Bri3bp (Bri3 binding protein) - Rat Genome Database

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Pathways
Gene: Bri3bp (Bri3 binding protein) Rattus norvegicus
Analyze
Symbol: Bri3bp
Name: Bri3 binding protein
RGD ID: 1561711
Description: Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human BRI3BP (BRI3 binding protein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BRI3-binding protein; LOC498176; similar to BRI3-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,838,098 - 36,849,919 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,838,098 - 36,849,919 (-)EnsemblGRCr8
mRatBN7.21231,176,742 - 31,188,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,173,971 - 31,188,572 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,347,442 - 32,359,299 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,958,867 - 32,970,726 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,010,791 - 32,022,648 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,576,018 - 36,587,839 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,576,020 - 36,587,839 (-)Ensemblrn6Rnor6.0
Rnor_5.01238,445,350 - 38,457,171 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,270,907 - 32,282,728 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,871,267 - 32,883,085 (-)NCBICelera
Cytogenetic Map12q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17943721  


Genomics

Comparative Map Data
Bri3bp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,838,098 - 36,849,919 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1236,838,098 - 36,849,919 (-)EnsemblGRCr8
mRatBN7.21231,176,742 - 31,188,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,173,971 - 31,188,572 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1232,347,442 - 32,359,299 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,958,867 - 32,970,726 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,010,791 - 32,022,648 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,576,018 - 36,587,839 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,576,020 - 36,587,839 (-)Ensemblrn6Rnor6.0
Rnor_5.01238,445,350 - 38,457,171 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,270,907 - 32,282,728 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,871,267 - 32,883,085 (-)NCBICelera
Cytogenetic Map12q14NCBI
BRI3BP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812124,993,645 - 125,051,167 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12124,993,645 - 125,031,231 (+)Ensemblhg38GRCh38
GRCh3712125,478,191 - 125,515,777 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612124,044,147 - 124,076,302 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412124,003,073 - 124,035,229NCBI
Celera12125,079,837 - 125,113,892 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,460,787 - 122,474,086 (+)NCBIHuRef
CHM1_112125,299,491 - 125,331,625 (+)NCBICHM1_1
T2T-CHM13v2.012124,998,843 - 125,059,692 (+)NCBIT2T-CHM13v2.0
Bri3bp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,518,632 - 125,537,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,518,632 - 125,537,434 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385125,441,568 - 125,460,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,441,568 - 125,460,370 (+)Ensemblmm10GRCm38
MGSCv375125,921,938 - 125,941,255 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365125,730,944 - 125,750,261 (+)NCBIMGSCv36mm8
Celera5122,463,614 - 122,482,895 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.21NCBI
Bri3bp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554824,710,937 - 4,716,534 (-)NCBIChiLan1.0ChiLan1.0
BRI3BP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210133,080,656 - 133,120,590 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112133,077,046 - 133,116,968 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,587,345 - 122,627,273 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,891,051 - 126,904,267 (+)NCBIPanPan1.1PanPan1.1panPan2
BRI3BP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,938,835 - 4,961,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,093,905 - 5,121,184 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0265,176,412 - 5,203,707 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,180,807 - 5,203,707 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,114,537 - 5,141,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,203,968 - 5,231,236 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,157,906 - 5,185,163 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bri3bp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118159,065,004 - 159,091,049 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558392,985 - 401,751 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936558392,685 - 401,569 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRI3BP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,180,103 - 28,202,072 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11428,180,130 - 28,202,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21429,887,796 - 29,904,793 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRI3BP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,351,911 - 120,384,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037124,895,679 - 124,933,257 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bri3bp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474724,078,187 - 24,095,925 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474724,078,274 - 24,093,028 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bri3bp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11628,460,214 - 28,472,087 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bri3bp
98 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:176
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000001295
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH135352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,177,062 - 31,177,257 (+)MAPPERmRatBN7.2
Rnor_6.01236,576,339 - 36,576,533NCBIRnor6.0
Rnor_5.01238,445,671 - 38,445,865UniSTSRnor5.0
RGSC_v3.41232,271,228 - 32,271,422UniSTSRGSC3.4
Celera1232,871,588 - 32,871,782UniSTS
RH 3.4 Map12471.9UniSTS
Cytogenetic Map12q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 355 191 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001295   ⟹   ENSRNOP00000001295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1236,576,020 - 36,587,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104714   ⟹   ENSRNOP00000092844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1236,838,098 - 36,849,919 (-)Ensembl
mRatBN7.2 Ensembl1231,173,971 - 31,188,572 (-)Ensembl
RefSeq Acc Id: NM_001017487   ⟹   NP_001017487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,838,098 - 36,849,919 (-)NCBI
mRatBN7.21231,176,742 - 31,188,563 (-)NCBI
Rnor_6.01236,576,018 - 36,587,839 (-)NCBI
Rnor_5.01238,445,350 - 38,457,171 (-)NCBI
RGSC_v3.41232,270,907 - 32,282,728 (-)RGD
Celera1232,871,267 - 32,883,085 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001017487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85334 (Get FASTA)   NCBI Sequence Viewer  
  EDM13552 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092844
  ENSRNOP00000092844.2
RefSeq Acc Id: NP_001017487   ⟸   NM_001017487
- Peptide Label: precursor
- UniProtKB: Q5U3Z5 (UniProtKB/TrEMBL),   A0A8I6AHD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001295   ⟸   ENSRNOT00000001295
Ensembl Acc Id: ENSRNOP00000092844   ⟸   ENSRNOT00000104714

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U3Z5-F1-model_v2 AlphaFold Q5U3Z5 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698600
Promoter ID:EPDNEW_R9124
Type:initiation region
Name:Bri3bp_1
Description:Bri3 binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,587,907 - 36,587,967EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561711 AgrOrtholog
BioCyc Gene G2FUF-19388 BioCyc
Ensembl Genes ENSRNOG00000000979 Ensembl
  ENSRNOG00000063640 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104714 ENTREZGENE
  ENSRNOT00000104714.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301029 IMAGE-MGC_LOAD
InterPro BRI3BP UniProtKB/TrEMBL
KEGG Report rno:498176 UniProtKB/TrEMBL
MGC_CLONE MGC:105518 IMAGE-MGC_LOAD
NCBI Gene 498176 ENTREZGENE
PANTHER BRI3-BINDING PROTEIN UniProtKB/TrEMBL
  PTHR31253 UniProtKB/TrEMBL
Pfam BRI3BP UniProtKB/TrEMBL
PhenoGen Bri3bp PhenoGen
RatGTEx ENSRNOG00000000979 RatGTEx
  ENSRNOG00000063640 RatGTEx
UniProt A0A8I6AHD0 ENTREZGENE, UniProtKB/TrEMBL
  Q5U3Z5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Bri3bp  Bri3 binding protein  LOC498176  similar to BRI3-binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498176  similar to BRI3-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL