Galc (galactosylceramidase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Galc (galactosylceramidase) Rattus norvegicus
Analyze
Symbol: Galc
Name: galactosylceramidase
RGD ID: 1359384
Description: Predicted to enable galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within myelination. Predicted to be located in membrane. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; cadmium atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: galactocerebrosidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,182,636 - 123,252,024 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6123,182,643 - 123,245,578 (-)EnsemblGRCr8
mRatBN7.26117,452,888 - 117,522,281 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,452,895 - 117,515,830 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6117,607,772 - 117,669,061 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06117,904,558 - 117,965,859 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,239,449 - 117,300,736 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,177,195 - 122,239,411 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,178,602 - 122,239,614 (-)Ensemblrn6Rnor6.0
Rnor_5.06131,392,298 - 131,454,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46122,355,659 - 122,416,986 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,018,409 - 115,078,607 (-)NCBICelera
RGSC_v3.16122,359,405 - 122,420,733 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosome  (IBA,IEA)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease. Andres Benito P, etal., Prion. 2018;12(3-4):216-225. doi: 10.1080/19336896.2018.1500076. Epub 2018 Jul 27.
2. Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome. Ang CW, etal., J Neuroimmunol. 2002 Sep;130(1-2):179-83. doi: 10.1016/s0165-5728(02)00209-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study. Meyer Sauteur PM, etal., Ann Neurol. 2016 Oct;80(4):566-80. doi: 10.1002/ana.24755. Epub 2016 Aug 26.
5. Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae. Meyer Sauteur PM, etal., Infect Immun. 2019 Jan 24;87(2). pii: IAI.00663-18. doi: 10.1128/IAI.00663-18. Print 2019 Feb.
6. Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae. Meyer Sauteur PM, etal., J Neuroimmunol. 2018 Jan 15;314:13-16. doi: 10.1016/j.jneuroim.2017.11.011. Epub 2017 Nov 16.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. Sakai N, etal., J Neurochem 1996 Mar;66(3):1118-24.
15. Saposins (sphingolipid activator proteins) in the twitcher mutant mouse. Shigematsu H, etal., J Neurochem. 1990 Nov;55(5):1659-62. doi: 10.1111/j.1471-4159.1990.tb04953.x.
Additional References at PubMed
PMID:11371512   PMID:11734583   PMID:18614015   PMID:23376485  


Genomics

Comparative Map Data
Galc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86123,182,636 - 123,252,024 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6123,182,643 - 123,245,578 (-)EnsemblGRCr8
mRatBN7.26117,452,888 - 117,522,281 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6117,452,895 - 117,515,830 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6117,607,772 - 117,669,061 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06117,904,558 - 117,965,859 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06117,239,449 - 117,300,736 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06122,177,195 - 122,239,411 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6122,178,602 - 122,239,614 (-)Ensemblrn6Rnor6.0
Rnor_5.06131,392,298 - 131,454,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46122,355,659 - 122,416,986 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6115,018,409 - 115,078,607 (-)NCBICelera
RGSC_v3.16122,359,405 - 122,420,733 (-)NCBI
Cytogenetic Map6q32NCBI
GALC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381487,933,014 - 87,993,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1487,837,820 - 87,993,665 (-)Ensemblhg38GRCh38
GRCh371488,399,358 - 88,460,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361487,469,111 - 87,529,660 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341487,469,112 - 87,529,596NCBI
Celera1468,445,026 - 68,505,593 (-)NCBICelera
Cytogenetic Map14q31.3NCBI
HuRef1468,569,486 - 68,630,135 (-)NCBIHuRef
CHM1_11488,337,479 - 88,398,139 (-)NCBICHM1_1
T2T-CHM13v2.01482,153,629 - 82,214,299 (-)NCBIT2T-CHM13v2.0
Galc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391298,168,543 - 98,226,565 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1298,168,553 - 98,225,718 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381298,202,287 - 98,259,459 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1298,202,294 - 98,259,459 (-)Ensemblmm10GRCm38
MGSCv371299,440,510 - 99,497,547 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361298,603,350 - 98,660,387 (-)NCBIMGSCv36mm8
Celera1299,428,771 - 99,484,984 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1249.83NCBI
Galc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543810,667,807 - 10,704,384 (-)Ensembl
ChiLan1.0NW_00495543810,667,807 - 10,704,386 (-)NCBIChiLan1.0ChiLan1.0
GALC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21589,071,492 - 89,132,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11488,287,998 - 88,349,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01468,545,070 - 68,605,730 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11487,905,098 - 87,965,769 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1487,905,098 - 87,965,770 (-)EnsemblpanPan2panpan1.1
GALC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1859,266,693 - 59,324,825 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl859,267,818 - 59,324,967 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha858,846,151 - 58,903,131 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0859,531,522 - 59,589,663 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl859,531,533 - 59,589,716 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1859,214,260 - 59,271,257 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0859,260,650 - 59,317,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0859,594,667 - 59,651,690 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Galc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864016,532,259 - 16,624,784 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648815,444,801 - 15,518,856 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648815,444,184 - 15,519,395 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GALC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7109,894,578 - 109,961,413 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17109,894,576 - 109,961,407 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27116,348,927 - 116,415,759 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GALC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12465,556,763 - 65,621,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2465,558,074 - 65,621,258 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605352,874,548 - 52,988,107 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Galc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473414,355,435 - 14,407,087 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473414,355,349 - 14,462,869 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Galc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17111,371,949 - 111,428,439 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Galc
687 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:468
Count of miRNA genes:241
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000005015
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH143148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26117,453,887 - 117,454,020 (+)MAPPERmRatBN7.2
Rnor_6.06122,178,195 - 122,178,327NCBIRnor6.0
Rnor_5.06131,393,298 - 131,393,430UniSTSRnor5.0
RGSC_v3.46122,355,058 - 122,355,190UniSTSRGSC3.4
Celera6115,017,808 - 115,017,940UniSTS
RH 3.4 Map6862.9UniSTS
Cytogenetic Map6q32UniSTS
RH134876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26117,452,963 - 117,453,164 (+)MAPPERmRatBN7.2
Rnor_6.06122,177,271 - 122,177,471NCBIRnor6.0
Rnor_5.06131,392,374 - 131,392,574UniSTSRnor5.0
RGSC_v3.46122,354,134 - 122,354,334UniSTSRGSC3.4
Celera6115,016,884 - 115,017,084UniSTS
RH 3.4 Map6862.9UniSTS
Cytogenetic Map6q32UniSTS
SHGC-152427  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26117,503,386 - 117,504,182 (+)MAPPERmRatBN7.2
Rnor_6.06125,303,851 - 125,304,646NCBIRnor6.0
Rnor_6.06122,227,137 - 122,227,932NCBIRnor6.0
Rnor_5.06131,442,240 - 131,443,035UniSTSRnor5.0
Rnor_5.06134,520,741 - 134,521,536UniSTSRnor5.0
RGSC_v3.46122,404,562 - 122,405,357UniSTSRGSC3.4
Celera6115,066,177 - 115,066,972UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY386370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005015   ⟹   ENSRNOP00000005015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,182,643 - 123,245,578 (-)Ensembl
mRatBN7.2 Ensembl6117,452,895 - 117,515,830 (-)Ensembl
Rnor_6.0 Ensembl6122,178,602 - 122,239,614 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094269   ⟹   ENSRNOP00000094632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,182,643 - 123,245,578 (-)Ensembl
mRatBN7.2 Ensembl6117,452,895 - 117,515,830 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138952   ⟹   ENSRNOP00000102789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6123,182,643 - 123,236,310 (-)Ensembl
RefSeq Acc Id: NM_001005888   ⟹   NP_001005888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,184,237 - 123,245,559 (-)NCBI
mRatBN7.26117,454,489 - 117,515,811 (-)NCBI
Rnor_6.06122,178,796 - 122,239,411 (-)NCBI
Rnor_5.06131,392,298 - 131,454,514 (-)NCBI
RGSC_v3.46122,355,659 - 122,416,986 (-)RGD
Celera6115,018,409 - 115,078,607 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594164   ⟹   XP_017449653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,244,380 (-)NCBI
mRatBN7.26117,452,888 - 117,515,558 (-)NCBI
Rnor_6.06122,177,195 - 122,238,228 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112331   ⟹   XP_038968259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,252,023 (-)NCBI
mRatBN7.26117,452,888 - 117,522,281 (-)NCBI
RefSeq Acc Id: XM_063261956   ⟹   XP_063118026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,245,564 (-)NCBI
RefSeq Acc Id: XM_063261957   ⟹   XP_063118027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,236,834 (-)NCBI
RefSeq Acc Id: XM_063261958   ⟹   XP_063118028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,244,380 (-)NCBI
RefSeq Acc Id: XM_063261959   ⟹   XP_063118029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,252,024 (-)NCBI
RefSeq Acc Id: XM_063261960   ⟹   XP_063118030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,243,313 (-)NCBI
RefSeq Acc Id: XM_063261961   ⟹   XP_063118031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,243,942 (-)NCBI
RefSeq Acc Id: XM_063261962   ⟹   XP_063118032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,237,186 (-)NCBI
RefSeq Acc Id: XM_063261963   ⟹   XP_063118033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,251,983 (-)NCBI
RefSeq Acc Id: XM_063261964   ⟹   XP_063118034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,244,380 (-)NCBI
RefSeq Acc Id: XM_063261965   ⟹   XP_063118035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,182,636 - 123,235,263 (-)NCBI
RefSeq Acc Id: XR_010052097
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86123,198,350 - 123,245,564 (-)NCBI
RefSeq Acc Id: NP_001005888   ⟸   NM_001005888
- Peptide Label: precursor
- UniProtKB: A0A0G2QC23 (UniProtKB/TrEMBL),   A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449653   ⟸   XM_017594164
- Peptide Label: isoform X4
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005015   ⟸   ENSRNOT00000005015
RefSeq Acc Id: XP_038968259   ⟸   XM_039112331
- Peptide Label: isoform X4
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094632   ⟸   ENSRNOT00000094269
RefSeq Acc Id: XP_063118029   ⟸   XM_063261959
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118033   ⟸   XM_063261963
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118026   ⟸   XM_063261956
- Peptide Label: isoform X1
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118034   ⟸   XM_063261964
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118028   ⟸   XM_063261958
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118031   ⟸   XM_063261961
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118030   ⟸   XM_063261960
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118032   ⟸   XM_063261962
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118027   ⟸   XM_063261957
- Peptide Label: isoform X2
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118035   ⟸   XM_063261965
- Peptide Label: isoform X3
- UniProtKB: A6JEE0 (UniProtKB/TrEMBL),   G3V6H1 (UniProtKB/TrEMBL),   Q5YKG1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102789   ⟸   ENSRNOT00000138952
Protein Domains
Glycosyl hydrolase family 59 C-terminal lectin   Glycosyl hydrolase family 59 catalytic   Glycosyl hydrolase family 59 central

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6H1-F1-model_v2 AlphaFold G3V6H1 1-684 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359384 AgrOrtholog
BioCyc Gene G2FUF-36543 BioCyc
Ensembl Genes ENSRNOG00000003759 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005015 ENTREZGENE
  ENSRNOT00000005015.8 UniProtKB/TrEMBL
  ENSRNOT00000094269.2 UniProtKB/TrEMBL
  ENSRNOT00000138952 ENTREZGENE
  ENSRNOT00000138952.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
  Exo-inulinase, domain 1 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  GH59_C UniProtKB/TrEMBL
  GH59_cat UniProtKB/TrEMBL
  Glyco_hydro_59 UniProtKB/TrEMBL
  Glyco_hydro_59_dom UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
KEGG Report rno:314360 UniProtKB/TrEMBL
NCBI Gene 314360 ENTREZGENE
PANTHER GALACTOCEREBROSIDASE UniProtKB/TrEMBL
  Glyco_hydro_59 UniProtKB/TrEMBL
Pfam Glyco_hydro_59 UniProtKB/TrEMBL
  Glyco_hydro_59_C UniProtKB/TrEMBL
  Glyco_hydro_59M UniProtKB/TrEMBL
PhenoGen Galc PhenoGen
PRINTS GLHYDRLASE59 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003759 RatGTEx
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
UniProt A0A0G2QC23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AML4_RAT UniProtKB/TrEMBL
  A0ABK0LH57_RAT UniProtKB/TrEMBL
  A6JEE0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6H1 ENTREZGENE, UniProtKB/TrEMBL
  Q5YKG1 ENTREZGENE
UniProt Secondary Q5YKG1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Galc  galactosylceramidase      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Galc  galactosylceramidase      Symbol and Name status set to provisional 70820 PROVISIONAL