Ccdc134 (coiled-coil domain containing 134) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ccdc134 (coiled-coil domain containing 134) Rattus norvegicus
Analyze
Symbol: Ccdc134
Name: coiled-coil domain containing 134
RGD ID: 1559657
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in positive regulation of signal transduction; regulation of ossification; and regulation of protein glycosylation. Predicted to act upstream of or within several processes, including angiogenesis; embryonic organ development; and ventricular system development. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and extracellular region. Predicted to be active in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to human CCDC134 (coiled-coil domain containing 134); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coiled-coil domain-containing protein 134; LOC500909; similar to hypothetical protein FLJ22349
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,526,537 - 115,539,155 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,524,666 - 115,539,152 (+)EnsemblGRCr8
mRatBN7.27113,644,557 - 113,659,050 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,644,639 - 113,659,050 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7115,403,041 - 115,414,538 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,626,544 - 117,638,041 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,595,985 - 117,607,482 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,362,471 - 123,376,930 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,364,312 - 123,376,221 (+)Ensemblrn6Rnor6.0
Rnor_5.07123,345,979 - 123,360,343 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,505,741 - 120,517,685 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,961,749 - 109,973,693 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
endoplasmic reticulum lumen  (IBA,IEA,ISO,ISS)
extracellular region  (IEA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:19946888   PMID:29115376  


Genomics

Comparative Map Data
Ccdc134
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,526,537 - 115,539,155 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,524,666 - 115,539,152 (+)EnsemblGRCr8
mRatBN7.27113,644,557 - 113,659,050 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,644,639 - 113,659,050 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7115,403,041 - 115,414,538 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,626,544 - 117,638,041 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,595,985 - 117,607,482 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,362,471 - 123,376,930 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,364,312 - 123,376,221 (+)Ensemblrn6Rnor6.0
Rnor_5.07123,345,979 - 123,360,343 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,505,741 - 120,517,685 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,961,749 - 109,973,693 (+)NCBICelera
Cytogenetic Map7q34NCBI
CCDC134
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,800,679 - 41,832,164 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,800,321 - 41,832,172 (+)Ensemblhg38GRCh38
GRCh372242,196,683 - 42,228,168 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,526,624 - 40,552,249 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2226,002,745 - 26,028,378 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,162,231 - 25,187,861 (+)NCBIHuRef
CHM1_12242,156,707 - 42,182,315 (+)NCBICHM1_1
T2T-CHM13v2.02242,279,285 - 42,310,775 (+)NCBIT2T-CHM13v2.0
Ccdc134
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,012,101 - 82,026,404 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,012,123 - 82,026,404 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381582,127,898 - 82,142,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,127,922 - 82,142,203 (+)Ensemblmm10GRCm38
MGSCv371581,958,352 - 81,972,633 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,955,251 - 81,969,455 (+)NCBIMGSCv36mm8
Celera1584,251,167 - 84,265,449 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.47NCBI
Ccdc134
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,249,272 - 27,265,635 (+)Ensembl
ChiLan1.0NW_00495541327,248,879 - 27,265,635 (+)NCBIChiLan1.0ChiLan1.0
CCDC134
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,629,631 - 51,661,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12254,328,938 - 54,360,324 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02222,692,503 - 22,724,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,778,244 - 40,810,549 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,778,254 - 40,804,191 (+)EnsemblpanPan2panpan1.1
Ccdc134
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,165,338 - 7,185,212 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492178,390 - 195,806 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936492180,135 - 195,599 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC134
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,785,947 - 6,799,913 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.156,785,957 - 6,800,816 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CCDC134
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,332,293 - 24,358,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,332,316 - 24,357,583 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045101,050,699 - 101,079,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc134
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247526,871,911 - 6,885,396 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247526,872,192 - 6,885,435 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ccdc134
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,858,785 - 251,871,903 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ccdc134
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:197
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000056048
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH143418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,658,771 - 113,658,872 (+)MAPPERmRatBN7.2
Rnor_6.07123,376,652 - 123,376,752NCBIRnor6.0
Rnor_5.07123,360,065 - 123,360,165UniSTSRnor5.0
RGSC_v3.47120,518,081 - 120,518,181UniSTSRGSC3.4
Celera7109,974,089 - 109,974,189UniSTS
RH 3.4 Map7893.2UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056048   ⟹   ENSRNOP00000052900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,524,666 - 115,539,152 (+)Ensembl
mRatBN7.2 Ensembl7113,644,639 - 113,659,050 (+)Ensembl
Rnor_6.0 Ensembl7123,364,312 - 123,376,221 (+)Ensembl
RefSeq Acc Id: NM_001024355   ⟹   NP_001019526
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,526,537 - 115,538,481 (+)NCBI
mRatBN7.27113,646,432 - 113,658,376 (+)NCBI
Rnor_6.07123,364,312 - 123,376,256 (+)NCBI
Rnor_5.07123,345,979 - 123,360,343 (+)NCBI
RGSC_v3.47120,505,741 - 120,517,685 (+)RGD
Celera7109,961,749 - 109,973,693 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079765   ⟹   XP_038935693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,529,838 - 115,539,155 (+)NCBI
mRatBN7.27113,648,477 - 113,659,050 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001019526 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88206 (Get FASTA)   NCBI Sequence Viewer  
  EDM15675 (Get FASTA)   NCBI Sequence Viewer  
  EDM15676 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052900
  ENSRNOP00000052900.2
GenBank Protein Q5M862 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019526   ⟸   NM_001024355
- Peptide Label: precursor
- UniProtKB: Q5M862 (UniProtKB/Swiss-Prot),   A6HT46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052900   ⟸   ENSRNOT00000056048
RefSeq Acc Id: XP_038935693   ⟸   XM_039079765
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M862-F1-model_v2 AlphaFold Q5M862 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559657 AgrOrtholog
BioCyc Gene G2FUF-32643 BioCyc
Ensembl Genes ENSRNOG00000007262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056048 ENTREZGENE
  ENSRNOT00000056048.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7381354 IMAGE-MGC_LOAD
InterPro Coiled-coil_dom_con_pro_134 UniProtKB/Swiss-Prot
KEGG Report rno:500909 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108917 IMAGE-MGC_LOAD
NCBI Gene 500909 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 134 UniProtKB/Swiss-Prot
  PTHR14735 UniProtKB/Swiss-Prot
Pfam ERK-JNK_inhib UniProtKB/Swiss-Prot
PhenoGen Ccdc134 PhenoGen
RatGTEx ENSRNOG00000007262 RatGTEx
UniProt A6HT46 ENTREZGENE, UniProtKB/TrEMBL
  CC134_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Ccdc134  coiled-coil domain containing 134  LOC500909  similar to hypothetical protein FLJ22349  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500909  similar to hypothetical protein FLJ22349      Symbol and Name status set to provisional 70820 PROVISIONAL