Dux4 (double homeobox 4) - Rat Genome Database

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Gene: Dux4 (double homeobox 4) Rattus norvegicus
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Symbol: Dux4
Name: double homeobox 4
RGD ID: 1311053
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation of G0 to G1 transition; negative regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of T cell differentiation. Predicted to be located in cytoplasm; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including DUXB (double homeobox B); INTERACTS WITH amphetamine; Cuprizon; methamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: double homeobox B-like; double homeobox B-like 1; double homeobox protein 4C-like; double homeobox protein B; Duxbl; Duxbl1; LOC306226; RGD1311053; similar to double homeobox protein
RGD Orthologs
Human
Mouse
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,565,290 - 1,575,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl161,567,553 - 1,575,468 (+)EnsemblGRCr8
mRatBN7.2161,558,430 - 1,570,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,558,766 - 1,568,565 (+)EnsemblmRatBN7.2
Rnor_6.0163,754,968 - 3,766,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,754,968 - 3,765,917 (-)Ensemblrn6Rnor6.0
Rnor_5.0163,720,950 - 3,732,462 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4161,600,636 - 1,606,916 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera161,534,238 - 1,545,775 (+)NCBICelera
RGSC_v3.1161,597,461 - 1,606,066 (+)NCBI
Cytogenetic Map16p16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nuclear membrane  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17588759   PMID:17984056   PMID:24589735   PMID:30315230   PMID:30322619  


Genomics

Comparative Map Data
Dux4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8161,565,290 - 1,575,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl161,567,553 - 1,575,468 (+)EnsemblGRCr8
mRatBN7.2161,558,430 - 1,570,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl161,558,766 - 1,568,565 (+)EnsemblmRatBN7.2
Rnor_6.0163,754,968 - 3,766,532 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,754,968 - 3,765,917 (-)Ensemblrn6Rnor6.0
Rnor_5.0163,720,950 - 3,732,462 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4161,600,636 - 1,606,916 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera161,534,238 - 1,545,775 (+)NCBICelera
RGSC_v3.1161,597,461 - 1,606,066 (+)NCBI
Cytogenetic Map16p16NCBI
DUX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384190,173,774 - 190,185,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4190,173,774 - 190,185,942 (+)Ensemblhg38GRCh38
Cytogenetic Map4q35.2NCBI
CHM1_14190,981,942 - 190,983,445 (+)NCBICHM1_1
T2T-CHM13v2.04193,541,579 - 193,553,139 (+)NCBIT2T-CHM13v2.0
Duxbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391425,979,011 - 25,990,590 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1425,979,001 - 25,990,512 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381425,978,560 - 25,990,166 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,118,349 - 26,129,763 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1425,978,577 - 25,990,088 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1426,257,962 - 26,269,436 (+)Ensemblmm10GRCm38
MGSCv371426,802,491 - 26,809,318 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361424,816,189 - 24,823,016 (+)NCBIMGSCv36mm8
Cytogenetic Map14A3NCBI
cM Map1415.3NCBI
LOC100683783
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11764,277,421 - 64,282,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,676,530 - 63,684,952 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01765,398,792 - 65,407,412 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11764,194,207 - 64,199,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01764,260,323 - 64,264,770 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,995,675 - 64,998,742 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
UU_Cfam_GSD_1.01764,999,186 - 65,004,132 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
DUX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037116,205,175 - 116,206,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Dux4
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:91
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000052224
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
631524Bp75Blood pressure QTL 750.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)161177108157035Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168392304234212Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 82 59 6 342 182 11 141 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000052224   ⟹   ENSRNOP00000044374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl161,567,553 - 1,575,468 (+)Ensembl
mRatBN7.2 Ensembl161,558,766 - 1,568,565 (+)Ensembl
Rnor_6.0 Ensembl163,754,968 - 3,762,877 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088284   ⟹   ENSRNOP00000075215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl163,759,627 - 3,765,917 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099184   ⟹   ENSRNOP00000079337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl161,567,553 - 1,573,008 (+)Ensembl
mRatBN7.2 Ensembl161,558,766 - 1,566,240 (+)Ensembl
RefSeq Acc Id: XM_063275801   ⟹   XP_063131871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8161,565,290 - 1,575,317 (+)NCBI
RefSeq Acc Id: XM_063275802   ⟹   XP_063131872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8161,565,290 - 1,575,317 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419931 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131871 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75080 (Get FASTA)   NCBI Sequence Viewer  
  EDL75081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044374
  ENSRNOP00000044374.4
  ENSRNOP00000079337.1
Ensembl Acc Id: ENSRNOP00000075215   ⟸   ENSRNOT00000088284
Ensembl Acc Id: ENSRNOP00000044374   ⟸   ENSRNOT00000052224
Ensembl Acc Id: ENSRNOP00000079337   ⟸   ENSRNOT00000099184
RefSeq Acc Id: XP_063131871   ⟸   XM_063275801
- UniProtKB: D3ZTT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131872   ⟸   XM_063275802
- UniProtKB: D3ZTT0 (UniProtKB/TrEMBL)
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTT0-F1-model_v2 AlphaFold D3ZTT0 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311053 AgrOrtholog
BioCyc Gene G2FUF-12261 BioCyc
Ensembl Genes ENSRNOG00000025408 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052224 ENTREZGENE
  ENSRNOT00000052224.7 UniProtKB/TrEMBL
  ENSRNOT00000099184.2 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_regulator UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
NCBI Gene 306226 ENTREZGENE
PANTHER DOUBLE HOMEOBOX PROTEIN 1-RELATED UniProtKB/TrEMBL
  MIX-TYPE HOMEOBOX GENE 1-RELATED UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PhenoGen Dux4 PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025408 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A8I5ZML2_RAT UniProtKB/TrEMBL
  D3ZTT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Dux4  double homeobox 4  Duxbl1  double homeobox B-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Duxbl1  double homeobox B-like 1  Duxbl  double homeobox B-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-18 Duxbl  double homeobox B-like  RGD1311053_predicted  similar to double homeobox protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311053_predicted  similar to double homeobox protein (predicted)  LOC306226_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306226_predicted  similar to double homeobox protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL