Tpx2 (TPX2, microtubule nucleation factor) - Rat Genome Database

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Gene: Tpx2 (TPX2, microtubule nucleation factor) Rattus norvegicus
Analyze
Symbol: Tpx2
Name: TPX2, microtubule nucleation factor
RGD ID: 1311894
Description: Predicted to enable several functions, including importin-alpha family protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in microtubule nucleation; negative regulation of microtubule depolymerization; and regulation of mitotic spindle organization. Predicted to act upstream of or within mitotic spindle assembly. Predicted to be located in axon hillock and spindle pole. Predicted to be active in spindle. Orthologous to human TPX2 (TPX2 microtubule nucleation factor); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311546; targeting protein for Xklp2; TPX2, microtubule-associated; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated protein homolog (Xenopus laevis); TPX2, microtubule-associated, homolog; TPX2, microtubule-associated, homolog (Xenopus laevis)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,778,709 - 161,820,941 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,778,742 - 161,820,724 (+)EnsemblGRCr8
mRatBN7.23141,318,428 - 141,360,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,318,455 - 141,360,468 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3145,223,400 - 145,265,675 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,807,225 - 153,849,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,546,693 - 151,589,001 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,327,965 - 148,370,187 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,327,965 - 148,370,187 (+)Ensemblrn6Rnor6.0
Rnor_5.03154,730,957 - 154,773,179 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43143,194,067 - 143,236,185 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3140,067,778 - 140,110,008 (+)NCBICelera
RGSC_v3.13143,117,960 - 143,141,592 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geraniol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
Nivalenol  (ISO)
NS-398  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
SP2509  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
Withanone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon hillock  (IEA,ISO)
intercellular bridge  (IEA,ISO)
microtubule  (IEA)
microtubule cytoskeleton  (IEA,ISO)
mitotic spindle  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)
spindle  (IEA,ISO)
spindle pole  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14580337   PMID:14718566   PMID:18662907   PMID:18663142   PMID:19668197   PMID:19801554   PMID:26165940   PMID:26414402  


Genomics

Comparative Map Data
Tpx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,778,709 - 161,820,941 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,778,742 - 161,820,724 (+)EnsemblGRCr8
mRatBN7.23141,318,428 - 141,360,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,318,455 - 141,360,468 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3145,223,400 - 145,265,675 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,807,225 - 153,849,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,546,693 - 151,589,001 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,327,965 - 148,370,187 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,327,965 - 148,370,187 (+)Ensemblrn6Rnor6.0
Rnor_5.03154,730,957 - 154,773,179 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43143,194,067 - 143,236,185 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3140,067,778 - 140,110,008 (+)NCBICelera
RGSC_v3.13143,117,960 - 143,141,592 (+)NCBI
Cytogenetic Map3q41NCBI
TPX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,739,290 - 31,801,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,739,248 - 31,801,805 (+)Ensemblhg38GRCh38
GRCh372030,327,093 - 30,389,603 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,790,565 - 29,853,264 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342029,790,564 - 29,853,264NCBI
Celera2027,083,256 - 27,145,950 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,115,888 - 27,178,524 (+)NCBIHuRef
CHM1_12030,230,786 - 30,293,470 (+)NCBICHM1_1
T2T-CHM13v2.02033,463,246 - 33,526,408 (+)NCBIT2T-CHM13v2.0
Tpx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,689,859 - 152,737,241 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,689,884 - 152,737,241 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382152,847,964 - 152,895,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,847,964 - 152,895,321 (+)Ensemblmm10GRCm38
MGSCv372152,673,700 - 152,721,057 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362152,539,504 - 152,585,459 (+)NCBIMGSCv36mm8
Celera2158,663,984 - 158,712,802 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Tpx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,171,329 - 29,232,891 (-)Ensembl
ChiLan1.0NW_00495542229,170,695 - 29,233,924 (-)NCBIChiLan1.0ChiLan1.0
TPX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,434,903 - 37,498,327 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,427,939 - 37,491,425 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,032,663 - 28,095,223 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,163,312 - 29,225,860 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,163,312 - 29,225,860 (+)EnsemblpanPan2panpan1.1
TPX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,209,494 - 21,273,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,209,588 - 21,269,893 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2420,845,578 - 20,920,421 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02421,885,095 - 21,959,895 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,896,261 - 21,958,406 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,163,021 - 21,238,221 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,268,270 - 21,343,512 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,698,941 - 21,774,244 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,287,395 - 170,338,871 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,718,795 - 18,767,951 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,718,801 - 18,773,315 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,431,395 - 35,485,065 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11735,431,271 - 35,484,814 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,431,363 - 40,452,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,131,907 - 36,191,254 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,134,760 - 36,191,425 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605090,722,904 - 90,781,107 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741709,322 - 772,423 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624741707,267 - 772,543 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tpx2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15132,171,740 - 132,212,675 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpx2
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:52
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000010851
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83161,799,270 - 161,799,493 (+)Marker Load Pipeline
mRatBN7.23141,339,013 - 141,339,236 (+)MAPPERmRatBN7.2
Rnor_6.03148,348,517 - 148,348,739NCBIRnor6.0
Rnor_5.03154,751,509 - 154,751,731UniSTSRnor5.0
RGSC_v3.43143,214,619 - 143,214,737UniSTSRGSC3.4
Celera3140,088,337 - 140,088,559UniSTS
RGSC_v3.13143,120,240 - 143,120,359RGD
RH 3.4 Map31268.9RGD
RH 3.4 Map31268.9UniSTS
RH 2.0 Map3840.4RGD
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010851   ⟹   ENSRNOP00000010851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,778,871 - 161,820,724 (+)Ensembl
mRatBN7.2 Ensembl3141,318,543 - 141,360,404 (+)Ensembl
Rnor_6.0 Ensembl3148,327,965 - 148,370,187 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088481   ⟹   ENSRNOP00000068619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,778,742 - 161,820,724 (+)Ensembl
mRatBN7.2 Ensembl3141,318,455 - 141,360,468 (+)Ensembl
Rnor_6.0 Ensembl3148,327,987 - 148,369,970 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104440   ⟹   ENSRNOP00000097456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,801,250 - 161,820,724 (+)Ensembl
mRatBN7.2 Ensembl3141,318,543 - 141,360,404 (+)Ensembl
RefSeq Acc Id: NM_001107790   ⟹   NP_001101260
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,720 - 161,820,941 (+)NCBI
mRatBN7.23141,318,456 - 141,360,684 (+)NCBI
Rnor_6.03148,327,965 - 148,370,187 (+)NCBI
Rnor_5.03154,730,957 - 154,773,179 (+)NCBI
RGSC_v3.43143,194,067 - 143,236,185 (+)RGD
Celera3140,067,778 - 140,110,008 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235270   ⟹   XP_006235332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,714 - 161,820,725 (+)NCBI
mRatBN7.23141,318,428 - 141,360,468 (+)NCBI
Rnor_6.03148,327,970 - 148,369,971 (+)NCBI
Rnor_5.03154,730,957 - 154,773,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235272   ⟹   XP_006235334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,714 - 161,820,725 (+)NCBI
mRatBN7.23141,318,428 - 141,360,468 (+)NCBI
Rnor_6.03148,327,970 - 148,369,971 (+)NCBI
Rnor_5.03154,730,957 - 154,773,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235273   ⟹   XP_006235335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,709 - 161,820,725 (+)NCBI
mRatBN7.23141,318,454 - 141,360,468 (+)NCBI
Rnor_6.03148,327,970 - 148,369,971 (+)NCBI
Rnor_5.03154,730,957 - 154,773,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235274   ⟹   XP_006235336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,714 - 161,820,725 (+)NCBI
mRatBN7.23141,318,428 - 141,360,468 (+)NCBI
Rnor_6.03148,327,970 - 148,369,971 (+)NCBI
Rnor_5.03154,730,957 - 154,773,179 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105059   ⟹   XP_038960987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,725 - 161,820,725 (+)NCBI
mRatBN7.23141,318,589 - 141,360,468 (+)NCBI
RefSeq Acc Id: XM_039105060   ⟹   XP_038960988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,899 - 161,820,725 (+)NCBI
mRatBN7.23141,318,589 - 141,360,468 (+)NCBI
RefSeq Acc Id: XM_039105061   ⟹   XP_038960989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,725 - 161,820,725 (+)NCBI
mRatBN7.23141,318,589 - 141,360,468 (+)NCBI
RefSeq Acc Id: XM_039105062   ⟹   XP_038960990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,725 - 161,820,725 (+)NCBI
mRatBN7.23141,318,589 - 141,360,468 (+)NCBI
RefSeq Acc Id: XM_039105064   ⟹   XP_038960992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,709 - 161,820,725 (+)NCBI
mRatBN7.23141,318,454 - 141,360,468 (+)NCBI
RefSeq Acc Id: XM_063283824   ⟹   XP_063139894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,725 - 161,820,725 (+)NCBI
RefSeq Acc Id: XM_063283825   ⟹   XP_063139895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,778,714 - 161,820,725 (+)NCBI
RefSeq Acc Id: NP_001101260   ⟸   NM_001107790
- UniProtKB: D3ZA78 (UniProtKB/TrEMBL),   A6KHR8 (UniProtKB/TrEMBL),   A0A8I6ARV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235335   ⟸   XM_006235273
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006235332   ⟸   XM_006235270
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006235336   ⟸   XM_006235274
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006235334   ⟸   XM_006235272
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000010851   ⟸   ENSRNOT00000010851
Ensembl Acc Id: ENSRNOP00000068619   ⟸   ENSRNOT00000088481
RefSeq Acc Id: XP_038960992   ⟸   XM_039105064
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960987   ⟸   XM_039105059
- Peptide Label: isoform X1
- UniProtKB: D3ZA78 (UniProtKB/TrEMBL),   A6KHR8 (UniProtKB/TrEMBL),   A0A8I6ARV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960989   ⟸   XM_039105061
- Peptide Label: isoform X1
- UniProtKB: D3ZA78 (UniProtKB/TrEMBL),   A6KHR8 (UniProtKB/TrEMBL),   A0A8I6ARV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960988   ⟸   XM_039105060
- Peptide Label: isoform X1
- UniProtKB: D3ZA78 (UniProtKB/TrEMBL),   A6KHR8 (UniProtKB/TrEMBL),   A0A8I6ARV3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960990   ⟸   XM_039105062
- Peptide Label: isoform X1
- UniProtKB: D3ZA78 (UniProtKB/TrEMBL),   A6KHR8 (UniProtKB/TrEMBL),   A0A8I6ARV3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097456   ⟸   ENSRNOT00000104440
RefSeq Acc Id: XP_063139895   ⟸   XM_063283825
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139894   ⟸   XM_063283824
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JT92 (UniProtKB/TrEMBL),   A0A8I6ARV3 (UniProtKB/TrEMBL)
Protein Domains
Aurora-A binding   TPX2 C-terminal   TPX2 central

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA78-F1-model_v2 AlphaFold D3ZA78 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692566
Promoter ID:EPDNEW_R3077
Type:initiation region
Name:Tpx2_1
Description:TPX2, microtubule nucleation factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,328,014 - 148,328,074EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311894 AgrOrtholog
BioCyc Gene G2FUF-47246 BioCyc
Ensembl Genes ENSRNOG00000008165 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010851 ENTREZGENE
  ENSRNOT00000010851.7 UniProtKB/TrEMBL
  ENSRNOT00000088481 ENTREZGENE
  ENSRNOT00000088481.3 UniProtKB/TrEMBL
  ENSRNOT00000104440 ENTREZGENE
  ENSRNOT00000104440.2 UniProtKB/TrEMBL
InterPro Aurora-A-bd UniProtKB/TrEMBL
  TPX2_central_dom UniProtKB/TrEMBL
  TPX2_dom_C UniProtKB/TrEMBL
  Xklp2_targeting_prot UniProtKB/TrEMBL
KEGG Report rno:311546 UniProtKB/TrEMBL
NCBI Gene 311546 ENTREZGENE
PANTHER PTHR14326 UniProtKB/TrEMBL
  TARGETING PROTEIN FOR XKLP2 UniProtKB/TrEMBL
Pfam Aurora-A_bind UniProtKB/TrEMBL
  TPX2 UniProtKB/TrEMBL
  TPX2_importin UniProtKB/TrEMBL
PhenoGen Tpx2 PhenoGen
RatGTEx ENSRNOG00000008165 RatGTEx
UniProt A0A0G2JT92 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARV3 ENTREZGENE, UniProtKB/TrEMBL
  A6KHR8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZA78 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Tpx2  TPX2, microtubule nucleation factor  Tpx2  TPX2, microtubule-associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Tpx2  TPX2, microtubule-associated  Tpx2  TPX2, microtubule-associated, homolog (Xenopus laevis)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Tpx2  TPX2, microtubule-associated, homolog (Xenopus laevis)  Tpx2  TPX2, microtubule-associated protein homolog (Xenopus laevis)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tpx2  TPX2, microtubule-associated protein homolog (Xenopus laevis)   Tpx2_predicted  TPX2, microtubule-associated protein homolog (Xenopus laevis) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tpx2_predicted  TPX2, microtubule-associated protein homolog (Xenopus laevis) (predicted)      Symbol and Name status set to approved 70820 APPROVED