Ctsll3 (cathepsin L-like 3) - Rat Genome Database

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Gene: Ctsll3 (cathepsin L-like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsll3
Name: cathepsin L-like 3
RGD ID: 1560071
Description: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cathepsin L1; LOC498691; procathepsin L; RGD1560071; similar to Cathepsin L-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,894,151 - 3,898,732 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,894,151 - 3,898,732 (+)EnsemblGRCr8
mRatBN7.2173,888,544 - 3,893,125 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,889,811 - 3,892,881 (+)EnsemblmRatBN7.2
Rnor_6.0174,256,311 - 4,259,625 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,256,299 - 4,273,170 (+)Ensemblrn6Rnor6.0
Rnor_5.0176,484,334 - 6,487,648 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,575,189 - 9,579,770 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,018,855 - 4,022,169 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IBA)
lysosome  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ctsll3
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000061398
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 18 8 5 6 1 34 1 5 69 55 2 2 18 5

Sequence


Ensembl Acc Id: ENSRNOT00000061398   ⟹   ENSRNOP00000058115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,894,151 - 3,898,732 (+)Ensembl
mRatBN7.2 Ensembl173,889,811 - 3,892,881 (+)Ensembl
RefSeq Acc Id: NM_001408676   ⟹   NP_001395605
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,894,151 - 3,898,732 (+)NCBI
mRatBN7.2173,888,544 - 3,893,125 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395605 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93861 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058115
  ENSRNOP00000058115.2
Ensembl Acc Id: ENSRNOP00000058115   ⟸   ENSRNOT00000061398
RefSeq Acc Id: NP_001395605   ⟸   NM_001408676
- Peptide Label: precursor
- UniProtKB: D3ZJV2 (UniProtKB/TrEMBL),   A6KAF3 (UniProtKB/TrEMBL)
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX50-F1-model_v2 AlphaFold A0A0G2JX50 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560071 AgrOrtholog
BioCyc Gene G2FUF-10470 BioCyc
Ensembl Genes ENSRNOG00000039954 Ensembl
  ENSRNOG00000069877 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061398 ENTREZGENE
  ENSRNOT00000061398.5 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
NCBI Gene 498691 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Ctsll3 PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039954 RatGTEx
  ENSRNOG00000069877 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6KAF3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ctsll3  cathepsin L-like 3  Ctsll3  cathepsin L-like 3  Data merged from RGD:149736104 737654 PROVISIONAL
2021-08-09 Ctsll3  cathepsin L-like 3      Symbol and Name status set to provisional 45752 PROVISIONAL
2010-04-23 Ctsll3  cathepsin L-like 3  RGD1560071  similar to Cathepsin L-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560071  similar to Cathepsin L-like   RGD1560071_predicted  similar to Cathepsin L-like (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560071_predicted  similar to Cathepsin L-like (predicted)  LOC498691  similar to Cathepsin L-like  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498691  similar to Cathepsin L-like      Symbol and Name status set to provisional 70820 PROVISIONAL