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Gene: Slc9a7 (solute carrier family 9 member A7) Rattus norvegicus

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Symbol:

Slc9a7

Name:

solute carrier family 9 member A7

RGD ID:

1561385

Description:

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of Golgi lumen acidification; and sodium ion import across plasma membrane. Predicted to be located in recycling endosome membrane and trans-Golgi network. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7); INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Nhe7; sodium/hydrogen exchanger 7; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7; solute carrier family 9 (sodium/hydrogen exchanger), member 7; solute carrier family 9, member 7; solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC9A7 (solute carrier family 9 member A7)	HGNC	Ensembl, NCBI, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc9a7 (solute carrier family 9 (sodium/hydrogen exchanger), member 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc9a7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC9A7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC9A7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc9a7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC9A7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC9A7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc9a7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc9a7 (solute carrier family 9 member A7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC9A7 (solute carrier family 9 member A7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PhylomeDB)
Homo sapiens (human):	SLC9A7 (solute carrier family 9 member A7)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc9a7 (solute carrier family 9 (sodium/hydrogen exchanger), member 7)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Mus musculus (house mouse):	Slc9a7 (solute carrier family 9 (sodium/hydrogen exchanger), member 7)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc9a7 (solute carrier family 9 member 7)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	NHX1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NHX1	Alliance	DIOPT (InParanoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Nhe3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nhx-5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc9a7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	slc9a7	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	4,767,578 - 4,948,602 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	4,767,915 - 4,948,602 (+)	Ensembl				GRCr8
mRatBN7.2	X	2,214,064 - 2,395,052 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	2,214,441 - 2,388,012 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	2,247,588 - 2,428,241 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	5,723,322 - 5,903,992 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	2,033,698 - 2,214,361 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	2,434,918 - 2,615,936 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	2,435,305 - 2,614,770 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	3,226,147 - 3,409,761 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	13,633,105 - 13,808,939 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	2,743,256 - 2,912,530 (+)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

X-linked intellectual developmental disorder 108 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-bromohexadecanoic acid (ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-iodothyronamine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

Azoxymethane (ISO)

Benzamil (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

choline (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

fonofos (ISO)

L-methionine (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

orphenadrine (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

PCB138 (ISO)

pirinixic acid (ISO)

potassium atom (ISO)

potassium chromate (ISO)

quinine (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sodium atom (ISO)

terbufos (ISO)

testosterone (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

monoatomic cation transport (IEA)

monoatomic ion transport (IEA)

potassium ion transmembrane transport (IBA,IEA)

proton transmembrane transport (IEA)

regulation of Golgi lumen acidification (ISO)

regulation of intracellular pH (IBA)

regulation of pH (IEA,ISO)

sodium ion import across plasma membrane (IBA)

sodium ion transmembrane transport (IEA)

sodium ion transport (IEA)

transmembrane transport (IEA)

Cellular Component

membrane (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

recycling endosome (IBA)

recycling endosome membrane (IEA,ISO)

trans-Golgi network (ISO)

Molecular Function

antiporter activity (IEA)

potassium:proton antiporter activity (IBA,ISO)

protein binding (ISO)

sodium:proton antiporter activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11279194	PMID:15840657	PMID:30335141

Genomics

Comparative Map Data

Slc9a7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	4,767,578 - 4,948,602 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	4,767,915 - 4,948,602 (+)	Ensembl				GRCr8
mRatBN7.2	X	2,214,064 - 2,395,052 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	2,214,441 - 2,388,012 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	2,247,588 - 2,428,241 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	5,723,322 - 5,903,992 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	2,033,698 - 2,214,361 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	2,434,918 - 2,615,936 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	2,435,305 - 2,614,770 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	3,226,147 - 3,409,761 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	13,633,105 - 13,808,939 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	2,743,256 - 2,912,530 (+)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

SLC9A7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	46,599,251 - 46,759,118 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	46,599,251 - 46,759,193 (-)	Ensembl			hg38	GRCh38
GRCh37	X	46,458,686 - 46,618,553 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	46,351,317 - 46,503,416 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	46,222,626 - 46,374,726	NCBI
Celera	X	50,658,215 - 50,810,335 (-)	NCBI		Celera
Cytogenetic Map	X	p11.3	NCBI
HuRef	X	44,170,288 - 44,254,619 (-)	NCBI		HuRef
CHM1_1	X	46,490,827 - 46,650,713 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	46,006,221 - 46,166,134 (-)	NCBI		T2T-CHM13v2.0

Slc9a7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	19,965,090 - 20,158,274 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	19,971,993 - 20,158,046 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	20,098,851 - 20,292,035 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	20,105,754 - 20,291,807 (-)	Ensembl			mm10	GRCm38
MGSCv37	X	19,682,881 - 19,868,890 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	19,262,714 - 19,448,723 (-)	NCBI		MGSCv36	mm8
Celera	X	18,234,853 - 18,421,077 (-)	NCBI		Celera
Cytogenetic Map	X	A1.3	NCBI

Slc9a7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955516	1,286,070 - 1,428,789 (+)	Ensembl
ChiLan1.0	NW_004955516	1,286,070 - 1,428,789 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC9A7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	48,227,846 - 48,387,778 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	48,231,436 - 48,391,151 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	39,037,499 - 39,197,421 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	46,898,953 - 47,057,674 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	46,906,644 - 47,057,705 (-)	Ensembl			panPan2	panpan1.1

SLC9A7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	40,240,169 - 40,389,167 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	40,245,654 - 40,389,423 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	14,616,012 - 14,764,673 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	40,378,163 - 40,523,311 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	40,379,864 - 40,523,703 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	40,363,040 - 40,511,661 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	40,350,111 - 40,499,013 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	40,443,100 - 40,592,043 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc9a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	32,605,876 - 32,746,453 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	12,452,720 - 12,587,192 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	12,450,702 - 12,587,196 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC9A7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	41,236,246 - 41,398,999 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	41,233,308 - 41,399,032 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	46,076,182 - 46,199,212 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC9A7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	43,806,085 - 43,958,985 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	43,806,349 - 43,958,959 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666076	9,060,922 - 9,208,835 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc9a7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624887	3,408,109 - 3,563,639 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624887	3,403,764 - 3,563,699 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc9a7
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	3,323,083 - 3,954,751 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc9a7
697 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	157
Count of miRNA genes:	121
Interacting mature miRNAs:	132
Transcripts:	ENSRNOT00000005623
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	44939387	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1970440	46970440	Rat
70166	Bp65	Blood pressure QTL 65	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	4001493	14046933	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	4001493	24470521	Rat

Markers in Region

PMC152551P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	2,281,592 - 2,281,856 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	2,480,869 - 2,481,133 (-)	MAPPER	mRatBN7.2
mRatBN7.2	12	11,665,050 - 11,665,317 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	2,509,978 - 2,510,240	NCBI	Rnor6.0
Rnor_6.0	12	13,717,782 - 13,718,048	NCBI	Rnor6.0
Rnor_5.0	12	15,747,795 - 15,748,061	UniSTS	Rnor5.0
Rnor_5.0	X	3,300,207 - 3,300,469	UniSTS	Rnor5.0
Celera	12	13,454,382 - 13,454,648	UniSTS
Celera	X	3,004,715 - 3,004,978	UniSTS
Cytogenetic Map	X	q12	UniSTS
Cytogenetic Map	12	p11	UniSTS

PMC275467P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	2,281,592 - 2,281,843 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	2,480,882 - 2,481,133 (-)	MAPPER	mRatBN7.2
mRatBN7.2	12	11,665,063 - 11,665,317 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	2,509,978 - 2,510,227	NCBI	Rnor6.0
Rnor_6.0	12	13,717,795 - 13,718,048	NCBI	Rnor6.0
Rnor_5.0	12	15,747,808 - 15,748,061	UniSTS	Rnor5.0
Rnor_5.0	X	3,300,207 - 3,300,456	UniSTS	Rnor5.0
Celera	12	13,454,395 - 13,454,648	UniSTS
Celera	X	3,004,728 - 3,004,978	UniSTS
Cytogenetic Map	X	q12	UniSTS
Cytogenetic Map	12	p11	UniSTS

PMC150974P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,665,202 - 11,666,036 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,717,934 - 13,718,767	NCBI	Rnor6.0
Rnor_5.0	12	15,747,947 - 15,748,780	UniSTS	Rnor5.0
RGSC_v3.4	12	12,049,161 - 12,049,994	UniSTS	RGSC3.4
RGSC_v3.4	X	13,700,285 - 13,700,891	UniSTS	RGSC3.4
Celera	12	13,454,534 - 13,455,367	UniSTS
Cytogenetic Map	12	p11	UniSTS
Cytogenetic Map	X	q12	UniSTS

RH138299

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	2,332,855 - 2,332,978 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	2,559,083 - 2,559,205	NCBI	Rnor6.0
Rnor_5.0	X	3,349,312 - 3,349,434	UniSTS	Rnor5.0
RGSC_v3.4	X	13,753,169 - 13,753,291	UniSTS	RGSC3.4
Celera	X	2,857,748 - 2,857,870	UniSTS
Cytogenetic Map	X	q12	UniSTS

Actb

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	2,281,288 - 2,281,798 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	2,480,927 - 2,481,437 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	2,509,674 - 2,510,182	NCBI	Rnor6.0
Rnor_5.0	X	3,299,903 - 3,300,411	UniSTS	Rnor5.0
RGSC_v3.4	X	13,700,476 - 13,700,985	UniSTS	RGSC3.4
Celera	12	13,453,754 - 13,454,454	UniSTS
Cytogenetic Map	X	q12	UniSTS
Cytogenetic Map	12	p11	UniSTS

PMC85795P4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	2,281,589 - 2,282,085 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	2,480,640 - 2,481,136 (-)	MAPPER	mRatBN7.2
mRatBN7.2	12	11,664,354 - 11,665,320 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,717,086 - 13,718,051	NCBI	Rnor6.0
Rnor_6.0	X	2,509,975 - 2,510,469	NCBI	Rnor6.0
Rnor_5.0	X	3,300,204 - 3,300,698	UniSTS	Rnor5.0
Rnor_5.0	12	15,747,099 - 15,748,064	UniSTS	Rnor5.0
Celera	12	13,453,686 - 13,454,651	UniSTS
Celera	X	3,004,486 - 3,004,981	UniSTS
Cytogenetic Map	12	p11	UniSTS
Cytogenetic Map	X	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	163	91	90	59	92	59	6	354	191	11	142	80	91	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005623 ⟹ ENSRNOP00000005623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	4,767,937 - 4,942,672 (+)	Ensembl
mRatBN7.2 Ensembl	X	2,214,441 - 2,388,012 (+)	Ensembl
Rnor_6.0 Ensembl	X	2,435,305 - 2,614,770 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169478 ⟹ ENSRNOP00000109119

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	X	4,767,915 - 4,948,602 (+)	Ensembl

RefSeq Acc Id:

NM_001401002 ⟹ NP_001387931

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	4,767,915 - 4,948,602 (+)	NCBI
mRatBN7.2	X	2,214,401 - 2,395,052 (+)	NCBI

RefSeq Acc Id:

XM_006256637 ⟹ XP_006256699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	4,767,578 - 4,948,602 (+)	NCBI
mRatBN7.2	X	2,214,064 - 2,395,052 (+)	NCBI
Rnor_6.0	X	2,434,919 - 2,615,936 (+)	NCBI
Rnor_5.0	X	3,226,147 - 3,409,761 (+)	NCBI

Sequence:

show sequence

TAGCGGTGGTGCTAAGGACAGGTCTGGAGACCTTGCAATGAATTGATCCAAGTTGATGTTTCTT
GCCAGGAGGGAATGACCTCTGCCGTTCCATTTAGGTAGCGTGGCAGCTGCTACTCAGGAACTGG
CTAACCTACCTCAGACAGTCTGACCAGGTACTCCTAGACAGGGCCAGCAGCTTAGCGCGGCGGA
AGGACTGGCCGCCCGCCGGACAGAGGGGAGGATAGAGCTCGCCCCGCCCGGACAGCCGGGTGGC
CTTGTCGCTCCTCTAGGCGGGGGACGAACAGGTGCGCGGGCGGGGGGCGGCGCTTGGGGATCCT
GCGCACTGCGCGCGCCCCTCCCCCGCAGCTTGGCGCAGCCCCGGCTAGGCGCTAGCAGCGGGAG
GAGGAGCTGCGGCCGTGGCCACCGGGGTTAGTCCGCCGCACCGCGGGAAGCTGCCGACGGCGCG
GGCTCTTGCTGGTCCCCGCGTGGAAAAGGCACGGGCGACCGCGGAGTCATGGAGCCTAGTGACG
CGGCGCGCCCGGGTCCCGGCAGAGCTGTTCCGGGGCTGTCGCCGCGGCTGCTGCTGCTGCCACT
GTTGCCCATGCTGCTGGGTCGGGGGCTGCGGGCTGGGGCCGCGGCCTCCTCCTCTGGGGCGGCG
GCTGAGGACAGCAGCGCCATGGAGGAGCTTGCCACTGAGAAGGAGGCGGAGGAGAGCCACCGGC
AGGACAGCGTGAGCCTGCTCACCTTCATCCTGCTGCTCACCCTCACCATCCTCACCATCTGGCT
TTTCAAGCACCGCCGGGTGCGTTTCCTTCACGAGACCGGACTGGCCATGATCTATGGGCTCATT
GTTGGAGTGATCCTGAGGTATGGCACCCCTGCTACCAGCGGTCGTGACAAGTCACTCAGCTGTA
CTCAGGAAGACAGAGCCTTTAGTACTTTATTAGTGAATGTCAGTGGGAAGTTCTTTGAATACAC
TCTGAAAGGAGAAATCAGCCCTGGCAAGATCAACAATGTGGAGCAGAATGACATGCTGCGGAAG
GTAACATTTGATCCAGAGGTATTTTTCAACATTCTGCTGCCTCCAATTATTTTCCATGCTGGAT
ACAGCTTAAAGAAGAGACACTTTTTCAGAAATCTTGGGTCAATTCTGGCCTATGCCTTTTTGGG
AACTGCAGTTTCCTGTTTCATTATTGGAAACCTTATGTATGGAGTGGTAAAACTCATGAAGATT
GTGGGCCAGCTCTCTGATAAATTTTACTACACAGATTGTCTCTTCTTTGGAGCAATTATTTCTG
CCACTGACCCAGTGACTGTGCTAGCAATCTTTAATGAACTGCATGCAGATGTGGATCTCTATGC
TCTTCTGTTCGGAGAGAGTGTCCTGAATGATGCAGTTGCCATTGTACTATCCTCGTCTATTGTT
GCTTACCAACCAGCAGGACTAAACACTCACGCGTTTGATGCTGCTGCCTTTTTTAAATCAGTTG
GCATTTTCCTAGGTATATTTAGTGGCTCTTTTACCATGGGAGCTGTAACTGGTGTTGTTACTGC
TCTAGTGACCAAGTTTACTAAGCTGCACTGCTTCCCCCTGCTGGAGACAGCACTTTTTTTCCTG
ATGTCCTGGAGCACATTTCTCCTGGCTGAAGCCTGTGGGTTTACAGGTGTTGTAGCTGTCCTTT
TCTGTGGGATTACACAAGCTCACTACACATATAACAACCTGTCAGTAGAGTCTCGAAGTCGAAG
CAAGCAGCTTTTTGAGGTGTTACACTTCCTGGCTGAGAACTTCATCTTCTCCTACATGGGCCTG
GCTCTGTTCACCTTCCAGAAGCACGTTTTCAGCCCCATTTTCATCATCGGAGCTTTTGTTGCTA
TCTTCCTGGGTAGGGCTGCACATATCTACCCACTCTCCTTCTTCCTCAACTTGGGCAGAAGGCA
TAAGATTGGCTGGAATTTTCAACACATGATGATGTTTTCAGGCCTGAGAGGAGCGATGGCATTT
GCACTGGCCATTCGTGACACAGCATCCTATTCCCGCCAGATGATGTTCACAACCACGCTGCTCA
TTGTCTTCTTCACTGTGTGGGTCATTGGTGGAGGCACGACACCCATGTTGTCATGGCTCAATAT
AAGAGTTGGTGTTGATCCAGATCAAGACCCGCCACCTAACAACGACAGCTTTCAAGTCTTACAA
GGGGATGGCCTGGATTCTGTTGGAGGAAGCCGGACAAAGCAGGAAAGTGCATGGATATTCAGGC
TGTGGTATAGTTTTGATCATAATTACTTGAAGCCAATTCTCACCCACAGTGGTCCCCCACTAAC
CACCACTCTCCCAGCCTGGTGTGGCTTGATGGCTCGATGTCTGACCAGTCCCCAGGTGTATGAT
AACCAAGAGCCACTGCGAGAAGATGACTCTGATTTCATCCTGACGGAAGGTGACCTCACCTTGA
CCTATGGAGATAGCACTGTGACAGCAAATGGCTCCTCAAGCTCCTACACAGCCTCCACGAGTCT
TGAGTGTGGTCGGAGAACAAAAAGCAGCTCTGAGGAAGTGCTTGAGCGAGACCTGGGAATGGGA
GACCAGAAGGTTTCCAGCCGGGGAACTCCCCTTGTGTTTCCACTGCAGGAAAATGCATGACTTA
CCTATAAATCCTGAGGGATCAGGGAGGCTCTCATAAGGGTGAGGATGGTCAAATGCCCCAGTGT
GTTTGATATGTTACATTGACTGTGTTAAAACTAATGCTTGCTTCAACGGGGCTTGAAACTCTCT
TACCACTCAAAACTTAACCCAAGACTCAGATGACGAAGCTGAAGTGTCTCTAAATTAAAGACAA
ATGTAGACCTATTCCCACTTTTTCACATAGTAGTACACTGTTTCAGAGTTAAACAAAACAATAG
CATGCTTTAATGGTCTCTCACTTCATCCTCCTGTAGCATCTGAGCATGGTGGGTTGGATAAGGG
GCTTCATCGCTACGCTATAGTGCCAGTCTAGCTGGCCCAAGAAACATCAAGTTGGGAGGACATG
TTAGACAAATGACAGTGAAGAAAGAAAGTGGGATCAGAATTCCAGTGGTGCCAGATGCTGGCGT
TGCACCAGATCATCCTCCTGTCACAGTCTTGCCTATTCTACTTGTGTTGCTCCTAGACTGAGGA
TTAGGAAGTATGTCCATAGGCTGGGGCCTTAGCTCAGTGGGAGAGTACTAGAGTACTTGCTGTA
GCTCACCAGACCCTGGGTTCTACCCCAGCACTGCAAAAATTGTGTGTATGTGCACAGGGGTTTT
CCAAGAGCATTTCAATATGGAGGTGGGCGGGGGTGGGGGGAGAAGTCTAGTTCCTTCTCTGGAA
ATCTTTATAAAAGAGTTACTGAAATGTTTAAAACCAAAGGCAAATCATGTTCTGTTCTTCTGTT
TTCATTAAATGAGGACTGGAGGTACTAGGAAACTGCTGATGATATCATGGCAATACTTATTTGA
CTTTTGAGGCTACCATGTGAGCCCACTGTCTAGAAGGTATCAGATATGAACTGAGATGTGTCCA
CCACAGGGTTTAAGGTAACATAGATATTGCTGTTTTCTGGGGGAAGATTAGGTAGCAAGAAACA
GAAGAGACCGTAGACTATAGTTTGAGGAAAGAGATTTTAATGTGAAAAATAACCTGTAAAGAAA
AGAAAAGATGGAAGTCTTTATTTTTATTTTACATAAATTTTACTTTAAAACATCCAAAAGAGAT
AATTCCAAAATCACACTACATAGAATATGGAACTTGCTTTGTTATAAATTATGAAAATATGTAT
GTTCAAGTAAACACTGAGTTTCCAATGCCAACTATTTCTATGACAAAAACTTCAATACTTATAA
TTACTTCCCCATTGTTACTATTTTCAACACCTAGAAGATGAAAATCATTCTGGTGCTTTGTTTC
AACCTGAACTTTTGTTACTAAAAATACATATCCAGAGCTTTTTAAATGAGTTAGTATTTCTGCT
TTCAGAATAGACAGGAAAGTCCAAAAACAAAACAAGAAAACAAACAAACAAAAAAACCCAAATC
TGACTTTTTAAAAC

hide sequence

RefSeq Acc Id:

XM_063280010 ⟹ XP_063136080

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	4,880,529 - 4,948,602 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001387931	(Get FASTA)	NCBI Sequence Viewer
	XP_006256699	(Get FASTA)	NCBI Sequence Viewer
	XP_063136080	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97690	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005623
	ENSRNOP00000005623.8
	ENSRNOP00000109119
	ENSRNOP00000109119.1

RefSeq Acc Id:

XP_006256699 ⟸ XM_006256637

- Peptide Label:

isoform X2

- Sequence:

show sequence

MEPSDAARPGPGRAVPGLSPRLLLLPLLPMLLGRGLRAGAAASSSGAAAEDSSAMEELATEKEA
EESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSGRD
KSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINNVEQNDMLRKVTFDPEVFFNILLPPI
IFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFF
GAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAA
FFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTG
VVAVLFCGITQAHYTYNNLSVESRSRSKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFII
GAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFALAIRDTASYSRQMMF
TTTLLIVFFTVWVIGGGTTPMLSWLNIRVGVDPDQDPPPNNDSFQVLQGDGLDSVGGSRTKQES
AWIFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLMARCLTSPQVYDNQEPLREDDSDFILTE
GDLTLTYGDSTVTANGSSSSYTASTSLECGRRTKSSSEEVLERDLGMGDQKVSSRGTPLVFPLQ
ENA

hide sequence

Ensembl Acc Id:

ENSRNOP00000005623 ⟸ ENSRNOT00000005623

RefSeq Acc Id:	NP_001387931 ⟸ NM_001401002
- UniProtKB:	D3ZCI2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136080 ⟸ XM_063280010
- Peptide Label:	isoform X1
- UniProtKB:	A6JZU5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109119 ⟸ ENSRNOT00000169478

Protein Domains

Cation/H+ exchanger transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZCI2-F1-model_v2	AlphaFold	D3ZCI2	1-359	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701700

Promoter ID:

EPDNEW_R12224

Type:

single initiation site

Name:

Slc9a7_1

Description:

solute carrier family 9 member A7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	2,435,264 - 2,435,324	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561385	AgrOrtholog
BioCyc Gene	G2FUF-3172	BioCyc
Ensembl Genes	ENSRNOG00000004150	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005623	ENTREZGENE
	ENSRNOT00000005623.8	UniProtKB/TrEMBL
	ENSRNOT00000169478	ENTREZGENE
	ENSRNOT00000169478.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.1330	UniProtKB/TrEMBL
InterPro	Cation/H_exchanger	UniProtKB/TrEMBL
	Cation/H_exchanger_cons-reg	UniProtKB/TrEMBL
	NaH_exchanger	UniProtKB/TrEMBL
	NHE-6/7/9	UniProtKB/TrEMBL
NCBI Gene	317170	ENTREZGENE
PANTHER	Cation/H_exchanger_cons-reg	UniProtKB/TrEMBL
	SODIUM/HYDROGEN EXCHANGER 7	UniProtKB/TrEMBL
Pfam	Na_H_Exchanger	UniProtKB/TrEMBL
PhenoGen	Slc9a7	PhenoGen
PRINTS	NAHEXCHNGR	UniProtKB/TrEMBL
	NAHEXCHNGR6	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004150	RatGTEx
UniProt	A0ABK0LXD6_RAT	UniProtKB/TrEMBL
	A6JZU5	ENTREZGENE, UniProtKB/TrEMBL
	D3ZCI2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Slc9a7	solute carrier family 9 member A7	Slc9a7	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc9a7	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	Slc9a7	solute carrier family 9 (sodium/hydrogen exchanger), member 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-02	Slc9a7	solute carrier family 9 (sodium/hydrogen exchanger), member 7	Slc9a7	solute carrier family 9 (sodium/hydrogen exchanger), isoform 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Slc9a7	solute carrier family 9 (sodium/hydrogen exchanger), isoform 7	Slc9a7_predicted	solute carrier family 9 (sodium/hydrogen exchanger), member 7 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Slc9a7_predicted	solute carrier family 9 (sodium/hydrogen exchanger), member 7 (predicted)		solute carrier family 9, member 7 (predicted)	Name updated	1299863	APPROVED
2006-03-07	Slc9a7_predicted	solute carrier family 9, member 7 (predicted)	Slc9a7	solute carrier family 9, member 7	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	Slc9a7	solute carrier family 9, member 7			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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