Prss23 (serine protease 23) - Rat Genome Database

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Gene: Prss23 (serine protease 23) Rattus norvegicus
Analyze
Symbol: Prss23
Name: serine protease 23
RGD ID: 1359545
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS23 (serine protease 23); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-dichloroaniline.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94216; protease, serine, 23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,815,301 - 152,835,005 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1152,813,670 - 152,947,871 (-)EnsemblGRCr8
mRatBN7.21143,402,725 - 143,422,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,401,396 - 143,422,091 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1151,348,875 - 151,357,260 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,525,264 - 158,533,649 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,399,177 - 151,407,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,732,528 - 153,742,111 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,732,532 - 153,752,541 (-)Ensemblrn6Rnor6.0
Rnor_5.01160,037,248 - 160,056,629 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41146,081,552 - 146,089,928 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1141,654,333 - 141,662,709 (-)NCBICelera
RGSC_v3.11146,159,962 - 146,168,334 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daidzein  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine betaine  (EXP)
hexestrol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component
extracellular region  (IEA)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. null JRS Domain-based curation
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19199708   PMID:23376485   PMID:24006456  


Genomics

Comparative Map Data
Prss23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81152,815,301 - 152,835,005 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1152,813,670 - 152,947,871 (-)EnsemblGRCr8
mRatBN7.21143,402,725 - 143,422,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,401,396 - 143,422,091 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1151,348,875 - 151,357,260 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01158,525,264 - 158,533,649 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01151,399,177 - 151,407,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01153,732,528 - 153,742,111 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,732,532 - 153,752,541 (-)Ensemblrn6Rnor6.0
Rnor_5.01160,037,248 - 160,056,629 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41146,081,552 - 146,089,928 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1141,654,333 - 141,662,709 (-)NCBICelera
RGSC_v3.11146,159,962 - 146,168,334 (-)NCBI
Cytogenetic Map1q32NCBI
PRSS23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,791,071 - 86,952,910 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,791,059 - 86,952,910 (+)Ensemblhg38GRCh38
GRCh371186,502,113 - 86,663,952 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361186,189,139 - 86,199,923 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341186,189,210 - 86,199,919NCBI
Celera1183,822,885 - 83,833,669 (+)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,800,718 - 82,811,496 (+)NCBIHuRef
CHM1_11186,397,209 - 86,407,989 (+)NCBICHM1_1
T2T-CHM13v2.01186,731,821 - 86,893,752 (+)NCBIT2T-CHM13v2.0
Prss23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,156,988 - 89,176,399 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,156,991 - 89,176,395 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38789,507,783 - 89,527,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,507,783 - 89,527,187 (-)Ensemblmm10GRCm38
MGSCv37796,656,295 - 96,666,096 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36789,382,977 - 89,392,744 (-)NCBIMGSCv36mm8
Celera786,863,519 - 86,873,318 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.9NCBI
Prss23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,202,383 - 6,213,521 (-)Ensembl
ChiLan1.0NW_0049554146,202,383 - 6,213,521 (-)NCBIChiLan1.0ChiLan1.0
PRSS23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2987,722,921 - 87,731,607 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11188,646,843 - 88,782,831 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,855,594 - 81,866,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,454,400 - 85,474,188 (+)NCBIPanPan1.1PanPan1.1panPan2
PRSS23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,792,212 - 12,813,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,793,373 - 12,803,136 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2112,658,486 - 12,678,952 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02112,975,225 - 12,995,800 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2112,975,421 - 12,986,206 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,761,501 - 12,771,319 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,834,999 - 12,853,659 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,889,347 - 12,900,934 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prss23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,961,118 - 72,963,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,560,765 - 14,561,913 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649814,560,730 - 14,563,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,603,733 - 20,625,139 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1920,603,676 - 20,623,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,893,335 - 22,913,017 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1178,058,332 - 78,067,030 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl178,065,492 - 78,066,643 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604347,654,998 - 47,665,912 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,167,528 - 3,175,781 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248453,164,746 - 3,176,328 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prss23
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12111,627,667 - 111,636,164 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prss23
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:56
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000023239
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
RH128535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,402,865 - 143,403,052 (+)MAPPERmRatBN7.2
Rnor_6.01153,732,670 - 153,732,856NCBIRnor6.0
Rnor_5.01160,037,390 - 160,037,576UniSTSRnor5.0
RGSC_v3.41146,081,693 - 146,081,879UniSTSRGSC3.4
Celera1141,654,474 - 141,654,660UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 38 59 6 302 138 11 136 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023239   ⟹   ENSRNOP00000023239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,814,917 - 152,947,181 (-)Ensembl
mRatBN7.2 Ensembl1143,402,725 - 143,422,091 (-)Ensembl
Rnor_6.0 Ensembl1153,732,534 - 153,740,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080927   ⟹   ENSRNOP00000068962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,814,917 - 152,824,883 (-)Ensembl
mRatBN7.2 Ensembl1143,402,712 - 143,411,626 (-)Ensembl
Rnor_6.0 Ensembl1153,732,532 - 153,752,541 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095166   ⟹   ENSRNOP00000084133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,813,670 - 152,823,801 (-)Ensembl
mRatBN7.2 Ensembl1143,401,396 - 143,411,169 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115268   ⟹   ENSRNOP00000089563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,815,337 - 152,947,143 (-)Ensembl
mRatBN7.2 Ensembl1143,402,734 - 143,421,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131130   ⟹   ENSRNOP00000112068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,814,697 - 152,947,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136799   ⟹   ENSRNOP00000110906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1152,814,663 - 152,824,782 (-)Ensembl
RefSeq Acc Id: NM_001007691   ⟹   NP_001007692
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,823,677 (-)NCBI
mRatBN7.21143,402,725 - 143,411,101 (-)NCBI
Rnor_6.01153,732,529 - 153,740,905 (-)NCBI
Rnor_5.01160,037,248 - 160,056,629 (-)NCBI
RGSC_v3.41146,081,552 - 146,089,928 (-)RGD
Celera1141,654,333 - 141,662,709 (-)RGD
Sequence:
RefSeq Acc Id: XM_017589170   ⟹   XP_017444659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,834,890 (-)NCBI
mRatBN7.21143,402,725 - 143,422,182 (-)NCBI
Rnor_6.01153,732,528 - 153,742,111 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039113084   ⟹   XP_038969012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,833,702 (-)NCBI
mRatBN7.21143,402,725 - 143,420,550 (-)NCBI
RefSeq Acc Id: XM_039113085   ⟹   XP_038969013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,834,749 (-)NCBI
mRatBN7.21143,402,725 - 143,422,177 (-)NCBI
RefSeq Acc Id: XM_039113089   ⟹   XP_038969017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,833,702 (-)NCBI
mRatBN7.21143,402,725 - 143,420,550 (-)NCBI
RefSeq Acc Id: XM_039113092   ⟹   XP_038969020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,823,756 (-)NCBI
mRatBN7.21143,402,725 - 143,411,174 (-)NCBI
RefSeq Acc Id: XM_063262736   ⟹   XP_063118806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81152,815,301 - 152,835,005 (-)NCBI
RefSeq Acc Id: NP_001007692   ⟸   NM_001007691
- Peptide Label: precursor
- UniProtKB: Q6AY61 (UniProtKB/Swiss-Prot),   A6I603 (UniProtKB/TrEMBL),   A0A8I6ALA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444659   ⟸   XM_017589170
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCB8 (UniProtKB/TrEMBL),   A0A8I6ALA9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068962   ⟸   ENSRNOT00000080927
Ensembl Acc Id: ENSRNOP00000023239   ⟸   ENSRNOT00000023239
RefSeq Acc Id: XP_038969013   ⟸   XM_039113085
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969017   ⟸   XM_039113089
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969012   ⟸   XM_039113084
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCB8 (UniProtKB/TrEMBL),   A0A8I6ALA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038969020   ⟸   XM_039113092
- Peptide Label: isoform X3
- UniProtKB: Q6AY61 (UniProtKB/Swiss-Prot),   A6I603 (UniProtKB/TrEMBL),   A0A8I6ALA9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084133   ⟸   ENSRNOT00000095166
Ensembl Acc Id: ENSRNOP00000089563   ⟸   ENSRNOT00000115268
RefSeq Acc Id: XP_063118806   ⟸   XM_063262736
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QCB8 (UniProtKB/TrEMBL),   A0A8I6ALA9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110906   ⟸   ENSRNOT00000136799
Ensembl Acc Id: ENSRNOP00000112068   ⟸   ENSRNOT00000131130
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY61-F1-model_v2 AlphaFold Q6AY61 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690181
Promoter ID:EPDNEW_R706
Type:initiation region
Name:Prss23_1
Description:protease, serine, 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01153,740,939 - 153,740,999EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359545 AgrOrtholog
BioCyc Gene G2FUF-58566 BioCyc
Ensembl Genes ENSRNOG00000017307 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023239 ENTREZGENE
  ENSRNOT00000095166 ENTREZGENE
  ENSRNOT00000095166.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115268 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130532 IMAGE-MGC_LOAD
InterPro Glutamyl_endopeptidase UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
KEGG Report rno:308807 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94216 IMAGE-MGC_LOAD
NCBI Gene 308807 ENTREZGENE
PANTHER SERINE PROTEASE UniProtKB/Swiss-Prot
  SERINE PROTEASE 23 UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss23 PhenoGen
PROSITE TRYPSIN_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017307 RatGTEx
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A0G2JU46_RAT UniProtKB/TrEMBL
  A0A8I6ALA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCB8 ENTREZGENE
  A6I603 ENTREZGENE, UniProtKB/TrEMBL
  PRS23_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss23  serine protease 23  Prss23  protease, serine, 23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Prss23  protease, serine, 23      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Prss23  protease, serine, 23      Symbol and Name status set to provisional 70820 PROVISIONAL