Champ1 (chromosome alignment maintaining phosphoprotein 1) - Rat Genome Database

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Gene: Champ1 (chromosome alignment maintaining phosphoprotein 1) Rattus norvegicus
Analyze
Symbol: Champ1
Name: chromosome alignment maintaining phosphoprotein 1
RGD ID: 1311283
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore; protein localization to kinetochore; and protein localization to microtubule. Predicted to be located in kinetochore and nucleus. Predicted to be active in nucleoplasm and spindle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 40. Orthologous to human CHAMP1 (chromosome alignment maintaining phosphoprotein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chromosome alignment-maintaining phosphoprotein 1; LOC306647; RGD1311283; similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H); Zfp828; zinc finger protein 828
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,436,172 - 82,447,144 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1682,434,823 - 82,458,984 (-)EnsemblGRCr8
mRatBN7.21675,733,958 - 75,744,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,733,805 - 75,744,984 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1681,014,434 - 81,025,580 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,467,964 - 84,479,110 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,717,822 - 79,728,765 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01680,839,373 - 80,850,340 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,839,374 - 80,850,340 (-)Ensemblrn6Rnor6.0
Rnor_5.01680,403,594 - 80,414,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41680,569,713 - 80,573,705 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1673,542,848 - 73,553,807 (-)NCBICelera
RGSC_v3.11680,571,519 - 80,573,925 (-)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
condensed chromosome  (ISO)
kinetochore  (IEA,ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)
spindle  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16176808   PMID:17070521   PMID:21063390  


Genomics

Comparative Map Data
Champ1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,436,172 - 82,447,144 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1682,434,823 - 82,458,984 (-)EnsemblGRCr8
mRatBN7.21675,733,958 - 75,744,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1675,733,805 - 75,744,984 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1681,014,434 - 81,025,580 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01684,467,964 - 84,479,110 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01679,717,822 - 79,728,765 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01680,839,373 - 80,850,340 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1680,839,374 - 80,850,340 (-)Ensemblrn6Rnor6.0
Rnor_5.01680,403,594 - 80,414,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41680,569,713 - 80,573,705 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1673,542,848 - 73,553,807 (-)NCBICelera
RGSC_v3.11680,571,519 - 80,573,925 (-)NCBI
Cytogenetic Map16q12.5NCBI
CHAMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813114,314,503 - 114,327,322 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13114,314,482 - 114,337,626 (+)Ensemblhg38GRCh38
GRCh3713115,079,978 - 115,092,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613114,098,117 - 114,110,899 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3413114,098,116 - 114,110,898NCBI
Celera1395,752,593 - 95,765,430 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1395,342,333 - 95,355,170 (+)NCBIHuRef
CHM1_113115,048,734 - 115,061,571 (+)NCBICHM1_1
T2T-CHM13v2.013113,523,561 - 113,536,364 (+)NCBIT2T-CHM13v2.0
Champ1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,919,699 - 13,931,637 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,919,641 - 13,931,639 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38813,869,641 - 13,881,639 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,869,641 - 13,881,639 (+)Ensemblmm10GRCm38
MGSCv37813,869,641 - 13,881,639 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36813,869,706 - 13,880,546 (+)NCBIMGSCv36mm8
Celera814,029,945 - 14,041,943 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.4NCBI
Champ1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554044,445 - 6,877 (-)Ensembl
ChiLan1.0NW_0049554043,228 - 14,695 (-)NCBIChiLan1.0ChiLan1.0
CHAMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214115,810,642 - 115,823,942 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113114,491,108 - 114,504,424 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01395,382,649 - 95,411,763 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113114,454,742 - 114,460,958 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13114,457,481 - 114,459,919 (+)EnsemblpanPan2panpan1.1
CHAMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12261,367,007 - 61,378,111 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2261,368,049 - 61,378,111 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2261,078,383 - 61,089,567 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02262,053,743 - 62,064,929 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2262,052,677 - 62,068,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12261,491,295 - 61,502,477 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02261,497,927 - 61,508,902 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02261,526,892 - 61,538,074 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Champ1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945196,220,651 - 196,229,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937030274,074 - 276,515 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004937030268,400 - 279,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHAMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1392,104,268 - 92,119,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl392,115,535 - 92,117,976 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604649,399,494 - 49,414,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Champ1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793111,025 - 113,526 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624793109,854 - 121,461 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Champ1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11369,900,606 - 69,915,327 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Champ1
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:361
Count of miRNA genes:224
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000000124
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat

Markers in Region
AU049290  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q12.5UniSTS
RH129359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21675,734,116 - 75,734,317 (+)MAPPERmRatBN7.2
Rnor_6.01680,839,532 - 80,839,732NCBIRnor6.0
Rnor_5.01680,403,753 - 80,403,953UniSTSRnor5.0
RGSC_v3.41680,569,868 - 80,570,068UniSTSRGSC3.4
Celera1673,543,003 - 73,543,203UniSTS
RH 3.4 Map16731.2UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000124   ⟹   ENSRNOP00000000124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1682,436,063 - 82,440,056 (-)Ensembl
mRatBN7.2 Ensembl1675,733,805 - 75,744,984 (-)Ensembl
Rnor_6.0 Ensembl1680,839,374 - 80,850,340 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171106   ⟹   ENSRNOP00000109900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1682,434,823 - 82,447,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172946   ⟹   ENSRNOP00000112545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1682,436,156 - 82,458,984 (-)Ensembl
RefSeq Acc Id: NM_001107329   ⟹   NP_001100799
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,436,172 - 82,447,144 (-)NCBI
mRatBN7.21675,733,958 - 75,744,931 (-)NCBI
Rnor_6.01680,839,377 - 80,850,340 (-)NCBI
Rnor_5.01680,403,594 - 80,414,561 (-)NCBI
RGSC_v3.41680,569,713 - 80,573,705 (-)RGD
Celera1673,542,848 - 73,553,807 (-)RGD
Sequence:
RefSeq Acc Id: NM_001419089   ⟹   NP_001406018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,436,172 - 82,447,144 (-)NCBI
mRatBN7.21675,733,958 - 75,744,931 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100799 (Get FASTA)   NCBI Sequence Viewer  
  NP_001406018 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68662 (Get FASTA)   NCBI Sequence Viewer  
  EDM08915 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000124
  ENSRNOP00000000124.3
  ENSRNOP00000109900
  ENSRNOP00000109900.1
  ENSRNOP00000112545.1
RefSeq Acc Id: NP_001100799   ⟸   NM_001107329
- UniProtKB: B5DEG7 (UniProtKB/TrEMBL),   A6IWF8 (UniProtKB/TrEMBL),   F7EUM4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000124   ⟸   ENSRNOT00000000124
RefSeq Acc Id: NP_001406018   ⟸   NM_001419089
- UniProtKB: B5DEG7 (UniProtKB/TrEMBL),   A6IWF8 (UniProtKB/TrEMBL),   F7EUM4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112545   ⟸   ENSRNOT00000172946
Ensembl Acc Id: ENSRNOP00000109900   ⟸   ENSRNOT00000171106
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEG7-F1-model_v2 AlphaFold B5DEG7 1-801 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311283 AgrOrtholog
BioCyc Gene G2FUF-10737 BioCyc
Ensembl Genes ENSRNOG00000000112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000124 ENTREZGENE
  ENSRNOT00000000124.7 UniProtKB/TrEMBL
  ENSRNOT00000171106 ENTREZGENE
  ENSRNOT00000171106.1 UniProtKB/TrEMBL
  ENSRNOT00000172946.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro CAMP UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:306647 UniProtKB/TrEMBL
NCBI Gene 306647 ENTREZGENE
PANTHER CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1 UniProtKB/TrEMBL
  PTHR37354 UniProtKB/TrEMBL
PhenoGen Champ1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000112 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A6IWF8 ENTREZGENE, UniProtKB/TrEMBL
  B5DEG7 ENTREZGENE
  F7EUM4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5DEG7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Champ1  chromosome alignment maintaining phosphoprotein 1  Zfp828  zinc finger protein 828  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Zfp828  zinc finger protein 828  RGD1311283_predicted  similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311283_predicted  similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) (predicted)  LOC306647_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306647_predicted  similar to Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL