Six6 (SIX homeobox 6) - Rat Genome Database

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Gene: Six6 (SIX homeobox 6) Rattus norvegicus
Analyze
Symbol: Six6
Name: SIX homeobox 6
RGD ID: 1310497
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in eye development and regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX6 (SIX homeobox 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein SIX6; LOC314221; sine oculis-related homeobox 6 homolog; sine oculis-related homeobox 6 homolog (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,357,883 - 97,375,415 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl697,370,435 - 97,375,415 (+)EnsemblGRCr8
mRatBN7.2691,634,568 - 91,639,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,634,568 - 91,639,548 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx692,018,849 - 92,023,830 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,318,341 - 92,323,320 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,746,271 - 91,751,250 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0695,816,749 - 95,821,729 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl695,816,749 - 95,821,729 (+)Ensemblrn6Rnor6.0
Rnor_5.06105,253,949 - 105,258,929 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4695,358,546 - 95,363,526 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera690,098,521 - 90,103,501 (+)NCBICelera
RGSC_v3.1695,362,002 - 95,364,621 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18836447  


Genomics

Comparative Map Data
Six6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,357,883 - 97,375,415 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl697,370,435 - 97,375,415 (+)EnsemblGRCr8
mRatBN7.2691,634,568 - 91,639,548 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl691,634,568 - 91,639,548 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx692,018,849 - 92,023,830 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,318,341 - 92,323,320 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0691,746,271 - 91,751,250 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0695,816,749 - 95,821,729 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl695,816,749 - 95,821,729 (+)Ensemblrn6Rnor6.0
Rnor_5.06105,253,949 - 105,258,929 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4695,358,546 - 95,363,526 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera690,098,521 - 90,103,501 (+)NCBICelera
RGSC_v3.1695,362,002 - 95,364,621 (+)NCBI
Cytogenetic Map6q24NCBI
SIX6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381460,509,146 - 60,512,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1460,509,146 - 60,512,850 (+)Ensemblhg38GRCh38
GRCh371460,975,864 - 60,979,568 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361460,045,775 - 60,048,278 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341460,045,774 - 60,048,278NCBI
Celera1441,026,094 - 41,028,681 (+)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1441,139,524 - 41,142,111 (+)NCBIHuRef
CHM1_11460,915,181 - 60,917,768 (+)NCBICHM1_1
T2T-CHM13v2.01454,715,467 - 54,719,149 (+)NCBIT2T-CHM13v2.0
Six6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391272,986,656 - 72,991,673 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1272,986,666 - 72,991,673 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381272,939,882 - 72,944,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1272,939,892 - 72,944,899 (+)Ensemblmm10GRCm38
MGSCv371274,040,932 - 74,045,886 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361273,858,783 - 73,863,737 (+)NCBIMGSCv36mm8
Celera1274,056,430 - 74,061,384 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.31NCBI
Six6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554669,120,227 - 9,122,109 (-)Ensembl
ChiLan1.0NW_0049554669,120,227 - 9,122,109 (-)NCBIChiLan1.0ChiLan1.0
SIX6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21561,643,273 - 61,647,028 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11460,859,815 - 60,862,566 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01441,113,282 - 41,117,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11459,376,109 - 59,378,691 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1459,376,109 - 59,378,691 (+)EnsemblpanPan2panpan1.1
SIX6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1835,565,838 - 35,568,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl835,566,018 - 35,567,838 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha835,319,324 - 35,322,130 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0835,799,002 - 35,801,808 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl835,799,431 - 35,801,814 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1835,410,717 - 35,413,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0835,488,932 - 35,491,738 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0835,849,383 - 35,852,189 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Six6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864069,472,537 - 69,475,310 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364954,716,629 - 4,719,162 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364954,716,359 - 4,719,162 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIX6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1189,497,815 - 189,503,500 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11189,497,807 - 189,503,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21210,607,141 - 210,610,641 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIX6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12437,700,468 - 37,703,103 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2437,700,513 - 37,705,814 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605325,947,042 - 25,950,937 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Six6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473440,620,662 - 40,622,967 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473440,620,782 - 40,623,165 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Six6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1787,205,618 - 87,210,561 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Six6
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:626
Count of miRNA genes:258
Interacting mature miRNAs:342
Transcripts:ENSRNOT00000008880
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat

Markers in Region
RH140800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,636,713 - 91,636,914 (+)MAPPERmRatBN7.2
Rnor_6.0695,818,895 - 95,819,095NCBIRnor6.0
Rnor_5.06105,256,095 - 105,256,295UniSTSRnor5.0
RGSC_v3.4695,360,692 - 95,360,892UniSTSRGSC3.4
Celera690,100,667 - 90,100,867UniSTS
RH 3.4 Map6656.5UniSTS
Cytogenetic Map6q24UniSTS
BB280418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,639,376 - 91,639,524 (+)MAPPERmRatBN7.2
Rnor_6.0695,821,558 - 95,821,705NCBIRnor6.0
Rnor_5.06105,258,758 - 105,258,905UniSTSRnor5.0
RGSC_v3.4695,363,355 - 95,363,502UniSTSRGSC3.4
Celera690,103,330 - 90,103,477UniSTS
Cytogenetic Map6q24UniSTS
RH142828  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,636,589 - 91,636,707 (+)MAPPERmRatBN7.2
Rnor_6.0695,818,771 - 95,818,888NCBIRnor6.0
Rnor_5.06105,255,971 - 105,256,088UniSTSRnor5.0
RGSC_v3.4695,360,568 - 95,360,685UniSTSRGSC3.4
Celera690,100,543 - 90,100,660UniSTS
RH 3.4 Map6660.2UniSTS
Cytogenetic Map6q24UniSTS
Six6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2691,634,736 - 91,636,425 (+)MAPPERmRatBN7.2
Rnor_6.0695,816,918 - 95,818,606NCBIRnor6.0
Rnor_5.06105,254,118 - 105,255,806UniSTSRnor5.0
RGSC_v3.4695,358,715 - 95,360,403UniSTSRGSC3.4
Celera690,098,690 - 90,100,378UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 1 6 78 21 19 7 7 7 5 40 25 1 67 2 25 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008880   ⟹   ENSRNOP00000008880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl697,370,435 - 97,375,415 (+)Ensembl
mRatBN7.2 Ensembl691,634,568 - 91,639,548 (+)Ensembl
Rnor_6.0 Ensembl695,816,749 - 95,821,729 (+)Ensembl
RefSeq Acc Id: NM_001108032   ⟹   NP_001101502
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,370,435 - 97,375,415 (+)NCBI
mRatBN7.2691,634,568 - 91,639,548 (+)NCBI
Rnor_6.0695,816,749 - 95,821,729 (+)NCBI
Rnor_5.06105,253,949 - 105,258,929 (+)NCBI
RGSC_v3.4695,358,546 - 95,363,526 (+)RGD
Celera690,098,521 - 90,103,501 (+)RGD
Sequence:
RefSeq Acc Id: XM_063261926   ⟹   XP_063117996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,357,883 - 97,372,840 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101502 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117996 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03604 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008880
  ENSRNOP00000008880.4
RefSeq Acc Id: NP_001101502   ⟸   NM_001108032
- UniProtKB: D3ZCC7 (UniProtKB/TrEMBL),   A6HC49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008880   ⟸   ENSRNOT00000008880
RefSeq Acc Id: XP_063117996   ⟸   XM_063261926
- Peptide Label: isoform X1
- UniProtKB: A6HC49 (UniProtKB/TrEMBL),   D3ZCC7 (UniProtKB/TrEMBL)
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCC7-F1-model_v2 AlphaFold D3ZCC7 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310497 AgrOrtholog
BioCyc Gene G2FUF-37125 BioCyc
Ensembl Genes ENSRNOG00000006296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008880 ENTREZGENE
  ENSRNOT00000008880.7 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  SIX1_SD UniProtKB/TrEMBL
KEGG Report rno:314221 UniProtKB/TrEMBL
NCBI Gene 314221 ENTREZGENE
PANTHER HOMEOBOX PROTEIN SIX UniProtKB/TrEMBL
  PTHR10390:SF12 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  SIX1_SD UniProtKB/TrEMBL
PhenoGen Six6 PhenoGen
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006296 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6HC49 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCC7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Six6  SIX homeobox 6  Six6  sine oculis-related homeobox 6 homolog (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Six6  sine oculis-related homeobox 6 homolog (Drosophila)   Six6_predicted  sine oculis-related homeobox 6 homolog (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Six6_predicted  sine oculis-related homeobox 6 homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED