Hsfy2 (heat shock transcription factor, Y linked 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hsfy2 (heat shock transcription factor, Y linked 2) Rattus norvegicus
Analyze
Symbol: Hsfy2
Name: heat shock transcription factor, Y linked 2
RGD ID: 1311885
Description: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to several human genes including HSFY2 (heat shock transcription factor Y-linked 2); INTERACTS WITH copper atom; copper(0); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock transcription factor, Y-linked 1; Hsfy1; LOC316409
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8965,676,744 - 65,678,157 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl965,676,751 - 65,678,157 (-)EnsemblGRCr8
mRatBN7.2958,182,415 - 58,183,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl958,182,253 - 58,184,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx966,682,537 - 66,683,950 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0971,798,442 - 71,799,855 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0970,116,517 - 70,117,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0963,289,937 - 63,291,350 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl963,289,944 - 63,291,350 (-)Ensemblrn6Rnor6.0
Rnor_5.0963,097,408 - 63,098,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4955,495,514 - 55,496,927 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera955,646,697 - 55,648,110 (-)NCBICelera
RGSC_v3.1955,642,502 - 55,643,909 (-)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Hsfy2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8965,676,744 - 65,678,157 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl965,676,751 - 65,678,157 (-)EnsemblGRCr8
mRatBN7.2958,182,415 - 58,183,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl958,182,253 - 58,184,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx966,682,537 - 66,683,950 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0971,798,442 - 71,799,855 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0970,116,517 - 70,117,930 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0963,289,937 - 63,291,350 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl963,289,944 - 63,291,350 (-)Ensemblrn6Rnor6.0
Rnor_5.0963,097,408 - 63,098,821 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4955,495,514 - 55,496,927 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera955,646,697 - 55,648,110 (-)NCBICelera
RGSC_v3.1955,642,502 - 55,643,909 (-)NCBI
Cytogenetic Map9q31NCBI
HSFY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y18,731,440 - 18,790,764 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblY18,731,440 - 18,773,735 (-)Ensemblhg38GRCh38
GRCh38.p14 EnsemblY18,546,691 - 18,588,963 (+)Ensemblhg38GRCh38
GRCh37Y20,893,326 - 20,935,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y19,352,714 - 19,395,009 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34Y19,321,825 - 19,323,746NCBI
CeleraY6,839,462 - 6,881,754 (+)NCBICelera
Cytogenetic MapYq11.222NCBI
HuRefY14,604,979 - 14,647,513 (-)NCBIHuRef
T2T-CHM13v2.0Y19,637,916 - 19,697,230 (-)NCBIT2T-CHM13v2.0
Hsfy2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,675,203 - 56,676,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,675,203 - 56,676,594 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38156,636,044 - 56,637,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,636,044 - 56,637,435 (-)Ensemblmm10GRCm38
MGSCv37156,692,888 - 56,694,295 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36156,580,600 - 56,581,988 (-)NCBIMGSCv36mm8
Celera157,150,974 - 57,152,382 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map128.72NCBI
LOC119868754
(Canis lupus familiaris - dog)		 No map positions available.

Variants

.
Variants in Hsfy2
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:75
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000058831
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH132405  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2958,182,632 - 58,182,828 (+)MAPPERmRatBN7.2
Rnor_6.0963,290,155 - 63,290,350NCBIRnor6.0
Rnor_5.0963,097,626 - 63,097,821UniSTSRnor5.0
RGSC_v3.4955,495,732 - 55,495,927UniSTSRGSC3.4
Celera955,646,915 - 55,647,110UniSTS
RH 3.4 Map9480.9UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 1 8 3 4 2 2 2 10 4 8 1 21 2

Sequence


Ensembl Acc Id: ENSRNOT00000058831   ⟹   ENSRNOP00000055621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl965,676,751 - 65,678,157 (-)Ensembl
mRatBN7.2 Ensembl958,182,253 - 58,184,500 (-)Ensembl
Rnor_6.0 Ensembl963,289,944 - 63,291,350 (-)Ensembl
RefSeq Acc Id: NM_001012132   ⟹   NP_001012132
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8965,676,744 - 65,678,157 (-)NCBI
mRatBN7.2958,182,415 - 58,183,828 (-)NCBI
Rnor_6.0963,289,937 - 63,291,350 (-)NCBI
Rnor_5.0963,097,408 - 63,098,821 (-)NCBI
RGSC_v3.4955,495,514 - 55,496,927 (-)RGD
Celera955,646,697 - 55,648,110 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012132 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83618 (Get FASTA)   NCBI Sequence Viewer  
  EDL99031 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055621
  ENSRNOP00000055621.1
RefSeq Acc Id: NP_001012132   ⟸   NM_001012132
- UniProtKB: Q5XIQ7 (UniProtKB/TrEMBL),   F7EQV5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055621   ⟸   ENSRNOT00000058831
Protein Domains
HSF-type DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIQ7-F1-model_v2 AlphaFold Q5XIQ7 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696673
Promoter ID:EPDNEW_R7198
Type:multiple initiation site
Name:Hsfy2_1
Description:heat shock transcription factor, Y linked 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0963,291,332 - 63,291,392EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311885 AgrOrtholog
BioCyc Gene G2FUF-27503 BioCyc
Ensembl Genes ENSRNOG00000038569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058831 ENTREZGENE
  ENSRNOT00000058831.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133881 IMAGE-MGC_LOAD
InterPro HSF_DNA_bd UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:316409 UniProtKB/TrEMBL
MGC_CLONE MGC:94387 IMAGE-MGC_LOAD
NCBI Gene 316409 ENTREZGENE
PANTHER PTHR10015 UniProtKB/TrEMBL
  PTHR10015:SF336 UniProtKB/TrEMBL
Pfam HSF_DNA-bind UniProtKB/TrEMBL
PhenoGen Hsfy2 PhenoGen
RatGTEx ENSRNOG00000038569 RatGTEx
SMART HSF UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt F7EQV5 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIQ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-12 Hsfy2  heat shock transcription factor, Y linked 2  Hsfy1  heat shock transcription factor, Y-linked 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Hsfy1  heat shock transcription factor, Y-linked 1  Hsfy1_predicted  heat shock transcription factor, Y-linked 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hsfy1_predicted  heat shock transcription factor, Y-linked 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED