Cct8l2 (chaperonin containing TCP1 subunit 8 like 2) - Rat Genome Database

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Gene: Cct8l2 (chaperonin containing TCP1 subunit 8 like 2) Rattus norvegicus
Analyze
Symbol: Cct8l2
Name: chaperonin containing TCP1 subunit 8 like 2
RGD ID: 1561536
Description: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. Orthologous to several human genes including CCT8L2 (chaperonin containing TCP1 subunit 8 like 2); INTERACTS WITH 6-propyl-2-thiouracil; cadmium dichloride; glycidol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cct8l1; chaperonin containing TCP1, subunit 8 (theta)-like 1; hypothetical protein LOC499967; LOC102553845; MGC125233; putative T-complex protein 1 subunit theta-like 2-like; similar to Gene model 443; T-complex protein 1 subunit theta-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8410,338,882 - 10,340,818 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl410,336,884 - 10,344,906 (-)EnsemblGRCr8
mRatBN7.249,605,035 - 9,606,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl49,605,000 - 9,607,208 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx414,601,253 - 14,603,189 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0410,415,526 - 10,417,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.048,768,111 - 8,770,047 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,044,744 - 6,046,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,044,792 - 6,046,477 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl46,060,709 - 6,062,641 (-)Ensemblrn6Rnor6.0
Rnor_5.046,066,927 - 6,068,863 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.445,004,039 - 5,005,975 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4712,543 - 714,479 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
protein folding  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:20193073  


Genomics

Comparative Map Data
Cct8l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8410,338,882 - 10,340,818 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl410,336,884 - 10,344,906 (-)EnsemblGRCr8
mRatBN7.249,605,035 - 9,606,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl49,605,000 - 9,607,208 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx414,601,253 - 14,603,189 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0410,415,526 - 10,417,462 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.048,768,111 - 8,770,047 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,044,744 - 6,046,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,044,792 - 6,046,477 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl46,060,709 - 6,062,641 (-)Ensemblrn6Rnor6.0
Rnor_5.046,066,927 - 6,068,863 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.445,004,039 - 5,005,975 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4712,543 - 714,479 (+)NCBICelera
Cytogenetic Map4q11NCBI
CCT8L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,590,751 - 16,592,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,590,751 - 16,592,810 (-)Ensemblhg38GRCh38
GRCh372217,071,641 - 17,073,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,451,648 - 15,453,700 (-)NCBIBuild 36Build 36hg18NCBI36
Celera22693,800 - 695,852 (-)NCBICelera
Cytogenetic Map22q11.1NCBI
HuRef22891,116 - 893,168 (-)NCBIHuRef
CHM1_12217,076,472 - 17,078,524 (-)NCBICHM1_1
T2T-CHM13v2.02217,267,300 - 17,269,359 (-)NCBIT2T-CHM13v2.0
Cct8l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,721,065 - 25,723,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,721,065 - 25,723,025 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38525,516,067 - 25,518,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl525,516,067 - 25,518,027 (+)Ensemblmm10GRCm38
MGSCv37525,021,885 - 25,023,845 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36525,026,215 - 25,028,096 (+)NCBIMGSCv36mm8
Celera522,452,648 - 22,454,608 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map512.35NCBI
Cct8l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554916,499,186 - 6,500,843 (+)Ensembl
ChiLan1.0NW_0049554916,498,532 - 6,500,957 (+)NCBIChiLan1.0ChiLan1.0
CCT8L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22327,005,564 - 27,011,795 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12229,555,612 - 29,561,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v022125,317 - 127,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17156,171,381 - 156,173,466 (+)NCBIPanPan1.1PanPan1.1panPan2
CCT8L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11616,250,801 - 16,252,784 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1616,251,061 - 16,252,728 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1616,867,836 - 16,869,815 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01617,981,309 - 17,983,288 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1617,981,565 - 17,983,232 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11616,355,482 - 16,357,461 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01616,936,068 - 16,938,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01616,987,705 - 16,989,684 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cct8l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051185,312,201 - 5,315,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365277,589,472 - 7,591,169 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365277,588,536 - 7,591,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCT8L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl184,979,436 - 4,981,076 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1184,979,300 - 4,981,545 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,324,623 - 5,326,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCT8L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121120,593,045 - 120,595,405 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21120,593,611 - 120,595,278 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607216,580,976 - 16,583,355 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cct8l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248004,501,854 - 4,504,128 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cct8l2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16154,695,698 - 154,697,778 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cct8l2
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000073925, ENSRNOT00000074846
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 2 36 97 63 57 20 84 20 12 244 159 11 61 48 93 37 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000073925   ⟹   ENSRNOP00000067222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl46,044,792 - 6,046,477 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074846   ⟹   ENSRNOP00000066908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl410,338,861 - 10,341,394 (-)Ensembl
mRatBN7.2 Ensembl49,605,000 - 9,607,208 (-)Ensembl
Rnor_6.0 Ensembl46,060,709 - 6,062,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141032   ⟹   ENSRNOP00000099846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl410,336,884 - 10,344,906 (-)Ensembl
RefSeq Acc Id: NM_001037794   ⟹   NP_001032883
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8410,338,882 - 10,340,818 (-)NCBI
mRatBN7.249,605,035 - 9,606,971 (-)NCBI
Rnor_6.046,044,744 - 6,046,680 (-)NCBI
Rnor_5.046,066,927 - 6,068,863 (-)NCBI
RGSC_v3.445,004,039 - 5,005,975 (-)RGD
Celera4712,543 - 714,479 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032883 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07459 (Get FASTA)   NCBI Sequence Viewer  
  EDL86393 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066908.2
  ENSRNOP00000099846
  ENSRNOP00000099846.1
RefSeq Acc Id: NP_001032883   ⟸   NM_001037794
- UniProtKB: Q3B7U6 (UniProtKB/TrEMBL),   M0RBH2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067222   ⟸   ENSRNOT00000073925
Ensembl Acc Id: ENSRNOP00000066908   ⟸   ENSRNOT00000074846
Ensembl Acc Id: ENSRNOP00000099846   ⟸   ENSRNOT00000141032

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3B7U6-F1-model_v2 AlphaFold Q3B7U6 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561536 AgrOrtholog
BioCyc Gene G2FUF-46087 BioCyc
Ensembl Genes ENSRNOG00000047114 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050369 Ensembl
Ensembl Transcript ENSRNOT00000074846.4 UniProtKB/TrEMBL
  ENSRNOT00000141032 ENTREZGENE
  ENSRNOT00000141032.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455506 IMAGE-MGC_LOAD
InterPro Chaperone_TCP-1 UniProtKB/TrEMBL
  Chaperonin_TCP-1_CS UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom UniProtKB/TrEMBL
  GROEL-like_equatorial UniProtKB/TrEMBL
  TCP-1-like_intermed UniProtKB/TrEMBL
KEGG Report rno:499967 UniProtKB/TrEMBL
MGC_CLONE MGC:125233 IMAGE-MGC_LOAD
NCBI Gene 499967 ENTREZGENE
PANTHER PTHR11353 UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PhenoGen Cct8l2 PhenoGen
PRINTS TCOMPLEXTCP1 UniProtKB/TrEMBL
PROSITE TCP1_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047114 RatGTEx
  ENSRNOG00000050369 RatGTEx
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
UniProt A0ABK0LDF2_RAT UniProtKB/TrEMBL
  M0RBH2 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7U6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-22 Cct8l2  chaperonin containing TCP1 subunit 8 like 2  Cct8l1  chaperonin containing TCP1, subunit 8 (theta)-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Cct8l1  chaperonin containing TCP1, subunit 8 (theta)-like 1  LOC102553845  putative T-complex protein 1 subunit theta-like 2-like  Data merged from RGD:7640698 737654 PROVISIONAL
2013-12-18 LOC102553845  putative T-complex protein 1 subunit theta-like 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Cct8l1  chaperonin containing TCP1, subunit 8 (theta)-like 1  MGC125233  similar to Gene model 443  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC125233  similar to Gene model 443      Symbol and Name status set to provisional 70820 PROVISIONAL