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Gene: Lair1 (leukocyte-associated immunoglobulin-like receptor 1) Rattus norvegicus
Analyze
Symbol:
Lair1
Name:
leukocyte-associated immunoglobulin-like receptor 1
RGD ID:
1560048
Description:
Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; vinclozolin.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LAIR-1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; rLAIR1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
LAIR1 (leukocyte associated immunoglobulin like receptor 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Lair1 (leukocyte-associated Ig-like receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LAIR1 (leukocyte associated immunoglobulin like receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
LAIR1 (leukocyte associated immunoglobulin like receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
LOC100515837 (leukocyte-associated immunoglobulin-like receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
LAIR1 (leukocyte associated immunoglobulin like receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Lair1 (leukocyte associated immunoglobulin like receptor 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
LAIR2 (leukocyte associated immunoglobulin like receptor 2) HGNC
OrthoDB, PhylomeDB, Treefam
Alliance orthologs 3
Homo sapiens (human):
LAIR1 (leukocyte associated immunoglobulin like receptor 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
LAIR2 (leukocyte associated immunoglobulin like receptor 2)
Alliance
DIOPT (OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Lair1 (leukocyte-associated Ig-like receptor 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 79,140,850 - 79,261,546 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 1 79,198,311 - 79,258,037 (+) Ensembl GRCr8 mRatBN7.2 1 70,068,571 - 70,187,851 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 70,157,681 - 70,185,807 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 1 75,546,105 - 75,573,943 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 84,110,429 - 84,138,264 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 77,273,413 - 77,301,247 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 1 73,752,192 - 73,870,421 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 73,837,944 - 73,868,695 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 1 74,679,905 - 74,688,244 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 1 69,571,996 - 69,601,974 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 1 66,932,886 - 66,963,631 (-) NCBI Celera Cytogenetic Map 1 q21 NCBI
JBrowse:
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Lair1 Rat 1,1-dichloroethene increases expression ISO Lair1 (Mus musculus) 6480464 vinylidene chloride results in increased expression of LAIR1 mRNA CTD PMID:26682919 Lair1 Rat 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of LAIR1 mRNA CTD PMID:27840820 Lair1 Rat 1,2-dimethylhydrazine increases expression ISO Lair1 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in increased expression of LAIR1 mRNA CTD PMID:22206623 Lair1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Lair1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of LAIR1 mRNA CTD PMID:26290441 Lair1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Lair1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of LAIR1 mRNA CTD PMID:26377647 Lair1 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Lair1 (Mus musculus) 6480464 2,2',4,4',5-brominated diphenyl ether affects the expression of LAIR1 mRNA CTD PMID:38648751 Lair1 Rat 4,4'-sulfonyldiphenol increases expression ISO LAIR1 (Homo sapiens) 6480464 bisphenol S results in increased expression of LAIR1 protein CTD PMID:34186270 Lair1 Rat 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid increases expression ISO LAIR1 (Homo sapiens) 6480464 Am 580 results in increased expression of LAIR1 mRNA CTD PMID:16982809 Lair1 Rat all-trans-retinoic acid increases expression ISO LAIR1 (Homo sapiens) 6480464 Tretinoin results in increased expression of LAIR1 mRNA CTD PMID:33167477 Lair1 Rat antirheumatic drug decreases expression ISO LAIR1 (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of LAIR1 mRNA CTD PMID:24449571 Lair1 Rat atrazine increases expression ISO LAIR1 (Homo sapiens) 6480464 Atrazine results in increased expression of LAIR1 mRNA CTD PMID:22378314 Lair1 Rat benzo[a]pyrene decreases expression ISO LAIR1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of LAIR1 mRNA CTD PMID:20064835|PMID:32234424 Lair1 Rat benzo[a]pyrene increases expression ISO LAIR1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of LAIR1 mRNA CTD PMID:30453624 Lair1 Rat benzo[a]pyrene decreases methylation ISO LAIR1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of LAIR1 5' UTR CTD PMID:27901495 Lair1 Rat benzo[a]pyrene affects methylation ISO LAIR1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of LAIR1 promoter CTD PMID:27901495 Lair1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LAIR1 mRNA CTD PMID:25181051 Lair1 Rat bisphenol A increases expression ISO LAIR1 (Homo sapiens) 6480464 bisphenol A results in increased expression of LAIR1 protein CTD PMID:34186270 Lair1 Rat bisphenol A multiple interactions ISO LAIR1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of LAIR1 gene CTD PMID:31601247 Lair1 Rat bisphenol A increases expression ISO Lair1 (Mus musculus) 6480464 bisphenol A results in increased expression of LAIR1 mRNA CTD PMID:38701888 Lair1 Rat butanal increases expression ISO LAIR1 (Homo sapiens) 6480464 butyraldehyde results in increased expression of LAIR1 mRNA CTD PMID:26079696 Lair1 Rat cannabidiol increases expression ISO LAIR1 (Homo sapiens) 6480464 Cannabidiol results in increased expression of LAIR1 protein CTD PMID:36810933 Lair1 Rat cannabidiol multiple interactions ISO LAIR1 (Homo sapiens) 6480464 LAIR1 protein affects the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; LAIR1 protein more ... CTD PMID:36810933 Lair1 Rat carbon nanotube increases expression ISO Lair1 (Mus musculus) 6480464 Nanotubes, Carbon analog results in increased expression of LAIR1 mRNA; Nanotubes, Carbon results in increased more ... CTD PMID:25554681 Lair1 Rat carmustine increases expression ISO LAIR1 (Homo sapiens) 6480464 Carmustine results in increased expression of LAIR1 mRNA CTD PMID:15980968 Lair1 Rat chloropicrin affects expression ISO LAIR1 (Homo sapiens) 6480464 chloropicrin affects the expression of LAIR1 mRNA CTD PMID:26352163 Lair1 Rat choline multiple interactions ISO Lair1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Lair1 Rat ciguatoxin CTX1B affects expression ISO Lair1 (Mus musculus) 6480464 Ciguatoxins affects the expression of LAIR1 mRNA CTD PMID:18353800 Lair1 Rat Dibutyl phosphate affects expression ISO LAIR1 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of LAIR1 mRNA CTD PMID:37042841 Lair1 Rat doxorubicin decreases expression ISO Lair1 (Mus musculus) 6480464 Doxorubicin results in decreased expression of LAIR1 mRNA CTD PMID:39631538 Lair1 Rat ethanol increases expression ISO Lair1 (Mus musculus) 6480464 Ethanol results in increased expression of LAIR1 mRNA CTD PMID:30319688 Lair1 Rat folic acid multiple interactions ISO Lair1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Lair1 Rat folic acid increases expression ISO Lair1 (Mus musculus) 6480464 Folic Acid results in increased expression of LAIR1 mRNA CTD PMID:25629700 Lair1 Rat fonofos increases methylation ISO LAIR1 (Homo sapiens) 6480464 Fonofos results in increased methylation of LAIR1 promoter CTD PMID:22847954 Lair1 Rat fulvestrant multiple interactions ISO LAIR1 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in increased methylation of LAIR1 gene CTD PMID:31601247 Lair1 Rat gardiquimod increases expression ISO LAIR1 (Homo sapiens) 6480464 gardiquimod results in increased expression of LAIR1 mRNA CTD PMID:28003376 Lair1 Rat gardiquimod multiple interactions ISO LAIR1 (Homo sapiens) 6480464 Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAIR1 mRNA] CTD PMID:28003376 Lair1 Rat genistein increases expression ISO Lair1 (Mus musculus) 6480464 Genistein results in increased expression of LAIR1 mRNA CTD PMID:22553218 Lair1 Rat GSK-J4 decreases expression ISO LAIR1 (Homo sapiens) 6480464 GSK-J4 results in decreased expression of LAIR1 mRNA CTD PMID:29301935 Lair1 Rat L-methionine multiple interactions ISO Lair1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Lair1 Rat lead diacetate decreases expression ISO Lair1 (Mus musculus) 6480464 lead acetate results in decreased expression of LAIR1 mRNA CTD PMID:21829687 Lair1 Rat lead(0) decreases expression ISO LAIR1 (Homo sapiens) 6480464 Lead results in decreased expression of LAIR1 mRNA CTD PMID:19921347 Lair1 Rat nickel atom decreases expression ISO LAIR1 (Homo sapiens) 6480464 Nickel results in decreased expression of LAIR1 mRNA CTD PMID:23195993 Lair1 Rat nickel atom increases expression ISO LAIR1 (Homo sapiens) 6480464 Nickel results in increased expression of LAIR1 mRNA CTD PMID:25583101 Lair1 Rat O-methyleugenol decreases expression ISO LAIR1 (Homo sapiens) 6480464 methyleugenol results in decreased expression of LAIR1 mRNA CTD PMID:32234424 Lair1 Rat ozone multiple interactions ISO LAIR1 (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of LAIR1 mRNA CTD PMID:35430440 Lair1 Rat paracetamol affects expression ISO Lair1 (Mus musculus) 6480464 Acetaminophen affects the expression of LAIR1 mRNA CTD PMID:17562736 Lair1 Rat paracetamol decreases expression ISO LAIR1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of LAIR1 mRNA CTD PMID:29067470 Lair1 Rat parathion increases methylation ISO LAIR1 (Homo sapiens) 6480464 Parathion results in increased methylation of LAIR1 promoter CTD PMID:22847954 Lair1 Rat pirinixic acid decreases expression ISO Lair1 (Mus musculus) 6480464 pirinixic acid results in decreased expression of LAIR1 mRNA CTD PMID:20813756 Lair1 Rat protein kinase inhibitor multiple interactions ISO LAIR1 (Homo sapiens) 6480464 Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of LAIR1 mRNA] CTD PMID:28003376 Lair1 Rat sodium arsenate increases expression ISO Lair1 (Mus musculus) 6480464 sodium arsenate results in increased expression of LAIR1 mRNA CTD PMID:39847705 Lair1 Rat sodium arsenite increases expression ISO LAIR1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of LAIR1 mRNA CTD PMID:34032870 Lair1 Rat sodium dichromate decreases expression ISO LAIR1 (Homo sapiens) 6480464 sodium bichromate results in decreased expression of LAIR1 mRNA CTD PMID:17685462 Lair1 Rat terbufos increases methylation ISO LAIR1 (Homo sapiens) 6480464 terbufos results in increased methylation of LAIR1 promoter CTD PMID:22847954 Lair1 Rat tert-butyl hydroperoxide decreases methylation ISO LAIR1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased methylation of LAIR1 intron CTD PMID:29432895 Lair1 Rat Theaflavin 3,3'-digallate affects expression ISO LAIR1 (Homo sapiens) 6480464 theaflavin-3,3'-digallate affects the expression of LAIR1 mRNA CTD PMID:34925699 Lair1 Rat titanium dioxide increases expression ISO Lair1 (Mus musculus) 6480464 titanium dioxide results in increased expression of LAIR1 mRNA CTD PMID:23557971|PMID:27760801 Lair1 Rat titanium dioxide decreases expression ISO Lair1 (Mus musculus) 6480464 titanium dioxide results in decreased expression of LAIR1 mRNA CTD PMID:29264374 Lair1 Rat triphenyl phosphate affects expression ISO LAIR1 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of LAIR1 mRNA CTD PMID:37042841 Lair1 Rat triptonide increases expression ISO Lair1 (Mus musculus) 6480464 triptonide results in increased expression of LAIR1 mRNA CTD PMID:33045310 Lair1 Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of LAIR1 mRNA CTD PMID:23555832
QTLs in Region (GRCr8)
1331732 Srn4 Serum renin concentration QTL 4 4.467 renin activity (VT:0005581) plasma renin activity level (CMO:0000116) 1 43457837 87558729 Rat 1578649 Bmd8 Bone mineral density QTL 8 4.9 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 1 51940904 101229020 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 39728272 132889942 Rat 4889929 Bss87 Bone structure and strength QTL 87 6.7 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 1 46302615 91302615 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 51941022 208479811 Rat 1331792 Rf29 Renal function QTL 29 4.589 urine potassium amount (VT:0010539) urine potassium level (CMO:0000128) 1 43457837 87558729 Rat 2313062 Bmd73 Bone mineral density QTL 73 3.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 1 46302615 91302615 Rat 8552900 Pigfal1 Plasma insulin-like growth factor 1 level QTL 1 7.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 43509952 88509952 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 1 51940904 168768703 Rat 1354643 Foco2 Food consumption QTL 2 7.17 0.0001 eating behavior trait (VT:0001431) food intake rate (CMO:0000427) 1 42122968 87122968 Rat 2313065 Bss67 Bone structure and strength QTL 67 3.1 0.0001 tibia area (VT:1000281) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 2313069 Bss68 Bone structure and strength QTL 68 2.9 0.0001 tibia size trait (VT:0100001) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 631495 Bp96 Blood pressure QTL 96 4.52 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 66404680 111404680 Rat 70225 Bp58 Blood pressure QTL 58 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34184556 172281316 Rat 2313075 Bss66 Bone structure and strength QTL 66 3.4 0.0001 tibia length (VT:0004357) tibia length (CMO:0000450) 1 46302615 91302615 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 4.6 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 1 66009857 160501508 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34565911 208798288 Rat 1331778 Rf28 Renal function QTL 28 4.66 urine potassium amount (VT:0010539) urine potassium excretion rate (CMO:0000761) 1 43457837 87558729 Rat 2313077 Bss69 Bone structure and strength QTL 69 3.5 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 1 46302615 91302615 Rat 1302788 Scl19 Serum cholesterol QTL 19 4.6 0.001 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 66400974 132889942 Rat 2313402 Anxrr24 Anxiety related response QTL 24 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 1 51511344 153680016 Rat 1331785 Rf27 Renal function QTL 27 4.643 urine sodium amount (VT:0006274) urine sodium level (CMO:0000129) 1 30708375 87558729 Rat 61342 Bp27 Blood pressure QTL 27 3.4 0.0006 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 65405637 96805205 Rat 1300172 Bp172 Blood pressure QTL 172 3.56 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 1 34565726 79565726 Rat 4889962 Bss94 Bone structure and strength QTL 94 3.8 tibia area (VT:1000281) tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722) 1 51909206 91302615 Rat 6903308 Scl36 Serum cholesterol QTL 36 2 0.0125 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 58769992 103769992 Rat 2313092 Bmd72 Bone mineral density QTL 72 2.5 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 46302615 91302615 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 1 66077886 111077886 Rat 2313097 Bss70 Bone structure and strength QTL 70 3.5 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 1 46302615 91302615 Rat 9589820 Insglur3 Insulin/glucose ratio QTL 3 10.75 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 1 43509952 88509952 Rat 152025249 Scl82 Serum cholesterol level QTL 82 4.77 blood cholesterol amount (VT:0000180) 1 52891222 109116986 Rat 1354599 Bw29 Body weight QTL 29 3.46 0.001 body mass (VT:0001259) body weight (CMO:0000012) 1 42122968 87122968 Rat 4889919 Bss86 Bone structure and strength QTL 86 4.1 tibia area (VT:1000281) tibia midshaft total cross-sectional area (CMO:0001715) 1 46302615 91302615 Rat 8552948 Pigfal11 Plasma insulin-like growth factor 1 level QTL 11 4.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 1 43509952 88509952 Rat
