Fbxo25 (F-box protein 25) - Rat Genome Database

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Gene: Fbxo25 (F-box protein 25) Rattus norvegicus
Analyze
Symbol: Fbxo25
Name: F-box protein 25
RGD ID: 1359105
Description: Predicted to be involved in protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human FBXO25 (F-box protein 25); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box only protein 25; LOC364637; similar to F-box only protein 25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,370,123 - 82,404,002 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1682,370,059 - 82,403,919 (-)EnsemblGRCr8
mRatBN7.21675,666,062 - 75,701,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,667,904 - 75,701,696 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1680,942,819 - 80,975,639 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,396,337 - 84,429,158 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,650,605 - 79,685,523 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01680,770,788 - 80,806,661 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,771,596 - 80,798,041 (-)Ensemblrn6Rnor6.0
Rnor_5.01680,338,197 - 80,370,971 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41680,505,562 - 80,536,104 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1673,476,800 - 73,510,576 (-)NCBICelera
RGSC_v3.11680,505,826 - 80,517,003 (-)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
protein ubiquitination  (IBA,IEA,ISO,ISS)

Cellular Component
cytoplasm  (IBA)
nucleolus  (ISO)
nucleus  (IBA,IEA,ISO,ISS)
SCF ubiquitin ligase complex  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:16278047   PMID:16714087  


Genomics

Comparative Map Data
Fbxo25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,370,123 - 82,404,002 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1682,370,059 - 82,403,919 (-)EnsemblGRCr8
mRatBN7.21675,666,062 - 75,701,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,667,904 - 75,701,696 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1680,942,819 - 80,975,639 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,396,337 - 84,429,158 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,650,605 - 79,685,523 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01680,770,788 - 80,806,661 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,771,596 - 80,798,041 (-)Ensemblrn6Rnor6.0
Rnor_5.01680,338,197 - 80,370,971 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41680,505,562 - 80,536,104 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1673,476,800 - 73,510,576 (-)NCBICelera
RGSC_v3.11680,505,826 - 80,517,003 (-)NCBI
Cytogenetic Map16q12.5NCBI
FBXO25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388406,958 - 477,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8406,428 - 477,967 (+)Ensemblhg38GRCh38
GRCh378356,958 - 427,967 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368346,808 - 409,876 (+)NCBIBuild 36Build 36hg18NCBI36
Celera8324,725 - 387,793 (+)NCBICelera
Cytogenetic Map8p23.3NCBI
HuRef8200,717 - 263,855 (+)NCBIHuRef
CHM1_18356,508 - 419,580 (+)NCBICHM1_1
T2T-CHM13v2.08204,109 - 275,198 (+)NCBIT2T-CHM13v2.0
Fbxo25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,957,667 - 13,992,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,957,803 - 13,990,522 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38813,907,736 - 13,942,875 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,907,803 - 13,940,522 (+)Ensemblmm10GRCm38
MGSCv37813,907,806 - 13,940,521 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36813,907,783 - 13,940,498 (+)NCBIMGSCv36mm8
Celera814,068,108 - 14,100,905 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.42NCBI
Fbxo25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540358,724,206 - 58,767,637 (-)Ensembl
ChiLan1.0NW_00495540358,724,206 - 58,767,637 (-)NCBIChiLan1.0ChiLan1.0
FBXO25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2715,086,592 - 15,158,191 (+)NCBINHGRI_mPanPan1-v2
Mhudiblu_PPA_v086,931,217 - 6,995,138 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18345,711 - 384,077 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8344,220 - 384,077 (+)EnsemblpanPan2panpan1.1
FBXO25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,413,769 - 37,476,356 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,429,761 - 37,476,053 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2538,013,927 - 38,081,105 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02537,648,859 - 37,716,428 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,658,737 - 37,712,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,592,215 - 37,659,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,430,157 - 37,497,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,605,737 - 37,672,828 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbxo25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494369,520 - 122,444 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493661574,789 - 122,872 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493661569,601 - 122,820 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1532,359,549 - 32,409,814 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11532,359,471 - 32,409,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FBXO25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18183,147 - 247,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8183,180 - 246,703 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605441,823,473 - 41,888,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624861139,947 - 190,622 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624861140,375 - 194,799 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fbxo25
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11369,836,901 - 69,867,422 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbxo25
298 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:285
Count of miRNA genes:189
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000065526
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065526   ⟹   ENSRNOP00000061613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1682,370,059 - 82,403,919 (-)Ensembl
mRatBN7.2 Ensembl1675,668,018 - 75,701,696 (-)Ensembl
Rnor_6.0 Ensembl1680,771,596 - 80,798,041 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117040   ⟹   ENSRNOP00000095529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1682,370,123 - 82,403,919 (-)Ensembl
mRatBN7.2 Ensembl1675,667,904 - 75,701,696 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143331   ⟹   ENSRNOP00000105725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1682,370,123 - 82,396,608 (-)Ensembl
RefSeq Acc Id: NM_001014239   ⟹   NP_001014261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,370,123 - 82,403,919 (-)NCBI
mRatBN7.21675,667,897 - 75,701,699 (-)NCBI
Rnor_6.01680,770,788 - 80,806,661 (-)NCBI
Rnor_5.01680,338,197 - 80,370,971 (-)NCBI
RGSC_v3.41680,505,562 - 80,536,104 (-)RGD
Celera1673,476,800 - 73,510,576 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094738   ⟹   XP_038950666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,370,123 - 82,404,002 (-)NCBI
mRatBN7.21675,666,062 - 75,701,770 (-)NCBI
RefSeq Acc Id: XM_039094739   ⟹   XP_038950667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,370,123 - 82,404,002 (-)NCBI
mRatBN7.21675,666,062 - 75,701,770 (-)NCBI
RefSeq Acc Id: XM_039094740   ⟹   XP_038950668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,370,123 - 82,404,002 (-)NCBI
mRatBN7.21675,666,062 - 75,701,770 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001014261 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950666 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950667 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950668 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82088 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061613
  ENSRNOP00000095529
GenBank Protein Q641X7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014261   ⟸   NM_001014239
- UniProtKB: Q641X7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061613   ⟸   ENSRNOT00000065526
RefSeq Acc Id: XP_038950668   ⟸   XM_039094740
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ARL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950667   ⟸   XM_039094739
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950666   ⟸   XM_039094738
- Peptide Label: isoform X1
- UniProtKB: F1M4T6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095529   ⟸   ENSRNOT00000117040
Ensembl Acc Id: ENSRNOP00000105725   ⟸   ENSRNOT00000143331
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641X7-F1-model_v2 AlphaFold Q641X7 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359105 AgrOrtholog
BioCyc Gene G2FUF-10739 BioCyc
Ensembl Genes ENSRNOG00000042464 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065526 ENTREZGENE
  ENSRNOT00000117040 ENTREZGENE
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133991 IMAGE-MGC_LOAD
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot
  FBX25/32 UniProtKB/Swiss-Prot
KEGG Report rno:364637 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95269 IMAGE-MGC_LOAD
NCBI Gene 364637 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 25 UniProtKB/Swiss-Prot
  PTHR13123 UniProtKB/Swiss-Prot
PhenoGen Fbxo25 PhenoGen
RatGTEx ENSRNOG00000042464 RatGTEx
Superfamily-SCOP SSF81383 UniProtKB/Swiss-Prot
UniProt A0A8I6ARL8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L6Y3_RAT UniProtKB/TrEMBL
  F1M4T6 ENTREZGENE, UniProtKB/TrEMBL
  FBX25_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Fbxo25  F-box protein 25  LOC364637  similar to F-box only protein 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC364637  similar to F-box only protein 25      Symbol and Name status set to provisional 70820 PROVISIONAL