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Gene: Gpr157 (G protein-coupled receptor 157) Rattus norvegicus

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Symbol:

Gpr157

Name:

G protein-coupled receptor 157

RGD ID:

1311096

Description:

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; circadian behavior; and radial glial cell differentiation. Predicted to be located in ciliary membrane. Predicted to be active in plasma membrane. Orthologous to human GPR157 (G protein-coupled receptor 157); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G-protein coupled receptor 157; LOC313725; MGC109533; probable G-protein coupled receptor 157

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR157 (G protein-coupled receptor 157)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gpr157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gpr157 (G protein-coupled receptor 157)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LDHAL6B (lactate dehydrogenase A like 6B)	HGNC	OMA
Homo sapiens (human):	LDHAL6A (lactate dehydrogenase A like 6A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GPR157 (G protein-coupled receptor 157)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr157 (G protein-coupled receptor 157)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpr157 (G protein-coupled receptor 157)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GPR1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gpr157	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	165,833,651 - 165,849,376 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	165,833,673 - 165,851,280 (+)	Ensembl				GRCr8
mRatBN7.2	5	160,550,703 - 160,566,432 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	160,550,713 - 160,566,432 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	163,267,195 - 163,282,912 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,089,378 - 165,105,226 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,045,749 - 165,061,597 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,109,691 - 167,125,380 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,109,691 - 167,125,380 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	170,750,442 - 170,766,069 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	167,205,605 - 167,223,745 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	158,812,331 - 158,828,028 (+)	NCBI		Celera
RGSC_v3.1	5	167,215,792 - 167,233,933 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

bortezomib (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

dimethylarsinic acid (ISO)

dioxygen (EXP)

doxorubicin (ISO)

entinostat (ISO)

folic acid (ISO)

gentamycin (EXP)

inulin (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methylarsonic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA)

cell differentiation (IEA)

cell surface receptor signaling pathway (IEA)

circadian behavior (IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA,ISO,ISS)

radial glial cell differentiation (IEA,ISO,ISS)

signal transduction (IEA)

Cellular Component

ciliary membrane (IEA,ISO,ISS)

membrane (IEA)

plasma membrane (IBA)

Molecular Function

G protein-coupled receptor activity (IBA,IEA,ISO,ISS)

transmembrane signaling receptor activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:27142930

Genomics

Comparative Map Data

Gpr157
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	165,833,651 - 165,849,376 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	165,833,673 - 165,851,280 (+)	Ensembl				GRCr8
mRatBN7.2	5	160,550,703 - 160,566,432 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	160,550,713 - 160,566,432 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	163,267,195 - 163,282,912 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,089,378 - 165,105,226 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,045,749 - 165,061,597 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,109,691 - 167,125,380 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,109,691 - 167,125,380 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	170,750,442 - 170,766,069 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	167,205,605 - 167,223,745 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	158,812,331 - 158,828,028 (+)	NCBI		Celera
RGSC_v3.1	5	167,215,792 - 167,233,933 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

GPR157
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	9,100,305 - 9,129,102 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	9,100,305 - 9,129,122 (-)	Ensembl			hg38	GRCh38
GRCh37	1	9,160,364 - 9,189,161 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	9,087,063 - 9,111,816 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	9,098,741 - 9,123,495	NCBI
Celera	1	8,273,844 - 8,298,831 (-)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	8,314,669 - 8,339,557 (-)	NCBI		HuRef
CHM1_1	1	9,154,653 - 9,179,610 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	8,634,357 - 8,663,346 (-)	NCBI		T2T-CHM13v2.0

Gpr157
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	150,171,960 - 150,190,457 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	150,171,822 - 150,190,384 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	150,087,503 - 150,105,927 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	150,087,365 - 150,105,927 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	149,461,612 - 149,480,036 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	148,931,165 - 148,948,167 (+)	NCBI		MGSCv36	mm8
Celera	4	152,363,542 - 152,381,935 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	80.89	NCBI

Gpr157
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	4,172,515 - 4,189,137 (+)	Ensembl
ChiLan1.0	NW_004955486	4,172,515 - 4,188,887 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR157
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	219,104,545 - 219,133,308 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	217,749,151 - 217,778,053 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	7,857,904 - 7,884,669 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	9,093,479 - 9,117,743 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	9,093,493 - 9,117,748 (-)	Ensembl			panPan2	panpan1.1

GPR157
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	62,453,338 - 62,471,614 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	62,454,921 - 62,508,970 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	62,470,724 - 62,489,028 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	62,680,187 - 62,698,261 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	62,682,328 - 62,698,261 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	62,678,315 - 62,696,346 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	62,541,859 - 62,560,054 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	62,946,549 - 62,964,604 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gpr157
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	32,780,436 - 32,796,613 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	3,264,403 - 3,281,931 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	3,264,409 - 3,281,857 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR157
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	69,557,701 - 69,581,643 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	69,558,940 - 69,581,656 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GPR157
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	122,631,383 - 122,650,163 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	122,632,218 - 122,649,115 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	26,596,694 - 26,671,603 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr157
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	3,109,407 - 3,123,912 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624818	3,109,457 - 3,123,819 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gpr157
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	10,656,866 - 10,672,405 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gpr157
87 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	168
Count of miRNA genes:	115
Interacting mature miRNAs:	144
Transcripts:	ENSRNOT00000055536
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	160111176	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	156396728	172190305	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	160071170	172129029	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	156396728	167181764	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	156289283	171137955	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Markers in Region

AA944747

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	160,563,129 - 160,563,323 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	167,122,078 - 167,122,271	NCBI	Rnor6.0
Rnor_5.0	5	170,762,767 - 170,762,960	UniSTS	Rnor5.0
RGSC_v3.4	5	167,219,708 - 167,219,901	UniSTS	RGSC3.4
Celera	5	158,824,726 - 158,824,919	UniSTS
RH 3.4 Map	5	1120.8	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	160	91	90	59	77	59	6	335	176	11	139	76	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC090013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055536 ⟹ ENSRNOP00000052398

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	165,833,673 - 165,851,280 (+)	Ensembl
mRatBN7.2 Ensembl	5	160,550,713 - 160,566,432 (+)	Ensembl
Rnor_6.0 Ensembl	5	167,109,691 - 167,125,380 (+)	Ensembl

RefSeq Acc Id:

NM_001012107 ⟹ NP_001012107

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	165,833,661 - 165,849,376 (+)	NCBI
mRatBN7.2	5	160,550,713 - 160,566,432 (+)	NCBI
Rnor_6.0	5	167,109,691 - 167,125,380 (+)	NCBI
Rnor_5.0	5	170,750,442 - 170,766,069 (+)	NCBI
RGSC_v3.4	5	167,205,605 - 167,223,745 (+)	RGD
Celera	5	158,812,331 - 158,828,028 (+)	RGD

Sequence:

show sequence

AGGACTCAGGGTAGGATTGTAGAGCTTAGCAGCAGGGAGTGGAGGGCGCCGCGGGGAGACGCCG
GCTGTGTAGTTGATAGACTGGGCGGGGCTGGGACGCAGGCGGGACCCGTGGGGACGCGAGCCCG
GGCGCCTTGATGCCCAGACAGAGGCGACCGCGGGCTCTGCTTGGTCACGACCTCTCGGCACCCT
TGGGCCTGTGCACCCTGGCCGTCTGCCCTTGGTCCCCAGCCGGCCATGCCCACACCCGCGCCTC
CCACCGAGCTGCTGCCGTGGGAGCGCGCGGTGGTACTGCTGTCCTGTGTGCTGTCAGCTCTGGG
CTCCGGCCTCCTGGTGGCCACGCACGCCCTGTGGCCTGACCTGCGTAGCCGGGCTCGGCGCCTG
CTACTCTTCCTGTCGCTGGCGGACCTGCTCTCGGCTGCCTCGTACTTCTACGGAGTGCTGCAGG
ACTTTGCGGGCACTTCGTGGGATTGCGTCCTTCAGGGCGCGCTCTCTACTTTCGCCAACACCAG
TTCCTTCTTCTGGACCGTGGCCATCGCCCTCTACCTATACCTCAATATCGTCCGAGCTACGCGC
GGGCCCTGCACGGACCACCTAGTCTGGGCTTTTCACCTCATCAGCTGGGGTGTCCCGTTGGCTA
TCACAGTGGCAGCCGTCTGTCTAAAGAAGATAGGCTACGATGCCTCTGATGTGTCCGTGGGCTG
GTGCTGGATCAACCTGGAGGCCGAGGACCGTGTCCTGTGGATGCTACTGACCGGGAAGCTGTGG
GAGATGCTGGCTTACATCTTGCTACCTCTGCTGTACCTTTTGGTCAGGAAGCACATCAACAGGG
CGCACCAGGCGCTCTCGGAGTACCGGCCCATCTGGGAGGGGCGCCAGCTGCAGCGAGGCTCCCC
CACCTCCATGGCTGATAAGAAACTGATCCTCATTCCCTTCATATTCATCTGCCTCCGGGTCTGG
AGCACCGTGCGCTTTGTCCTGACCCTCTGTGGCTCCCCGGTTGTGCAGGCACCGGTGCTGGTTG
TTCTACATGGCATTGGAAACACCTTCCAGGGAGGGGCCAACTGCATCATGTTTGTCCTCTGCAC
CCGGGCGGTCCGCACAAGGCTCTTCTCTCTCTGCTGCTGCTATCCTCGGCCCCCCACCCAGAAC
CCTCCTGGGGCTTCCATTCCCCCCAAGATGGGGGAATCTCAGGAATCCAGACGGACCCCAGAAG
TGCCCAGCACTTGAATAGTTGGTTTCCCTCACTGTTCTCGCTGGTGCTGCCTTCCTGGTTCCTG
CTTCAGGATTCGGGGACCAAGCACACTGGAAGCCTCGCCTAGTGAAGCTCGGAGCCCGGTGGAG
AGGCAGCCATCAGTGTGGACTCTTCCACCTCCCAGAATCACAGGCAGGCAGTGCATTCCTTGCA
CACTCGAGTCCCTGGTTTAGTGGGGTTTGATTGTGTGAGCACAAAGACCGTGAGATTCAGCCAT
GCAGGATACTGCCCGGACACAGTTTCCCGGTGTCCCCGGGCCACCAGAGCTGTTTACAGATGGA
TCCACACCTGTGGACCCATCCCAGGCATGACCGAACATCTTCTTGGATCCCAGACATCACAGTA
TGGAGTCCAGGTTTGCCAGGGTGTTGAGAATCCCTAGAGACCCTGAGGGTAATCAGCAGTGCTG
GTCAGCAGAGGGTAACATCCTTAGACTAGGTCCCAAGTCCACCCAAGTCACAGAGGAATGCCAT
CATTGATCAAAACCACCCAGGCCCACGCTCATGGGAATCTCACGGAGTCTCTGCGTGGGTCATC
CGTCACCCCTCGATGTTTATTACATCTGAATTTCAGCACAGGCCAGAGTCCAGAGTCCTGGCCA
TTAGTCAATCACTTAGCATCCACGTCCCCTCCCAGTACTAGGACAGAAGGTAGCTCAGCTCCCA
GTCCCTGTGGACGCCTGCTGTTCTCACAGAACCCTGTCCTCACGGTGACTCATACAGGGGTGAG
TGGGGAGCGGGGTCTGGTTCTGCACTTTGCTTAGGAAAAGGTGGAACTGATTCTACCCCGAAGG
TCAATGTTTTAAGATTCAGCCTCAGGCTGGACCTGTAGCTCAGTGTAGTTTCCAGGTTGGTCCT
AGCACCCAAAATACAAAGAGCCTCTGTGTTTTGTTTTGTATTTATCTGGGGGATAGGATTCTGA
GATGATTGCATTTTATTTTACGTTTTGAAACAGGGTCTCATGGACCTGCTGACCTGGAACTTGC
TAGGTAGATCAGGCTGGCCTCAAACTCACAGAGATCCACCTGCCTCTGCCCCCTGATGATTAGA
TTTTTAAAAAATGTTTTGTTTTGTTGTGTTGTGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039110103 ⟹ XP_038966031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	165,833,651 - 165,847,631 (+)	NCBI
mRatBN7.2	5	160,550,703 - 160,564,687 (+)	NCBI

RefSeq Acc Id:

XR_005504463

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	165,833,651 - 165,847,627 (+)	NCBI
mRatBN7.2	5	160,550,703 - 160,564,682 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012107	(Get FASTA)	NCBI Sequence Viewer
	XP_038966031	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH90013	(Get FASTA)	NCBI Sequence Viewer
	EDL81177	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052398
	ENSRNOP00000052398.1
GenBank Protein	Q5FVG1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012107 ⟸ NM_001012107

- UniProtKB:

Q5FVG1 (UniProtKB/Swiss-Prot), A6IUC6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPTPAPPTELLPWERAVVLLSCVLSALGSGLLVATHALWPDLRSRARRLLLFLSLADLLSAASY
FYGVLQDFAGTSWDCVLQGALSTFANTSSFFWTVAIALYLYLNIVRATRGPCTDHLVWAFHLIS
WGVPLAITVAAVCLKKIGYDASDVSVGWCWINLEAEDRVLWMLLTGKLWEMLAYILLPLLYLLV
RKHINRAHQALSEYRPIWEGRQLQRGSPTSMADKKLILIPFIFICLRVWSTVRFVLTLCGSPVV
QAPVLVVLHGIGNTFQGGANCIMFVLCTRAVRTRLFSLCCCYPRPPTQNPPGASIPPKMGESQE
SRRTPEVPST

hide sequence

Ensembl Acc Id:

ENSRNOP00000052398 ⟸ ENSRNOT00000055536

RefSeq Acc Id:	XP_038966031 ⟸ XM_039110103
- Peptide Label:	isoform X1

Protein Domains

G-protein coupled receptors family 1 profile G-protein coupled receptors family 2 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVG1-F1-model_v2	AlphaFold	Q5FVG1	1-330	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311096	AgrOrtholog
BioCyc Gene	G2FUF-39082	BioCyc
Ensembl Genes	ENSRNOG00000017528	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000055536	ENTREZGENE
	ENSRNOT00000055536.2	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7324631	IMAGE-MGC_LOAD
InterPro	GCR1-cAMP_receptor	UniProtKB/Swiss-Prot
	GPCR_2-like	UniProtKB/Swiss-Prot
	GPCR_2_secretin-like	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
KEGG Report	rno:313725	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109533	IMAGE-MGC_LOAD
NCBI Gene	313725	ENTREZGENE
PANTHER	G PROTEIN-COUPLED RECEPTOR 157-RELATED	UniProtKB/Swiss-Prot
	G-PROTEIN COUPLED RECEPTOR 157	UniProtKB/Swiss-Prot
Pfam	7tm_2	UniProtKB/Swiss-Prot
PhenoGen	Gpr157	PhenoGen
PRINTS	GCR1CAMPR	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017528	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A6IUC6	ENTREZGENE, UniProtKB/TrEMBL
	GP157_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Gpr157	G protein-coupled receptor 157	Gpr157_predicted	G protein-coupled receptor 157 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Gpr157_predicted	G protein-coupled receptor 157 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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