Vgll3 (vestigial-like family member 3) - Rat Genome Database

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Pathways
Gene: Vgll3 (vestigial-like family member 3) Rattus norvegicus
Analyze
Symbol: Vgll3
Name: vestigial-like family member 3
RGD ID: 1560030
Description: Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human VGLL3 (vestigial like family member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498038; RGD1560030; similar to colon carcinoma related protein; transcription cofactor vestigial-like protein 3; vestigial like 3; vestigial like 3 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,089,484 - 17,136,501 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1117,089,597 - 17,138,937 (+)EnsemblGRCr8
mRatBN7.2113,642,993 - 3,692,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,643,069 - 3,689,140 (+)EnsemblmRatBN7.2
Rnor_6.0113,119,509 - 3,168,883 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,119,885 - 3,164,751 (+)Ensemblrn6Rnor6.0
Rnor_5.0113,097,556 - 3,146,588 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4113,348,763 - 3,394,087 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera113,617,060 - 3,666,333 (+)NCBICelera
Cytogenetic Map11p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nitrofen  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17689488   PMID:32814879  


Genomics

Comparative Map Data
Vgll3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81117,089,484 - 17,136,501 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1117,089,597 - 17,138,937 (+)EnsemblGRCr8
mRatBN7.2113,642,993 - 3,692,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,643,069 - 3,689,140 (+)EnsemblmRatBN7.2
Rnor_6.0113,119,509 - 3,168,883 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,119,885 - 3,164,751 (+)Ensemblrn6Rnor6.0
Rnor_5.0113,097,556 - 3,146,588 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4113,348,763 - 3,394,087 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera113,617,060 - 3,666,333 (+)NCBICelera
Cytogenetic Map11p12NCBI
VGLL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38386,937,973 - 86,991,149 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl386,876,388 - 86,991,149 (-)Ensemblhg38GRCh38
GRCh37386,987,123 - 87,040,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36387,069,813 - 87,122,947 (-)NCBIBuild 36Build 36hg18NCBI36
Celera387,739,047 - 87,793,404 (-)NCBICelera
Cytogenetic Map3p12.1NCBI
HuRef387,000,438 - 87,053,543 (-)NCBIHuRef
CHM1_1386,939,749 - 86,992,814 (-)NCBICHM1_1
T2T-CHM13v2.0387,012,305 - 87,065,510 (-)NCBIT2T-CHM13v2.0
Vgll3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391665,612,075 - 65,663,254 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1665,612,143 - 65,663,254 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381665,815,189 - 65,866,368 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1665,815,257 - 65,866,368 (+)Ensemblmm10GRCm38
MGSCv371665,815,878 - 65,863,311 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361665,733,678 - 65,781,326 (+)NCBIMGSCv36mm8
MGSCv361666,265,561 - 66,314,128 (+)NCBIMGSCv36mm8
Celera1666,081,364 - 66,128,723 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1637.34NCBI
Vgll3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554076,258,251 - 6,287,397 (+)Ensembl
ChiLan1.0NW_0049554076,247,557 - 6,293,133 (+)NCBIChiLan1.0ChiLan1.0
VGLL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2287,005,764 - 87,133,600 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1387,087,730 - 87,138,166 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0387,066,497 - 87,119,625 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1389,183,186 - 89,233,290 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl389,165,559 - 89,233,239 (-)EnsemblpanPan2panpan1.1
VGLL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1311,037,001 - 1,151,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl311,036,652 - 1,143,670 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha311,078,747 - 1,196,263 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0311,020,681 - 1,138,576 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl311,020,693 - 1,066,261 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.131999,127 - 1,046,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0311,047,879 - 1,095,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0311,350,874 - 1,468,572 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vgll3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049712,528,231 - 2,583,681 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366102,528,670 - 2,577,951 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366102,528,420 - 2,579,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VGLL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13168,790,207 - 168,836,927 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113168,790,024 - 168,839,962 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213179,675,642 - 179,725,107 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VGLL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12289,927,526 - 89,972,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2289,928,227 - 89,973,245 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604176,754,073 - 76,804,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vgll3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247893,232,287 - 3,271,600 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247893,226,581 - 3,271,940 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vgll3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1477,084,693 - 77,128,902 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vgll3
472 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:82
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000042316
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 135 81 80 49 30 49 6 281 130 11 114 78 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000042316   ⟹   ENSRNOP00000051348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1117,089,597 - 17,138,937 (+)Ensembl
mRatBN7.2 Ensembl113,643,069 - 3,689,140 (+)Ensembl
Rnor_6.0 Ensembl113,119,885 - 3,164,751 (+)Ensembl
RefSeq Acc Id: NM_001427793   ⟹   NP_001414722
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,089,592 - 17,136,501 (+)NCBI
RefSeq Acc Id: NM_001427794   ⟹   NP_001414723
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,090,244 - 17,136,501 (+)NCBI
RefSeq Acc Id: XM_006247981   ⟹   XP_006248043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,089,484 - 17,134,795 (+)NCBI
mRatBN7.2113,642,993 - 3,692,590 (+)NCBI
Rnor_6.0113,119,509 - 3,168,883 (+)NCBI
Rnor_5.0113,097,556 - 3,146,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247982   ⟹   XP_006248044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81117,089,487 - 17,134,795 (+)NCBI
mRatBN7.2113,642,998 - 3,692,590 (+)NCBI
Rnor_6.0113,119,511 - 3,168,883 (+)NCBI
Rnor_5.0113,097,556 - 3,146,588 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001414722 (Get FASTA)   NCBI Sequence Viewer  
  NP_001414723 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248043 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248044 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75911 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051348
  ENSRNOP00000051348.4
RefSeq Acc Id: XP_006248043   ⟸   XM_006247981
- Peptide Label: isoform X1
- UniProtKB: A6K4X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248044   ⟸   XM_006247982
- Peptide Label: isoform X2
- UniProtKB: A6K4X1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051348   ⟸   ENSRNOT00000042316
RefSeq Acc Id: NP_001414722   ⟸   NM_001427793
- Peptide Label: isoform 1
- UniProtKB: D3ZZ09 (UniProtKB/TrEMBL),   A6K4X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414723   ⟸   NM_001427794
- Peptide Label: isoform 2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ09-F1-model_v2 AlphaFold D3ZZ09 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698001
Promoter ID:EPDNEW_R8525
Type:single initiation site
Name:Vgll3_1
Description:vestigial-like family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0113,119,801 - 3,119,861EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560030 AgrOrtholog
BioCyc Gene G2FUF-22305 BioCyc
Ensembl Genes ENSRNOG00000028774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042316 ENTREZGENE
  ENSRNOT00000042316.7 UniProtKB/TrEMBL
InterPro DUF_TDU UniProtKB/TrEMBL
  Vg_Tdu UniProtKB/TrEMBL
NCBI Gene 498038 ENTREZGENE
PANTHER PTHR15950 UniProtKB/TrEMBL
  TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 3 UniProtKB/TrEMBL
Pfam Vg_Tdu UniProtKB/TrEMBL
PhenoGen Vgll3 PhenoGen
RatGTEx ENSRNOG00000028774 RatGTEx
SMART TDU UniProtKB/TrEMBL
UniProt A6K4X1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZ09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Vgll3  vestigial-like family member 3  Vgll3  vestigial like 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Vgll3  vestigial like 3 (Drosophila)  RGD1560030_predicted  similar to colon carcinoma related protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560030_predicted  similar to colon carcinoma related protein (predicted)  LOC498038  similar to colon carcinoma related protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498038  similar to colon carcinoma related protein      Symbol and Name status set to provisional 70820 PROVISIONAL