365   PMID:27398160  


Genomics

Comparative Map Data
Fscb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8688,264,133 - 88,266,925 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl688,109,663 - 88,266,941 (-)EnsemblGRCr8
mRatBN7.2682,527,849 - 82,530,641 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx682,853,462 - 82,856,254 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0683,152,822 - 83,155,614 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0682,602,830 - 82,605,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0686,220,260 - 86,223,052 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,220,260 - 86,223,052 (-)Ensemblrn6Rnor6.0
Rnor_5.0695,722,718 - 95,725,510 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4685,795,682 - 85,798,474 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera681,098,527 - 81,101,319 (-)NCBICelera
Cytogenetic Map6q24NCBI
FSCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381444,504,149 - 44,507,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1444,504,149 - 44,507,283 (-)Ensemblhg38GRCh38
GRCh371444,973,352 - 44,976,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361444,043,294 - 44,046,208 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341444,043,297 - 44,046,208NCBI
Celera1424,834,054 - 24,837,201 (-)NCBICelera
Cytogenetic Map14q21.2NCBI
HuRef1425,084,764 - 25,087,947 (-)NCBIHuRef
CHM1_11444,911,512 - 44,914,659 (-)NCBICHM1_1
T2T-CHM13v2.01438,695,562 - 38,698,696 (-)NCBIT2T-CHM13v2.0
Fscb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391264,518,107 - 64,521,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1264,518,104 - 64,521,464 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381264,471,333 - 64,474,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1264,471,330 - 64,474,690 (-)Ensemblmm10GRCm38
MGSCv371265,572,320 - 65,575,885 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361265,390,107 - 65,393,503 (-)NCBIMGSCv36mm8
MGSCv361259,015,128 - 59,018,524 (-)NCBIMGSCv36mm8
Celera1265,602,165 - 65,605,766 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1226.96NCBI
Fscb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540917,433,213 - 17,435,957 (+)NCBIChiLan1.0ChiLan1.0
FSCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21545,680,187 - 45,683,247 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11444,896,698 - 44,899,758 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01425,124,746 - 25,127,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11443,453,313 - 43,456,049 (-)NCBIPanPan1.1PanPan1.1panPan2
FSCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1822,004,599 - 22,033,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl822,004,789 - 22,007,425 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha821,822,933 - 21,851,708 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0822,163,499 - 22,192,396 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl822,163,689 - 22,192,545 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1821,826,346 - 21,855,159 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0821,891,700 - 21,920,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0822,229,047 - 22,257,861 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fscb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864053,978,548 - 53,981,509 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365834,707,636 - 4,710,286 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11174,732,612 - 174,734,834 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21194,527,331 - 194,530,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FSCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12421,611,678 - 21,614,404 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605310,670,844 - 10,673,537 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fscb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473124,149,780 - 24,152,409 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fscb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1777,289,804 - 77,292,188 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fscb
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:16
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000046828
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 3 2 18 9 9 4 4 4 1 16 7 17 2 33 5 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000046828   ⟹   ENSRNOP00000051161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl686,220,260 - 86,223,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131907   ⟹   ENSRNOP00000108760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl688,109,663 - 88,266,941 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165206   ⟹   ENSRNOP00000104983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl688,113,308 - 88,266,941 (-)Ensembl
RefSeq Acc Id: NM_001271107   ⟹   NP_001258036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8688,264,133 - 88,266,925 (-)NCBI
mRatBN7.2682,527,849 - 82,530,641 (-)NCBI
Rnor_6.0686,220,260 - 86,223,052 (-)NCBI
Rnor_5.0695,722,718 - 95,725,510 (-)NCBI
Celera681,098,527 - 81,101,319 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98054 (Get FASTA)   NCBI Sequence Viewer  
  Q4V7A4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258036   ⟸   NM_001271107
- UniProtKB: Q4V7A4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051161   ⟸   ENSRNOT00000046828
Ensembl Acc Id: ENSRNOP00000104983   ⟸   ENSRNOT00000165206
Ensembl Acc Id: ENSRNOP00000108760   ⟸   ENSRNOT00000131907

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7A4-F1-model_v2 AlphaFold Q4V7A4 1-812 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694621
Promoter ID:EPDNEW_R5146
Type:multiple initiation site
Name:Fscb_1
Description:fibrous sheath CABYR binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0686,223,071 - 86,223,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561721 AgrOrtholog
BioCyc Gene G2FUF-37340 BioCyc
Ensembl Genes ENSRNOG00000032241 Ensembl
  ENSRNOG00000086903 Ensembl
IMAGE_CLONE IMAGE:7457680 IMAGE-MGC_LOAD
InterPro FSCB UniProtKB/Swiss-Prot
KEGG Report rno:500659 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116212 IMAGE-MGC_LOAD
NCBI Gene 500659 ENTREZGENE
PANTHER FIBROUS SHEATH CABYR-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR36135 UniProtKB/Swiss-Prot
PhenoGen Fscb PhenoGen
RatGTEx ENSRNOG00000032241 RatGTEx
  ENSRNOG00000086903 RatGTEx
UniProt A0ABK0LHP7_RAT UniProtKB/TrEMBL
  A0ABK0LS16_RAT UniProtKB/TrEMBL
  FSCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Fscb  fibrous sheath CABYR binding protein  LOC500659  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500659  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL