Rnase17 (ribonuclease 17) - Rat Genome Database

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Gene: Rnase17 (ribonuclease 17) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rnase17
Name: ribonuclease 17
RGD ID: 1359245
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to human RNASE2 (ribonuclease A family member 2) and RNASE3 (ribonuclease A family member 3); INTERACTS WITH nitrofen; titanium dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: R1; R17; ribonuclease 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,972,687 - 26,973,646 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21524,499,178 - 24,500,140 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,499,178 - 24,500,095 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,270,511 - 27,270,978 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,225,673 - 28,226,140 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,479,070 - 26,479,537 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,204,043 - 28,204,929 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,204,224 - 28,204,691 (-)Ensemblrn6Rnor6.0
Rnor_5.01532,033,992 - 32,034,882 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,259,616 - 27,260,083NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11527,275,315 - 27,275,783NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15676279  


Genomics

Variants

.
Variants in Rnase17
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:44
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000048941
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH133047  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1524,766,542 - 24,766,758UniSTS
Celera1524,864,784 - 24,865,001UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
4 5 12 36 47 27 24 27 2 69 40 4 8 1 18 20

Sequence


Ensembl Acc Id: ENSRNOT00000048941   ⟹   ENSRNOP00000050225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,499,178 - 24,500,095 (-)Ensembl
Rnor_6.0 Ensembl1528,204,224 - 28,204,691 (-)Ensembl
RefSeq Acc Id: NM_001012232   ⟹   NP_001012232
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,972,864 - 26,973,331 (-)NCBI
mRatBN7.21524,499,359 - 24,499,826 (-)NCBI
Rnor_6.01528,204,224 - 28,204,691 (-)NCBI
Rnor_5.01532,033,992 - 32,034,882 (-)NCBI
RGSC_v3.41527,259,616 - 27,260,083 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770561   ⟹   XP_008768783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,972,687 - 26,973,646 (-)NCBI
mRatBN7.21524,499,178 - 24,500,140 (-)NCBI
Rnor_6.01528,204,043 - 28,204,929 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012232 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768783 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD51661 (Get FASTA)   NCBI Sequence Viewer  
  AAV87197 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050225.2
  ENSRNOP00000076490
RefSeq Acc Id: NP_001012232   ⟸   NM_001012232
- Peptide Label: precursor
- UniProtKB: Q5GAM2 (UniProtKB/TrEMBL),   Q9R134 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768783   ⟸   XM_008770561
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000050225   ⟸   ENSRNOT00000048941
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GAM2-F1-model_v2 AlphaFold Q5GAM2 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359245 AgrOrtholog
BioCyc Gene G2FUF-14009 BioCyc
Ensembl Genes ENSRNOG00000050295 Ensembl
  ENSRNOG00000063957 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000077288 ENTREZGENE
Ensembl Transcript ENSRNOT00000048941.3 UniProtKB/TrEMBL
  ENSRNOT00000105605 ENTREZGENE
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:497195 UniProtKB/TrEMBL
NCBI Gene 497195 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/TrEMBL
  PTHR11437 UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PhenoGen Rnase17 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050295 RatGTEx
  ENSRNOG00000063957 RatGTEx
  ENSRNOG00000077288 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP SSF54076 UniProtKB/TrEMBL
UniProt Q5GAM2 ENTREZGENE, UniProtKB/TrEMBL
  Q9R134 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Rnase17  ribonuclease 17      Symbol and Name updated 1559027 APPROVED
2005-07-29 Rnase17  ribonuclease 17      Symbol and Name status set to provisional 70820 PROVISIONAL