Ppidl1 (peptidylprolyl isomerase D-like 1) - Rat Genome Database

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Gene: Ppidl1 (peptidylprolyl isomerase D-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ppidl1
Name: peptidylprolyl isomerase D-like 1
RGD ID: 1560149
Description: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Orthologous to human PPID (peptidylprolyl isomerase D); PARTICIPATES IN calcium/calcium-mediated signaling pathway; Huntington's disease pathway; Parkinson's disease pathway; INTERACTS WITH (+)-schisandrin B; tetrachloromethane; thioacetamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC501204; peptidyl-prolyl cis-trans isomerase D; RGD1560149; similar to peptidylprolyl isomerase D
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,290,284 - 120,291,608 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9120,290,334 - 120,291,446 (+)EnsemblGRCr8
mRatBN7.29112,843,668 - 112,844,916 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9112,843,665 - 112,844,992 (+)EnsemblmRatBN7.2
Rnor_6.09121,456,762 - 121,458,035 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,456,623 - 121,457,951 (+)Ensemblrn6Rnor6.0
Rnor_5.09120,902,997 - 120,904,294 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49112,262,168 - 112,263,280 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9109,958,032 - 109,959,305 (+)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
protein folding  (IBA,IEA)

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IBA)
nucleoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:89
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000056255
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat

Markers in Region
RH128961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29112,844,790 - 112,844,970 (+)MAPPERmRatBN7.2
mRatBN7.22164,739,652 - 164,739,832 (+)MAPPERmRatBN7.2
Rnor_6.02178,366,646 - 178,366,825NCBIRnor6.0
Rnor_6.09121,457,850 - 121,458,029NCBIRnor6.0
Rnor_5.09120,904,093 - 120,904,272UniSTSRnor5.0
Rnor_5.02197,702,099 - 197,702,278UniSTSRnor5.0
RGSC_v3.42171,007,735 - 171,007,914UniSTSRGSC3.4
RGSC_v3.49112,263,241 - 112,263,420UniSTSRGSC3.4
Celera9109,959,120 - 109,959,299UniSTS
Celera2158,836,229 - 158,836,408UniSTS
Cytogenetic Map9q38UniSTS
Cytogenetic Map2q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 85 84 53 84 53 6 333 184 11 144 72 88 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056255   ⟹   ENSRNOP00000066795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9120,290,334 - 120,291,446 (+)Ensembl
mRatBN7.2 Ensembl9112,843,665 - 112,844,992 (+)Ensembl
Rnor_6.0 Ensembl9121,456,623 - 121,457,951 (+)Ensembl
RefSeq Acc Id: XM_056984638   ⟹   XP_056840618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,290,284 - 120,291,608 (+)NCBI
mRatBN7.29112,843,668 - 112,844,916 (+)NCBI
Protein Sequences
Protein RefSeqs XP_056840618 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90962 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066795.4
  ENSRNOP00000093695.1
Ensembl Acc Id: ENSRNOP00000066795   ⟸   ENSRNOT00000056255
RefSeq Acc Id: XP_056840618   ⟸   XM_056984638
- UniProtKB: M0RB67 (UniProtKB/TrEMBL),   A6KFB0 (UniProtKB/TrEMBL),   A0A8I6GKS0 (UniProtKB/TrEMBL)
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RB67-F1-model_v2 AlphaFold M0RB67 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560149 AgrOrtholog
BioCyc Gene G2FUF-26309 BioCyc
Ensembl Genes ENSRNOG00000027408 UniProtKB/TrEMBL
  ENSRNOG00000037230 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056255.6 UniProtKB/TrEMBL
  ENSRNOT00000097015.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  2.40.100.10 UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom UniProtKB/TrEMBL
  Cyclophilin-like_PPIase_dom UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
NCBI Gene 501204 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/TrEMBL
PhenoGen Ppidl1 PhenoGen
PRINTS CSAPPISMRASE UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027408 RatGTEx
  ENSRNOG00000037230 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
  SSF50891 UniProtKB/TrEMBL
UniProt A0A8I6GKS0 ENTREZGENE, UniProtKB/TrEMBL
  A6KFB0 ENTREZGENE, UniProtKB/TrEMBL
  M0RB67 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Ppidl1  peptidylprolyl isomerase D-like 1  RGD1560149  similar to peptidylprolyl isomerase D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560149  similar to peptidylprolyl isomerase D   RGD1560149_predicted  similar to peptidylprolyl isomerase D (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560149_predicted  similar to peptidylprolyl isomerase D (predicted)  LOC501204  similar to peptidylprolyl isomerase D  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501204  similar to peptidylprolyl isomerase D      Symbol and Name status set to provisional 70820 PROVISIONAL