Vom1r21 (vomeronasal 1 receptor 21) - Rat Genome Database

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Gene: Vom1r21 (vomeronasal 1 receptor 21) Rattus norvegicus
Analyze
Symbol: Vom1r21
Name: vomeronasal 1 receptor 21
RGD ID: 1359719
Description: Predicted to enable pheromone binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; response to pheromone; and sensory perception of chemical stimulus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human VN1R4 (vomeronasal 1 receptor 4); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: V1rf3; vomernasal 1 receptor Vom1r21; vomeronasal 1 receptor, 21; vomeronasal 1 receptor, F3; vomeronasal type-1 receptor 4; vomeronasal V1r-type receptor V1rf3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,636,830 - 69,637,753 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,636,830 - 69,637,753 (+)EnsemblGRCr8
mRatBN7.2160,963,939 - 60,964,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl160,961,052 - 60,970,529 (+)EnsemblmRatBN7.2
Rnor_6.01928,377,249 - 28,378,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1928,377,249 - 28,378,118 (+)Ensemblrn6Rnor6.0
Rnor_5.01939,317,209 - 39,318,078 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4158,877,734 - 58,878,603 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera157,082,890 - 57,083,759 (+)NCBICelera
RGSC_v3.1158,880,678 - 58,881,548 (+)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19952141  


Genomics

Comparative Map Data
Vom1r21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,636,830 - 69,637,753 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,636,830 - 69,637,753 (+)EnsemblGRCr8
mRatBN7.2160,963,939 - 60,964,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl160,961,052 - 60,970,529 (+)EnsemblmRatBN7.2
Rnor_6.01928,377,249 - 28,378,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1928,377,249 - 28,378,118 (+)Ensemblrn6Rnor6.0
Rnor_5.01939,317,209 - 39,318,078 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4158,877,734 - 58,878,603 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera157,082,890 - 57,083,759 (+)NCBICelera
RGSC_v3.1158,880,678 - 58,881,548 (+)NCBI
Cytogenetic Map1q12NCBI
VN1R4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381953,266,676 - 53,267,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1953,266,676 - 53,267,723 (-)Ensemblhg38GRCh38
GRCh371953,769,929 - 53,770,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361958,461,825 - 58,462,730 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341958,461,824 - 58,462,730NCBI
Celera1950,811,899 - 50,812,804 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,090,647 - 50,091,552 (-)NCBIHuRef
CHM1_11953,771,924 - 53,772,829 (-)NCBICHM1_1
T2T-CHM13v2.01956,346,170 - 56,347,217 (-)NCBIT2T-CHM13v2.0
Vmn1r237
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391721,534,279 - 21,535,148 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1721,532,127 - 21,535,174 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381721,314,017 - 21,314,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1721,311,865 - 21,314,912 (+)Ensemblmm10GRCm38
MGSCv371721,450,981 - 21,451,850 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361721,018,714 - 21,019,583 (+)NCBIMGSCv36mm8
MGSCv361720,370,997 - 20,371,866 (+)NCBIMGSCv36mm8
Celera7145,993,369 - 145,994,238 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1711.4NCBI
LOC100971599
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22059,294,074 - 59,294,981 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11961,212,480 - 61,213,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01950,185,819 - 50,186,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,066,520 - 59,067,427 (-)NCBIPanPan1.1PanPan1.1panPan2
VN1R4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,754,428 - 103,755,378 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,619,140 - 103,620,090 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01104,210,210 - 104,211,160 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11103,841,645 - 103,842,595 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,603,998 - 103,604,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01104,323,517 - 104,324,467 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC110261298
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1657,751,417 - 57,752,358 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Vom1r21
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:64
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000059668
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
1 1 12 1 1 11 6

Sequence


Ensembl Acc Id: ENSRNOT00000059668   ⟹   ENSRNOP00000056420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1928,377,249 - 28,378,118 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100429   ⟹   ENSRNOP00000088566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl160,961,052 - 60,970,529 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114331   ⟹   ENSRNOP00000083428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl160,961,052 - 60,970,529 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128245   ⟹   ENSRNOP00000112663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,636,830 - 69,637,753 (+)Ensembl
RefSeq Acc Id: NM_001009510   ⟹   NP_001009510
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,636,830 - 69,637,753 (+)NCBI
mRatBN7.2160,963,939 - 60,964,862 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001009510 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000112663
  ENSRNOP00000112663.1
Ensembl Acc Id: ENSRNOP00000056420   ⟸   ENSRNOT00000059668
Ensembl Acc Id: ENSRNOP00000088566   ⟸   ENSRNOT00000100429
Ensembl Acc Id: ENSRNOP00000083428   ⟸   ENSRNOT00000114331
RefSeq Acc Id: NP_001009510   ⟸   NM_001009510
- UniProtKB: Q5J3H1 (UniProtKB/TrEMBL),   A6KB88 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000112663   ⟸   ENSRNOT00000128245
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5J3H1-F1-model_v2 AlphaFold Q5J3H1 1-289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359719 AgrOrtholog
BioCyc Gene G2FUF-61185 BioCyc
Ensembl Genes ENSRNOG00000039019 Ensembl
  ENSRNOG00000064479 Ensembl
  ENSRNOG00000078543 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000128245 ENTREZGENE
  ENSRNOT00000128245.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Vmron_rcpt_1 UniProtKB/TrEMBL
KEGG Report rno:494229 UniProtKB/TrEMBL
NCBI Gene 494229 ENTREZGENE
PANTHER PTHR24062 UniProtKB/TrEMBL
Pfam V1R UniProtKB/TrEMBL
PhenoGen Vom1r21 PhenoGen
PRINTS VOMERONASL1R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039019 RatGTEx
  ENSRNOG00000064479 RatGTEx
  ENSRNOG00000078543 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6KB88 ENTREZGENE, UniProtKB/TrEMBL
  Q5J3H1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Vom1r21  vomeronasal 1 receptor 21  Vom1r21  vomeronasal 1 receptor 21  Data merged from RGD:149736441 737654 PROVISIONAL
2021-08-09 Vom1r21  vomeronasal 1 receptor 21      Symbol and Name status set to provisional 45752 PROVISIONAL
2011-01-20 Vom1r21  vomeronasal 1 receptor 21  Vom1r21  vomeronasal 1 receptor, 21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-08 Vom1r21  vomeronasal 1 receptor, 21  V1rf3  vomeronasal 1 receptor, F3  Symbol and Name updated 2325755 APPROVED
2008-07-23 V1rf3  vomeronasal 1 receptor, F3      Name updated 1299863 APPROVED
2008-03-07 V1rf3  vomeronasal 1 receptor, F3  V1rf3  vomeronasal V1r-type receptor V1rf3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 V1rf3  vomeronasal V1r-type receptor V1rf3      Symbol and Name status set to provisional 70820 PROVISIONAL