Cyp2r1 (cytochrome P450, family 2, subfamily r, polypeptide 1) - Rat Genome Database

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Gene: Cyp2r1 (cytochrome P450, family 2, subfamily r, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2r1
Name: cytochrome P450, family 2, subfamily r, polypeptide 1
RGD ID: 1311866
Description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and vitamin D3 25-hydroxylase activity. Predicted to be involved in organic acid metabolic process; vitamin D metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in artery disease (multiple); brain infarction; obesity; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1B. Orthologous to human CYP2R1 (cytochrome P450 family 2 subfamily R member 1); PARTICIPATES IN steroid biosynthetic pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361631; vitamin D 25-hydroxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,166,984 - 178,232,191 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,219,704 - 178,232,423 (-)EnsemblGRCr8
mRatBN7.21168,749,302 - 168,798,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,751,038 - 168,797,759 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,105,729 - 177,118,195 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,291,785 - 184,304,251 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,004,432 - 177,016,901 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1177,463,318 - 177,475,780 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1182,504,169 - 182,516,638 (-)NCBILyon_Normotensive
Lyon_Hypertensive1179,171,478 - 179,183,947 (-)NCBILyon_Hypertensive
F344_StmMcwi1177,414,897 - 177,427,366 (-)NCBIF344_StmMcwi
Rnor_6.01184,060,521 - 184,106,604 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,093,920 - 184,106,200 (-)Ensemblrn6Rnor6.0
Rnor_5.01191,032,655 - 191,078,746 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,593,057 - 172,605,512 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1166,625,863 - 166,638,315 (-)NCBICelera
RGSC_v3.11172,729,161 - 172,741,682 (-)NCBI
Cytogenetic Map1q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caesium atom  (EXP)
calciol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
disulfiram  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
inulin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
obeticholic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tebuconazole  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vitamin D, Hypertension, and Ischemic Stroke in 116 655 Individuals From the General Population: A Genetic Study. Afzal S and Nordestgaard BG, Hypertension. 2017 Jul 31:HYPERTENSIONAHA.117.09411. doi: 10.1161/HYPERTENSIONAHA.117.09411.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Triangular relationship between single nucleotide polymorphisms in the CYP2R1 gene (rs10741657 and rs12794714), 25-hydroxyvitamin d levels, and coronary artery disease incidence. Hassanein SI, etal., Biomarkers. 2014 Sep;19(6):488-92. doi: 10.3109/1354750X.2014.939226. Epub 2014 Jul 8.
4. Association of circulating 25-hydroxyvitamin D levels with hypertension and blood pressure values in Korean adults: A Mendelian randomization study on a subset of the Korea National Health and Nutrition Survey 2011-2012 population. Kwak SY, etal., Nutr Res Pract. 2019 Dec;13(6):498-508. doi: 10.4162/nrp.2019.13.6.498. Epub 2019 Aug 13.
5. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Ma R, etal., Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E928-35. doi: 10.1152/ajpendo.00279.2012. Epub 2012 Aug 7.
6. Vitamin-D dysregulation in early- and late-onset preeclampsia: A gestational-age matched study. Martin CB, etal., J Steroid Biochem Mol Biol. 2020 Oct;203:105729. doi: 10.1016/j.jsbmb.2020.105729. Epub 2020 Jul 15.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase. Rahmaniyan M, etal., Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E753-60. Epub 2004 Dec 7.
11. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Ramos-Lopez E, etal., Diabetes Metab Res Rev. 2007 Nov;23(8):631-6.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat. Tissandie E, etal., Arch Toxicol. 2006 Aug;80(8):473-80. Epub 2006 Feb 25.
17. Chronic contamination with 137Cesium affects Vitamin D3 metabolism in rats. Tissandie E, etal., Toxicology. 2006 Aug 1;225(1):75-80. Epub 2006 May 19.
18. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
19. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Vimaleswaran KS, etal., Lancet Diabetes Endocrinol. 2014 Sep;2(9):719-29. doi: 10.1016/S2213-8587(14)70113-5. Epub 2014 Jun 25.
20. Effect of Cytochrome P450 Family 2 Subfamily R Member 1 Variants on the Predisposition of Coronary Heart Disease in the Chinese Han Population. Wang Q, etal., Front Cardiovasc Med. 2021 Jun 28;8:652729. doi: 10.3389/fcvm.2021.652729. eCollection 2021.
21. Whole-Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke. Xie Y, etal., Stroke. 2023 Mar;54(3):800-809. doi: 10.1161/STROKEAHA.122.040883. Epub 2023 Feb 10.
22. The influence of CYP2R1 polymorphisms and gene-obesity interaction with hypertension risk in a Chinese rural population. Xu Z, etal., Nutr Metab Cardiovasc Dis. 2022 Jan;32(1):241-248. doi: 10.1016/j.numecd.2021.11.003. Epub 2021 Nov 11.
23. Associations of genetic polymorphisms of the vitamin D pathway with blood pressure in a Han Chinese population. Ye X, etal., Clin Exp Hypertens. 2019;41(5):460-465. doi: 10.1080/10641963.2018.1506469. Epub 2018 Sep 7.
Additional References at PubMed
PMID:12477932   PMID:12867411   PMID:15465040   PMID:18511070   PMID:18797846  


Genomics

Comparative Map Data
Cyp2r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,166,984 - 178,232,191 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,219,704 - 178,232,423 (-)EnsemblGRCr8
mRatBN7.21168,749,302 - 168,798,079 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,751,038 - 168,797,759 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,105,729 - 177,118,195 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,291,785 - 184,304,251 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,004,432 - 177,016,901 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1177,463,318 - 177,475,780 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1182,504,169 - 182,516,638 (-)NCBILyon_Normotensive
Lyon_Hypertensive1179,171,478 - 179,183,947 (-)NCBILyon_Hypertensive
F344_StmMcwi1177,414,897 - 177,427,366 (-)NCBIF344_StmMcwi
Rnor_6.01184,060,521 - 184,106,604 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,093,920 - 184,106,200 (-)Ensemblrn6Rnor6.0
Rnor_5.01191,032,655 - 191,078,746 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41172,593,057 - 172,605,512 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1166,625,863 - 166,638,315 (-)NCBICelera
RGSC_v3.11172,729,161 - 172,741,682 (-)NCBI
Cytogenetic Map1q34NCBI
CYP2R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,877,440 - 14,892,443 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,877,440 - 14,892,247 (-)Ensemblhg38GRCh38
GRCh371114,898,986 - 14,913,989 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,856,131 - 14,870,327 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341114,856,183 - 14,870,327NCBI
Celera1115,026,672 - 15,040,868 (-)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,581,996 - 14,596,194 (-)NCBIHuRef
CHM1_11114,898,541 - 14,912,738 (-)NCBICHM1_1
T2T-CHM13v2.01114,973,806 - 14,988,811 (-)NCBIT2T-CHM13v2.0
Cyp2r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,149,358 - 114,162,283 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,148,917 - 114,162,207 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387114,550,123 - 114,563,048 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,549,682 - 114,562,972 (-)Ensemblmm10GRCm38
MGSCv377121,693,680 - 121,706,486 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367114,341,347 - 114,354,153 (-)NCBIMGSCv36mm8
Celera7114,506,181 - 114,518,984 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.79NCBI
LOC102024786
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541429,928,644 - 29,948,484 (-)Ensembl
ChiLan1.0NW_00495541429,929,130 - 29,948,151 (-)NCBIChiLan1.0ChiLan1.0
CYP2R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,241,939 - 17,263,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,200,836 - 17,224,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,960,651 - 14,989,083 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,656,939 - 14,671,584 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,656,939 - 14,671,584 (-)EnsemblpanPan2panpan1.1
CYP2R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,553,883 - 37,579,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,552,732 - 37,606,725 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2137,053,097 - 37,079,853 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02138,647,594 - 38,674,701 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2138,649,539 - 38,674,887 (-)EnsemblROS_Cfam_1.0 Ensembl
Cyp2r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,848,045 - 47,866,726 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,881,087 - 3,900,302 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,881,630 - 3,897,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl244,375,520 - 44,396,334 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1244,375,432 - 44,394,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,676,732 - 47,695,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1150,030,366 - 50,043,833 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl150,031,218 - 50,047,403 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038147,527,420 - 147,540,720 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101724787
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,667,234 - 6,677,992 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247666,667,662 - 6,678,045 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116891632
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1286,987,098 - 86,999,558 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp2r1
457 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:55
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000067609
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Wox75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,791,280 - 168,791,507 (+)MAPPERmRatBN7.2
Rnor_6.01184,099,770 - 184,099,996NCBIRnor6.0
Rnor_5.01191,071,906 - 191,072,132UniSTSRnor5.0
RGSC_v3.41172,599,054 - 172,599,280UniSTSRGSC3.4
Celera1166,631,860 - 166,632,083UniSTS
Cytogenetic Map1q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 65 165 91 90 59 88 59 6 349 185 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067609   ⟹   ENSRNOP00000063152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,219,704 - 178,232,423 (-)Ensembl
mRatBN7.2 Ensembl1168,751,038 - 168,797,759 (-)Ensembl
Rnor_6.0 Ensembl1184,093,920 - 184,106,200 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112180   ⟹   ENSRNOP00000088981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,219,704 - 178,232,174 (-)Ensembl
mRatBN7.2 Ensembl1168,783,875 - 168,797,759 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115216   ⟹   ENSRNOP00000083680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,783,875 - 168,797,759 (-)Ensembl
RefSeq Acc Id: NM_001108499   ⟹   NP_001101969
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,219,708 - 178,232,163 (-)NCBI
mRatBN7.21168,785,284 - 168,797,739 (-)NCBI
Dahl_SR_JrHsd1177,463,322 - 177,475,769 (-)NCBI
Lyon_Normotensive1182,504,173 - 182,516,627 (-)NCBI
Lyon_Hypertensive1179,171,482 - 179,183,936 (-)NCBI
F344_StmMcwi1177,414,901 - 177,427,355 (-)NCBI
Rnor_6.01184,094,019 - 184,106,228 (-)NCBI
Rnor_5.01191,032,655 - 191,078,746 (-)NCBI
RGSC_v3.41172,593,057 - 172,605,512 (-)RGD
Celera1166,625,863 - 166,638,315 (-)RGD
Sequence:
RefSeq Acc Id: NM_001401627   ⟹   NP_001388556
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,219,704 - 178,232,174 (-)NCBI
mRatBN7.21168,785,280 - 168,797,750 (-)NCBI
Dahl_SR_JrHsd1177,463,318 - 177,475,780 (-)NCBI
Lyon_Normotensive1182,504,169 - 182,516,638 (-)NCBI
Lyon_Hypertensive1179,171,478 - 179,183,947 (-)NCBI
F344_StmMcwi1177,414,897 - 177,427,366 (-)NCBI
RefSeq Acc Id: XM_017589389   ⟹   XP_017444878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,218,289 - 178,232,191 (-)NCBI
mRatBN7.21168,780,367 - 168,798,079 (-)NCBI
Rnor_6.01184,092,606 - 184,106,603 (-)NCBI
Sequence:
RefSeq Acc Id: XR_010054618
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,166,984 - 178,232,191 (-)NCBI
RefSeq Acc Id: XR_010054620
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,166,984 - 178,232,191 (-)NCBI
RefSeq Acc Id: NP_001101969   ⟸   NM_001108499
- Peptide Label: isoform 2
- UniProtKB: A6I8B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444878   ⟸   XM_017589389
- Peptide Label: isoform X1
- UniProtKB: F7FAJ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063152   ⟸   ENSRNOT00000067609
Ensembl Acc Id: ENSRNOP00000083680   ⟸   ENSRNOT00000115216
Ensembl Acc Id: ENSRNOP00000088981   ⟸   ENSRNOT00000112180
RefSeq Acc Id: NP_001388556   ⟸   NM_001401627
- Peptide Label: isoform 1
- UniProtKB: A0A8I6A0G3 (UniProtKB/TrEMBL),   A6I8A9 (UniProtKB/TrEMBL),   F7FAJ1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7FAJ1-F1-model_v2 AlphaFold F7FAJ1 1-436 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690331
Promoter ID:EPDNEW_R856
Type:multiple initiation site
Name:Cyp2r1_1
Description:cytochrome P450, family 2, subfamily r, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,106,192 - 184,106,252EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311866 AgrOrtholog
BioCyc Gene G2FUF-57735 BioCyc
BioCyc Pathway PWY-6076 [vitamin D3 biosynthesis] BioCyc
BioCyc Pathway Image PWY-6076 BioCyc
Ensembl Genes ENSRNOG00000011367 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067609 ENTREZGENE
  ENSRNOT00000067609.5 UniProtKB/TrEMBL
  ENSRNOT00000112180.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
NCBI Gene 361631 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
  VITAMIN D 25-HYDROXYLASE UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PharmGKB CYP2R1 RGD
PhenoGen Cyp2r1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011367 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A8I6A0G3 ENTREZGENE
  A0A8I6GHN7_RAT UniProtKB/TrEMBL
  A6I8A9 ENTREZGENE, UniProtKB/TrEMBL
  A6I8B0 ENTREZGENE, UniProtKB/TrEMBL
  F7FAJ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyp2r1  cytochrome P450, family 2, subfamily r, polypeptide 1   Cyp2r1_predicted  cytochrome P450, family 2, subfamily r, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyp2r1_predicted  cytochrome P450, family 2, subfamily r, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED