Sash3 (SAM and SH3 domain containing 3) - Rat Genome Database

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Gene: Sash3 (SAM and SH3 domain containing 3) Rattus norvegicus
Analyze
Symbol: Sash3
Name: SAM and SH3 domain containing 3
RGD ID: 1560293
Description: Predicted to be involved in several processes, including positive regulation of B cell proliferation; positive regulation of adaptive immune response; and positive regulation of immunoglobulin production. Predicted to act upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and positive regulation of organ growth. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 102. Orthologous to human SASH3 (SAM and SH3 domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC317578; MGC189506; RGD1560293; SAM and SH3 domain-containing protein 3; similar to RIKEN cDNA 1200013B08
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,204,717 - 132,219,421 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX132,204,543 - 132,219,419 (+)EnsemblGRCr8
mRatBN7.2X127,326,815 - 127,341,521 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,326,859 - 127,341,519 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX129,452,837 - 129,467,495 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,023,434 - 133,038,098 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,549,991 - 130,564,647 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X134,979,637 - 134,994,351 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,979,646 - 134,994,349 (+)Ensemblrn6Rnor6.0
Rnor_5.0X135,052,951 - 135,067,689 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X134,511,776 - 134,526,489 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX126,277,336 - 126,292,010 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16227612  


Genomics

Comparative Map Data
Sash3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,204,717 - 132,219,421 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX132,204,543 - 132,219,419 (+)EnsemblGRCr8
mRatBN7.2X127,326,815 - 127,341,521 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,326,859 - 127,341,519 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX129,452,837 - 129,467,495 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,023,434 - 133,038,098 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,549,991 - 130,564,647 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X134,979,637 - 134,994,351 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,979,646 - 134,994,349 (+)Ensemblrn6Rnor6.0
Rnor_5.0X135,052,951 - 135,067,689 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X134,511,776 - 134,526,489 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX126,277,336 - 126,292,010 (+)NCBICelera
Cytogenetic MapXq36NCBI
SASH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X129,779,949 - 129,795,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX129,779,949 - 129,795,201 (+)Ensemblhg38GRCh38
GRCh37X128,913,925 - 128,929,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,741,641 - 128,756,858 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X128,639,494 - 128,654,709NCBI
CeleraX129,300,396 - 129,315,681 (+)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX118,315,088 - 118,330,679 (+)NCBIHuRef
CHM1_1X128,825,238 - 128,840,527 (+)NCBICHM1_1
T2T-CHM13v2.0X128,098,744 - 128,113,978 (+)NCBIT2T-CHM13v2.0
Sash3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,235,313 - 47,250,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,235,313 - 47,250,442 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X48,146,436 - 48,161,565 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,146,436 - 48,161,565 (+)Ensemblmm10GRCm38
MGSCv37X45,499,704 - 45,514,740 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X44,391,154 - 44,406,190 (+)NCBIMGSCv36mm8
CeleraX35,648,999 - 35,664,024 (+)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX25.54NCBI
Sash3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554735,222,408 - 5,237,260 (-)Ensembl
ChiLan1.0NW_0049554735,224,635 - 5,237,066 (-)NCBIChiLan1.0ChiLan1.0
SASH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X129,203,040 - 129,218,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X129,206,616 - 129,221,925 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X118,909,980 - 118,924,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X129,207,049 - 129,222,342 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX129,207,049 - 129,222,342 (+)EnsemblpanPan2panpan1.1
SASH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X100,989,605 - 101,003,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX100,989,685 - 101,001,885 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX87,163,546 - 87,177,092 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X102,841,088 - 102,854,632 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX102,841,145 - 102,854,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X100,259,370 - 100,272,917 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X102,105,560 - 102,119,104 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X101,883,353 - 101,896,898 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sash3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,222,104 - 99,235,375 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364791,750,746 - 1,765,361 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364791,752,180 - 1,765,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SASH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,373,954 - 106,389,444 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X106,373,871 - 106,389,454 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,142,841 - 122,158,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SASH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X105,057,782 - 105,072,994 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX105,057,570 - 105,073,354 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606542,472,786 - 42,488,013 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sash3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247979,001,795 - 9,018,027 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247979,001,846 - 9,017,441 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sash3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X110,247,426 - 110,262,166 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sash3
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:208
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000006035
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 160 91 90 59 92 59 6 355 191 11 133 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000006035   ⟹   ENSRNOP00000006035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX132,204,543 - 132,219,419 (+)Ensembl
mRatBN7.2 EnsemblX127,326,859 - 127,341,519 (+)Ensembl
Rnor_6.0 EnsemblX134,979,646 - 134,994,349 (+)Ensembl
RefSeq Acc Id: NM_001134992   ⟹   NP_001128464
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,204,760 - 132,219,421 (+)NCBI
mRatBN7.2X127,326,859 - 127,341,521 (+)NCBI
Rnor_6.0X134,979,690 - 134,994,351 (+)NCBI
Rnor_5.0X135,052,951 - 135,067,689 (+)NCBI
RGSC_v3.4X134,511,776 - 134,526,489 (+)RGD
CeleraX126,277,336 - 126,292,010 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257530   ⟹   XP_006257592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,204,717 - 132,219,421 (+)NCBI
mRatBN7.2X127,326,815 - 127,341,521 (+)NCBI
Rnor_6.0X134,979,637 - 134,994,351 (+)NCBI
Rnor_5.0X135,052,951 - 135,067,689 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001128464 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257592 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69091 (Get FASTA)   NCBI Sequence Viewer  
  EDM10906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006035
  ENSRNOP00000006035.5
RefSeq Acc Id: NP_001128464   ⟸   NM_001134992
- UniProtKB: B5DFK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257592   ⟸   XM_006257530
- Peptide Label: isoform X1
- UniProtKB: F7EM42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006035   ⟸   ENSRNOT00000006035
Protein Domains
SAM   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFK2-F1-model_v2 AlphaFold B5DFK2 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702009
Promoter ID:EPDNEW_R12533
Type:initiation region
Name:Sash3_1
Description:SAM and SH3 domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X134,979,694 - 134,979,754EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560293 AgrOrtholog
BioCyc Gene G2FUF-1139 BioCyc
Ensembl Genes ENSRNOG00000004409 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006035 ENTREZGENE
  ENSRNOT00000006035.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro SAM UniProtKB/TrEMBL
  SAM-SH3_domain_protein UniProtKB/TrEMBL
  SAM/SH3_domain-containing UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  SASH3_SH3 UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:317578 UniProtKB/TrEMBL
NCBI Gene 317578 ENTREZGENE
PANTHER PTHR12301:SF5 UniProtKB/TrEMBL
  SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED UniProtKB/TrEMBL
Pfam SAM_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
  SLY UniProtKB/TrEMBL
PhenoGen Sash3 PhenoGen
PROSITE SAM_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004409 RatGTEx
SMART SAM UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SAM_homology UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
UniProt B5DFK2 ENTREZGENE, UniProtKB/TrEMBL
  F7EM42 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Sash3  SAM and SH3 domain containing 3  RGD1560293_predicted  similar to RIKEN cDNA 1200013B08 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560293_predicted  similar to RIKEN cDNA 1200013B08 (predicted)  LOC317578  similar to RIKEN cDNA 1200013B08  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317578  similar to RIKEN cDNA 1200013B08      Symbol and Name status set to provisional 70820 PROVISIONAL