Dnajc28 (DnaJ heat shock protein family (Hsp40) member C28) - Rat Genome Database

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Gene: Dnajc28 (DnaJ heat shock protein family (Hsp40) member C28) Rattus norvegicus
Analyze
Symbol: Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
RGD ID: 1359589
Description: Orthologous to human DNAJC28 (DnaJ heat shock protein family (Hsp40) member C28); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DnaJ (Hsp40) homolog, subfamily C, member 28; dnaJ homolog subfamily C member 28; LOC360699; similar to J domain protein C21orf55
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,341,528 - 44,344,348 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1144,338,646 - 44,344,482 (-)EnsemblGRCr8
mRatBN7.21130,855,566 - 30,858,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,853,526 - 30,858,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1139,549,461 - 39,552,283 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,220,897 - 32,223,719 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,386,144 - 31,388,964 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,770,164 - 31,772,984 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,770,165 - 31,772,984 (-)Ensemblrn6Rnor6.0
Rnor_5.01135,378,903 - 35,381,723 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41131,584,546 - 31,587,366 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1130,522,999 - 30,525,819 (-)NCBICelera
RGSC_v3.11131,623,609 - 31,626,429 (-)NCBI
Cytogenetic Map11q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Dnajc28
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,341,528 - 44,344,348 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1144,338,646 - 44,344,482 (-)EnsemblGRCr8
mRatBN7.21130,855,566 - 30,858,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,853,526 - 30,858,441 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1139,549,461 - 39,552,283 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,220,897 - 32,223,719 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,386,144 - 31,388,964 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,770,164 - 31,772,984 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,770,165 - 31,772,984 (-)Ensemblrn6Rnor6.0
Rnor_5.01135,378,903 - 35,381,723 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41131,584,546 - 31,587,366 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1130,522,999 - 30,525,819 (-)NCBICelera
RGSC_v3.11131,623,609 - 31,626,429 (-)NCBI
Cytogenetic Map11q11NCBI
DNAJC28
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382133,488,055 - 33,491,716 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2133,486,096 - 33,491,749 (-)Ensemblhg38GRCh38
GRCh372134,860,362 - 34,864,023 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,782,108 - 33,785,893 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342133,779,706 - 33,785,650NCBI
Celera2120,059,872 - 20,063,657 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,338,558 - 20,342,237 (-)NCBIHuRef
CHM1_12134,422,926 - 34,426,712 (-)NCBICHM1_1
T2T-CHM13v2.02131,869,887 - 31,873,548 (-)NCBIT2T-CHM13v2.0
Dnajc28
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,411,142 - 91,415,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,411,142 - 91,415,914 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381691,614,257 - 91,618,999 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,614,254 - 91,619,026 (-)Ensemblmm10GRCm38
MGSCv371691,614,502 - 91,619,244 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361691,504,585 - 91,507,852 (-)NCBIMGSCv36mm8
Celera1692,691,065 - 92,695,807 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1653.17NCBI
Dnajc28
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540732,928,663 - 32,929,814 (-)Ensembl
ChiLan1.0NW_00495540732,928,655 - 32,931,331 (-)NCBIChiLan1.0ChiLan1.0
DNAJC28
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22229,600,313 - 29,610,429 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12124,459,721 - 24,472,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02119,855,277 - 19,859,734 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12133,228,657 - 33,232,587 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,228,694 - 33,229,860 (-)EnsemblpanPan2panpan1.1
DNAJC28
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13128,113,339 - 28,117,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,101,274 - 28,115,460 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03128,308,485 - 28,322,743 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,318,372 - 28,322,491 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,185,232 - 28,189,613 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,189,061 - 28,203,254 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,689,189 - 28,703,416 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnajc28
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,664,722 - 28,668,968 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,800,298 - 8,801,458 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365008,798,884 - 8,802,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJC28
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,108,383 - 197,114,455 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113197,104,842 - 197,114,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213206,920,530 - 206,924,916 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJC28
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,690,499 - 58,695,302 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,693,679 - 58,694,848 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660711,192,277 - 1,196,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajc28
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,717,745 - 21,718,902 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474521,715,732 - 21,720,373 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnajc28
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1452,983,330 - 52,986,179 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnajc28
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:28
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000002771
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 76 59 6 339 176 11 140 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002771   ⟹   ENSRNOP00000002771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,853,743 - 30,858,417 (-)Ensembl
Rnor_6.0 Ensembl1131,770,165 - 31,772,984 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118466   ⟹   ENSRNOP00000089995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,853,526 - 30,858,441 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124209   ⟹   ENSRNOP00000100121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,338,646 - 44,344,482 (-)Ensembl
RefSeq Acc Id: NM_001014124   ⟹   NP_001014146
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,341,528 - 44,344,348 (-)NCBI
mRatBN7.21130,855,566 - 30,858,386 (-)NCBI
Rnor_6.01131,770,164 - 31,772,984 (-)NCBI
Rnor_5.01135,378,903 - 35,381,723 (-)NCBI
RGSC_v3.41131,584,546 - 31,587,366 (-)RGD
Celera1130,522,999 - 30,525,819 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014146 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79055 (Get FASTA)   NCBI Sequence Viewer  
  EDM10732 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000100121
  ENSRNOP00000100121.1
RefSeq Acc Id: NP_001014146   ⟸   NM_001014124
- UniProtKB: Q6AYG2 (UniProtKB/TrEMBL),   A0A8I6ACY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002771   ⟸   ENSRNOT00000002771
Ensembl Acc Id: ENSRNOP00000089995   ⟸   ENSRNOT00000118466
Ensembl Acc Id: ENSRNOP00000100121   ⟸   ENSRNOT00000124209
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYG2-F1-model_v2 AlphaFold Q6AYG2 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698058
Promoter ID:EPDNEW_R8583
Type:single initiation site
Name:Dnajc28_1
Description:DnaJ heat shock protein family member C28
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01131,773,012 - 31,773,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359589 AgrOrtholog
BioCyc Gene G2FUF-21878 BioCyc
Ensembl Genes ENSRNOG00000002026 Ensembl
  ENSRNOG00000079381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000124209 ENTREZGENE
  ENSRNOT00000124209.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115421 IMAGE-MGC_LOAD
InterPro DnaJ_C_subfamily_28 UniProtKB/TrEMBL
  DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_homolog_subfam-C_membr-28 UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
KEGG Report rno:360699 UniProtKB/TrEMBL
MGC_CLONE MGC:93998 IMAGE-MGC_LOAD
NCBI Gene 360699 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY C MEMBER 28 UniProtKB/TrEMBL
  OS08G0560600 PROTEIN UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/TrEMBL
  DUF1992 UniProtKB/TrEMBL
PhenoGen Dnajc28 PhenoGen
PROSITE DNAJ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002026 RatGTEx
  ENSRNOG00000079381 RatGTEx
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP DnaJ_N UniProtKB/TrEMBL
UniProt A0A8I6ACY5 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYG2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajc28  DnaJ heat shock protein family (Hsp40) member C28  Dnajc28  DnaJ (Hsp40) homolog, subfamily C, member 28  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-17 Dnajc28  DnaJ (Hsp40) homolog, subfamily C, member 28  LOC360699  similar to J domain protein C21orf55  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC360699  similar to J domain protein C21orf55      Symbol and Name status set to provisional 70820 PROVISIONAL