Sdhc (succinate dehydrogenase complex subunit C) - Rat Genome Database

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Gene: Sdhc (succinate dehydrogenase complex subunit C) Rattus norvegicus
Analyze
Symbol: Sdhc
Name: succinate dehydrogenase complex subunit C
RGD ID: 1359454
Description: Predicted to enable heme binding activity and protein-membrane adaptor activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C); PARTICIPATES IN citric acid cycle pathway; electron transport chain pathway; fumaric aciduria pathway; INTERACTS WITH 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil; amiodarone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC95158; succinate dehydrogenase complex, subunit C; succinate dehydrogenase complex, subunit C, integral membrane protein; succinate dehydrogenase cytochrome b560 subunit, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,077,133 - 86,098,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,077,134 - 86,098,044 (-)EnsemblGRCr8
mRatBN7.21383,544,652 - 83,565,560 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,544,652 - 83,566,253 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,050,394 - 86,071,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,448,631 - 87,469,514 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,680,351 - 84,701,243 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,498,047 - 89,518,979 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,498,048 - 89,518,939 (-)Ensemblrn6Rnor6.0
Rnor_5.01394,125,548 - 94,146,440 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,014,569 - 87,035,239 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,176,204 - 83,197,047 (-)NCBICelera
RGSC_v3.11387,203,453 - 87,224,123 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chlorobiphenyl  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
doxorubicin  (ISO)
eugenol  (EXP)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
indometacin  (EXP)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
mancozeb  (ISO)
melittin  (ISO)
methidathion  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Succinate dehydrogenase deficiency in human. Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
5. Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23. Hirawake H, etal., Cytogenet Cell Genet 1997;79(1-2):132-8.
6. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Ishii T, etal., Cancer Res 2005 Jan 1;65(1):203-9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Niemann S and Muller U, Nat Genet. 2000 Nov;26(3):268-70.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A and Fernandez-Vizarra E, Essays Biochem. 2018 Jul 20;62(3):255-270. doi: 10.1042/EBC20170098. Print 2018 Jul 20.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:14651853   PMID:15989954   PMID:16120479   PMID:17480203   PMID:18614015   PMID:19808025  


Genomics

Comparative Map Data
Sdhc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,077,133 - 86,098,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1386,077,134 - 86,098,044 (-)EnsemblGRCr8
mRatBN7.21383,544,652 - 83,565,560 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,544,652 - 83,566,253 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1386,050,394 - 86,071,277 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,448,631 - 87,469,514 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,680,351 - 84,701,243 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,498,047 - 89,518,979 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,498,048 - 89,518,939 (-)Ensemblrn6Rnor6.0
Rnor_5.01394,125,548 - 94,146,440 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41387,014,569 - 87,035,239 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1383,176,204 - 83,197,047 (-)NCBICelera
RGSC_v3.11387,203,453 - 87,224,123 (-)NCBI
Cytogenetic Map13q24NCBI
SDHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,314,381 - 161,363,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,314,381 - 161,363,206 (+)Ensemblhg38GRCh38
GRCh371161,284,171 - 161,332,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,550,790 - 159,601,165 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341158,097,242 - 158,146,049NCBI
Celera1134,351,304 - 134,401,671 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,641,002 - 132,691,319 (+)NCBIHuRef
CHM1_11162,680,387 - 162,730,796 (+)NCBICHM1_1
T2T-CHM13v2.01160,451,814 - 160,500,650 (+)NCBIT2T-CHM13v2.0
Sdhc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,956,726 - 170,978,209 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,954,734 - 170,978,172 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381171,129,157 - 171,150,640 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,127,165 - 171,150,603 (-)Ensemblmm10GRCm38
MGSCv371173,059,288 - 173,080,734 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361172,965,840 - 172,987,277 (-)NCBIMGSCv36mm8
Celera1173,578,731 - 173,598,849 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.99NCBI
Sdhc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546813,049,848 - 13,083,156 (+)Ensembl
ChiLan1.0NW_00495546813,050,359 - 13,083,932 (+)NCBIChiLan1.0ChiLan1.0
SDHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,491,404 - 88,542,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,181,669 - 88,232,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,724,663 - 136,773,038 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,635,250 - 140,683,390 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,635,685 - 140,682,736 (+)EnsemblpanPan2panpan1.1
SDHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,162,850 - 21,200,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,162,421 - 21,200,333 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3821,237,330 - 21,275,269 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03821,280,197 - 21,318,198 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,275,939 - 21,318,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,177,285 - 21,215,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,583,510 - 21,621,477 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,991,569 - 22,029,750 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sdhc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,383,971 - 7,428,187 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903601,355 - 636,092 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936903592,641 - 636,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,130,379 - 89,169,118 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1489,135,410 - 89,169,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,992,639 - 97,026,545 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SDHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,613,618 - 2,658,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,670,467 - 1,715,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479454,143 - 98,292 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479455,907 - 97,991 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sdhc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11050,290,245 - 50,311,185 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sdhc
188 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:80
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000004228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
AA900320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21383,544,834 - 83,545,029 (+)MAPPERmRatBN7.2
Rnor_6.01389,498,230 - 89,498,424NCBIRnor6.0
Rnor_5.01394,125,731 - 94,125,925UniSTSRnor5.0
RGSC_v3.41387,014,752 - 87,014,946UniSTSRGSC3.4
Celera1383,176,387 - 83,176,581UniSTS
RH 3.4 Map13567.6UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004228   ⟹   ENSRNOP00000004228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,077,134 - 86,098,044 (-)Ensembl
mRatBN7.2 Ensembl1383,544,652 - 83,566,253 (-)Ensembl
Rnor_6.0 Ensembl1389,498,048 - 89,518,939 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110173   ⟹   ENSRNOP00000083218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,077,134 - 86,098,044 (-)Ensembl
mRatBN7.2 Ensembl1383,544,652 - 83,566,253 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117201   ⟹   ENSRNOP00000077353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1386,077,134 - 86,093,608 (-)Ensembl
mRatBN7.2 Ensembl1383,544,655 - 83,561,127 (-)Ensembl
RefSeq Acc Id: NM_001005534   ⟹   NP_001005534
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,077,133 - 86,098,025 (-)NCBI
mRatBN7.21383,544,652 - 83,565,546 (-)NCBI
Rnor_6.01389,498,047 - 89,518,939 (-)NCBI
Rnor_5.01394,125,548 - 94,146,440 (-)NCBI
RGSC_v3.41387,014,569 - 87,035,239 (-)RGD
Celera1383,176,204 - 83,197,047 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272122   ⟹   XP_063128192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,077,133 - 86,095,138 (-)NCBI
RefSeq Acc Id: NP_001005534   ⟸   NM_001005534
- UniProtKB: Q641Z9 (UniProtKB/TrEMBL),   F7FI92 (UniProtKB/TrEMBL),   A0A8I5Y7P2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004228   ⟸   ENSRNOT00000004228
Ensembl Acc Id: ENSRNOP00000083218   ⟸   ENSRNOT00000110173
Ensembl Acc Id: ENSRNOP00000077353   ⟸   ENSRNOT00000117201
RefSeq Acc Id: XP_063128192   ⟸   XM_063272122
- Peptide Label: isoform X1
- UniProtKB: A6JFU1 (UniProtKB/TrEMBL),   A6JFT8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641Z9-F1-model_v2 AlphaFold Q641Z9 1-169 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698994
Promoter ID:EPDNEW_R9518
Type:multiple initiation site
Name:Sdhc_1
Description:succinate dehydrogenase complex subunit C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,518,958 - 89,519,018EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359454 AgrOrtholog
BioCyc Gene G2FUF-17388 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-5690 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000003163 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004228 ENTREZGENE
  ENSRNOT00000004228.7 UniProtKB/TrEMBL
  ENSRNOT00000110173.2 UniProtKB/TrEMBL
  ENSRNOT00000117201.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1300.10 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130052 IMAGE-MGC_LOAD
InterPro SQR/QFR_C/D UniProtKB/TrEMBL
  Succ_DH_cyt_bsu_CS UniProtKB/TrEMBL
  Succ_DH_cytb556 UniProtKB/TrEMBL
  Succ_DH_Fumarate_Rdtase_TM-su UniProtKB/TrEMBL
KEGG Report rno:289217 UniProtKB/TrEMBL
MGC_CLONE MGC:95158 IMAGE-MGC_LOAD
NCBI Gene 289217 ENTREZGENE
PANTHER PTHR10978 UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Sdh_cyt UniProtKB/TrEMBL
PhenoGen Sdhc PhenoGen
PIRSF SDH_cyt_b560 UniProtKB/TrEMBL
PROSITE SDH_CYT_1 UniProtKB/TrEMBL
  SDH_CYT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003163 RatGTEx
Superfamily-SCOP SSF81343 UniProtKB/TrEMBL
UniProt A0A8I5Y7P2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYU8_RAT UniProtKB/TrEMBL
  A6JFT8 ENTREZGENE, UniProtKB/TrEMBL
  A6JFT9_RAT UniProtKB/TrEMBL
  A6JFU1 ENTREZGENE, UniProtKB/TrEMBL
  F7FI92 ENTREZGENE, UniProtKB/TrEMBL
  Q641Z9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Sdhc  succinate dehydrogenase complex subunit C  Sdhc  succinate dehydrogenase complex, subunit C, integral membrane protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Sdhc  succinate dehydrogenase complex, subunit C, integral membrane protein    succinate dehydrogenase complex, subunit C  Name updated 1299863 APPROVED
2005-07-29 Sdhc  succinate dehydrogenase complex, subunit C      Symbol and Name status set to provisional 70820 PROVISIONAL