Asb12 (ankyrin repeat and SOCS box-containing 12) - Rat Genome Database

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Gene: Asb12 (ankyrin repeat and SOCS box-containing 12) Rattus norvegicus
Analyze
Symbol: Asb12
Name: ankyrin repeat and SOCS box-containing 12
RGD ID: 1561142
Description: Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and SOCS box protein 12; ankyrin repeat and SOCS box-containing protein 12; MGC125221
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X64,338,223 - 64,487,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX64,338,225 - 64,425,500 (-)EnsemblGRCr8
mRatBN7.2X60,328,325 - 60,478,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX60,328,328 - 60,415,619 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX61,798,577 - 61,886,086 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X65,299,093 - 65,386,606 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X62,878,056 - 62,965,560 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X64,714,337 - 64,800,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX64,714,335 - 64,800,435 (-)Ensemblrn6Rnor6.0
Rnor_5.0X65,613,501 - 65,699,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X83,013,812 - 83,102,298 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX60,748,301 - 60,835,640 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
ubiquitin ligase complex  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16325183  


Genomics

Comparative Map Data
Asb12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X64,338,223 - 64,487,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX64,338,225 - 64,425,500 (-)EnsemblGRCr8
mRatBN7.2X60,328,325 - 60,478,031 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX60,328,328 - 60,415,619 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX61,798,577 - 61,886,086 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X65,299,093 - 65,386,606 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X62,878,056 - 62,965,560 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X64,714,337 - 64,800,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX64,714,335 - 64,800,435 (-)Ensemblrn6Rnor6.0
Rnor_5.0X65,613,501 - 65,699,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X83,013,812 - 83,102,298 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX60,748,301 - 60,835,640 (-)NCBICelera
Cytogenetic MapXq22NCBI
ASB12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X64,224,194 - 64,230,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX64,224,194 - 64,230,607 (-)Ensemblhg38GRCh38
GRCh37X63,444,074 - 63,450,487 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X63,360,801 - 63,362,228 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X63,227,096 - 63,228,524NCBI
CeleraX63,790,909 - 63,792,336 (-)NCBICelera
Cytogenetic MapXq11.2NCBI
HuRefX57,267,791 - 57,274,235 (-)NCBIHuRef
CHM1_1X63,336,514 - 63,342,953 (-)NCBICHM1_1
T2T-CHM13v2.0X62,649,469 - 62,655,882 (-)NCBIT2T-CHM13v2.0
Asb12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X94,513,125 - 94,601,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX94,513,807 - 94,601,593 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X95,469,527 - 95,558,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX95,470,201 - 95,557,987 (-)Ensemblmm10GRCm38
MGSCv37X92,665,538 - 92,673,468 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X91,672,918 - 91,680,848 (-)NCBIMGSCv36mm8
CeleraX82,496,210 - 82,504,159 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.99NCBI
Asb12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554754,433,390 - 4,437,337 (+)Ensembl
ChiLan1.0NW_0049554754,429,854 - 4,436,633 (+)NCBIChiLan1.0ChiLan1.0
ASB12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X63,757,167 - 63,759,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X63,760,773 - 63,763,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X53,348,975 - 53,443,379 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X63,430,743 - 63,524,962 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX63,430,743 - 63,437,181 (-)EnsemblpanPan2panpan1.1
ASB12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X49,459,926 - 49,465,761 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX49,462,751 - 49,469,686 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX40,298,160 - 40,300,942 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X49,786,908 - 49,789,690 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX49,783,615 - 49,793,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X48,442,339 - 48,445,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X49,741,613 - 49,744,395 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X49,195,543 - 49,198,325 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Asb12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X52,681,728 - 52,688,167 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366353,447,345 - 3,453,762 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366353,447,347 - 3,453,762 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX50,877,166 - 50,878,674 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X50,877,158 - 50,883,739 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ASB12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X54,606,229 - 54,619,813 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX54,606,233 - 54,612,632 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660831,863,505 - 1,866,180 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248982,685,887 - 2,693,086 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248982,686,067 - 2,692,631 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Asb12
375 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000005663
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X6103585667175160Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
RH128635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X60,328,347 - 60,328,557 (+)MAPPERmRatBN7.2
Rnor_6.0X64,714,372 - 64,714,581NCBIRnor6.0
Rnor_5.0X65,613,536 - 65,613,745UniSTSRnor5.0
RGSC_v3.4X83,013,834 - 83,014,043UniSTSRGSC3.4
CeleraX60,748,323 - 60,748,532UniSTS
Cytogenetic MapXq31UniSTS
AU047577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X60,370,299 - 60,370,501 (+)MAPPERmRatBN7.2
mRatBN7.2X60,370,299 - 60,370,746 (+)MAPPERmRatBN7.2
Rnor_6.0X64,756,394 - 64,756,595NCBIRnor6.0
Rnor_6.0X64,756,394 - 64,756,954NCBIRnor6.0
Rnor_5.0X65,654,758 - 65,655,318UniSTSRnor5.0
Rnor_5.0X65,654,758 - 65,654,959UniSTSRnor5.0
RGSC_v3.4X83,056,556 - 83,056,757UniSTSRGSC3.4
CeleraX60,790,108 - 60,790,303UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 62 99 53 61 31 9 31 6 181 96 10 78 38 82 30 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000005663   ⟹   ENSRNOP00000005663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX64,338,225 - 64,425,500 (-)Ensembl
mRatBN7.2 EnsemblX60,328,328 - 60,415,619 (-)Ensembl
Rnor_6.0 EnsemblX64,714,350 - 64,800,435 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076012   ⟹   ENSRNOP00000068355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX60,329,190 - 60,339,551 (-)Ensembl
Rnor_6.0 EnsemblX64,715,214 - 64,726,210 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076297   ⟹   ENSRNOP00000067942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX64,714,350 - 64,715,823 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086265   ⟹   ENSRNOP00000074473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX64,714,335 - 64,726,241 (-)Ensembl
RefSeq Acc Id: NM_001037367   ⟹   NP_001032444
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,338,223 - 64,425,727 (-)NCBI
mRatBN7.2X60,328,326 - 60,415,846 (-)NCBI
Rnor_6.0X64,714,350 - 64,800,662 (-)NCBI
Rnor_5.0X65,613,501 - 65,699,198 (-)NCBI
RGSC_v3.4X83,013,812 - 83,102,298 (-)RGD
CeleraX60,748,301 - 60,835,640 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257044   ⟹   XP_006257106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,338,223 - 64,349,479 (-)NCBI
mRatBN7.2X60,328,325 - 60,339,657 (-)NCBI
Rnor_6.0X64,714,337 - 64,726,231 (-)NCBI
Rnor_5.0X65,613,501 - 65,699,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099991   ⟹   XP_038955919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,338,223 - 64,487,615 (-)NCBI
mRatBN7.2X60,328,325 - 60,478,031 (-)NCBI
RefSeq Acc Id: XM_063280265   ⟹   XP_063136335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,338,223 - 64,425,714 (-)NCBI
RefSeq Acc Id: NP_001032444   ⟸   NM_001037367
- UniProtKB: Q32Q00 (UniProtKB/TrEMBL),   F6RJR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257106   ⟸   XM_006257044
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000074473   ⟸   ENSRNOT00000086265
Ensembl Acc Id: ENSRNOP00000067942   ⟸   ENSRNOT00000076297
Ensembl Acc Id: ENSRNOP00000068355   ⟸   ENSRNOT00000076012
Ensembl Acc Id: ENSRNOP00000005663   ⟸   ENSRNOT00000005663
RefSeq Acc Id: XP_038955919   ⟸   XM_039099991
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136335   ⟸   XM_063280265
- Peptide Label: isoform X1
- UniProtKB: F6RJR3 (UniProtKB/TrEMBL),   Q32Q00 (UniProtKB/TrEMBL)
Protein Domains
SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32Q00-F1-model_v2 AlphaFold Q32Q00 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701852
Promoter ID:EPDNEW_R12371
Type:single initiation site
Name:Asb12_1
Description:ankyrin repeat and SOCS box-containing 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X64,726,210 - 64,726,270EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561142 AgrOrtholog
BioCyc Gene G2FUF-2208 BioCyc
Ensembl Genes ENSRNOG00000004197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005663 ENTREZGENE
  ENSRNOT00000005663.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453889 IMAGE-MGC_LOAD
InterPro Ankyrin-SOCS_box_domain UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  SOCS_box_dom_like UniProtKB/TrEMBL
  SOCS_C UniProtKB/TrEMBL
KEGG Report rno:503446 UniProtKB/TrEMBL
MGC_CLONE MGC:125221 IMAGE-MGC_LOAD
NCBI Gene 503446 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  SOWAH (DROSOPHILA) HOMOLOG UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PhenoGen Asb12 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004197 RatGTEx
SMART ANK UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF158235 UniProtKB/TrEMBL
UniProt F6RJR3 ENTREZGENE, UniProtKB/TrEMBL
  Q32Q00 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Asb12  ankyrin repeat and SOCS box-containing 12  Asb12  ankyrin repeat and SOCS box-containing protein 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Asb12  ankyrin repeat and SOCS box-containing protein 12      Symbol and Name status set to provisional 70820 PROVISIONAL