Rnd3 (Rho family GTPase 3) - Rat Genome Database

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Gene: Rnd3 (Rho family GTPase 3) Rattus norvegicus
Analyze
Symbol: Rnd3
Name: Rho family GTPase 3
RGD ID: 1359690
Description: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. Orthologous to human RND3 (Rho family GTPase 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Arhe; ras homolog gene family, member E; rho-related GTP-binding protein RhoE; RHOE
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,981,142 - 55,998,494 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl355,980,355 - 55,998,536 (-)EnsemblGRCr8
mRatBN7.2335,571,929 - 35,589,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl335,571,143 - 35,589,327 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx338,969,914 - 38,987,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0347,554,663 - 47,572,026 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0345,332,304 - 45,350,239 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0336,643,374 - 36,660,727 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl336,642,587 - 36,660,758 (-)Ensemblrn6Rnor6.0
Rnor_5.0341,757,186 - 41,774,539 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4332,101,433 - 32,118,785 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera333,730,327 - 33,747,679 (-)NCBICelera
RGSC_v3.1331,997,804 - 32,015,157 (-)NCBI
Cytogenetic Map3q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
lithium chloride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
SL-327  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RhoE binds to ROCK I and inhibits downstream signaling. Riento K, etal., Mol Cell Biol. 2003 Jun;23(12):4219-29.
6. RhoE inhibits cell cycle progression and Ras-induced transformation. Villalonga P, etal., Mol Cell Biol 2004 Sep;24(18):7829-40.
Additional References at PubMed
PMID:12477932   PMID:14732713   PMID:16311049   PMID:21423176   PMID:23376485   PMID:23762244   PMID:32705255   PMID:38724005  


Genomics

Comparative Map Data
Rnd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,981,142 - 55,998,494 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl355,980,355 - 55,998,536 (-)EnsemblGRCr8
mRatBN7.2335,571,929 - 35,589,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl335,571,143 - 35,589,327 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx338,969,914 - 38,987,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0347,554,663 - 47,572,026 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0345,332,304 - 45,350,239 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0336,643,374 - 36,660,727 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl336,642,587 - 36,660,758 (-)Ensemblrn6Rnor6.0
Rnor_5.0341,757,186 - 41,774,539 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4332,101,433 - 32,118,785 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera333,730,327 - 33,747,679 (-)NCBICelera
RGSC_v3.1331,997,804 - 32,015,157 (-)NCBI
Cytogenetic Map3q12NCBI
RND3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382150,468,193 - 150,487,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2150,468,195 - 150,539,011 (-)Ensemblhg38GRCh38
GRCh372151,324,707 - 151,344,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,032,955 - 151,052,426 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342151,150,216 - 151,169,688NCBI
Celera2144,938,960 - 144,958,449 (-)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2143,221,253 - 143,240,784 (-)NCBIHuRef
CHM1_12151,330,489 - 151,349,997 (-)NCBICHM1_1
T2T-CHM13v2.02150,918,573 - 150,938,077 (-)NCBIT2T-CHM13v2.0
Rnd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39251,020,451 - 51,039,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl251,020,450 - 51,039,123 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38251,130,439 - 51,149,111 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl251,130,438 - 51,149,111 (-)Ensemblmm10GRCm38
MGSCv37250,985,959 - 51,004,631 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36250,952,448 - 50,971,120 (-)NCBIMGSCv36mm8
Celera252,814,575 - 52,833,308 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map229.63NCBI
Rnd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544016,106,555 - 16,113,338 (-)Ensembl
ChiLan1.0NW_00495544016,106,555 - 16,113,337 (-)NCBIChiLan1.0ChiLan1.0
RND3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21324,453,723 - 24,473,246 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B24,468,716 - 24,488,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B9,387,338 - 9,406,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B154,813,235 - 154,832,768 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B154,810,039 - 154,832,768 (-)EnsemblpanPan2panpan1.1
RND3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11951,889,693 - 51,909,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1951,891,494 - 51,909,033 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1952,002,669 - 52,022,012 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01953,352,354 - 53,372,496 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1953,352,356 - 53,373,467 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11952,048,081 - 52,066,346 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.11952,034,519 - 52,038,409 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01952,130,759 - 52,149,808 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01953,545,000 - 53,564,447 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rnd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303114,618,761 - 114,636,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646926,981,318 - 27,000,739 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646926,981,358 - 26,998,902 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RND3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl151,715,207 - 1,734,414 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1151,715,589 - 1,732,605 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215999,583 - 1,008,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RND3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11035,877,147 - 35,897,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1035,877,153 - 35,897,286 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040163,652,947 - 163,672,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248663,345,774 - 3,364,345 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248663,346,747 - 3,363,962 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rnd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1528,953,305 - 28,971,678 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rnd3
116 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:326
Count of miRNA genes:178
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000006111
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)34542360958601291Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat

Markers in Region
RH143020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,572,114 - 35,572,385 (+)MAPPERmRatBN7.2
Rnor_6.0336,643,560 - 36,643,830NCBIRnor6.0
Rnor_5.0341,757,372 - 41,757,642UniSTSRnor5.0
RGSC_v3.4332,101,619 - 32,101,889UniSTSRGSC3.4
Celera333,730,513 - 33,730,783UniSTS
RH 3.4 Map3426.2UniSTS
Cytogenetic Map3q12UniSTS
RH128302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,571,348 - 35,571,546 (+)MAPPERmRatBN7.2
Rnor_6.0336,642,794 - 36,642,991NCBIRnor6.0
Rnor_5.0341,756,606 - 41,756,803UniSTSRnor5.0
RGSC_v3.4332,100,853 - 32,101,050UniSTSRGSC3.4
Celera333,729,747 - 33,729,944UniSTS
RH 3.4 Map3421.9UniSTS
Cytogenetic Map3q12UniSTS
RH142874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,578,739 - 35,578,889 (+)MAPPERmRatBN7.2
Rnor_6.0336,650,185 - 36,650,334NCBIRnor6.0
Rnor_5.0341,763,997 - 41,764,146UniSTSRnor5.0
RGSC_v3.4332,108,244 - 32,108,393UniSTSRGSC3.4
Celera333,737,138 - 33,737,287UniSTS
Cytogenetic Map3q12UniSTS
RH139131  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,578,606 - 35,578,728 (+)MAPPERmRatBN7.2
Rnor_6.0336,650,052 - 36,650,173NCBIRnor6.0
Rnor_5.0341,763,864 - 41,763,985UniSTSRnor5.0
RGSC_v3.4332,108,111 - 32,108,232UniSTSRGSC3.4
Celera333,737,005 - 33,737,126UniSTS
RH 3.4 Map3429.0UniSTS
Cytogenetic Map3q12UniSTS
RH140139  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map3445.9UniSTS
Cytogenetic Map3q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 82 59 6 346 182 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006111   ⟹   ENSRNOP00000006111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl355,980,355 - 55,998,536 (-)Ensembl
mRatBN7.2 Ensembl335,571,143 - 35,589,327 (-)Ensembl
Rnor_6.0 Ensembl336,642,587 - 36,660,758 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095476   ⟹   ENSRNOP00000079889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl355,983,892 - 55,998,536 (-)Ensembl
mRatBN7.2 Ensembl335,574,679 - 35,589,327 (-)Ensembl
RefSeq Acc Id: NM_001007641   ⟹   NP_001007642
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8355,981,142 - 55,998,494 (-)NCBI
mRatBN7.2335,571,929 - 35,589,283 (-)NCBI
Rnor_6.0336,643,374 - 36,660,727 (-)NCBI
Rnor_5.0341,757,186 - 41,774,539 (-)NCBI
RGSC_v3.4332,101,433 - 32,118,785 (-)RGD
Celera333,730,327 - 33,747,679 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007642 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68142 (Get FASTA)   NCBI Sequence Viewer  
  AAR23526 (Get FASTA)   NCBI Sequence Viewer  
  EDM00453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006111
  ENSRNOP00000006111.3
GenBank Protein Q6SA80 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007642   ⟸   NM_001007641
- UniProtKB: Q6SA80 (UniProtKB/Swiss-Prot),   B4F757 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006111   ⟸   ENSRNOT00000006111
Ensembl Acc Id: ENSRNOP00000079889   ⟸   ENSRNOT00000095476

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6SA80-F1-model_v2 AlphaFold Q6SA80 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692072
Promoter ID:EPDNEW_R2597
Type:single initiation site
Name:Rnd3_1
Description:Rho family GTPase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0336,660,769 - 36,660,829EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359690 AgrOrtholog
BioCyc Gene G2FUF-49746 BioCyc
Ensembl Genes ENSRNOG00000004624 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006111 ENTREZGENE
  ENSRNOT00000006111.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  RhoE UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rho UniProtKB/Swiss-Prot
KEGG Report rno:295588 UniProtKB/Swiss-Prot
NCBI Gene 295588 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rnd3 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RHO UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004624 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZNJ1_RAT UniProtKB/TrEMBL
  B4F757 ENTREZGENE, UniProtKB/TrEMBL
  Q6SA80 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Rnd3  Rho family GTPase 3  Arhe  ras homolog gene family, member E  Symbol and Name updated 1299863 APPROVED
2005-07-29 Arhe  ras homolog gene family, member E      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction mouse homolog binds the amino-terminal region of the Rock1 protein in the kinase domain; does not compete with carboxy-terminal Rhoa binding 1559164