Itln1 (intelectin 1) - Rat Genome Database

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Gene: Itln1 (intelectin 1) Rattus norvegicus
Analyze
Symbol: Itln1
Name: intelectin 1
RGD ID: 1561048
Description: Predicted to enable calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Predicted to be involved in positive regulation of D-glucose import; protein homotrimerization; and response to nematode. Predicted to be located in brush border membrane and membrane raft. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Orthologous to several human genes including ITLN1 (intelectin 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: intelectin 1 (galactofuranose binding); intelectin 1 (galactofuranose binding)-like; intelectin-1; LOC498284; MGC124684; similar to intelectin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,464,641 - 86,490,655 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,464,669 - 86,490,651 (+)EnsemblGRCr8
mRatBN7.21383,932,234 - 83,958,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,948,124 - 83,958,227 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,453,887 - 86,463,994 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,852,107 - 87,862,214 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,087,662 - 85,097,769 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,919,570 - 89,929,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,919,667 - 89,929,770 (+)Ensemblrn6Rnor6.0
Rnor_5.01394,546,165 - 94,556,303 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,445,119 - 87,455,226 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,578,295 - 83,588,402 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability. Kadoglou NP, etal., Atherosclerosis. 2014 Aug;235(2):606-12. doi: 10.1016/j.atherosclerosis.2014.05.957. Epub 2014 Jun 8.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies. Valencia-Martínez A, etal., J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4078-e4085. doi: 10.1210/clinem/dgac414.
Additional References at PubMed
PMID:16531507   PMID:16866365   PMID:17420014   PMID:19056867   PMID:23376485   PMID:23382219   PMID:25002582   PMID:25869566   PMID:26144294   PMID:26148048   PMID:28017783   PMID:30794687  
PMID:33739937   PMID:38652961  


Genomics

Comparative Map Data
Itln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,464,641 - 86,490,655 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,464,669 - 86,490,651 (+)EnsemblGRCr8
mRatBN7.21383,932,234 - 83,958,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,948,124 - 83,958,227 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,453,887 - 86,463,994 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,852,107 - 87,862,214 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,087,662 - 85,097,769 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,919,570 - 89,929,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,919,667 - 89,929,770 (+)Ensemblrn6Rnor6.0
Rnor_5.01394,546,165 - 94,556,303 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,445,119 - 87,455,226 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,578,295 - 83,588,402 (+)NCBICelera
Cytogenetic Map13q24NCBI
ITLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,876,540 - 160,885,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,876,539 - 160,893,012 (-)Ensemblhg38GRCh38
GRCh371160,846,330 - 160,854,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,112,954 - 159,121,584 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341157,659,404 - 157,668,033NCBI
Celera1133,914,518 - 133,923,141 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,202,640 - 132,211,271 (-)NCBIHuRef
CHM1_11162,241,723 - 162,250,352 (-)NCBICHM1_1
T2T-CHM13v2.01160,013,580 - 160,022,212 (-)NCBIT2T-CHM13v2.0
Itln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,345,691 - 171,362,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,345,690 - 171,362,862 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381171,518,123 - 171,535,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,518,122 - 171,535,294 (-)Ensemblmm10GRCm38
MGSCv371173,448,254 - 173,465,424 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361173,354,798 - 173,371,968 (-)NCBIMGSCv36mm8
Celera1174,384,162 - 174,390,323 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.49NCBI
Itln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,568,381 - 12,683,472 (-)Ensembl
ChiLan1.0NW_00495546812,568,465 - 12,573,663 (-)NCBIChiLan1.0ChiLan1.0
ITLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,962,311 - 88,972,593 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,703,069 - 88,712,799 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,233,093 - 136,242,888 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,156,335 - 140,165,211 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,156,335 - 140,165,211 (-)EnsemblpanPan2panpan1.1
Itln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,983,119 - 6,990,790 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936903191,836 - 199,448 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITLN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1489,625,966 - 89,637,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,610,137 - 97,621,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,051,929 - 3,088,690 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,078,856 - 3,089,055 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660382,119,371 - 2,129,068 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794419,503 - 434,139 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Itln1
174 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000006196
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 54 31 31 8 15 8 6 77 40 2 40 13 46 23 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000006196   ⟹   ENSRNOP00000006196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,480,463 - 86,490,651 (+)Ensembl
mRatBN7.2 Ensembl1383,948,124 - 83,958,227 (+)Ensembl
Rnor_6.0 Ensembl1389,919,667 - 89,929,770 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154691   ⟹   ENSRNOP00000099961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,464,669 - 86,490,651 (+)Ensembl
RefSeq Acc Id: NM_001034946   ⟹   NP_001030118
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,480,548 - 86,490,655 (+)NCBI
mRatBN7.21383,948,124 - 83,958,231 (+)NCBI
Rnor_6.01389,919,667 - 89,929,774 (+)NCBI
Rnor_5.01394,546,165 - 94,556,303 (+)NCBI
RGSC_v3.41387,445,119 - 87,455,226 (+)RGD
Celera1383,578,295 - 83,588,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598901   ⟹   XP_017454390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,464,659 - 86,490,655 (+)NCBI
mRatBN7.21383,932,234 - 83,958,243 (+)NCBI
Rnor_6.01389,919,570 - 89,929,774 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090984   ⟹   XP_038946912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,464,659 - 86,490,655 (+)NCBI
mRatBN7.21383,932,234 - 83,958,243 (+)NCBI
RefSeq Acc Id: XM_063272546   ⟹   XP_063128616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,464,641 - 86,490,655 (+)NCBI
RefSeq Acc Id: NP_001030118   ⟸   NM_001034946
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_017454390   ⟸   XM_017598901
- Peptide Label: isoform X1
- UniProtKB: A6JG02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006196   ⟸   ENSRNOT00000006196
RefSeq Acc Id: XP_038946912   ⟸   XM_039090984
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128616   ⟸   XM_063272546
- Peptide Label: isoform X1
- UniProtKB: A6JG02 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099961   ⟸   ENSRNOT00000154691
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PT30-F1-model_v2 AlphaFold E9PT30 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699010
Promoter ID:EPDNEW_R9535
Type:single initiation site
Name:Itln1_1
Description:intelectin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,919,656 - 89,919,716EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561048 AgrOrtholog
BioCyc Gene G2FUF-17362 BioCyc
Ensembl Genes ENSRNOG00000004678 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006196 ENTREZGENE
  ENSRNOT00000006196.6 UniProtKB/TrEMBL
  ENSRNOT00000154691 ENTREZGENE
  ENSRNOT00000154691.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7931002 IMAGE-MGC_LOAD
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
KEGG Report rno:498284 UniProtKB/TrEMBL
MGC_CLONE MGC:124684 IMAGE-MGC_LOAD
NCBI Gene 498284 ENTREZGENE
PANTHER INTELECTIN UniProtKB/TrEMBL
  INTELECTIN-1A-RELATED UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PhenoGen Itln1 PhenoGen
PROSITE FIBRINOGEN_C_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004678 RatGTEx
Superfamily-SCOP Fibrinogen_a/b/g_C UniProtKB/TrEMBL
UniProt A0ABK0LAA8_RAT UniProtKB/TrEMBL
  A6JG02 ENTREZGENE, UniProtKB/TrEMBL
  E9PT30_RAT UniProtKB/TrEMBL
  Q499T8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Itln1  intelectin 1  Itln1  intelectin 1 (galactofuranose binding)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Itln1  intelectin 1 (galactofuranose binding)  LOC100363780  intelectin 1 (galactofuranose binding)-like  Data merged from RGD:2322372 1643240 APPROVED
2010-05-06 LOC100363780  intelectin 1 (galactofuranose binding)-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Itln1  intelectin 1 (galactofuranose binding)  LOC498284  similar to intelectin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498284  similar to intelectin      Symbol and Name status set to provisional 70820 PROVISIONAL