Fmo6 (flavin containing monooxygenase 6) - Rat Genome Database

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Gene: Fmo6 (flavin containing monooxygenase 6) Rattus norvegicus
Analyze
Symbol: Fmo6
Name: flavin containing monooxygenase 6
RGD ID: 1559491
Description: Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in taurine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FMO6P (flavin containing dimethylaniline monoxygenase 6, pseudogene); INTERACTS WITH copper atom; copper(0); endosulfan.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC304922; putative dimethylaniline monooxygenase [N-oxide-forming] 6; RGD1559491; similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6); similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6)
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,793,600 - 77,821,958 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1377,793,095 - 77,821,510 (-)EnsemblGRCr8
mRatBN7.21375,256,617 - 75,288,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,260,368 - 75,288,769 (-)EnsemblmRatBN7.2
Rnor_6.01380,791,355 - 80,819,915 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,791,565 - 80,819,218 (-)Ensemblrn6Rnor6.0
Rnor_5.01385,685,992 - 85,713,617 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41378,609,883 - 78,638,130 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1375,002,242 - 75,030,098 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fmo6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,793,600 - 77,821,958 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1377,793,095 - 77,821,510 (-)EnsemblGRCr8
mRatBN7.21375,256,617 - 75,288,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,260,368 - 75,288,769 (-)EnsemblmRatBN7.2
Rnor_6.01380,791,355 - 80,819,915 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,791,565 - 80,819,218 (-)Ensemblrn6Rnor6.0
Rnor_5.01385,685,992 - 85,713,617 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41378,609,883 - 78,638,130 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1375,002,242 - 75,030,098 (-)NCBICelera
Cytogenetic Map13q22NCBI
FMO6P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,137,740 - 171,161,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,138,212 - 171,161,396 (+)Ensemblhg38GRCh38
GRCh38.p14 Ensembl1171,137,740 - 171,161,568 (+)Ensemblhg38GRCh38
GRCh371171,106,879 - 171,130,702 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,373,503 - 169,397,326 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1144,216,786 - 144,240,611 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,330,466 - 142,354,284 (+)NCBIHuRef
CHM1_11172,529,076 - 172,552,900 (+)NCBICHM1_1
T2T-CHM13v2.01170,494,118 - 170,517,942 (+)NCBIT2T-CHM13v2.0
Fmo6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,744,120 - 162,765,135 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,744,120 - 162,765,084 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381162,916,551 - 162,937,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,916,551 - 162,937,515 (-)Ensemblmm10GRCm38
MGSCv371164,846,682 - 164,867,356 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361164,753,398 - 164,784,923 (-)NCBIMGSCv36mm8
Celera1165,353,657 - 165,374,296 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
LOC490346
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,686,016 - 27,702,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,206,910 - 27,230,238 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0727,487,556 - 27,504,514 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1727,337,948 - 27,354,616 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,372,751 - 27,389,466 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,614,991 - 27,631,655 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100523745
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1963,777,449 - 63,801,780 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,061,690 - 70,077,568 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Fmo6
339 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:76
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000072922
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 9 28 46 51 50 23 23 23 6 179 83 11 17 63 68 27 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000072922   ⟹   ENSRNOP00000064509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1377,793,095 - 77,821,510 (-)Ensembl
mRatBN7.2 Ensembl1375,260,368 - 75,288,769 (-)Ensembl
Rnor_6.0 Ensembl1380,791,565 - 80,819,218 (-)Ensembl
RefSeq Acc Id: XM_006250206   ⟹   XP_006250268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,793,600 - 77,821,958 (-)NCBI
mRatBN7.21375,256,617 - 75,288,167 (-)NCBI
Rnor_6.01380,791,355 - 80,819,915 (-)NCBI
Rnor_5.01385,685,992 - 85,713,617 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006250268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064509
  ENSRNOP00000064509.1
RefSeq Acc Id: XP_006250268   ⟸   XM_006250206
- UniProtKB: M0R553 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064509   ⟸   ENSRNOT00000072922

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R553-F1-model_v2 AlphaFold M0R553 1-532 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559491 AgrOrtholog
BioCyc Gene G2FUF-17635 BioCyc
Ensembl Genes ENSRNOG00000049851 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072922 ENTREZGENE
  ENSRNOT00000072922.3 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/TrEMBL
  Flavin_mOase_3 UniProtKB/TrEMBL
  FMO UniProtKB/TrEMBL
KEGG Report rno:304922 UniProtKB/TrEMBL
NCBI Gene 304922 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/TrEMBL
PhenoGen Fmo6 PhenoGen
PIRSF FMO UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/TrEMBL
  FMOXYGENASE3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049851 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt M0R553 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Fmo6  flavin containing monooxygenase 6  RGD1559491_predicted  similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-10 RGD1559491_predicted  similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (predicted)    similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1559491_predicted  similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6) (predicted)  LOC304922  similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304922  similar to Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6)      Symbol and Name status set to provisional 70820 PROVISIONAL