Tmprss11e (transmembrane serine protease 11E) - Rat Genome Database

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Gene: Tmprss11e (transmembrane serine protease 11E) Rattus norvegicus
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Symbol: Tmprss11e
Name: transmembrane serine protease 11E
RGD ID: 1561698
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in cognition and proteolysis. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Orthologous to human TMPRSS11E (transmembrane serine protease 11E); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305265; RGD1561698; similar to type II transmembrane serine protease; transmembrane protease serine 11E; transmembrane protease, serine 11e
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,638,418 - 21,683,029 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,638,418 - 21,683,029 (+)EnsemblGRCr8
mRatBN7.21421,283,587 - 21,328,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,282,823 - 21,327,184 (+)EnsemblmRatBN7.2
Rnor_6.01423,061,005 - 23,114,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,089,699 - 23,111,252 (+)Ensemblrn6Rnor6.0
Rnor_5.01422,965,473 - 23,009,450 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,915,649 - 22,944,788 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,767,820 - 20,821,298 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15328353   PMID:23227193  


Genomics

Comparative Map Data
Tmprss11e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,638,418 - 21,683,029 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,638,418 - 21,683,029 (+)EnsemblGRCr8
mRatBN7.21421,283,587 - 21,328,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,282,823 - 21,327,184 (+)EnsemblmRatBN7.2
Rnor_6.01423,061,005 - 23,114,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,089,699 - 23,111,252 (+)Ensemblrn6Rnor6.0
Rnor_5.01422,965,473 - 23,009,450 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,915,649 - 22,944,788 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,767,820 - 20,821,298 (+)NCBICelera
Cytogenetic Map14p21NCBI
TMPRSS11E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38468,447,463 - 68,497,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl468,447,463 - 68,497,604 (+)Ensemblhg38GRCh38
GRCh37469,313,181 - 69,363,322 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,995,762 - 69,045,917 (+)NCBIBuild 36Build 36hg18NCBI36
Celera466,773,145 - 66,823,292 (+)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef465,226,444 - 65,276,593 (+)NCBIHuRef
CHM1_1469,349,862 - 69,400,004 (+)NCBICHM1_1
T2T-CHM13v2.0471,888,583 - 71,938,685 (+)NCBIT2T-CHM13v2.0
Tmprss11e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,853,045 - 86,893,666 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,853,045 - 86,893,674 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38586,705,186 - 86,745,807 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,705,186 - 86,745,815 (-)Ensemblmm10GRCm38
MGSCv37587,134,211 - 87,174,832 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36587,779,747 - 87,820,368 (-)NCBIMGSCv36mm8
Celera583,925,147 - 83,965,832 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
TMPRSS11E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2361,412,724 - 61,462,852 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1461,615,431 - 61,665,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0455,559,762 - 55,609,900 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1461,953,318 - 62,003,437 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl461,953,256 - 62,015,111 (-)EnsemblpanPan2panpan1.1
LOC482176
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,709,560 - 58,752,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1358,712,601 - 58,781,418 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1358,638,959 - 58,687,758 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01359,412,025 - 59,454,732 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11359,059,225 - 59,101,893 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01358,543,619 - 58,586,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01359,562,588 - 59,605,048 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100623351
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl865,969,359 - 66,014,444 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1865,969,353 - 66,014,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,391,979 - 70,436,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235591
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17483,747 - 521,490 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7486,135 - 521,327 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666066558,445 - 608,490 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss11e
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v111199,191 - 240,410 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmprss11e
554 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000036948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
D14Arb16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81421,572,345 - 21,572,472 (+)Marker Load Pipeline
mRatBN7.21421,217,508 - 21,217,635 (+)MAPPERmRatBN7.2
Rnor_6.01423,003,903 - 23,004,027NCBIRnor6.0
Rnor_5.01422,901,186 - 22,901,310UniSTSRnor5.0
RGSC_v3.41422,837,174 - 22,837,299RGDRGSC3.4
RGSC_v3.41422,837,175 - 22,837,299UniSTSRGSC3.4
Celera1420,710,575 - 20,710,704UniSTS
RGSC_v3.11422,837,174 - 22,837,299RGD
SHRSP x BN Map1410.1899RGD
SHRSP x BN Map1410.1899UniSTS
Cytogenetic Map14p21UniSTS
D14Mco8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81421,641,219 - 21,641,424 (+)Marker Load Pipeline
mRatBN7.21421,286,388 - 21,286,593 (+)MAPPERmRatBN7.2
Rnor_6.01423,072,638 - 23,072,841NCBIRnor6.0
Rnor_5.01422,969,921 - 22,970,124UniSTSRnor5.0
RGSC_v3.41422,905,910 - 22,906,115RGDRGSC3.4
RGSC_v3.41422,905,911 - 22,906,115UniSTSRGSC3.4
Celera1420,779,475 - 20,779,679UniSTS
RGSC_v3.11422,905,910 - 22,906,115RGD
Cytogenetic Map14p21UniSTS
WI-17713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,301,288 - 21,301,444 (+)MAPPERmRatBN7.2
Rnor_6.01423,087,535 - 23,087,690NCBIRnor6.0
Rnor_5.01422,984,818 - 22,984,973UniSTSRnor5.0
RGSC_v3.41422,920,809 - 22,920,964UniSTSRGSC3.4
Celera1420,794,371 - 20,794,526UniSTS
Cytogenetic Map14p21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 1 5 32 22 26 9 7 9 6 98 18 1 22 64 52 17 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000036948   ⟹   ENSRNOP00000037162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,638,418 - 21,683,029 (+)Ensembl
mRatBN7.2 Ensembl1421,282,823 - 21,327,184 (+)Ensembl
Rnor_6.0 Ensembl1423,089,699 - 23,111,252 (+)Ensembl
RefSeq Acc Id: NM_001419628   ⟹   NP_001406557
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,638,418 - 21,683,029 (+)NCBI
mRatBN7.21421,283,587 - 21,328,203 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001406557 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89831 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037162
  ENSRNOP00000037162.5
Ensembl Acc Id: ENSRNOP00000037162   ⟸   ENSRNOT00000036948
RefSeq Acc Id: NP_001406557   ⟸   NM_001419628
- UniProtKB: F1M2C4 (UniProtKB/TrEMBL),   A6JCQ9 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M2C4-F1-model_v2 AlphaFold F1M2C4 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561698 AgrOrtholog
BioCyc Gene G2FUF-16081 BioCyc
Ensembl Genes ENSRNOG00000022255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036948 ENTREZGENE
  ENSRNOT00000036948.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/TrEMBL
InterPro Pept_S1A_HAT/DESC1 UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  SEA_dom UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene 305265 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED UniProtKB/TrEMBL
Pfam SEA UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen Tmprss11e PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE SEA UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022255 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF82671 UniProtKB/TrEMBL
UniProt A6JCQ9 ENTREZGENE, UniProtKB/TrEMBL
  F1M2C4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss11e  transmembrane serine protease 11E  Tmprss11e  transmembrane protease, serine 11e  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tmprss11e  transmembrane protease, serine 11e   Tmprss11e_predicted  transmembrane protease, serine 11e (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tmprss11e_predicted  transmembrane protease, serine 11e (predicted)  RGD1561698_predicted  similar to type II transmembrane serine protease (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1561698_predicted  similar to type II transmembrane serine protease (predicted)  LOC305265  similar to type II transmembrane serine protease  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305265  similar to type II transmembrane serine protease      Symbol and Name status set to provisional 70820 PROVISIONAL