Cyp4f17 (cytochrome P450, family 4, subfamily f, polypeptide 17) - Rat Genome Database

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Gene: Cyp4f17 (cytochrome P450, family 4, subfamily f, polypeptide 17) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp4f17 (Ensembl: Cyp4f39)
Name: cytochrome P450, family 4, subfamily f, polypeptide 17 (Ensembl:cytochrome P450, family 4, subfamily f, polypeptide 39)
RGD ID: 1561655
Description: ENCODES a protein that exhibits heme binding (inferred); iron ion binding (inferred); metal ion binding (inferred); INVOLVED IN small molecule metabolic process (inferred); PARTICIPATES IN arachidonic acid metabolic pathway; FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500801; RGD1561655; similar to Cytochrome P450 4F6 (CYPIVF6)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,169,366 - 12,186,731 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,169,922 - 12,187,540 (+)EnsemblGRCr8
mRatBN7.2711,518,985 - 11,536,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,433,371 - 11,536,181 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,338,424 - 14,374,826 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,215,853 - 16,252,255 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,087,516 - 14,103,583 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,527,797 - 14,545,775 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0714,550,167 - 14,551,959 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,528,822 - 14,545,751 (+)Ensemblrn6Rnor6.0
Rnor_5.0714,681,199 - 14,698,524 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0714,702,925 - 14,704,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,095,557 - 13,111,638 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera79,629,016 - 9,645,072 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cyp4f17
200 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:79
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000060284
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH133867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,535,779 - 11,535,970 (+)MAPPERmRatBN7.2
Rnor_6.0714,551,538 - 14,551,728NCBIRnor6.0
Rnor_6.0714,545,348 - 14,545,538NCBIRnor6.0
Rnor_5.0714,704,287 - 14,704,477UniSTSRnor5.0
Rnor_5.0714,698,097 - 14,698,287UniSTSRnor5.0
RGSC_v3.4713,111,211 - 13,111,401UniSTSRGSC3.4
Celera79,644,645 - 9,644,835UniSTS
RH 3.4 Map762.7UniSTS
Cytogenetic Map7q11UniSTS
AU046372  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8712,182,754 - 12,182,892 (+)Marker Load Pipeline
mRatBN7.2711,532,237 - 11,532,375 (+)MAPPERmRatBN7.2
Rnor_6.0714,541,805 - 14,541,942NCBIRnor6.0
Rnor_6.0714,547,997 - 14,548,134NCBIRnor6.0
Rnor_5.0714,700,746 - 14,700,883UniSTSRnor5.0
Rnor_5.0714,694,554 - 14,694,691UniSTSRnor5.0
RGSC_v3.4713,107,669 - 13,107,806UniSTSRGSC3.4
Celera79,641,091 - 9,641,228UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 56 145 64 60 48 72 48 6 281 150 11 132 70 81 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007548   ⟹   ENSRNOP00000007548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,433,371 - 11,536,181 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000060284   ⟹   ENSRNOP00000057034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,519,439 - 11,536,181 (+)Ensembl
Rnor_6.0 Ensembl714,529,483 - 14,545,751 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075589   ⟹   ENSRNOP00000067362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,519,439 - 11,535,992 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093239   ⟹   ENSRNOP00000076221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,529,584 - 14,540,494 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093545   ⟹   ENSRNOP00000076271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,539,608 - 14,545,228 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,538,044 - 14,541,065 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,528,822 - 14,537,222 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093687   ⟹   ENSRNOP00000076248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,433,371 - 11,505,552 (+)Ensembl
RefSeq Acc Id: NM_001191986   ⟹   NP_001178915
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,170,645 - 12,186,724 (+)NCBI
mRatBN7.2711,520,127 - 11,536,207 (+)NCBI
Rnor_6.0714,529,483 - 14,545,775 (+)NCBI
Rnor_5.0714,681,199 - 14,698,524 (+)NCBI
Celera79,629,016 - 9,645,072 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241085   ⟹   XP_006241147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,169,366 - 12,186,731 (+)NCBI
mRatBN7.2711,518,985 - 11,536,208 (+)NCBI
Rnor_6.0714,527,797 - 14,545,775 (+)NCBI
Rnor_5.0714,681,199 - 14,698,524 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264097   ⟹   XP_063120167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,169,366 - 12,186,731 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178915 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241147 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120167 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057034
  ENSRNOP00000057034.2
  ENSRNOP00000067362.3
RefSeq Acc Id: NP_001178915   ⟸   NM_001191986
- UniProtKB: D4AB65 (UniProtKB/TrEMBL),   A0A8J8Y394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241147   ⟸   XM_006241085
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000076271   ⟸   ENSRNOT00000093545
Ensembl Acc Id: ENSRNOP00000076221   ⟸   ENSRNOT00000093239
Ensembl Acc Id: ENSRNOP00000057034   ⟸   ENSRNOT00000060284
Ensembl Acc Id: ENSRNOP00000007548   ⟸   ENSRNOT00000007548
Ensembl Acc Id: ENSRNOP00000076248   ⟸   ENSRNOT00000093687
Ensembl Acc Id: ENSRNOP00000067362   ⟸   ENSRNOT00000075589
RefSeq Acc Id: XP_063120167   ⟸   XM_063264097
- Peptide Label: isoform X2
- UniProtKB: A0A8J8Y394 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AB65-F1-model_v2 AlphaFold D4AB65 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695073
Promoter ID:EPDNEW_R5596
Type:initiation region
Name:Cyp4f17_1
Description:cytochrome P450, family 4, subfamily f, polypeptide 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0714,528,798 - 14,528,858EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561655 AgrOrtholog
BioCyc Gene G2FUF-34823 BioCyc
Ensembl Genes ENSRNOG00000029478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000062306 Ensembl
Ensembl Transcript ENSRNOT00000060284 ENTREZGENE
  ENSRNOT00000060284.6 UniProtKB/TrEMBL
  ENSRNOT00000075589.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_Monoox UniProtKB/TrEMBL
KEGG Report rno:500801 UniProtKB/TrEMBL
NCBI Gene 500801 ENTREZGENE
PANTHER CYTOCHROME P450 CYP4F13-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp4f17 PhenoGen
PRINTS EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029478 RatGTEx
  ENSRNOG00000062306 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A8J8Y394 ENTREZGENE, UniProtKB/TrEMBL
  D4AB65 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyp4f17  cytochrome P450, family 4, subfamily f, polypeptide 17   Cyp4f17_predicted  cytochrome P450, family 4, subfamily f, polypeptide 17 (predicted)  'predicted' is removed 2292626 APPROVED
2007-07-06 Cyp4f17_predicted  cytochrome P450, family 4, subfamily f, polypeptide 17 (predicted)  RGD1561655_predicted  similar to Cytochrome P450 4F6 (CYPIVF6) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1561655_predicted  similar to Cytochrome P450 4F6 (CYPIVF6) (predicted)  LOC500801  similar to Cytochrome P450 4F6 (CYPIVF6)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500801  similar to Cytochrome P450 4F6 (CYPIVF6)      Symbol and Name status set to provisional 70820 PROVISIONAL