Armcx2 (armadillo repeat containing, X-linked 2) - Rat Genome Database

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Gene: Armcx2 (armadillo repeat containing, X-linked 2) Rattus norvegicus
Analyze
Symbol: Armcx2
Name: armadillo repeat containing, X-linked 2
RGD ID: 1359132
Description: Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ALEX2 protein; armadillo repeat-containing X-linked protein 2; LOC367903; similar to armadillo repeat protein ALEX2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,273,915 - 102,278,789 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX102,273,565 - 102,278,905 (-)EnsemblGRCr8
mRatBN7.2X97,980,662 - 97,985,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,980,660 - 97,985,552 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX99,654,873 - 99,659,646 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X103,171,433 - 103,176,206 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,667,987 - 100,672,760 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,617,383 - 105,622,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,617,385 - 105,622,156 (-)Ensemblrn6Rnor6.0
Rnor_5.0X105,506,649 - 105,511,422 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X122,260,901 - 122,266,470 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX99,020,283 - 99,025,056 (-)NCBICelera
RGSC_v3.1X122,334,335 - 122,339,903 (-)NCBI
Cytogenetic MapXq32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Kurochkin IV, etal., Biochem Biophys Res Commun 2001 Jan 12;280(1):340-7.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, etal., Dev Dyn 2005 May;233(1):188-93.
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:34800366  


Genomics

Comparative Map Data
Armcx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,273,915 - 102,278,789 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX102,273,565 - 102,278,905 (-)EnsemblGRCr8
mRatBN7.2X97,980,662 - 97,985,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,980,660 - 97,985,552 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX99,654,873 - 99,659,646 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X103,171,433 - 103,176,206 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,667,987 - 100,672,760 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,617,383 - 105,622,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,617,385 - 105,622,156 (-)Ensemblrn6Rnor6.0
Rnor_5.0X105,506,649 - 105,511,422 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X122,260,901 - 122,266,470 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX99,020,283 - 99,025,056 (-)NCBICelera
RGSC_v3.1X122,334,335 - 122,339,903 (-)NCBI
Cytogenetic MapXq32NCBI
ARMCX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,655,281 - 101,659,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,655,157 - 101,659,924 (-)Ensemblhg38GRCh38
GRCh37X100,910,267 - 100,914,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,796,923 - 100,801,519 (-)NCBIBuild 36Build 36hg18NCBI36
CeleraX101,430,845 - 101,435,442 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,717,786 - 90,722,384 (-)NCBIHuRef
CHM1_1X100,804,126 - 100,808,723 (-)NCBICHM1_1
T2T-CHM13v2.0X100,099,916 - 100,104,489 (-)NCBIT2T-CHM13v2.0
Armcx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,704,891 - 133,709,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,704,894 - 133,709,970 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X134,804,142 - 134,809,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,804,145 - 134,809,221 (-)Ensemblmm10GRCm38
MGSCv37X131,338,681 - 131,343,760 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X130,150,511 - 130,155,358 (-)NCBIMGSCv36mm8
CeleraX117,689,899 - 117,695,175 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.27NCBI
Armcx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,756,429 - 7,758,366 (-)Ensembl
ChiLan1.0NW_0049555037,756,032 - 7,760,573 (-)NCBIChiLan1.0ChiLan1.0
ARMCX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X101,252,466 - 101,257,077 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,255,947 - 101,260,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,855,629 - 90,860,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,984,392 - 100,988,995 (-)NCBIPanPan1.1PanPan1.1panPan2
ARMCX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,517,183 - 75,521,486 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,517,407 - 75,519,218 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X76,937,039 - 76,941,529 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,937,039 - 76,941,484 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,501,328 - 74,505,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X76,161,775 - 76,166,267 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,924,469 - 75,928,961 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Armcx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,820,100 - 62,825,624 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813649,468 - 653,615 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936813649,463 - 655,013 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARMCX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,213,947 - 83,224,391 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X83,213,939 - 83,218,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,075,719 - 97,085,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARMCX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,972,285 - 89,975,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606514,902,697 - 14,907,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Armcx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624902863,592 - 865,532 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624902861,362 - 865,926 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Armcx2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X87,098,645 - 87,103,468 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Armcx2
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:382
Count of miRNA genes:231
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000029511
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
UniSTS:238078  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X97,982,617 - 97,982,920 (+)MAPPERmRatBN7.2
Rnor_6.0X105,619,339 - 105,619,641NCBIRnor6.0
Rnor_5.0X105,508,605 - 105,508,907UniSTSRnor5.0
RGSC_v3.4X122,263,653 - 122,263,955UniSTSRGSC3.4
CeleraX99,022,239 - 99,022,541UniSTS
Cytogenetic MapXq34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 63 59 6 324 163 11 140 78 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000029511   ⟹   ENSRNOP00000030098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX102,273,565 - 102,278,905 (-)Ensembl
mRatBN7.2 EnsemblX97,980,660 - 97,985,213 (-)Ensembl
Rnor_6.0 EnsemblX105,617,385 - 105,622,156 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096671   ⟹   ENSRNOP00000078959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX102,273,914 - 102,278,867 (-)Ensembl
mRatBN7.2 EnsemblX97,980,670 - 97,985,552 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169270   ⟹   ENSRNOP00000107846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX102,273,915 - 102,278,867 (-)Ensembl
RefSeq Acc Id: NM_001014274   ⟹   NP_001014296
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X102,273,915 - 102,278,688 (-)NCBI
mRatBN7.2X97,980,662 - 97,985,435 (-)NCBI
Rnor_6.0X105,617,383 - 105,622,156 (-)NCBI
Rnor_5.0X105,506,649 - 105,511,422 (-)NCBI
RGSC_v3.4X122,260,901 - 122,266,470 (-)RGD
CeleraX99,020,283 - 99,025,056 (-)RGD
Sequence:
RefSeq Acc Id: XM_008773429   ⟹   XP_008771651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X102,273,915 - 102,278,789 (-)NCBI
mRatBN7.2X97,980,662 - 97,985,523 (-)NCBI
Rnor_6.0X105,617,383 - 105,622,209 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001014296 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771651 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81886 (Get FASTA)   NCBI Sequence Viewer  
  EDM07000 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030098
  ENSRNOP00000030098.5
  ENSRNOP00000078959.1
  ENSRNOP00000107846
  ENSRNOP00000107846.1
RefSeq Acc Id: NP_001014296   ⟸   NM_001014274
- UniProtKB: Q642B5 (UniProtKB/TrEMBL),   D4A765 (UniProtKB/TrEMBL),   A0A8I5ZLU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771651   ⟸   XM_008773429
- Peptide Label: isoform X1
- UniProtKB: Q642B5 (UniProtKB/TrEMBL),   D4A765 (UniProtKB/TrEMBL),   A0A8I5ZLU9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030098   ⟸   ENSRNOT00000029511
Ensembl Acc Id: ENSRNOP00000078959   ⟸   ENSRNOT00000096671
Ensembl Acc Id: ENSRNOP00000107846   ⟸   ENSRNOT00000169270
Protein Domains
Armadillo repeat-containing

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q642B5-F1-model_v2 AlphaFold Q642B5 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701937
Promoter ID:EPDNEW_R12461
Type:multiple initiation site
Name:Armcx2_1
Description:armadillo repeat containing, X-linked 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X105,622,175 - 105,622,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359132 AgrOrtholog
BioCyc Gene G2FUF-1670 BioCyc
Ensembl Genes ENSRNOG00000025705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029511 ENTREZGENE
  ENSRNOT00000029511.7 UniProtKB/TrEMBL
  ENSRNOT00000096671.2 UniProtKB/TrEMBL
  ENSRNOT00000169270 ENTREZGENE
  ENSRNOT00000169270.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108660 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Armadillo UniProtKB/TrEMBL
  Armcx_regulator UniProtKB/TrEMBL
  DUF634 UniProtKB/TrEMBL
KEGG Report rno:367903 UniProtKB/TrEMBL
MGC_CLONE MGC:93762 IMAGE-MGC_LOAD
NCBI Gene 367903 ENTREZGENE
PANTHER ARMADILLO REPEAT CONTAINING PROTEIN UniProtKB/TrEMBL
  ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 2 UniProtKB/TrEMBL
Pfam DUF634 UniProtKB/TrEMBL
PhenoGen Armcx2 PhenoGen
RatGTEx ENSRNOG00000025705 RatGTEx
SMART ARM UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5ZLU9 ENTREZGENE, UniProtKB/TrEMBL
  D4A765 ENTREZGENE
  Q642B5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A765 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Armcx2  armadillo repeat containing, X-linked 2  LOC367903  similar to armadillo repeat protein ALEX2  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC367903  similar to armadillo repeat protein ALEX2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression down-regulated in a variety of epithelially derived human tumors suggesting a role in tumor suppression 1556584