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Gene: Lypd1 (Ly6/Plaur domain containing 1) Rattus norvegicus

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Symbol:

Lypd1

Name:

Ly6/Plaur domain containing 1

RGD ID:

1549754

Description:

Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within several processes, including behavioral fear response; cholinergic synaptic transmission; and negative regulation of protein localization to plasma membrane. Predicted to be located in membrane. Orthologous to human LYPD1 (LY6/PLAUR domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ly6/PLAUR domain-containing protein 1; Lypdc1; MGC95169

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LYPD1 (LY6/PLAUR domain containing 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lypd1 (Ly6/Plaur domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lypd1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LYPD1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LYPD1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lypd1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LYPD1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LYPD1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lypd1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lypd1 (LY6/PLAUR domain containing 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AMZ1 (archaelysin family metallopeptidase 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	LYPD1 (LY6/PLAUR domain containing 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lypd1 (Ly6/Plaur domain containing 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lypd1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	39,874,937 - 39,922,385 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	39,879,096 - 39,922,338 (-)	Ensembl				GRCr8
mRatBN7.2	13	37,326,459 - 37,368,515 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	37,326,464 - 37,368,493 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	39,920,305 - 39,962,362 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	41,208,329 - 41,250,396 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	38,474,263 - 38,516,301 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	42,219,884 - 42,263,024 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	42,219,887 - 42,263,024 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	47,327,522 - 47,368,232 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	38,399,429 - 38,441,498 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	37,122,178 - 37,163,486 (-)	NCBI		Celera
Cytogenetic Map	13	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

acetylcholine (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

Archazolid B (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epibatidine (EXP)

epoxiconazole (ISO)

furan (EXP)

imidacloprid (EXP)

indole-3-methanol (EXP)

malathion (ISO)

maneb (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methamphetamine (EXP)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

PCB138 (ISO)

pentanal (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

propanal (ISO)

resveratrol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (IBA,ISO)

behavioral fear response (ISO)

negative regulation of protein localization to plasma membrane (ISO)

response to nicotine (ISO)

synaptic transmission, cholinergic (ISO)

Cellular Component

membrane (ISO)

plasma membrane (IEA)

side of membrane (IEA)

synapse (IEA)

Molecular Function

acetylcholine receptor binding (ISO)

acetylcholine receptor inhibitor activity (IBA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:17488974	PMID:19246390	PMID:26276394

Genomics

Comparative Map Data

Lypd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	39,874,937 - 39,922,385 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	39,879,096 - 39,922,338 (-)	Ensembl				GRCr8
mRatBN7.2	13	37,326,459 - 37,368,515 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	37,326,464 - 37,368,493 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	39,920,305 - 39,962,362 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	41,208,329 - 41,250,396 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	38,474,263 - 38,516,301 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	42,219,884 - 42,263,024 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	42,219,887 - 42,263,024 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	47,327,522 - 47,368,232 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	38,399,429 - 38,441,498 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	37,122,178 - 37,163,486 (-)	NCBI		Celera
Cytogenetic Map	13	q12	NCBI

LYPD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	132,643,286 - 132,671,526 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	132,643,286 - 132,671,579 (-)	Ensembl			hg38	GRCh38
GRCh37	2	133,400,859 - 133,429,099 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	133,118,807 - 133,145,540 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	133,236,157 - 133,261,510	NCBI
Celera	2	127,117,594 - 127,144,318 (-)	NCBI		Celera
Cytogenetic Map	2	q21.2	NCBI
HuRef	2	125,395,959 - 125,422,502 (-)	NCBI		HuRef
CHM1_1	2	133,407,570 - 133,434,311 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	133,081,646 - 133,109,877 (-)	NCBI		T2T-CHM13v2.0

Lypd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	125,795,359 - 125,841,134 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	125,795,359 - 125,840,838 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	125,867,622 - 125,913,175 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	125,867,622 - 125,913,101 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	127,768,616 - 127,808,791 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	127,699,589 - 127,739,760 (-)	NCBI		MGSCv36	mm8
Celera	1	128,530,811 - 128,571,285 (-)	NCBI		Celera
Cytogenetic Map	1	E3	NCBI
cM Map	1	54.7	NCBI

Lypd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	236,012 - 266,028 (-)	Ensembl
ChiLan1.0	NW_004955440	236,012 - 266,028 (-)	NCBI	ChiLan1.0	ChiLan1.0

LYPD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	42,240,694 - 42,271,060 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	42,255,666 - 42,286,041 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	27,170,199 - 27,201,789 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	136,738,362 - 136,769,816 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	136,738,362 - 136,769,150 (-)	Ensembl			panPan2	panpan1.1

LYPD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	35,586,096 - 35,630,468 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	35,586,283 - 35,630,160 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	35,815,887 - 35,859,926 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	37,021,072 - 37,065,212 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	37,021,072 - 37,066,459 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	35,669,400 - 35,713,519 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	35,829,430 - 35,873,495 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	37,048,312 - 37,092,444 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lypd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	85,418,630 - 85,457,503 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	56,168,734 - 56,197,997 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	56,163,531 - 56,199,067 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LYPD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	19,522,828 - 19,567,886 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	19,522,045 - 19,559,819 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	22,097,652 - 22,135,312 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LYPD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	16,910,145 - 16,941,915 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666061	5,577,790 - 5,609,350 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lypd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	32,045,612 - 32,073,548 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624732	32,045,585 - 32,075,013 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lypd1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	9,750,998 - 9,769,650 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lypd1
253 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	170
Count of miRNA genes:	111
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000004741
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
61453	Pur1	Proteinuria QTL 1	18.06		urine total protein amount (VT:0000032)	urine protein level (CMO:0000591)	13	37087983	39968353	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Markers in Region

D13Rat37

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	39,913,272 - 39,913,445 (+)	Marker Load Pipeline
Rnor_5.0	13	47,360,968 - 47,361,095	NCBI	Rnor5.0
Rnor_5.0	13	47,360,969 - 47,361,095	NCBI	Rnor5.0
RGSC_v3.4	13	38,433,870 - 38,434,043	RGD	RGSC3.4
RGSC_v3.4	13	38,433,871 - 38,434,043	UniSTS	RGSC3.4
Celera	13	37,155,638 - 37,155,810	UniSTS
RGSC_v3.1	13	38,447,913 - 38,448,086	RGD
RH 2.0 Map	13	215.1	RGD
FHH x ACI Map	13	9.21	RGD
Cytogenetic Map	13	q11	UniSTS

D13Rat114

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	39,903,577 - 39,903,706 (+)	Marker Load Pipeline
mRatBN7.2	13	37,350,949 - 37,351,078 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	42,246,348 - 42,246,476	NCBI	Rnor6.0
Rnor_5.0	13	47,351,275 - 47,351,403	UniSTS	Rnor5.0
RGSC_v3.4	13	38,424,175 - 38,424,304	RGD	RGSC3.4
RGSC_v3.4	13	38,424,176 - 38,424,304	UniSTS	RGSC3.4
Celera	13	37,145,918 - 37,146,066	UniSTS
RGSC_v3.1	13	38,438,218 - 38,438,347	RGD
SHRSP x BN Map	13	7.9399	UniSTS
SHRSP x BN Map	13	7.9399	RGD
Cytogenetic Map	13	q11	UniSTS

AI853408

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	37,326,758 - 37,326,876 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	42,220,184 - 42,220,301	NCBI	Rnor6.0
Rnor_5.0	13	47,327,822 - 47,327,939	UniSTS	Rnor5.0
RGSC_v3.4	13	38,399,729 - 38,399,846	UniSTS	RGSC3.4
Celera	13	37,122,478 - 37,122,595	UniSTS
Cytogenetic Map	13	q11	UniSTS

RH137955

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	37,328,073 - 37,328,220 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	42,221,499 - 42,221,645	NCBI	Rnor6.0
Rnor_5.0	13	47,329,137 - 47,329,283	UniSTS	Rnor5.0
RGSC_v3.4	13	38,401,044 - 38,401,190	UniSTS	RGSC3.4
Celera	13	37,123,793 - 37,123,939	UniSTS
Cytogenetic Map	13	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	158	91	90	59	54	59	6	318	154	11	133	81	91	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213690	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004741 ⟹ ENSRNOP00000004741

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	39,879,096 - 39,922,225 (-)	Ensembl
mRatBN7.2 Ensembl	13	37,326,464 - 37,368,493 (-)	Ensembl
Rnor_6.0 Ensembl	13	42,219,887 - 42,263,024 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000174164 ⟹ ENSRNOP00000106326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	39,879,096 - 39,922,338 (-)	Ensembl

RefSeq Acc Id:

NM_001007727 ⟹ NP_001007728

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	39,879,091 - 39,921,121 (-)	NCBI
mRatBN7.2	13	37,326,459 - 37,368,493 (-)	NCBI
Rnor_6.0	13	42,219,884 - 42,263,024 (-)	NCBI
Rnor_5.0	13	47,327,522 - 47,368,232 (-)	NCBI
RGSC_v3.4	13	38,399,429 - 38,441,498 (-)	RGD
Celera	13	37,122,178 - 37,163,486 (-)	RGD

Sequence:

show sequence

GTGCTCCGGATCGCCAGTAGTTCTTCAAGCCTCAGCAGCCAACTCCTACAGAGGCGCGGCGCTC
CGCCCCAGGGAGCGCGAACCCGAGGAGCCTGGGACCAGCCTCTGGGAGCCCCGGGCGCGGGCGA
TGCGGGCGCCGCGGGCGACACCTGCGGCTCCTCTCGGTGGCAGCCGTCGCCTGGGCGGCAGCAG
CGCGAGCCTCGGCAGCCTCCGCAGCTACAGTGGCCGCGGCCGGAACAGCCTCCGCTGCGGTCGT
TGTCTCTGATGCTCTTGCCCGCTCCCGGCCCTGCCGATCCGGGAGGATGTGGGTTCTCGGCATC
GCAGCAACTTTTTGCGGATTGTTCTGGCTTCCAGGGCTGGCGCTGCAAATTCAGTGCTACCAGT
GTGAAGAATTTCAGCTGAACAACGATTGCTCGTCCCCTGAGTTCATAGTCAATTGCACCGTGAA
CGTTCAAGACATGTGTCAGAAAGAAGTGATGGAGCAAAGTGCGGGGATCATGTACCGGAAGTCG
TGTGCATCGTCAGCAGCCTGCCTCATCGCCTCAGCTGGGTACCAGTCCTTCTGTTCTCCCGGGA
AACTGAACTCCGTGTGTATCAGTTGCTGCAACACCCCTCTTTGCAACGGGCCGAGGCCCAAGAA
GAGAGGCAGCTCCGCTTCGGCCATTAGGCCGGAGCTTTTTACCACCGTCCTGTTCTTCAACTTA
GCCCTCTGCTTGGCACACTGCTGAAGCTAAAGGAGATGCCCACCCCTGCTGCCTCATCTGTCCG
GCCCTTCCTCTCTCACCTTCCCGAGTCTCTTCTGGCTGTCCTTCTATTCTGGGTAGACAAGGGA
GTCCTTTTGTTCCCTTTCGAGTAACAAGATTGTGTGCACAAATACTTTTGTAAGCTCTGAACCA
ATTCACAATTTCCGTGTGTAGTTGAAGAAAAAGCATGGAGCAGAAAGCCCAGACCCTCCCATCC
CAATCTGGTTAACCACCGCCAAGGCTATCCTGGAAGAATCAGCCCTTAGAAGTCATTGAGATAT
GTGTCTGTCTTTCCCAAAGCCTGGAGCTTCCATTCTGTCCCAATAGGAGTCACAGTCTATTCGG
GGGCTGCGGCGTGAAGGTAACTTTGCATCTGTGGGAGGGAAGAACCAGTTTCTGCTCAAGGCTT
CTAACTTGACATTCACACTTCCTGCTCCTGTAAACTATTTTCTGTGGCGGAACCAGCAGGTTTG
GTCTCTGAGCCGGTCTGTGGTGACTCAGGACTCAAGGGCTGGTGCTCGCCCTCTAGAGGCTTAG
CCTCCGCCTGAAAAGTGCTTAAGAAAACCTTGTTAGTTCTCCGGGAGGAAGAGTTACTACGCCG
GGAGGCTAGGAAGATGAGCGGGCTTCGGGCTGAGCGGCTGCTGTTTTTGGTAGAGCTGAAGTAG
GCACGCTGCTGTTTCTCCTGGTTGGCATGCTGCAGAGTCAGCCGGCAGCAGAGAACCTGCCAGA
AAACCTTCCGGAACTGCTGAGAAGACACGTTGTAGAGGAGAGGGTTGACCACGGAGCTGAGGTA
GAAGAAGGTGTCGGAGAAGGGGAGGAGGATCATGTACGCCTTGAAGTACGACTTGGTCCAGTCA
TGTTTGGGTTTTGCTGCGGCCATGATCCGTCGGATCTGATTTGGCATCCAACACACGGCCAGTG
TCACCACGATCAGTCCTGGGCAGGCGAGAAGAGGAGAGAAAAGGAGACGGGGAGAAAAACAGCA
TGAGAACAAAAATAAATAAATAAACACCCATAAAATATTCAGCCCCTTGGTTCTGTTGCTTACT
GGCTGGGAAACGGTACCAATCTTTCAGTGCTGTGCTTGACGGCTTCTTTTTTTGCCACCGGCAA
AGGAGAATTTAATGCTGCTTCAAGCTCAGGGGACTTGGCTATGTTAAAAAGCGTTAAATGCTTT
CGACAGTGTATTTATACCTGTGGATGCCTGTTAATTTTCAAAATGTTTTCATTGTTGCTCGTGA
ATCCAGAAAATATCTCATGTTGGCCATAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017598845 ⟹ XP_017454334

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	39,874,937 - 39,921,143 (-)	NCBI
mRatBN7.2	13	37,327,486 - 37,368,515 (-)	NCBI
Rnor_6.0	13	42,220,993 - 42,262,899 (-)	NCBI

Sequence:

show sequence

CGATGCGGGCGCCGCGGGCGACACCTGCGGCTCCTCTCGGTGGCAGCCGTCGCCTGGGCGGCAG
CAGCGCGACAACTTTTTGCGGATTGTTCTGGCTTCCAGGGCTGGCGCTGCAAATTCAGTGCTAC
CAGTGTGAAGAATTTCAGCTGAACAACGATTGCTCGTCCCCTGAGTTCATAGTCAATTGCACCG
TGAACGTTCAAGACATGTGTCAGAAAGAAGTGATGGAGCAAAGTGCGGGGATCATGTACCGGAA
GTCGTGTGCATCGTCAGCAGCCTGCCTCATCGCCTCAGCTGGGTACCAGTCCTTCTGTTCTCCC
GGGAAACTGAACTCCGTGTGTATCAGTTGCTGCAACACCCCTCTTTGCAACGGGCCGAGGCCCA
AGAAGAGAGGCAGCTCCGCTTCGGCCATTAGGCCGGAGCTTTTTACCACCGTCCTGTTCTTCAA
CTTAGCCCTCTGCTTGGCACACTGCTGAAGCTAAAGGAGATGCCCACCCCTGCTGCCTCATCTG
TCCGGCCCTTCCTCTCTCACCTTCCCGAGTCTCTTCTGGCTGTCCTTCTATTCTGGGTAGACAA
GGGAGTCCTTTTGTTCCCTTTCGAGTAACAAGATTGTGTGCACAAATACTTTTGTAAGCTCTGA
ACCAATTCACAAT

hide sequence

RefSeq Acc Id:

XM_063272437 ⟹ XP_063128507

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	39,874,937 - 39,920,761 (-)	NCBI

RefSeq Acc Id:

XM_063272438 ⟹ XP_063128508

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	39,874,937 - 39,922,385 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007728	(Get FASTA)	NCBI Sequence Viewer
	XP_017454334	(Get FASTA)	NCBI Sequence Viewer
	XP_063128507	(Get FASTA)	NCBI Sequence Viewer
	XP_063128508	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82032	(Get FASTA)	NCBI Sequence Viewer
	EDL87970	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004741.3
	ENSRNOP00000106326
GenBank Protein	Q66H42	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007728 ⟸ NM_001007727
- Peptide Label:	precursor
- UniProtKB:	Q66H42 (UniProtKB/Swiss-Prot), A6K825 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWVLGIAATFCGLFWLPGLALQIQCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSAG IMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPKKRGSSASAIRPELFTT VLFFNLALCLAHC hide sequence

RefSeq Acc Id:	XP_017454334 ⟸ XM_017598845
- Peptide Label:	isoform X3
- Sequence:	show sequence MRAPRATPAAPLGGSRRLGGSSATTFCGLFWLPGLALQIQCYQCEEFQLNNDCSSPEFIVNCTV NVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPK KRGSSASAIRPELFTTVLFFNLALCLAHC hide sequence

Ensembl Acc Id:

ENSRNOP00000004741 ⟸ ENSRNOT00000004741

RefSeq Acc Id:	XP_063128508 ⟸ XM_063272438
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063128507 ⟸ XM_063272437
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000106326 ⟸ ENSRNOT00000174164

Protein Domains

UPAR/Ly6

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66H42-F1-model_v2	AlphaFold	Q66H42	1-141	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549754	AgrOrtholog
BioCyc Gene	G2FUF-18451	BioCyc
Ensembl Genes	ENSRNOG00000003453	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000004741.6	UniProtKB/Swiss-Prot
	ENSRNOT00000174164	ENTREZGENE
IMAGE_CLONE	IMAGE:7130639	IMAGE-MGC_LOAD
InterPro	LY6_UPA_recep-like	UniProtKB/Swiss-Prot
	Snake_toxin-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:360838	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95169	IMAGE-MGC_LOAD
NCBI Gene	360838	ENTREZGENE
PANTHER	CD59 GLYCOPROTEIN	UniProtKB/Swiss-Prot
	LY6/PLAUR DOMAIN-CONTAINING PROTEIN 1	UniProtKB/Swiss-Prot
Pfam	UPAR_LY6	UniProtKB/Swiss-Prot
PhenoGen	Lypd1	PhenoGen
RatGTEx	ENSRNOG00000003453	RatGTEx
Superfamily-SCOP	SSF57302	UniProtKB/Swiss-Prot
UniProt	A0ABK0LZB5_RAT	UniProtKB/TrEMBL
	A6K825	ENTREZGENE, UniProtKB/TrEMBL
	A9CMA2_RAT	UniProtKB/TrEMBL
	LYPD1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Lypd1	Ly6/Plaur domain containing 1	Lypdc1		Symbol updated	1299863	APPROVED
2005-09-15	Lypdc1	Ly6/Plaur domain containing 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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