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Gene: Cavin4 (caveolae associated protein 4) Rattus norvegicus

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Symbol:

Cavin4

Name:

caveolae associated protein 4

RGD ID:

1310395

Description:

Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in caveola. Orthologous to human CAVIN4 (caveolae associated protein 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

caveolae-associated protein 4; LOC313225; Murc; muscle-related coiled-coil protein; muscle-restricted coiled-coil protein; RGD1310395; similar to RIKEN cDNA 2310039E09

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CAVIN4 (caveolae associated protein 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cavin4 (caveolae associated 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cavin4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CAVIN4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CAVIN4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cavin4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CAVIN4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CAVIN4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cavin4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cavin4 (caveolae associated protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cavin4 (caveolae associated 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CAVIN4 (caveolae associated protein 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cavin4a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cavin4b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cavin4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cavin4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	67,792,171 - 67,893,094 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	67,792,392 - 67,803,254 (+)	Ensembl				GRCr8
mRatBN7.2	5	62,996,906 - 63,007,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	62,996,865 - 63,007,678 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	64,974,561 - 64,982,412 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	66,793,881 - 66,801,733 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	66,763,332 - 66,771,181 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	64,413,005 - 64,420,849 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	64,412,895 - 64,423,725 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	68,926,895 - 68,934,739 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	65,357,777 - 65,365,621 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	64,592,108 - 64,599,951 (-)	NCBI		Celera
RGSC_v3.1	5	65,362,889 - 65,370,734 (+)	NCBI
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

arsenite(3-) (ISO)

atrazine (EXP)

bisphenol A (EXP,ISO)

chlorpyrifos (EXP)

daunorubicin (ISO)

DDE (ISO)

doxorubicin (ISO)

furan (EXP)

mitoxantrone (ISO)

okadaic acid (ISO)

perfluorooctanoic acid (EXP)

potassium chloride (ISO)

potassium chromate (ISO)

sunitinib (ISO)

triclosan (ISO)

tris(2-butoxyethyl) phosphate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

DNA-templated transcription (IEA)

muscle organ development (IEA)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of gene expression (IBA,IEA,ISO)

Cellular Component

caveola (IBA,IDA,IEA,ISO)

cytoplasm (IBA,IEA,ISO)

cytosol (IEA)

plasma membrane (IDA,IEA,ISO,ISS)

sarcolemma (IEA)

sarcomere (IEA)

Z disc (IEA,ISO)

Molecular Function

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by a1-adrenergic receptors.	Ogata T, etal., Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3811-6. doi: 10.1073/pnas.1315359111. Epub 2014 Feb 24.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18332105	PMID:19525939	PMID:21642240	PMID:26497963	PMID:30951783	PMID:31505169

Genomics

Comparative Map Data

Cavin4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	67,792,171 - 67,893,094 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	67,792,392 - 67,803,254 (+)	Ensembl				GRCr8
mRatBN7.2	5	62,996,906 - 63,007,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	62,996,865 - 63,007,678 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	64,974,561 - 64,982,412 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	66,793,881 - 66,801,733 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	66,763,332 - 66,771,181 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	64,413,005 - 64,420,849 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	64,412,895 - 64,423,725 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	68,926,895 - 68,934,739 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	65,357,777 - 65,365,621 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	64,592,108 - 64,599,951 (-)	NCBI		Celera
RGSC_v3.1	5	65,362,889 - 65,370,734 (+)	NCBI
Cytogenetic Map	5	q22	NCBI

CAVIN4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	100,576,867 - 100,588,389 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	100,578,033 - 100,588,402 (+)	Ensembl			hg38	GRCh38
GRCh37	9	103,340,361 - 103,350,671 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	102,380,157 - 102,390,001 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	9	73,853,560 - 73,863,400 (+)	NCBI		Celera
Cytogenetic Map	9	q31.1	NCBI
HuRef	9	72,939,042 - 72,949,352 (+)	NCBI		HuRef
CHM1_1	9	103,486,816 - 103,497,108 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	112,748,569 - 112,760,082 (+)	NCBI		T2T-CHM13v2.0

Cavin4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	48,663,514 - 48,673,492 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	48,663,514 - 48,673,502 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	48,663,514 - 48,673,492 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	48,663,514 - 48,673,502 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	48,676,386 - 48,686,364 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	48,684,657 - 48,694,593 (+)	NCBI		MGSCv36	mm8
Celera	4	48,687,179 - 48,697,159 (+)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	26.23	NCBI

Cavin4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	25,181,438 - 25,188,632 (-)	Ensembl
ChiLan1.0	NW_004955419	25,181,395 - 25,188,951 (-)	NCBI	ChiLan1.0	ChiLan1.0

CAVIN4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	38,772,797 - 38,783,514 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	38,775,169 - 38,785,886 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	71,788,601 - 71,799,310 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	99,785,397 - 99,796,121 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	99,785,397 - 99,796,114 (+)	Ensembl			panPan2	panpan1.1

CAVIN4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	57,452,229 - 57,462,933 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	57,452,347 - 57,460,463 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	55,895,496 - 55,906,219 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	58,579,567 - 58,590,283 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	58,580,742 - 58,590,219 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	57,077,571 - 57,088,014 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	57,103,190 - 57,113,636 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	57,802,519 - 57,812,964 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cavin4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	172,320,785 - 172,330,229 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	8,868,721 - 8,876,019 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	8,868,295 - 8,882,398 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CAVIN4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	242,308,977 - 242,320,047 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	242,310,017 - 242,319,977 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	270,670,749 - 270,680,300 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CAVIN4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	38,852,824 - 38,863,132 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	38,853,613 - 38,861,918 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666035	3,691,234 - 3,701,578 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cavin4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624825	441,987 - 452,926 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cavin4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	101,739,029 - 101,748,421 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cavin4
863 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	18
Interacting mature miRNAs:	18
Transcripts:	ENSRNOT00000010561
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	65089051	103648916	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	64589016	93503770	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	64589016	91762830	Rat

Markers in Region

RH144033

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,996,207 - 62,996,313 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,412,238 - 64,412,343	NCBI	Rnor6.0
Rnor_5.0	5	68,926,128 - 68,926,233	UniSTS	Rnor5.0
RGSC_v3.4	5	65,357,010 - 65,357,115	UniSTS	RGSC3.4
Celera	5	64,600,613 - 64,600,718	UniSTS
RH 3.4 Map	5	415.4	UniSTS
Cytogenetic Map	5	q22	UniSTS

RH138909

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,995,933 - 62,996,059 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,411,964 - 64,412,089	NCBI	Rnor6.0
Rnor_5.0	5	68,925,854 - 68,925,979	UniSTS	Rnor5.0
RGSC_v3.4	5	65,356,736 - 65,356,861	UniSTS	RGSC3.4
Celera	5	64,600,867 - 64,600,992	UniSTS
RH 3.4 Map	5	416.6	UniSTS
Cytogenetic Map	5	q22	UniSTS

BE118719

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	62,999,163 - 62,999,332 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	64,415,194 - 64,415,362	NCBI	Rnor6.0
Rnor_5.0	5	68,929,084 - 68,929,252	UniSTS	Rnor5.0
RGSC_v3.4	5	65,359,966 - 65,360,134	UniSTS	RGSC3.4
Celera	5	64,597,595 - 64,597,763	UniSTS
RH 3.4 Map	5	412.3	UniSTS
Cytogenetic Map	5	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	63	154	61	62	31	21	31	6	239	116	11	134	68	83	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107931	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066386	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU487255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010561 ⟹ ENSRNOP00000010561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	67,792,392 - 67,803,254 (+)	Ensembl
mRatBN7.2 Ensembl	5	62,996,865 - 63,007,678 (+)	Ensembl
Rnor_6.0 Ensembl	5	64,412,895 - 64,423,725 (+)	Ensembl

RefSeq Acc Id:

NM_001107931 ⟹ NP_001101401

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,792,432 - 67,803,203 (+)	NCBI
mRatBN7.2	5	62,996,906 - 63,007,677 (+)	NCBI
Rnor_6.0	5	64,413,005 - 64,420,849 (+)	NCBI
Rnor_5.0	5	68,926,895 - 68,934,739 (+)	NCBI
RGSC_v3.4	5	65,357,777 - 65,365,621 (+)	RGD
Celera	5	64,592,108 - 64,599,951 (-)	RGD

Sequence:

show sequence

ATGGAACACAATGGATCTGCTTCAAATGCTGGTAAAATCCACCAGAACCGATTGTCAAGTGTGA
CTGAAGATGAAGACCAGGACGCAGCTCTCACAATTGTGACTGTGCTGGACAGGGTGGCCACCGT
CGTGGACAGCGTGCAGGCAAGCCAGAAGAGAATCGAGGAGAGACACAGAGAGATGGGGAACGCC
ATCAAGTCTGTCCAGATAGACCTGCTGAAGCTCTCACAATCACACAGCAACACGGGCTACGTTG
TTAACAAGCTGTTTGAGAAGACCCGGAAAGTCAGCGCTCACATTAAAGATGTGAAGGCCCGGGT
AGAGAAGCAACAGGTTCGAGTAACCAAAGTCGAAACCAAGCAAGAAGAAATAATGAAGAAGAAC
AAGTTCCGCGTGGTAATCTTCCAGGAGGATGTTCCCTGCCCCGCATCCCTGTCTGTTGTTAAAG
ACAGAAGCCTGCCGGAGAACGAGGAGGAAGCTGAGGAAGTCTTCGATCCCCCGATCGATCTCTC
ATCGGATGAAGAATACTATGTTGAAGAAAGCAGATCTGCCAGGCTTAGAAAGTCAGGCAAAGAG
CACATCGATCATATTAAGAAGGCATTTTCCAAAGAAAACATGCAGAAGACGCGGCAGAATTTTG
ATAAGAAAGTGAGTGGAATTAGAACCAGGATAGTTACACCTGAGAGAAGAGAGAGGCTGAGGCA
GTCAGGAGAGAGGCTGAGGCAGTCGGGGGAGAGGCTGAGGCAGTCGGGGGAAAGATTTAAGAAA
TCGATCTCAAATGCCACCCCCTCCAAGGAAGCTTTTAAGATCCGGAGCCTTAGAAAACCGAAGG
ACCCCAAGGCAGAAGGCCAGGAGGTAGACAGGGGGATGGGGGTGGACATCATCTCAGGTAGCCT
GGCTCTGGGGCCCATCCATGAGTTCCACTCTGATGGGTTCAGTGAAACAGAAAAGGAGGTGACC
AAAGTAGGGTACATTCCCCAAGAGGGAGGGGACCCCCCAACGCCTGAGCCTTTGAAGGTGACCT
TTAAACCTCAGGTGAGAGTAGAGGATGACGAGTCACTCCTGTTGGAATTAAAGCAGTCCTCATA
G

hide sequence

RefSeq Acc Id:

XM_063287620 ⟹ XP_063143690

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,831,079 (+)	NCBI

RefSeq Acc Id:

XM_063287621 ⟹ XP_063143691

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,792,171 - 67,840,261 (+)	NCBI

RefSeq Acc Id:

XM_063287622 ⟹ XP_063143692

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,792,171 - 67,840,242 (+)	NCBI

RefSeq Acc Id:

XM_063287623 ⟹ XP_063143693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,792,171 - 67,818,959 (+)	NCBI

RefSeq Acc Id:

XR_010066384

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066385

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066386

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066387

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066388

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066389

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066390

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066391

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066392

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,893,094 (+)	NCBI

RefSeq Acc Id:

XR_010066393

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,893,094 (+)	NCBI

RefSeq Acc Id:

XR_010066394

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,893,094 (+)	NCBI

RefSeq Acc Id:

XR_010066395

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

RefSeq Acc Id:

XR_010066396

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	67,799,776 - 67,857,307 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101401	(Get FASTA)	NCBI Sequence Viewer
	XP_063143690	(Get FASTA)	NCBI Sequence Viewer
	XP_063143691	(Get FASTA)	NCBI Sequence Viewer
	XP_063143692	(Get FASTA)	NCBI Sequence Viewer
	XP_063143693	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACA62937	(Get FASTA)	NCBI Sequence Viewer
	B1PRL5	(Get FASTA)	NCBI Sequence Viewer
	EDL78187	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010561
	ENSRNOP00000010561.2

RefSeq Acc Id:

NP_001101401 ⟸ NM_001107931

- UniProtKB:

B1PRL5 (UniProtKB/Swiss-Prot), A6KJE9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVATVVDSVQASQKRIEERHREMGNA
IKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKN
KFRVVIFQEDVPCPASLSVVKDRSLPENEEEAEEVFDPPIDLSSDEEYYVEESRSARLRKSGKE
HIDHIKKAFSKENMQKTRQNFDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKK
SISNATPSKEAFKIRSLRKPKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDGFSETEKEVT
KVGYIPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS

hide sequence

Ensembl Acc Id:

ENSRNOP00000010561 ⟸ ENSRNOT00000010561

RefSeq Acc Id:	XP_063143691 ⟸ XM_063287621
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063143692 ⟸ XM_063287622
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063143693 ⟸ XM_063287623
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063143690 ⟸ XM_063287620
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1PRL5-F1-model_v2	AlphaFold	B1PRL5	1-362	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693726

Promoter ID:

EPDNEW_R4250

Type:

initiation region

Name:

Cavin4_1

Description:

caveolae associated protein 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	64,412,895 - 64,412,955	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310395	AgrOrtholog
BioCyc Gene	G2FUF-41348	BioCyc
Ensembl Genes	ENSRNOG00000008027	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010561	ENTREZGENE
	ENSRNOT00000010561.5	UniProtKB/Swiss-Prot
InterPro	Cavin_fam	UniProtKB/Swiss-Prot
KEGG Report	rno:313225	UniProtKB/Swiss-Prot
NCBI Gene	313225	ENTREZGENE
PANTHER	PTHR15240	UniProtKB/Swiss-Prot
	PTHR15240:SF4	UniProtKB/Swiss-Prot
Pfam	PTRF_SDPR	UniProtKB/Swiss-Prot
PhenoGen	Cavin4	PhenoGen
RatGTEx	ENSRNOG00000008027	RatGTEx
UniProt	A6KJE9	ENTREZGENE, UniProtKB/TrEMBL
	B1PRL5	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-29	Cavin4	caveolae associated protein 4	Murc	muscle-related coiled-coil protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-05	Murc	muscle-related coiled-coil protein	Murc	muscle-restricted coiled-coil protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-31	Murc	muscle-restricted coiled-coil protein	RGD1310395_predicted	similar to RIKEN cDNA 2310039E09 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1310395_predicted	similar to RIKEN cDNA 2310039E09 (predicted)	LOC313225_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313225_predicted	similar to RIKEN cDNA 2310039E09 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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