Lpcat2b (lysophosphatidylcholine acyltransferase 2b) - Rat Genome Database

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Gene: Lpcat2b (lysophosphatidylcholine acyltransferase 2b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2b
RGD ID: 1310837
Description: Predicted to enable lysophosphatidic acid acyltransferase activity. Predicted to be involved in phospholipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acyltransferase like 1B; acyltransferase-like 1-B; Aytl1b; LOC289439; Lpcat2bp; lysophosphatidylcholine acyltransferase 2-B; MGC114541; RGD1310837; similar to hypothetical protein A330042H22
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,483,471 - 2,486,878 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,483,475 - 2,486,878 (-)EnsemblGRCr8
mRatBN7.2142,338,564 - 2,341,972 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,281,526 - 2,342,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx142,220,130 - 2,223,543 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,521,939 - 3,525,351 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,215,718 - 2,219,120 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,355,890 - 3,359,300 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,355,894 - 3,359,300 (-)Ensemblrn6Rnor6.0
Rnor_5.0143,359,374 - 3,362,781 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,897,559 - 2,900,969 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,356,078 - 2,359,485 (-)NCBICelera
RGSC_v3.1142,897,558 - 2,900,969 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Variants

.
Variants in Lpcat2b
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:18
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000043421
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 5 3 74 14 26 6 9 6 2 44 16 76 18 29 20 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000080875   ⟹   ENSRNOP00000074601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,483,475 - 2,486,878 (-)Ensembl
mRatBN7.2 Ensembl142,291,258 - 2,342,022 (-)Ensembl
Rnor_6.0 Ensembl143,355,894 - 3,359,300 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096698   ⟹   ENSRNOP00000089831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl142,281,526 - 2,342,022 (-)Ensembl
RefSeq Acc Id: NM_001025631   ⟹   NP_001020802
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,483,471 - 2,486,878 (-)NCBI
mRatBN7.2142,338,564 - 2,341,972 (-)NCBI
Rnor_6.0143,355,890 - 3,359,300 (-)NCBI
Rnor_5.0143,359,374 - 3,362,781 (-)NCBI
RGSC_v3.4142,897,559 - 2,900,969 (-)RGD
Celera142,356,078 - 2,359,485 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020802 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97476 (Get FASTA)   NCBI Sequence Viewer  
  EDL83970 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074601
  ENSRNOP00000074601.1
  ENSRNOP00000089831.1
GenBank Protein Q4V8A1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020802   ⟸   NM_001025631
- UniProtKB: Q4V8A1 (UniProtKB/Swiss-Prot),   A6KPJ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074601   ⟸   ENSRNOT00000080875
Ensembl Acc Id: ENSRNOP00000089831   ⟸   ENSRNOT00000096698
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8A1-F1-model_v2 AlphaFold Q4V8A1 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699160
Promoter ID:EPDNEW_R9685
Type:multiple initiation site
Name:Lpcat2b_1
Description:lysophosphatidylcholine acyltransferase 2b
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0143,359,313 - 3,359,373EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310837 AgrOrtholog
BioCyc Gene G2FUF-16622 BioCyc
Ensembl Genes ENSRNOG00000055849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080875 ENTREZGENE
  ENSRNOT00000080875.2 UniProtKB/Swiss-Prot
  ENSRNOT00000096698.1 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7457927 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  LPCAT1-like UniProtKB/Swiss-Prot
  Plipid/glycerol_acylTrfase UniProtKB/Swiss-Prot
KEGG Report rno:289439 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114541 IMAGE-MGC_LOAD
NCBI Gene 289439 ENTREZGENE
PANTHER LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 2B UniProtKB/Swiss-Prot
  PHOSPHOLIPID ACYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam Acyltransferase UniProtKB/Swiss-Prot
  EF-hand_1 UniProtKB/Swiss-Prot
  EF-hand_5 UniProtKB/Swiss-Prot
PhenoGen Lpcat2b PhenoGen
PRINTS RECOVERIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055849 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
  PlsC UniProtKB/Swiss-Prot
Superfamily-SCOP Glycerol-3-phosphate (1)-acyltransferase UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
UniProt A6KPJ5 ENTREZGENE, UniProtKB/TrEMBL
  PCT2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-02-18 Lpcat2b  lysophosphatidylcholine acyltransferase 2b  Lpcat2bp  lysophosphatidylcholine acyltransferase 2b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Aytl1b  acyltransferase like 1B  RGD1310837  similar to hypothetical protein A330042H22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310837  similar to hypothetical protein A330042H22  RGD1310837_predicted  similar to hypothetical protein A330042H22 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310837_predicted  similar to hypothetical protein A330042H22 (predicted)  LOC289439_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289439_predicted  similar to hypothetical protein A330042H22 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL