Grem2 (gremlin 2, DAN family BMP antagonist) - Rat Genome Database

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Gene: Grem2 (gremlin 2, DAN family BMP antagonist) Rattus norvegicus
Analyze
Symbol: Grem2
Name: gremlin 2, DAN family BMP antagonist
RGD ID: 1560008
Description: Predicted to enable several functions, including BMP binding activity; heparin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and sequestering of BMP from receptor via BMP binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gremlin 2; gremlin 2 homolog, cysteine knot superfamily; gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis); gremlin 2, cysteine knot superfamily, homolog; gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-2; LOC289264; RGD1560008; similar to PRDC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81389,310,897 - 89,403,856 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1389,310,662 - 89,404,312 (-)EnsemblGRCr8
mRatBN7.21386,778,543 - 86,871,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1389,276,244 - 89,369,076 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,676,524 - 90,769,358 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,861,272 - 87,954,062 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,894,431 - 92,988,137 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)Ensemblrn6Rnor6.0
Rnor_5.01397,359,449 - 97,453,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41390,528,920 - 90,622,303 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1386,379,414 - 86,472,331 (-)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
indometacin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23063586   PMID:23850456   PMID:24614542   PMID:34049478  


Genomics

Comparative Map Data
Grem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81389,310,897 - 89,403,856 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1389,310,662 - 89,404,312 (-)EnsemblGRCr8
mRatBN7.21386,778,543 - 86,871,509 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1389,276,244 - 89,369,076 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01390,676,524 - 90,769,358 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01387,861,272 - 87,954,062 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01392,894,431 - 92,988,137 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)Ensemblrn6Rnor6.0
Rnor_5.01397,359,449 - 97,453,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41390,528,920 - 90,622,303 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1386,379,414 - 86,472,331 (-)NCBICelera
Cytogenetic Map13q24NCBI
GREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,489,573 - 240,612,155 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,489,573 - 240,612,155 (-)Ensemblhg38GRCh38
GRCh371240,652,873 - 240,775,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,719,496 - 238,842,085 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341236,979,833 - 237,101,430NCBI
Celera1213,908,963 - 214,031,592 (-)NCBICelera
Cytogenetic Map1q43NCBI
HuRef1211,110,745 - 211,233,432 (-)NCBIHuRef
CHM1_11241,924,855 - 242,047,766 (-)NCBICHM1_1
T2T-CHM13v2.01239,900,834 - 240,023,520 (-)NCBIT2T-CHM13v2.0
Grem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391174,661,352 - 174,749,386 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1174,661,351 - 174,749,385 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381174,833,785 - 174,921,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1174,833,785 - 174,921,819 (-)Ensemblmm10GRCm38
MGSCv371176,763,916 - 176,851,950 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361176,670,460 - 176,758,494 (-)NCBIMGSCv36mm8
Celera1181,920,779 - 182,009,726 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map181.08NCBI
Grem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540611,245,960 - 11,343,677 (+)Ensembl
ChiLan1.0NW_00495540611,245,960 - 11,343,677 (+)NCBIChiLan1.0ChiLan1.0
GREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218,546,639 - 8,671,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan118,770,127 - 8,895,198 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01216,037,977 - 216,163,020 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,023,212 - 221,148,149 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,026,605 - 221,027,111 (-)EnsemblpanPan2panpan1.1
GREM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1732,048,151 - 32,157,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl732,048,183 - 32,157,146 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha731,588,241 - 31,697,847 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0731,872,605 - 31,982,246 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl731,870,255 - 31,981,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1731,710,419 - 31,820,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0731,741,770 - 31,851,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0731,980,916 - 32,090,573 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934444,922,948 - 45,027,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365269,720,335 - 9,823,370 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365269,820,276 - 9,821,907 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,885,280 - 11,885,780 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11011,884,198 - 11,904,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21014,102,376 - 14,122,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GREM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12577,600,306 - 77,724,090 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2577,602,803 - 77,603,309 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605579,707,875 - 79,832,479 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grem2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477110,967,542 - 10,968,048 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477110,965,170 - 11,072,462 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grem2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11053,411,273 - 53,414,827 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grem2
798 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:699
Count of miRNA genes:292
Interacting mature miRNAs:386
Transcripts:ENSRNOT00000004803
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138933312992500981Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
D13Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81389,333,129 - 89,333,251 (+)Marker Load Pipeline
mRatBN7.21386,800,776 - 86,800,898 (+)MAPPERmRatBN7.2
Rnor_6.01392,916,662 - 92,916,783NCBIRnor6.0
Rnor_5.01397,381,680 - 97,381,801UniSTSRnor5.0
RGSC_v3.41390,551,150 - 90,551,272RGDRGSC3.4
RGSC_v3.41390,551,151 - 90,551,272UniSTSRGSC3.4
Celera1386,401,644 - 86,401,765UniSTS
RGSC_v3.11390,740,035 - 90,740,156RGD
RH 3.4 Map13573.9UniSTS
RH 3.4 Map13573.9RGD
RH 2.0 Map13638.1RGD
SHRSP x BN Map1340.7498RGD
Cytogenetic Map13q24UniSTS
RH127350  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,778,737 - 86,778,951 (+)MAPPERmRatBN7.2
Rnor_6.01392,894,626 - 92,894,839NCBIRnor6.0
Rnor_5.01397,359,644 - 97,359,857UniSTSRnor5.0
RGSC_v3.41390,529,115 - 90,529,328UniSTSRGSC3.4
Celera1386,379,609 - 86,379,822UniSTS
RH 3.4 Map13585.8UniSTS
Cytogenetic Map13q24UniSTS
BF388208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,779,656 - 86,779,872 (+)MAPPERmRatBN7.2
Rnor_6.01392,895,545 - 92,895,760NCBIRnor6.0
Rnor_5.01397,360,563 - 97,360,778UniSTSRnor5.0
RGSC_v3.41390,530,034 - 90,530,249UniSTSRGSC3.4
Celera1386,380,528 - 86,380,743UniSTS
RH 3.4 Map13583.4UniSTS
Cytogenetic Map13q24UniSTS
BE110247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21386,812,758 - 86,812,910 (+)MAPPERmRatBN7.2
Rnor_6.01392,928,642 - 92,928,793NCBIRnor6.0
Rnor_5.01397,393,660 - 97,393,811UniSTSRnor5.0
RGSC_v3.41390,563,132 - 90,563,283UniSTSRGSC3.4
Celera1386,413,621 - 86,413,772UniSTS
RH 3.4 Map13584.6UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 60 141 91 90 59 27 59 6 269 120 10 118 72 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000004803   ⟹   ENSRNOP00000004803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1389,310,820 - 89,404,167 (-)Ensembl
mRatBN7.2 Ensembl1386,778,500 - 86,871,615 (-)Ensembl
Rnor_6.0 Ensembl1392,894,431 - 92,988,137 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122922   ⟹   ENSRNOP00000103399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1389,310,900 - 89,353,856 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171146   ⟹   ENSRNOP00000107184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1389,310,662 - 89,404,312 (-)Ensembl
RefSeq Acc Id: NM_001105974   ⟹   NP_001099444
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81389,310,897 - 89,403,856 (-)NCBI
mRatBN7.21386,778,543 - 86,871,509 (-)NCBI
Rnor_6.01392,894,431 - 92,988,137 (-)NCBI
Rnor_5.01397,359,449 - 97,453,188 (-)NCBI
RGSC_v3.41390,528,920 - 90,622,303 (-)RGD
Celera1386,379,414 - 86,472,331 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099444 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94766 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004803
  ENSRNOP00000004803.4
  ENSRNOP00000103399.1
  ENSRNOP00000107184.1
RefSeq Acc Id: NP_001099444   ⟸   NM_001105974
- Peptide Label: precursor
- UniProtKB: D3ZXD0 (UniProtKB/TrEMBL),   A6JGB0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004803   ⟸   ENSRNOT00000004803
Ensembl Acc Id: ENSRNOP00000107184   ⟸   ENSRNOT00000171146
Ensembl Acc Id: ENSRNOP00000103399   ⟸   ENSRNOT00000122922
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXD0-F1-model_v2 AlphaFold D3ZXD0 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699040
Promoter ID:EPDNEW_R9563
Type:multiple initiation site
Name:Grem2_1
Description:gremlin 2, DAN family BMP antagonist
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01392,988,138 - 92,988,198EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560008 AgrOrtholog
BioCyc Gene G2FUF-17247 BioCyc
Ensembl Genes ENSRNOG00000003616 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004803 ENTREZGENE
  ENSRNOT00000004803.7 UniProtKB/TrEMBL
  ENSRNOT00000122922.1 UniProtKB/TrEMBL
  ENSRNOT00000171146.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  DAN UniProtKB/TrEMBL
  Gremlin_precursor UniProtKB/TrEMBL
KEGG Report rno:289264 UniProtKB/TrEMBL
NCBI Gene 289264 ENTREZGENE
PANTHER GREMLIN 1 UniProtKB/TrEMBL
  GREMLIN-2 UniProtKB/TrEMBL
Pfam DAN UniProtKB/TrEMBL
PhenoGen Grem2 PhenoGen
PIRSF Gremlin_precursor UniProtKB/TrEMBL
PROSITE CTCK_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003616 RatGTEx
SMART SM00041 UniProtKB/TrEMBL
UniProt A6JGB0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXD0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Grem2  gremlin 2, DAN family BMP antagonist  Grem2  gremlin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Grem2  gremlin 2  Grem2  gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-24 Grem2  gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)  Grem2  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Grem2  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)   Grem2_predicted  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Grem2_predicted  gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) (predicted)  RGD1560008_predicted  similar to PRDC (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560008_predicted  similar to PRDC (predicted)  LOC289264  similar to PRDC  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC289264  similar to PRDC      Symbol and Name status set to provisional 70820 PROVISIONAL