Gpr25 (G protein-coupled receptor 25) - Rat Genome Database

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Gene: Gpr25 (G protein-coupled receptor 25) Rattus norvegicus
Analyze
Symbol: Gpr25
Name: G protein-coupled receptor 25
RGD ID: 1311611
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GPR25 (G protein-coupled receptor 25); INTERACTS WITH amphetamine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363993; probable G-protein coupled receptor 25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,264,516 - 50,266,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1350,264,518 - 50,267,692 (-)EnsemblGRCr8
mRatBN7.21347,712,815 - 47,714,721 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,713,592 - 47,714,671 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1350,320,913 - 50,322,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,609,001 - 51,610,903 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,876,026 - 48,877,944 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,135,815 - 53,139,180 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,136,174 - 53,137,253 (-)Ensemblrn6Rnor6.0
Rnor_5.01358,188,054 - 58,189,133 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41349,299,541 - 49,300,620 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1348,025,422 - 48,028,552 (-)NCBICelera
RGSC_v3.11349,313,620 - 49,320,619 (-)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Gpr25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,264,516 - 50,266,422 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1350,264,518 - 50,267,692 (-)EnsemblGRCr8
mRatBN7.21347,712,815 - 47,714,721 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,713,592 - 47,714,671 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1350,320,913 - 50,322,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,609,001 - 51,610,903 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,876,026 - 48,877,944 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,135,815 - 53,139,180 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,136,174 - 53,137,253 (-)Ensemblrn6Rnor6.0
Rnor_5.01358,188,054 - 58,189,133 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41349,299,541 - 49,300,620 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1348,025,422 - 48,028,552 (-)NCBICelera
RGSC_v3.11349,313,620 - 49,320,619 (-)NCBI
Cytogenetic Map13q13NCBI
GPR25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381200,872,981 - 200,874,178 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1200,872,981 - 200,874,178 (+)Ensemblhg38GRCh38
GRCh371200,842,109 - 200,843,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,108,789 - 199,109,874 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341197,573,822 - 197,574,908NCBI
Celera1173,966,237 - 173,967,322 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,009,206 - 172,010,429 (+)NCBIHuRef
CHM1_11202,264,763 - 202,265,986 (+)NCBICHM1_1
T2T-CHM13v2.01200,129,959 - 200,131,156 (+)NCBIT2T-CHM13v2.0
Gpr25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391136,186,652 - 136,188,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1136,187,535 - 136,188,611 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381136,258,914 - 136,260,926 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,259,797 - 136,260,873 (-)Ensemblmm10GRCm38
MGSCv371138,155,491 - 138,157,450 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361138,075,822 - 138,077,311 (-)NCBIMGSCv36mm8
MGSCv361137,131,083 - 137,132,509 (-)NCBIMGSCv36mm8
Celera1138,894,811 - 138,896,597 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.61NCBI
Gpr25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,065,610 - 37,066,674 (+)Ensembl
ChiLan1.0NW_00495540637,065,511 - 37,066,771 (+)NCBIChiLan1.0ChiLan1.0
GPR25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2148,505,463 - 48,516,012 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1148,469,060 - 48,474,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,473,049 - 176,474,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11180,776,104 - 180,777,932 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1180,776,181 - 180,777,215 (+)EnsemblpanPan2panpan1.1
GPR25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.172,303,398 - 2,305,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl72,304,913 - 2,305,986 (-)EnsemblcanFam3CanFam3.1
Gpr25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934474,249,014 - 74,251,401 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,484,708 - 3,485,793 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,484,082 - 3,485,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,369,321 - 23,370,418 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11023,369,202 - 23,370,620 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GPR25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,529,682 - 28,533,545 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,530,364 - 28,531,449 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605529,329,854 - 29,331,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,754,779 - 9,755,873 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248079,753,874 - 9,755,905 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr25
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:100
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000011368
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134778041850392939Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 18 98 28 38 12 90 12 3 171 118 5 89 28 44 26 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000011368   ⟹   ENSRNOP00000011368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1350,264,518 - 50,267,692 (-)Ensembl
mRatBN7.2 Ensembl1347,713,592 - 47,714,671 (-)Ensembl
Rnor_6.0 Ensembl1353,136,174 - 53,137,253 (-)Ensembl
RefSeq Acc Id: NM_001398594   ⟹   NP_001385523
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,264,516 - 50,266,422 (-)NCBI
mRatBN7.21347,712,815 - 47,714,721 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385523 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09662 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011368
  ENSRNOP00000011368.3
Ensembl Acc Id: ENSRNOP00000011368   ⟸   ENSRNOT00000011368
RefSeq Acc Id: NP_001385523   ⟸   NM_001398594
- UniProtKB: D4A7G6 (UniProtKB/TrEMBL),   A6ICI5 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7G6-F1-model_v2 AlphaFold D4A7G6 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311611 AgrOrtholog
BioCyc Gene G2FUF-18176 BioCyc
Ensembl Genes ENSRNOG00000008603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011368 ENTREZGENE
  ENSRNOT00000011368.6 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  ATII_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
NCBI Gene 363993 ENTREZGENE
PANTHER CELL ADHESION MOLECULE UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR 25 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr25 PhenoGen
PRINTS ANGIOTENSINR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008603 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6ICI5 ENTREZGENE, UniProtKB/TrEMBL
  D4A7G6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Gpr25  G protein-coupled receptor 25   Gpr25_predicted  G protein-coupled receptor 25 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr25_predicted  G protein-coupled receptor 25 (predicted)      Symbol and Name status set to approved 70820 APPROVED