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Gene: Gpr65 (G-protein coupled receptor 65) Rattus norvegicus

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Symbol:

Gpr65

Name:

G-protein coupled receptor 65

RGD ID:

1311832

Description:

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including positive regulation of T-helper cell differentiation; positive regulation of interleukin-22 production; and positive regulation of stress fiber assembly. Predicted to be located in membrane. Predicted to be active in early endosome membrane; late endosome membrane; and plasma membrane. Orthologous to human GPR65 (G protein-coupled receptor 65); INTERACTS WITH acetamide; alpha-Zearalanol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC299242; psychosine receptor; T cell death associated protein 8; Tdag8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR65 (G protein-coupled receptor 65)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr65 (G-protein coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gpr65 (G protein-coupled receptor 65)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GPR65 (G protein-coupled receptor 65)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GPR65 (G protein-coupled receptor 65)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr65 (G-protein coupled receptor 65)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr65 (G-protein coupled receptor 65)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpr65 (G protein-coupled receptor 65)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	gnrr-4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gpr65	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr65	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	123,245,534 - 123,262,758 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	123,219,633 - 123,266,285 (+)	Ensembl				GRCr8
mRatBN7.2	6	117,515,786 - 117,536,514 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	117,515,648 - 117,536,512 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	117,684,709 - 117,685,722 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	117,981,508 - 117,982,521 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	117,316,387 - 117,317,400 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	122,248,528 - 122,256,115 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	122,254,841 - 122,256,251 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	131,454,591 - 131,471,218 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	122,432,615 - 122,433,628 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	115,094,236 - 115,095,249 (+)	NCBI		Celera
RGSC_v3.1	6	122,436,361 - 122,453,748 (+)	NCBI
Cytogenetic Map	6	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

carmustine (ISO)

carrageenan (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

dioxygen (ISO)

diquat (ISO)

disodium selenite (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

L-methionine (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

pentanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SCH 23390 (EXP)

silicon dioxide (ISO)

sulforaphane (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trovafloxacin (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA,IEA,ISO)

cellular response to acidic pH (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

positive regulation of interleukin-22 production (ISO)

positive regulation of stress fiber assembly (IEA,ISO)

positive regulation of T-helper cell differentiation (ISO)

response to acidic pH (IEA,ISO)

signal transduction (IEA)

Cellular Component

early endosome membrane (IEA,ISO)

late endosome membrane (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15618224	PMID:19501050	PMID:28365474

Genomics

Comparative Map Data

Gpr65
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	123,245,534 - 123,262,758 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	123,219,633 - 123,266,285 (+)	Ensembl				GRCr8
mRatBN7.2	6	117,515,786 - 117,536,514 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	117,515,648 - 117,536,512 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	117,684,709 - 117,685,722 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	117,981,508 - 117,982,521 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	117,316,387 - 117,317,400 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	122,248,528 - 122,256,115 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	122,254,841 - 122,256,251 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	131,454,591 - 131,471,218 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	122,432,615 - 122,433,628 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	115,094,236 - 115,095,249 (+)	NCBI		Celera
RGSC_v3.1	6	122,436,361 - 122,453,748 (+)	NCBI
Cytogenetic Map	6	q32	NCBI

GPR65
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	88,005,135 - 88,014,811 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	88,005,135 - 88,014,811 (+)	Ensembl			hg38	GRCh38
GRCh37	14	88,471,479 - 88,481,155 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	87,541,249 - 87,548,168 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	87,541,248 - 87,548,167	NCBI
Celera	14	68,517,156 - 68,526,848 (+)	NCBI		Celera
Cytogenetic Map	14	q31.3	NCBI
HuRef	14	68,641,596 - 68,651,288 (+)	NCBI		HuRef
CHM1_1	14	88,409,597 - 88,419,284 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	82,225,763 - 82,235,439 (+)	NCBI		T2T-CHM13v2.0

Gpr65
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	98,234,894 - 98,242,981 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	98,234,894 - 98,242,903 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	98,268,635 - 98,276,722 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	98,268,635 - 98,276,644 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	99,506,867 - 99,514,842 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	98,669,707 - 98,677,682 (+)	NCBI		MGSCv36	mm8
Celera	12	99,494,305 - 99,502,244 (+)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	49.84	NCBI

Gpr65
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	10,729,659 - 10,730,660 (+)	Ensembl
ChiLan1.0	NW_004955438	10,724,069 - 10,730,868 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR65
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	89,149,357 - 89,153,296 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	88,365,863 - 88,369,802 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	68,617,219 - 68,624,158 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	87,977,315 - 87,984,261 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	87,983,034 - 87,984,047 (+)	Ensembl			panPan2	panpan1.1

GPR65
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	59,334,544 - 59,351,039 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	59,349,839 - 59,350,864 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	58,912,864 - 58,929,346 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	59,607,011 - 59,616,667 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	8	59,280,991 - 59,297,479 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	59,327,401 - 59,343,876 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	59,661,433 - 59,677,920 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gpr65
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	16,523,596 - 16,530,390 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	15,544,149 - 15,545,156 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	15,544,075 - 15,545,344 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR65
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	109,985,307 - 109,989,280 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	109,978,913 - 109,997,688 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	116,433,252 - 116,443,651 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR65
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	65,633,121 - 65,641,256 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	65,640,041 - 65,641,054 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	52,998,491 - 53,006,498 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr65
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	14,333,151 - 14,334,155 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624734	14,332,974 - 14,339,786 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gpr65
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	111,442,599 - 111,444,521 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gpr65
144 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	22
Count of miRNA genes:	22
Interacting mature miRNAs:	22
Transcripts:	ENSRNOT00000005055
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	114241077	147156653	Rat
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	112483610	147156653	Rat
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	110921244	147156653	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	118366855	147156653	Rat
1298087	Iddm18	Insulin dependent diabetes mellitus QTL 18		0.0001	urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	6	122236101	147156653	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	121444670	147156653	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	55	134	87	86	55	92	55	6	335	178	11	113	78	85	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039112063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF405799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005055 ⟹ ENSRNOP00000005055

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	122,254,841 - 122,256,251 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097200 ⟹ ENSRNOP00000078802

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	123,250,652 - 123,266,285 (+)	Ensembl
mRatBN7.2 Ensembl	6	117,515,648 - 117,536,512 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112227 ⟹ ENSRNOP00000094255

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	117,515,648 - 117,536,512 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000134563 ⟹ ENSRNOP00000105322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	123,244,005 - 123,263,284 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139166 ⟹ ENSRNOP00000107635

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	123,248,039 - 123,263,284 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161307 ⟹ ENSRNOP00000099482

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	123,244,252 - 123,263,284 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000169123 ⟹ ENSRNOP00000107465

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	123,219,633 - 123,263,284 (+)	Ensembl

RefSeq Acc Id:

NM_001106751 ⟹ NP_001100221

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	123,254,754 - 123,262,758 (+)	NCBI
mRatBN7.2	6	117,525,012 - 117,533,016 (+)	NCBI
Rnor_6.0	6	122,255,040 - 122,256,053 (+)	NCBI
Rnor_5.0	6	131,454,591 - 131,471,218 (+)	NCBI
RGSC_v3.4	6	122,432,615 - 122,433,628 (+)	RGD
Celera	6	115,094,236 - 115,095,249 (+)	RGD

Sequence:

show sequence

ATGACGATGAACAGCACATGTGTTGAAGAACAGCATGACCTGGACCACTATTTGTTCCCAGTGG
TCTACATATTTGTGTTTATAGTCAGCGTCCCAGCCAACATCGGCTCTTTATGTGTATCTTTTCT
GCAAGCGAAGAAGGAAAATGAACTAGGAGTTTACCTCTTCAGTCTGTCACTGTCAGATCTGCTG
TATGCGTTGACGCTGCCTCTCTGGATAAACTACACTTGGAATAAAGACAACTGGACGCTCTCTC
CCACCTTGTGCAAAGGAAGCGTTTTCTTCACCTACCTGAACTTTTACAGCAGCACGGCCTTCCT
CACTTGCATTGCCTTGGACCGCTATTTAGCAGTCGTCTACCCTCTAAGGTTTTCTTTTCTAAGA
ACAAGAAGATTTGCATTTATCACCAGCCTGTCTATCTGGATATTGGAATCCGTCTTTAACTCCA
TCCTTCTGTGGGAAGACGAAACAAGTGTCGAATACTGTGATGCAGAGAAATCTAATTTCACTCT
CTGCTATGACAAATACCCTCTGGAGAAGTGGCAGATAAACCTTAACCTGTTCAGGACTTTCCTG
GGCTACGCAATACCCTTGGTCACCATCATGATCTGCAACCATAAAGTCTACCGCGCCGTGAAGC
ACAACCAAGCTACGGAAAACAACGAAAGGAGACGGATCATAAAGCTGCTTGCCAGCATCACGCT
GACTTTCATCTTATGCTTTACCCCTTTCCACGTGATGGTGCTCATCCGCTGCATTTTAGAGCGC
AACGTGAACTTCAATAACAAGACTGGAAAGCAGACATTTACGGTGTACAGAATCACAGTGGCCC
TGACGAGTCTAAACTGTGTCGCCGATCCAATTCTCTACTGTTTCGTGACGGAAACCGGGAGATC
CGATATGTGGAACATATTAAAAGTGTGTGCTAGGAAGCGCAATAGATCCCGAGGACAAAAAAGA
GACATACTTTCTGTGTCCACAAGAGATACCATAGAACTGGAGATTATAGAATAA

hide sequence

RefSeq Acc Id:

XM_008764761 ⟹ XP_008762983

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	123,245,786 - 123,262,741 (+)	NCBI
mRatBN7.2	6	117,515,921 - 117,536,514 (+)	NCBI
Rnor_6.0	6	122,248,528 - 122,256,115 (+)	NCBI

Sequence:

show sequence

CTTCCTCATTGGCTTATGACAAAATACGAGCGCAATTTCCTGTCCCCACAACACTACTGGTTTC
TCTTCTTGATACAAGCAGAGTTGCCACCCTCCTCAGACAAGAGAAGCATCACTCCAGAAACGGA
ATCAGGACACTTTTAAAAGAACGCCCGGTGGTATGAAAATAAAACCAGGGTGTTCACAGCTTCA
CCAATCTCCAATCTCCTGTAAGATTCAAAAGAACAGATGAGAGGCTAAAATCCCATGATTCTAA
ACATGAAGACTTCTGATGGTTAAATCTAATTAACTGCTTTAAATCACCGCCAGGAGCTTGGATC
CTGACTTCTGGCAGTAATAGTCTGTGTAAAACTTCGATCTATAATCACTCTCTCAATGCCTGGA
TGCACTAATCAGAAACATAAGACACTGAGAGAAAACCCTGAGAGAAAGAGACTTTAACATTGAC
AATTTACAAGGCGAGAGTCCTTTCCCCATTTACAGCCTAAGAAGTAATGTAATAGCCACTGTAA
AGAAAAAATGACGATGAACAGCACATGTGTTGAAGAACAGCATGACCTGGACCACTATTTGTTC
CCAGTGGTCTACATATTTGTGTTTATAGTCAGCGTCCCAGCCAACATCGGCTCTTTATGTGTAT
CTTTTCTGCAAGCGAAGAAGGAAAATGAACTAGGAGTTTACCTCTTCAGTCTGTCACTGTCAGA
TCTGCTGTATGCGTTGACGCTGCCTCTCTGGATAAACTACACTTGGAATAAAGACAACTGGACG
CTCTCTCCCACCTTGTGCAAAGGAAGCGTTTTCTTCACCTACCTGAACTTTTACAGCAGCACGG
CCTTCCTCACTTGCATTGCCTTGGACCGCTATTTAGCAGTCGTCTACCCTCTAAGGTTTTCTTT
TCTAAGAACAAGAAGATTTGCATTTATCACCAGCCTGTCTATCTGGATATTGGAATCCGTCTTT
AACTCCATCCTTCTGTGGGAAGACGAAACAAGTGTCGAATACTGTGATGCAGAGAAATCTAATT
TCACTCTCTGCTATGACAAATACCCTCTGGAGAAGTGGCAGATAAACCTTAACCTGTTCAGGAC
TTTCCTGGGCTACGCAATACCCTTGGTCACCATCATGATCTGCAACCATAAAGTCTACCGCGCC
GTGAAGCACAACCAAGCTACGGAAAACAACGAAAGGAGACGGATCATAAAGCTGCTTGCCAGCA
TCACGCTGACTTTCATCTTATGCTTTACCCCTTTCCACGTGATGGTGCTCATCCGCTGCATTTT
AGAGCGCAACGTGAACTTCAATAACAAGACTGGAAAGCAGACATTTACGGTGTACAGAATCACA
GTGGCCCTGACGAGTCTAAACTGTGTCGCCGATCCAATTCTCTACTGTTTCGTGACGGAAACCG
GGAGATCCGATATGTGGAACATATTAAAAGTGTGTGCTAGGAAGCGCAATAGATCCCGAGGACA
AAAAAGAGACATACTTTCTGTGTCCACAAGAGATACCATAGAACTGGAGATTATAGAATAAAAA
GTAGAGGCCGGTTAAGTTACATGATATTATCTAATAAAAATTATACTTTGGAAAAGAAA

hide sequence

RefSeq Acc Id:

XM_039112061 ⟹ XP_038967989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	123,245,860 - 123,262,741 (+)	NCBI
mRatBN7.2	6	117,515,921 - 117,536,514 (+)	NCBI

RefSeq Acc Id:

XM_039112062 ⟹ XP_038967990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	123,245,534 - 123,262,741 (+)	NCBI
mRatBN7.2	6	117,515,786 - 117,536,514 (+)	NCBI

RefSeq Acc Id:

XM_039112063 ⟹ XP_038967991

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	123,250,127 - 123,262,741 (+)	NCBI
mRatBN7.2	6	117,520,916 - 117,536,514 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100221	(Get FASTA)	NCBI Sequence Viewer
	XP_008762983	(Get FASTA)	NCBI Sequence Viewer
	XP_038967989	(Get FASTA)	NCBI Sequence Viewer
	XP_038967990	(Get FASTA)	NCBI Sequence Viewer
	XP_038967991	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABN51177	(Get FASTA)	NCBI Sequence Viewer
	EDL81685	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078802
	ENSRNOP00000078802.1
	ENSRNOP00000099482
	ENSRNOP00000099482.1
	ENSRNOP00000105322
	ENSRNOP00000105322.1
	ENSRNOP00000107465
	ENSRNOP00000107465.1
	ENSRNOP00000107635
	ENSRNOP00000107635.1

RefSeq Acc Id:

NP_001100221 ⟸ NM_001106751

- UniProtKB:

B0YIR8 (UniProtKB/TrEMBL), A0A8I6AHC6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTMNSTCVEEQHDLDHYLFPVVYIFVFIVSVPANIGSLCVSFLQAKKENELGVYLFSLSLSDLL
YALTLPLWINYTWNKDNWTLSPTLCKGSVFFTYLNFYSSTAFLTCIALDRYLAVVYPLRFSFLR
TRRFAFITSLSIWILESVFNSILLWEDETSVEYCDAEKSNFTLCYDKYPLEKWQINLNLFRTFL
GYAIPLVTIMICNHKVYRAVKHNQATENNERRRIIKLLASITLTFILCFTPFHVMVLIRCILER
NVNFNNKTGKQTFTVYRITVALTSLNCVADPILYCFVTETGRSDMWNILKVCARKRNRSRGQKR
DILSVSTRDTIELEIIE

hide sequence

RefSeq Acc Id:	XP_008762983 ⟸ XM_008764761
- Peptide Label:	isoform X1
- UniProtKB:	B0YIR8 (UniProtKB/TrEMBL), A0A8I6AHC6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTMNSTCVEEQHDLDHYLFPVVYIFVFIVSVPANIGSLCVSFLQAKKENELGVYLFSLSLSDLL YALTLPLWINYTWNKDNWTLSPTLCKGSVFFTYLNFYSSTAFLTCIALDRYLAVVYPLRFSFLR TRRFAFITSLSIWILESVFNSILLWEDETSVEYCDAEKSNFTLCYDKYPLEKWQINLNLFRTFL GYAIPLVTIMICNHKVYRAVKHNQATENNERRRIIKLLASITLTFILCFTPFHVMVLIRCILER NVNFNNKTGKQTFTVYRITVALTSLNCVADPILYCFVTETGRSDMWNILKVCARKRNRSRGQKR DILSVSTRDTIELEIIE hide sequence

Ensembl Acc Id:

ENSRNOP00000005055 ⟸ ENSRNOT00000005055

RefSeq Acc Id:	XP_038967990 ⟸ XM_039112062
- Peptide Label:	isoform X1
- UniProtKB:	B0YIR8 (UniProtKB/TrEMBL), A0A8I6AHC6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967989 ⟸ XM_039112061
- Peptide Label:	isoform X1
- UniProtKB:	B0YIR8 (UniProtKB/TrEMBL), A0A8I6AHC6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967991 ⟸ XM_039112063
- Peptide Label:	isoform X1
- UniProtKB:	B0YIR8 (UniProtKB/TrEMBL), A0A8I6AHC6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000094255 ⟸ ENSRNOT00000112227

Ensembl Acc Id:

ENSRNOP00000078802 ⟸ ENSRNOT00000097200

Ensembl Acc Id:

ENSRNOP00000099482 ⟸ ENSRNOT00000161307

Ensembl Acc Id:

ENSRNOP00000107465 ⟸ ENSRNOT00000169123

Ensembl Acc Id:

ENSRNOP00000105322 ⟸ ENSRNOT00000134563

Ensembl Acc Id:

ENSRNOP00000107635 ⟸ ENSRNOT00000139166

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B0YIR8-F1-model_v2	AlphaFold	B0YIR8	1-337	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311832	AgrOrtholog
BioCyc Gene	G2FUF-36542	BioCyc
Ensembl Genes	ENSRNOG00000003806	Ensembl
	ENSRNOG00000065590	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000097200	ENTREZGENE
	ENSRNOT00000097200.2	UniProtKB/TrEMBL
	ENSRNOT00000134563	ENTREZGENE
	ENSRNOT00000134563.1	UniProtKB/TrEMBL
	ENSRNOT00000139166	ENTREZGENE
	ENSRNOT00000139166.1	UniProtKB/TrEMBL
	ENSRNOT00000161307	ENTREZGENE
	ENSRNOT00000161307.1	UniProtKB/TrEMBL
	ENSRNOT00000169123	ENTREZGENE
	ENSRNOT00000169123.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	7TM_GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_supfam	UniProtKB/TrEMBL
	Psych_rcpt	UniProtKB/TrEMBL
KEGG Report	rno:299242	UniProtKB/TrEMBL
NCBI Gene	299242	ENTREZGENE
PANTHER	G PROTEIN-COUPLED RECEPTOR 65	UniProtKB/TrEMBL
	LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Gpr65	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	PSYCHOSINER	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003806	RatGTEx
	ENSRNOG00000065590	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A8I6AHC6	ENTREZGENE, UniProtKB/TrEMBL
	B0YIR8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Gpr65	G-protein coupled receptor 65	Gpr65_predicted	G-protein coupled receptor 65 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gpr65_predicted	G-protein coupled receptor 65 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD