Aox2 (aldehyde oxidase 2) - Rat Genome Database

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Gene: Aox2 (aldehyde oxidase 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Aox2
Name: aldehyde oxidase 2
RGD ID: 1359668
Description: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and protein homodimerization activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol; PARTICIPATES IN monoterpenoid biosynthetic pathway; niacin metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH acetamide; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde oxidase 2 pseudogene; aldehyde oxidase 3-like 1; aldehyde oxidase homolog 3; Aox2p; Aox3l1; azaheterocycle hydroxylase 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,322,291 - 67,411,694 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,322,598 - 67,410,363 (+)EnsemblGRCr8
mRatBN7.2959,828,403 - 59,916,175 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl959,828,084 - 59,916,146 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,321,349 - 68,409,382 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,437,270 - 73,525,311 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0971,755,358 - 71,843,386 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd971,049,778 - 71,137,879 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive966,825,100 - 66,913,190 (+)NCBILyon_Normotensive
Lyon_Hypertensive966,961,159 - 67,049,248 (+)NCBILyon_Hypertensive
F344_StmMcwi968,876,342 - 68,964,431 (+)NCBIF344_StmMcwi
Rnor_6.0965,175,455 - 65,265,149 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,177,511 - 65,265,149 (+)Ensemblrn6Rnor6.0
Rnor_5.0964,973,842 - 65,072,447 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4956,948,950 - 57,038,897 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,271,035 - 57,358,789 (+)NCBICelera
RGSC_v3.1957,095,931 - 57,185,868 (+)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, etal., J Biol Chem 2004 Nov 26;279(48):50482-98. Epub 2004 Sep 20.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23263164  


Genomics

Variants

.
Variants in Aox2
589 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:149
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000048027
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
BF398906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,862,631 - 59,862,721 (+)MAPPERmRatBN7.2
Rnor_6.0965,211,645 - 65,211,734NCBIRnor6.0
Rnor_5.0965,019,072 - 65,019,161UniSTSRnor5.0
RGSC_v3.4956,983,723 - 56,983,812UniSTSRGSC3.4
Celera957,305,227 - 57,305,316UniSTS
RH 3.4 Map9482.6UniSTS
Cytogenetic Map9q31UniSTS
BQ211911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,890,877 - 59,891,047 (+)MAPPERmRatBN7.2
Rnor_6.0965,239,884 - 65,240,053NCBIRnor6.0
Rnor_5.0965,047,310 - 65,047,479UniSTSRnor5.0
RGSC_v3.4957,013,499 - 57,013,668UniSTSRGSC3.4
Celera957,333,530 - 57,333,699UniSTS
RH 3.4 Map9483.8UniSTS
Cytogenetic Map9q31UniSTS
BQ208531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2959,888,074 - 59,888,258 (+)MAPPERmRatBN7.2
Rnor_6.0965,237,081 - 65,237,264NCBIRnor6.0
Rnor_5.0965,044,507 - 65,044,690UniSTSRnor5.0
RGSC_v3.4957,010,696 - 57,010,879UniSTSRGSC3.4
Celera957,330,727 - 57,330,910UniSTS
RH 3.4 Map9483.3UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 22 118 91 88 59 21 59 6 231 75 9 95 73 84 29 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000048027   ⟹   ENSRNOP00000047535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,322,598 - 67,410,363 (+)Ensembl
mRatBN7.2 Ensembl959,828,084 - 59,916,146 (+)Ensembl
Rnor_6.0 Ensembl965,177,511 - 65,265,149 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095499   ⟹   ENSRNOP00000079851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,322,598 - 67,394,978 (+)Ensembl
mRatBN7.2 Ensembl959,828,084 - 59,900,790 (+)Ensembl
RefSeq Acc Id: NM_001008522   ⟹   NP_001008522
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,322,598 - 67,410,363 (+)NCBI
mRatBN7.2959,828,403 - 59,916,175 (+)NCBI
Dahl_SR_JrHsd971,049,778 - 71,137,879 (+)NCBI
Lyon_Normotensive966,825,100 - 66,913,190 (+)NCBI
Lyon_Hypertensive966,961,159 - 67,049,248 (+)NCBI
F344_StmMcwi968,876,342 - 68,964,431 (+)NCBI
Rnor_6.0965,177,511 - 65,265,149 (+)NCBI
Rnor_5.0964,973,842 - 65,072,447 (+)NCBI
RGSC_v3.4956,948,950 - 57,038,897 (+)RGD
Celera957,271,035 - 57,358,789 (+)RGD
Sequence:
RefSeq Acc Id: XM_063267188   ⟹   XP_063123258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,322,291 - 67,411,694 (+)NCBI
RefSeq Acc Id: XM_063267189   ⟹   XP_063123259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,322,291 - 67,358,850 (+)NCBI
RefSeq Acc Id: XM_063267190   ⟹   XP_063123260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,322,435 - 67,395,800 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001008522 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123258 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123259 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123260 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV68255 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047535
GenBank Protein Q5QE78 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008522   ⟸   NM_001008522
- UniProtKB: Q5QE78 (UniProtKB/Swiss-Prot),   D4A6S5 (UniProtKB/Swiss-Prot),   A0A096P6M6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047535   ⟸   ENSRNOT00000048027
Ensembl Acc Id: ENSRNOP00000079851   ⟸   ENSRNOT00000095499
RefSeq Acc Id: XP_063123258   ⟸   XM_063267188
- Peptide Label: isoform X1
- UniProtKB: Q5QE78 (UniProtKB/Swiss-Prot),   D4A6S5 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123259   ⟸   XM_063267189
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123260   ⟸   XM_063267190
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZNK8 (UniProtKB/TrEMBL)
Protein Domains
2Fe-2S ferredoxin-type   FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QE78-F1-model_v2 AlphaFold Q5QE78 1-1345 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359668 AgrOrtholog
BioCyc Gene G2FUF-27455 BioCyc
Ensembl Genes ENSRNOG00000033923 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000048027 ENTREZGENE
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot
  3.30.43.10 UniProtKB/Swiss-Prot
  3.30.465.10 UniProtKB/Swiss-Prot
  [2Fe-2S]-binding domain UniProtKB/Swiss-Prot
  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead UniProtKB/Swiss-Prot
  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain UniProtKB/Swiss-Prot
  CO dehydrogenase flavoprotein, C-terminal domain UniProtKB/Swiss-Prot
InterPro 2Fe-2S-bd UniProtKB/Swiss-Prot
  2Fe-2S-bd_dom_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  2Fe2S_fd_BS UniProtKB/Swiss-Prot
  Ald_Oxase/Xan_DH_a/b UniProtKB/Swiss-Prot
  Ald_Oxase/Xan_DH_a/b_sf UniProtKB/Swiss-Prot
  Ald_Oxase/xanthine_DH UniProtKB/Swiss-Prot
  Aldehyde_oxidase UniProtKB/Swiss-Prot
  AldOxase/xan_DH_MoCoBD2 UniProtKB/Swiss-Prot
  AldOxase/xan_DH_Mopterin-bd UniProtKB/Swiss-Prot
  AldOxase/xan_DH_Mopterin-bd_sf UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
  CO_DH_flav_C UniProtKB/Swiss-Prot
  CO_DH_flav_C_dom_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH UniProtKB/Swiss-Prot
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot
  Mopterin_DH_FAD-bd UniProtKB/Swiss-Prot
KEGG Report rno:316421 UniProtKB/Swiss-Prot
NCBI Gene 316421 ENTREZGENE
PANTHER XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot
  XANTHINE DEHYDROGENASE UniProtKB/Swiss-Prot
Pfam Ald_Xan_dh_C UniProtKB/Swiss-Prot
  Ald_Xan_dh_C2 UniProtKB/Swiss-Prot
  CO_deh_flav_C UniProtKB/Swiss-Prot
  FAD_binding_5 UniProtKB/Swiss-Prot
  Fer2 UniProtKB/Swiss-Prot
  Fer2_2 UniProtKB/Swiss-Prot
  MoCoBD_2 UniProtKB/Swiss-Prot
PhenoGen Aox2 PhenoGen
PIRSF Xanthine_DH UniProtKB/Swiss-Prot
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot
  2FE2S_FER_2 UniProtKB/Swiss-Prot
  FAD_PCMH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033923 RatGTEx
SMART Ald_Xan_dh_C UniProtKB/Swiss-Prot
  CO_deh_flav_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47741 UniProtKB/Swiss-Prot
  SSF54292 UniProtKB/Swiss-Prot
  SSF54665 UniProtKB/Swiss-Prot
  SSF55447 UniProtKB/Swiss-Prot
  SSF56003 UniProtKB/Swiss-Prot
  SSF56176 UniProtKB/Swiss-Prot
UniProt A0A096P6M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNK8 ENTREZGENE, UniProtKB/TrEMBL
  AOXB_RAT UniProtKB/Swiss-Prot
  D4A6S5 ENTREZGENE
  Q5QE78 ENTREZGENE
UniProt Secondary D4A6S5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-26 Aox2  aldehyde oxidase 2  Aox3l1  aldehyde oxidase 3-like 1  Name and Symbol changed 629549 APPROVED
2013-01-14 Aox2p  aldehyde oxidase 2 pseudogene  Aox3l1  aldehyde oxidase 3-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Aox3l1  aldehyde oxidase 3-like 1  Aox2  aldehyde oxidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Aox2  aldehyde oxidase 2      Symbol and Name status set to provisional 70820 PROVISIONAL