Prdm10 (PR/SET domain 10) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Prdm10 (PR/SET domain 10) Rattus norvegicus
Analyze
Symbol: Prdm10
Name: PR/SET domain 10
RGD ID: 1560384
Description: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of transcription repressor complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome. Orthologous to human PRDM10 (PR/SET domain 10); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC500964; PR domain 10; PR domain containing 10; PR domain zinc finger protein 10; RGD1560384; similar to PR domain containing 10 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,982,210 - 38,085,907 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl837,982,403 - 38,085,907 (+)EnsemblGRCr8
mRatBN7.2829,724,011 - 29,827,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,724,245 - 29,826,080 (+)EnsemblmRatBN7.2
Rnor_6.0832,419,921 - 32,526,357 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,452,885 - 32,526,351 (+)Ensemblrn6Rnor6.0
Rnor_5.0832,445,116 - 32,551,157 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4831,067,787 - 31,137,510 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera831,182,995 - 31,286,272 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription repressor complex  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:31143550  


Genomics

Comparative Map Data
Prdm10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,982,210 - 38,085,907 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl837,982,403 - 38,085,907 (+)EnsemblGRCr8
mRatBN7.2829,724,011 - 29,827,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,724,245 - 29,826,080 (+)EnsemblmRatBN7.2
Rnor_6.0832,419,921 - 32,526,357 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,452,885 - 32,526,351 (+)Ensemblrn6Rnor6.0
Rnor_5.0832,445,116 - 32,551,157 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4831,067,787 - 31,137,510 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera831,182,995 - 31,286,272 (+)NCBICelera
Cytogenetic Map8q13NCBI
PRDM10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811129,899,711 - 130,002,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11129,899,706 - 130,002,853 (-)Ensemblhg38GRCh38
GRCh3711129,769,606 - 129,872,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,274,811 - 129,377,940 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411129,274,811 - 129,322,727NCBI
Celera11126,937,763 - 127,040,883 (-)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11125,721,900 - 125,824,816 (-)NCBIHuRef
CHM1_111129,655,207 - 129,758,324 (-)NCBICHM1_1
T2T-CHM13v2.011129,935,739 - 130,038,861 (-)NCBIT2T-CHM13v2.0
Prdm10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39931,187,406 - 31,293,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,191,834 - 31,293,019 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38931,276,110 - 31,381,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,280,538 - 31,381,723 (+)Ensemblmm10GRCm38
MGSCv37931,122,692 - 31,186,128 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36931,064,672 - 31,128,108 (+)NCBIMGSCv36mm8
Celera928,576,073 - 28,639,529 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.77NCBI
Prdm10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541230,852,969 - 30,917,510 (-)Ensembl
ChiLan1.0NW_00495541230,855,909 - 30,929,998 (-)NCBIChiLan1.0ChiLan1.0
PRDM10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29130,581,304 - 130,685,566 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111131,691,376 - 131,796,261 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011124,712,440 - 124,816,141 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111128,607,595 - 128,710,159 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11128,607,600 - 128,710,156 (-)EnsemblpanPan2panpan1.1
PRDM10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,845,250 - 4,941,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,879,192 - 4,939,649 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha54,905,820 - 5,002,476 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.054,854,894 - 4,900,174 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,838,922 - 4,900,187 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,866,219 - 4,962,418 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,847,919 - 4,944,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,875,898 - 4,972,604 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prdm10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,016,843 - 112,116,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365722,371,495 - 2,433,527 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365722,369,096 - 2,433,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDM10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl956,657,270 - 56,749,482 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1956,657,270 - 56,749,487 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2962,881,051 - 62,960,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDM10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,982,207 - 121,086,938 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,982,993 - 121,044,928 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660435,014,790 - 5,113,060 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdm10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248124,287,749 - 4,390,020 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248124,283,179 - 4,389,520 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prdm10
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1827,002,378 - 27,103,109 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prdm10
1318 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:26
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000010423, ENSRNOT00000060621
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
D8Got39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,751,676 - 29,751,880 (+)MAPPERmRatBN7.2
Rnor_6.0832,449,811 - 32,450,014NCBIRnor6.0
Rnor_5.0832,474,611 - 32,474,814UniSTSRnor5.0
RGSC_v3.4831,064,589 - 31,064,793RGDRGSC3.4
RGSC_v3.4831,064,590 - 31,064,793UniSTSRGSC3.4
Celera831,212,863 - 31,213,064UniSTS
RGSC_v3.1831,073,356 - 31,073,559RGD
RH 3.4 Map8244.2UniSTS
RH 3.4 Map8244.2RGD
RH 2.0 Map8176.7RGD
Cytogenetic Map8q13UniSTS
D8M9Mit188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,803,357 - 29,803,788 (+)MAPPERmRatBN7.2
Rnor_6.0832,501,960 - 32,502,390NCBIRnor6.0
Rnor_5.0832,526,760 - 32,527,190UniSTSRnor5.0
RGSC_v3.4831,116,263 - 31,116,693UniSTSRGSC3.4
Celera831,264,532 - 31,264,963UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 355 192 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010423   ⟹   ENSRNOP00000010423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,982,403 - 38,085,907 (+)Ensembl
mRatBN7.2 Ensembl829,724,245 - 29,826,080 (+)Ensembl
Rnor_6.0 Ensembl832,452,885 - 32,526,351 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094753   ⟹   ENSRNOP00000087282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,982,403 - 38,085,907 (+)Ensembl
mRatBN7.2 Ensembl829,724,245 - 29,826,080 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113679   ⟹   ENSRNOP00000078533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,982,403 - 38,029,433 (+)Ensembl
mRatBN7.2 Ensembl829,724,245 - 29,771,277 (+)Ensembl
RefSeq Acc Id: NM_001427772   ⟹   NP_001414701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,982,403 - 38,085,907 (+)NCBI
RefSeq Acc Id: XM_017595995   ⟹   XP_017451484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,982,210 - 38,085,907 (+)NCBI
mRatBN7.2829,724,011 - 29,827,757 (+)NCBI
Rnor_6.0832,419,924 - 32,526,357 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001414701 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451484 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83311 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010423.7
  ENSRNOP00000078533.1
  ENSRNOP00000087282
  ENSRNOP00000087282.1
RefSeq Acc Id: XP_017451484   ⟸   XM_017595995
- Peptide Label: isoform X1
- UniProtKB: D3ZQ79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010423   ⟸   ENSRNOT00000010423
Ensembl Acc Id: ENSRNOP00000087282   ⟸   ENSRNOT00000094753
Ensembl Acc Id: ENSRNOP00000078533   ⟸   ENSRNOT00000113679
RefSeq Acc Id: NP_001414701   ⟸   NM_001427772
- UniProtKB: D3ZQ79 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQ79-F1-model_v2 AlphaFold D3ZQ79 1-1146 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560384 AgrOrtholog
BioCyc Gene G2FUF-31257 BioCyc
Ensembl Genes ENSRNOG00000007853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010423.9 UniProtKB/TrEMBL
  ENSRNOT00000094753 ENTREZGENE
  ENSRNOT00000094753.2 UniProtKB/TrEMBL
  ENSRNOT00000113679.2 UniProtKB/TrEMBL
Gene3D-CATH 2.170.270.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro PRDM10_PR/SET UniProtKB/TrEMBL
  SET_dom UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/TrEMBL
  Zinc_finger UniProtKB/TrEMBL
  Zinc_finger/UBP_domain UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 500964 ENTREZGENE
PANTHER GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN UniProtKB/TrEMBL
  PR DOMAIN ZINC FINGER PROTEIN 10 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam PRDM2_PR UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-met UniProtKB/TrEMBL
PhenoGen Prdm10 PhenoGen
PROSITE SET UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007853 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
  SSF82199 UniProtKB/TrEMBL
UniProt A0A8I5ZN18_RAT UniProtKB/TrEMBL
  A0A8I6A7P1_RAT UniProtKB/TrEMBL
  D3ZQ79 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Prdm10  PR/SET domain 10  Prdm10  PR domain 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prdm10  PR domain 10  Prdm10  PR domain containing 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Prdm10  PR domain containing 10  RGD1560384_predicted  similar to PR domain containing 10 isoform 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560384_predicted  similar to PR domain containing 10 isoform 2 (predicted)  LOC500964  similar to PR domain containing 10 isoform 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500964  similar to PR domain containing 10 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL