Advanced Search (OLGA)

Gene: Capza2 (capping actin protein of muscle Z-line subunit alpha 2) Rattus norvegicus

Analyze

Symbol:

Capza2

Name:

capping actin protein of muscle Z-line subunit alpha 2

RGD ID:

1549770

Description:

Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Predicted to be located in brush border and membrane. Predicted to be part of F-actin capping protein complex. Predicted to be active in cortical cytoskeleton. Orthologous to human CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2); INTERACTS WITH 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

capping actin protein of muscle Z-line alpha subunit 2; capping protein (actin filament) muscle Z-line, alpha 2; capZ alpha-2; F-actin-capping protein subunit alpha-2; MGC124519

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	46,944,040 - 46,979,930 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	46,895,701 - 46,979,938 (+)	Ensembl				GRCr8
mRatBN7.2	4	45,978,142 - 46,014,032 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	45,977,807 - 46,013,864 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	50,970,338 - 51,006,220 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	46,891,344 - 46,927,228 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	45,307,193 - 45,343,027 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	48,705,059 - 48,740,898 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	4	46,145,965 - 46,181,849 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	4	46,699,872 - 46,735,706 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	4	46,512,917 - 46,548,755 (+)	NCBI		F344_StmMcwi
Rnor_6.0	4	44,936,290 - 44,972,270 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	44,936,290 - 44,972,267 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	45,541,352 - 45,577,242 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	43,293,339 - 43,329,229 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	41,250,212 - 41,286,106 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

intellectual disability (ISO,ISS)

renal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,4,6-tribromophenol (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

acetylsalicylic acid (ISO)

actinomycin D (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsenous acid (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chrysene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

glyphosate (ISO)

gold atom (ISO)

gold(0) (ISO)

isoflavones (EXP)

ivermectin (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

microcystin-LR (EXP)

N-nitrosodiethylamine (ISO)

nicotine (ISO)

nocodazole (ISO)

Nutlin-3 (ISO)

okadaic acid (ISO)

ozone (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP)

piroxicam (ISO)

resveratrol (ISO)

simvastatin (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IBA)

actin filament capping (IEA)

barbed-end actin filament capping (IBA,IEA)

Cellular Component

brush border (ISO)

cortical cytoskeleton (IBA,ISO)

cytosol (IEA)

F-actin capping protein complex (IBA,IEA,ISO)

membrane (ISO)

Molecular Function

actin binding (IEA)

actin filament binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:18723693	PMID:19056867	PMID:19806181	PMID:20458337	PMID:22114352	PMID:23106098	PMID:23376485	PMID:23533145	PMID:24625528	PMID:29476059	PMID:30053369
PMID:35352799

Genomics

Comparative Map Data

Capza2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	46,944,040 - 46,979,930 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	46,895,701 - 46,979,938 (+)	Ensembl				GRCr8
mRatBN7.2	4	45,978,142 - 46,014,032 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	45,977,807 - 46,013,864 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	50,970,338 - 51,006,220 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	46,891,344 - 46,927,228 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	45,307,193 - 45,343,027 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	48,705,059 - 48,740,898 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	4	46,145,965 - 46,181,849 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	4	46,699,872 - 46,735,706 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	4	46,512,917 - 46,548,755 (+)	NCBI		F344_StmMcwi
Rnor_6.0	4	44,936,290 - 44,972,270 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	44,936,290 - 44,972,267 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	45,541,352 - 45,577,242 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	43,293,339 - 43,329,229 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	41,250,212 - 41,286,106 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

CAPZA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	116,862,587 - 116,922,049 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	116,811,070 - 116,922,049 (+)	Ensembl			hg38	GRCh38
GRCh37	7	116,502,641 - 116,562,103 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	116,289,799 - 116,346,549 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	116,096,513 - 116,153,263	NCBI
Celera	7	111,310,094 - 111,366,812 (+)	NCBI		Celera
Cytogenetic Map	7	q31.2	NCBI
HuRef	7	110,868,260 - 110,924,832 (+)	NCBI		HuRef
CHM1_1	7	116,436,160 - 116,492,983 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	118,177,775 - 118,237,215 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	115,898,010 - 115,954,766 (+)	NCBI

Capza2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	17,637,009 - 17,666,971 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	17,636,233 - 17,666,971 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	17,637,010 - 17,666,972 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	17,636,234 - 17,666,972 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	17,587,098 - 17,616,534 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	17,587,098 - 17,616,534 (+)	NCBI		MGSCv36	mm8
Celera	6	17,711,860 - 17,741,278 (+)	NCBI		Celera
Cytogenetic Map	6	A2	NCBI
cM Map	6	7.96	NCBI

Capza2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	22,597,650 - 22,625,363 (+)	Ensembl
ChiLan1.0	NW_004955432	22,595,169 - 22,625,363 (+)	NCBI	ChiLan1.0	ChiLan1.0

CAPZA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	153,694,979 - 153,749,042 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	5,705,245 - 5,759,301 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	108,835,083 - 108,889,112 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	121,553,544 - 121,584,566 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	121,551,401 - 121,584,566 (+)	Ensembl			panPan2	panpan1.1

CAPZA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	55,763,586 - 55,824,629 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	55,763,249 - 55,824,629 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	55,158,956 - 55,219,790 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	55,804,051 - 55,865,221 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	55,803,837 - 55,867,161 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	55,833,570 - 55,894,697 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	55,521,744 - 55,582,875 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	55,892,878 - 55,954,033 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Capza2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	44,455,305 - 44,495,534 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936589	2,194,332 - 2,234,653 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936589	2,194,332 - 2,234,547 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CAPZA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	29,310,759 - 29,365,143 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	29,316,384 - 29,365,062 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	31,363,726 - 31,412,413 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CAPZA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	85,543,297 - 85,598,346 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	85,543,271 - 85,601,370 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	18,135,221 - 18,190,773 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Capza2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624827	2,477,645 - 2,529,055 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624827	2,476,987 - 2,529,067 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Capza2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	121,291,079 - 121,325,682 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Capza2
202 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	133
Count of miRNA genes:	103
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000039017
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	13080146	58080146	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	15644309	60644309	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	44425024	89425024	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1331807	Rf31	Renal function QTL 31	2.988		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	4	40490442	75726188	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	18900697	63900697	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
61475	Aia2	Adjuvant induced arthritis QTL 2	5.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	40471453	75939996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	22288453	63245191	Rat
8552807	Vie4	Viral induced encephalitis QTL 4	7.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	18900697	63900697	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	18913151	63913151	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	27862204	62997402	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21925151	66925151	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
11530004	Niddm71	Non-insulin dependent diabetes mellitus QTL 71		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	4	33538816	53719714	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat

Markers in Region

BF407498

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	45,977,011 - 45,977,127 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,935,160 - 44,935,275	NCBI	Rnor6.0
Rnor_5.0	4	45,540,222 - 45,540,337	UniSTS	Rnor5.0
RGSC_v3.4	4	43,292,209 - 43,292,324	UniSTS	RGSC3.4
Celera	4	41,249,082 - 41,249,197	UniSTS
RH 3.4 Map	4	282.8	UniSTS
Cytogenetic Map	4	q21	UniSTS

AA924038

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	46,013,643 - 46,013,849 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,971,882 - 44,972,087	NCBI	Rnor6.0
Rnor_5.0	4	45,576,854 - 45,577,059	UniSTS	Rnor5.0
RGSC_v3.4	4	43,328,841 - 43,329,046	UniSTS	RGSC3.4
Celera	4	41,285,718 - 41,285,923	UniSTS
RH 3.4 Map	4	284.8	UniSTS
Cytogenetic Map	4	q21	UniSTS

ECD20142

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	45,978,180 - 45,978,414 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	44,936,329 - 44,936,562	NCBI	Rnor6.0
Rnor_5.0	4	45,541,391 - 45,541,624	UniSTS	Rnor5.0
RGSC_v3.4	4	43,293,378 - 43,293,611	UniSTS	RGSC3.4
Celera	4	41,250,251 - 41,250,484	UniSTS
Cytogenetic Map	4	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC087041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC123138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DP000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000090451 ⟹ ENSRNOP00000072041

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	46,944,060 - 46,979,938 (+)	Ensembl
mRatBN7.2 Ensembl	4	45,978,190 - 46,013,646 (+)	Ensembl
Rnor_6.0 Ensembl	4	44,936,290 - 44,972,267 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106630 ⟹ ENSRNOP00000097945

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	46,944,007 - 46,979,543 (+)	Ensembl
mRatBN7.2 Ensembl	4	45,978,106 - 46,013,593 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117690 ⟹ ENSRNOP00000086194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	46,943,589 - 46,979,932 (+)	Ensembl
mRatBN7.2 Ensembl	4	45,977,807 - 46,013,864 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135564 ⟹ ENSRNOP00000099181

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	46,944,129 - 46,979,932 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144381 ⟹ ENSRNOP00000103021

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	46,949,414 - 46,979,932 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169051 ⟹ ENSRNOP00000107173

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	46,895,701 - 46,979,932 (+)	Ensembl

RefSeq Acc Id:

NM_001009180 ⟹ NP_001009180

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	46,944,040 - 46,979,930 (+)	NCBI
mRatBN7.2	4	45,978,142 - 46,014,032 (+)	NCBI
Dahl_SR_JrHsd	4	48,705,059 - 48,740,898 (+)	NCBI
Lyon_Normotensive	4	46,145,965 - 46,181,849 (+)	NCBI
Lyon_Hypertensive	4	46,699,872 - 46,735,706 (+)	NCBI
F344_StmMcwi	4	46,512,917 - 46,548,755 (+)	NCBI
Rnor_6.0	4	44,936,290 - 44,972,270 (+)	NCBI
Rnor_5.0	4	45,541,352 - 45,577,242 (+)	NCBI
RGSC_v3.4	4	43,293,339 - 43,329,229 (+)	RGD
Celera	4	41,250,212 - 41,286,106 (+)	RGD

Sequence:

show sequence

GGGGAAGTCAGGTGGCCGCTGCTGCCACCAGCGCCACGGTTTGTCGCCAGAAGGAAGATGGCGG
ATCTGGAGGAGCAGTTGTCCGATGAGGAGAAGGTACGTATAGCAGCAAAATTCATCATTCATGC
CCCTCCTGGAGAATTTAATGAGGTTTTTAATGATGTTCGATTATTGCTTAATAATGATAATCTT
CTCAGGGAAGGAGCAGCACATGCATTTGCACAGTATAACCTGGACCAGTTTACACCAGTAAAAA
TTGAAGGCTATGAAGATCAGGTCTTGATAACAGAACATGGAGACTTGGGAAATGGAAAATTTTT
GGATCCAAAAAACAGAATCTGTTTCAAATTTGATCATTTAAGAAAAGAAGCAACTGATCCAAGG
CCCTATGAAGCAGAAAATGCCATTGAATCCTGGAGAACTTCAGTAGAAACTGCACTGCGAGCTT
ATGTAAAAGAGCATTATCCCAATGGGGTCTGCACTGTGTATGGCAAAAAAGTAGATGGGCAGCA
AACCATTATTGCATGCATCGAAAGCCATCAGTTTCAAGCAAAAAACTTTTGGAATGGTCGTTGG
AGGTCAGAGTGGAAGTTTACAGTCACTCCTTCCACCACCCAGGTGGTTGGCATTTTGAAAATTC
AGGTTCATTATTATGAAGATGGTAATGTTCAGCTAGTGAGTCATAAAGATATACAAGATTCCCT
CACAGTATCTAATGAGGTGCAAACAGCAAAAGAATTTATAAAGATTGTAGAAGCTGCAGAAAAT
GAATACCAGACTGCCATCAGTGAGAACTATCAGACAATGTCGGACACTACCTTCAAAGCCTTAC
GTCGACAGTTGCCAGTGACACGTACTAAGATCGACTGGAACAAGATCCTTAGCTACAAGATTGG
CAAAGAGATGCAGAATGCATAAATGAAAATTGCATGAGCAGATTGTTTTAGTGTCTTCGCGTTA
CAAAAATTATTGCAAAAGTATTCTGAGCTGTCAGCTGCCCAGTGAGGTGGGCTGTTGCATCTAA
GATCACTGTAATTAAGTAGTGTGGTTAGAGCACAGAGCTTAGCTAATAACCTTGTTCCATTTCC
TTTGTTCAGAGGGTTGGACATGAGTTTAGATCAGTATCTTACTCTGTTCCTCCTTTCCAAGTAT
CTCTCTTTCTCTCTTTCTCTCTCTCTCTCTCTCTCTCTGTTCCTTTTCCTACAGTGAAGAGGTG
ATCCCTCTGGGTCATGTCTAAAGGATTTTAAATATCTCAAAAGTATCTTATTTACTGTAACCCT
GAAATTGTCTCTGGCCTGTAAAAAGGGCAACTTCTGATGTGACCGCAGGTATTTTTAGTGGAGT
CAGTAGTGGACACTCTAGTTAAGGTGGTTGATGGACTTAGCCATACATGCTGCTAAAGAAATTG
TCTACCTTTTCCTTTCACCTCTTCTGGCGTGGGAGATGGAGACTAGAGGGCGAGCATTTTCTAC
ACCAGTCACGTTTAAACCTTCTCAGTAAGGTTATTTAGCTAGCTTAGTGTCTAACTAAACTTTT
TTAAAACAAGGCCAAGGTCTGTTGCTGTTTTGAGATTCTGAAATTAAATGAGAATACTTATTTC
AGAAATGCATTTAATGCTTTTTTTCTTGTGACAGTTATGCAAATTAGCTTGAATTCCATATGTT
CCTGAGTTATTTTTATCACAAAGCCACAAGTGTATTATAAGGCAGATTGTAATATATATATAAT
CCTGAACTCATGAACATGTCTCAGCTGATTCTCCCTCCCCTTGGATTGAAAACTGAATTTTATT
GTGACATTAAAATGGCAAAATTTGGTATTTATTTGAGTAAAAAAAAAATCATCAGTGAATCATA
CACTATTTTAAAATACTTTCTTTGTATATTGTCATTCTTAACAAGTTGTAAATTAGAAAATTTG
GGAGTCCACATGGTATGCAACTGCATCTTTTGTTTTCCATTTTCCTATGCATCGTAAGCATGTG
TGTAATACGTTAAATATATCTCCTGACACCACAGGAATTCGAGCCTCGGTGAACGTCGGCATTT
ACTATAAAGGAGTTGGTGGATTTGTGGTTTCATTCAGTAGTTTTGCTGCTTATGCTCGAGTGGA
ATCCATTTCTCACATACTCCTGCAGACATCTGGGCCTGGAATTTTTTTTTAAACACCACTTTTA
CTATGTATAATAAAATATTTCATTAGCTTGAATTGTATAGATTTTTAAAAATTCAATGAGAGCA
TGTTGTTTAATTTCTTTTTAAAATCACTGTTGGGCTTTGAAAGCATTGCAAATATATGACATTG
TGACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001009180	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI01868	(Get FASTA)	NCBI Sequence Viewer
	AAR16310	(Get FASTA)	NCBI Sequence Viewer
	EDM15117	(Get FASTA)	NCBI Sequence Viewer
	EDM15118	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072041
GenBank Protein	Q3T1K5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001009180 ⟸ NM_001009180

- UniProtKB:

Q3T1K5 (UniProtKB/Swiss-Prot), A6IE30 (UniProtKB/TrEMBL), A0A8L2R4Z5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTP
VKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETAL
RAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGIL
KIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFK
ALRRQLPVTRTKIDWNKILSYKIGKEMQNA

hide sequence

Ensembl Acc Id:

ENSRNOP00000072041 ⟸ ENSRNOT00000090451

Ensembl Acc Id:

ENSRNOP00000097945 ⟸ ENSRNOT00000106630

Ensembl Acc Id:

ENSRNOP00000086194 ⟸ ENSRNOT00000117690

Ensembl Acc Id:

ENSRNOP00000103021 ⟸ ENSRNOT00000144381

Ensembl Acc Id:

ENSRNOP00000107173 ⟸ ENSRNOT00000169051

Ensembl Acc Id:

ENSRNOP00000099181 ⟸ ENSRNOT00000135564

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3T1K5-F1-model_v2	AlphaFold	Q3T1K5	1-286	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692893

Promoter ID:

EPDNEW_R3417

Type:

initiation region

Name:

Capza2_1

Description:

capping actin protein of muscle Z-line alpha subunit 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	44,936,322 - 44,936,382	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549770	AgrOrtholog
BioCyc Gene	G2FUF-45546	BioCyc
Ensembl Genes	ENSRNOG00000056207	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000090451	ENTREZGENE
Gene3D-CATH	3.30.1140.60	UniProtKB/Swiss-Prot
	3.90.1150.210	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7938377	IMAGE-MGC_LOAD
InterPro	CapZ_alpha	UniProtKB/Swiss-Prot
	CapZ_alpha/beta	UniProtKB/Swiss-Prot
	CapZ_alpha/beta_2	UniProtKB/Swiss-Prot
	CapZ_alpha_1	UniProtKB/Swiss-Prot
	F-actin_cap_asu_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:493810	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124519	IMAGE-MGC_LOAD
NCBI Gene	493810	ENTREZGENE
PANTHER	F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-2	UniProtKB/Swiss-Prot
	PTHR10653	UniProtKB/Swiss-Prot
Pfam	F-actin_cap_A	UniProtKB/Swiss-Prot
PhenoGen	Capza2	PhenoGen
PRINTS	FACTINCAPA	UniProtKB/Swiss-Prot
PROSITE	F_ACTIN_CAPPING_A_1	UniProtKB/Swiss-Prot
	F_ACTIN_CAPPING_A_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000056207	RatGTEx
Superfamily-SCOP	SSF90096	UniProtKB/Swiss-Prot
UniProt	A0A8I6A4U7_RAT	UniProtKB/TrEMBL
	A0A8I6ATN5_RAT	UniProtKB/TrEMBL
	A0A8L2R4Z5	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L5V4_RAT	UniProtKB/TrEMBL
	A0ABK0LPJ5_RAT	UniProtKB/TrEMBL
	A0ABK0LT32_RAT	UniProtKB/TrEMBL
	A6IE30	ENTREZGENE, UniProtKB/TrEMBL
	A6IE31_RAT	UniProtKB/TrEMBL
	CAZA2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-03	Capza2	capping actin protein of muscle Z-line subunit alpha 2	Capza2	capping actin protein of muscle Z-line alpha subunit 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-11	Capza2	capping actin protein of muscle Z-line alpha subunit 2	Capza2	capping protein (actin filament) muscle Z-line, alpha 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-15	Capza2	capping protein (actin filament) muscle Z-line, alpha 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI