Pus1 (pseudouridine synthase 1) - Rat Genome Database

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Gene: Pus1 (pseudouridine synthase 1) Rattus norvegicus
Analyze
Symbol: Pus1
Name: pseudouridine synthase 1
RGD ID: 1311871
Description: Predicted to enable several functions, including RNA binding activity; tRNA pseudouridine synthase activity; and transcription coactivator activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304567; MGC112655; pseudouridylate synthase 1; pseudouridylate synthase 1 homolog; tRNA pseudouridine synthase 1; tRNA pseudouridine synthase A; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,539,659 - 51,548,975 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1251,540,212 - 51,548,973 (+)EnsemblGRCr8
mRatBN7.21245,880,364 - 45,889,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,880,440 - 45,889,196 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1247,055,896 - 47,064,646 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,661,351 - 47,670,116 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,721,879 - 46,730,643 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,936,721 - 51,945,930 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,937,175 - 51,945,928 (+)Ensemblrn6Rnor6.0
Rnor_5.01253,675,092 - 53,684,281 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41246,024,978 - 46,033,733 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,439,849 - 47,448,604 (+)NCBICelera
RGSC_v3.11245,889,104 - 45,897,858 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
deoxynivalenol  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
mitochondrion  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10094309   PMID:11027153   PMID:11085940   PMID:12477932   PMID:15327771   PMID:15489334   PMID:15772074   PMID:22102571   PMID:22658674   PMID:22681889   PMID:23707380   PMID:24722331  


Genomics

Comparative Map Data
Pus1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,539,659 - 51,548,975 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1251,540,212 - 51,548,973 (+)EnsemblGRCr8
mRatBN7.21245,880,364 - 45,889,196 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,880,440 - 45,889,196 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1247,055,896 - 47,064,646 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,661,351 - 47,670,116 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,721,879 - 46,730,643 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,936,721 - 51,945,930 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,937,175 - 51,945,928 (+)Ensemblrn6Rnor6.0
Rnor_5.01253,675,092 - 53,684,281 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41246,024,978 - 46,033,733 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,439,849 - 47,448,604 (+)NCBICelera
RGSC_v3.11245,889,104 - 45,897,858 (+)NCBI
Cytogenetic Map12q16NCBI
PUS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,929,276 - 131,945,896 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12131,929,200 - 131,945,896 (+)Ensemblhg38GRCh38
GRCh3712132,413,821 - 132,430,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,979,742 - 130,994,357 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412131,080,271 - 131,094,632NCBI
Celera12132,032,281 - 132,046,846 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,299,517 - 129,314,189 (+)NCBIHuRef
CHM1_112132,234,704 - 132,249,366 (+)NCBICHM1_1
T2T-CHM13v2.012131,977,320 - 131,993,946 (+)NCBIT2T-CHM13v2.0
Pus1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,921,533 - 110,928,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,921,533 - 110,928,525 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385110,773,667 - 110,780,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,773,667 - 110,780,659 (-)Ensemblmm10GRCm38
MGSCv375111,202,686 - 111,209,634 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365111,013,969 - 111,020,917 (-)NCBIMGSCv36mm8
Celera5107,905,692 - 107,912,636 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.7NCBI
Pus1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482748,394 - 756,747 (-)Ensembl
ChiLan1.0NW_004955482749,265 - 756,964 (-)NCBIChiLan1.0ChiLan1.0
PUS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210140,020,955 - 140,036,202 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112140,017,411 - 140,032,719 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012129,583,040 - 129,598,328 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112134,011,927 - 134,027,160 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12134,011,932 - 134,027,160 (+)EnsemblpanPan2panpan1.1
PUS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126955,413 - 965,561 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26955,462 - 966,155 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha26999,050 - 1,009,405 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0261,017,083 - 1,027,425 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,017,131 - 1,027,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126954,195 - 964,550 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,050,823 - 1,061,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026973,978 - 984,323 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pus1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,521,435 - 122,532,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,192,651 - 2,199,602 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366602,192,583 - 2,199,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PUS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1423,400,584 - 23,418,132 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11423,400,575 - 23,418,470 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,852,142 - 24,870,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PUS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,307,955 - 127,327,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,308,053 - 127,328,301 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037117,632,671 - 117,650,593 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pus1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,698,816 - 27,709,514 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474727,699,397 - 27,707,592 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pus1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11643,562,397 - 43,571,474 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:54
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000056780
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056780   ⟹   ENSRNOP00000053623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1251,540,212 - 51,548,973 (+)Ensembl
mRatBN7.2 Ensembl1245,880,440 - 45,889,194 (+)Ensembl
Rnor_6.0 Ensembl1251,937,175 - 51,945,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102180   ⟹   ENSRNOP00000090656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1251,540,229 - 51,548,973 (+)Ensembl
mRatBN7.2 Ensembl1245,880,877 - 45,889,196 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106367   ⟹   ENSRNOP00000087894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,880,572 - 45,889,196 (+)Ensembl
RefSeq Acc Id: NM_001025563   ⟹   NP_001020734
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,540,219 - 51,548,975 (+)NCBI
mRatBN7.21245,880,440 - 45,889,196 (+)NCBI
Rnor_6.01251,937,175 - 51,945,930 (+)NCBI
Rnor_5.01253,675,092 - 53,684,281 (+)NCBI
RGSC_v3.41246,024,978 - 46,033,733 (+)RGD
Celera1247,439,849 - 47,448,604 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249547   ⟹   XP_006249609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,539,659 - 51,548,975 (+)NCBI
mRatBN7.21245,880,364 - 45,889,196 (+)NCBI
Rnor_6.01251,936,725 - 51,945,930 (+)NCBI
Rnor_5.01253,675,092 - 53,684,281 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598352   ⟹   XP_017453841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,540,216 - 51,548,975 (+)NCBI
mRatBN7.21245,880,633 - 45,889,196 (+)NCBI
Rnor_6.01251,936,721 - 51,945,930 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271365   ⟹   XP_063127435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,539,659 - 51,548,975 (+)NCBI
RefSeq Acc Id: NP_001020734   ⟸   NM_001025563
- UniProtKB: Q4KM92 (UniProtKB/Swiss-Prot),   B1WBN5 (UniProtKB/TrEMBL),   A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249609   ⟸   XM_006249547
- Peptide Label: isoform X1
- UniProtKB: A6J293 (UniProtKB/TrEMBL),   A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453841   ⟸   XM_017598352
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053623   ⟸   ENSRNOT00000056780
Ensembl Acc Id: ENSRNOP00000087894   ⟸   ENSRNOT00000106367
Ensembl Acc Id: ENSRNOP00000090656   ⟸   ENSRNOT00000102180
RefSeq Acc Id: XP_063127435   ⟸   XM_063271365
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANT6 (UniProtKB/TrEMBL),   A0A8I6A863 (UniProtKB/TrEMBL),   A6J292 (UniProtKB/TrEMBL)
Protein Domains
Pseudouridine synthase I TruA alpha/beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KM92-F1-model_v2 AlphaFold Q4KM92 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698734
Promoter ID:EPDNEW_R9258
Type:initiation region
Name:Pus1_1
Description:pseudouridylate synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01251,937,167 - 51,937,227EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311871 AgrOrtholog
BioCyc Gene G2FUF-18818 BioCyc
Ensembl Genes ENSRNOG00000037500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000056780 ENTREZGENE
  ENSRNOT00000056780.2 UniProtKB/Swiss-Prot
  ENSRNOT00000102180 ENTREZGENE
Gene3D-CATH 3.30.70.580 UniProtKB/Swiss-Prot
  3.30.70.660 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9027947 IMAGE-MGC_LOAD
InterPro PsdUridine_synth_cat_dom_sf UniProtKB/Swiss-Prot
  PsdUridine_synth_TruA UniProtKB/Swiss-Prot
  PsdUridine_synth_TruA_a/b_dom UniProtKB/Swiss-Prot
  PsdUridine_synth_TruA_C UniProtKB/Swiss-Prot
  PUS1/PUS2-like UniProtKB/Swiss-Prot
  TruA/RsuA/RluB/E/F_N UniProtKB/Swiss-Prot
KEGG Report rno:304567 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187275 IMAGE-MGC_LOAD
NCBI Gene 304567 ENTREZGENE
PANTHER PTHR11142 UniProtKB/Swiss-Prot
  TRNA PSEUDOURIDINE SYNTHASE A UniProtKB/Swiss-Prot
Pfam PseudoU_synth_1 UniProtKB/Swiss-Prot
PhenoGen Pus1 PhenoGen
RatGTEx ENSRNOG00000037500 RatGTEx
Superfamily-SCOP SSF55120 UniProtKB/Swiss-Prot
UniProt A0A8I6A863 ENTREZGENE
  A0A8I6ANT6 ENTREZGENE, UniProtKB/TrEMBL
  A6J292 ENTREZGENE, UniProtKB/TrEMBL
  A6J293 ENTREZGENE, UniProtKB/TrEMBL
  B1WBN5 ENTREZGENE, UniProtKB/TrEMBL
  Q4KM92 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-21 Pus1  pseudouridine synthase 1  Pus1  pseudouridylate synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Pus1  pseudouridylate synthase 1  Pus1  pseudouridine synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Pus1  pseudouridine synthase 1  Pus1_predicted  pseudouridine synthase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pus1_predicted  pseudouridine synthase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED