Ccl19 (C-C motif chemokine ligand 19) - Rat Genome Database

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Gene: Ccl19 (C-C motif chemokine ligand 19) Rattus norvegicus
Analyze
Symbol: Ccl19
Name: C-C motif chemokine ligand 19
RGD ID: 1310336
Description: Predicted to enable CCR10 chemokine receptor binding activity; CCR7 chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including positive regulation of T cell activation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Orthologous to human CCL19 (C-C motif chemokine ligand 19); PARTICIPATES IN chemokine mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 19; chemokine (C-C motif) ligand 19; LOC362506
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,759,220 - 61,761,164 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl561,759,220 - 61,772,022 (-)EnsemblGRCr8
mRatBN7.2556,963,364 - 56,965,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,963,364 - 56,965,308 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,937,715 - 58,939,661 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,756,547 - 60,758,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,742,641 - 60,744,587 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd561,884,310 - 61,886,254 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive563,463,236 - 63,465,180 (-)NCBILyon_Normotensive
Lyon_Hypertensive562,781,481 - 62,783,425 (-)NCBILyon_Hypertensive
F344_StmMcwi556,655,936 - 56,657,882 (-)NCBIF344_StmMcwi
Rnor_6.0558,181,025 - 58,182,969 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,181,026 - 58,183,017 (-)Ensemblrn6Rnor6.0
Rnor_5.0562,705,391 - 62,707,335 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4559,221,738 - 59,223,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera555,555,525 - 55,557,469 (-)NCBICelera
RGSC_v3.1559,221,917 - 59,223,865 (-)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asperentin  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
Brevianamide A  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
capecitabine  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cobalt atom  (ISO)
cyclosporin A  (EXP)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (ISO)
eugenol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
furan  (EXP)
gentamycin  (EXP)
graphene oxide  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
potassium dichromate  (ISO)
pyridaben  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sterigmatocystin  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA,ISO)
CCL19-activated CCR7 signaling pathway  (ISO)
cell chemotaxis  (IEA)
cell maturation  (ISO)
cell migration  (IEA)
cellular response to prostaglandin E stimulus  (ISO)
chemokine-mediated signaling pathway  (IBA)
chemotaxis  (IEA)
dendritic cell chemotaxis  (ISO)
eosinophil chemotaxis  (IBA)
establishment of T cell polarity  (ISO)
immune response  (IEA)
immunological synapse formation  (ISO)
inflammatory response  (IBA,IEA)
mature conventional dendritic cell differentiation  (ISO)
myeloid dendritic cell chemotaxis  (ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration  (IBA)
positive regulation of cell motility  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of dendritic cell dendrite assembly  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of phospholipase C/protein kinase C signal transduction  (ISO)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 1 cell differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
regulation of cell projection assembly  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to nitric oxide  (ISO)
signal transduction  (IEA)
T cell costimulation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection. Eppert BL, etal., Infect Immun. 2010 May;78(5):2099-107. Epub 2010 Feb 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Expression of macrophage inflammatory protein-3 beta/CCL19 in pulmonary sarcoidosis. Gibejova A, etal., Am J Respir Crit Care Med. 2003 Jun 15;167(12):1695-703. Epub 2003 Mar 5.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. CCR7 deficiency on dendritic cells enhances fungal clearance in a murine model of pulmonary invasive aspergillosis. Hartigan AJ, etal., J Immunol. 2009 Oct 15;183(8):5171-9. Epub 2009 Sep 25.
6. Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Kaur D, etal., Am J Respir Crit Care Med. 2006 Dec 1;174(11):1179-88. Epub 2006 Sep 7.
7. In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity. Khader SA, etal., J Immunol. 2009 Dec 15;183(12):8004-14. Epub .
8. Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines. Langer R, etal., J Am Soc Nephrol. 2004 Nov;15(11):2893-901.
9. Dendritic cells accumulate in human fibrotic interstitial lung disease. Marchal-Somme J, etal., Am J Respir Crit Care Med. 2007 Nov 15;176(10):1007-14. Epub 2007 Aug 23.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. Takamura K, etal., J Immunol. 2007 Nov 1;179(9):5897-906.
Additional References at PubMed
PMID:9507024   PMID:10706668   PMID:12200351   PMID:12609829   PMID:12729902   PMID:12949249   PMID:14592837   PMID:15059845   PMID:15778365   PMID:15845453   PMID:16027136   PMID:16249377  
PMID:19008373   PMID:20002784   PMID:21051556   PMID:23341447   PMID:25086360   PMID:25754930   PMID:28859865  


Genomics

Comparative Map Data
Ccl19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,759,220 - 61,761,164 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl561,759,220 - 61,772,022 (-)EnsemblGRCr8
mRatBN7.2556,963,364 - 56,965,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,963,364 - 56,965,308 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,937,715 - 58,939,661 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,756,547 - 60,758,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,742,641 - 60,744,587 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd561,884,310 - 61,886,254 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive563,463,236 - 63,465,180 (-)NCBILyon_Normotensive
Lyon_Hypertensive562,781,481 - 62,783,425 (-)NCBILyon_Hypertensive
F344_StmMcwi556,655,936 - 56,657,882 (-)NCBIF344_StmMcwi
Rnor_6.0558,181,025 - 58,182,969 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,181,026 - 58,183,017 (-)Ensemblrn6Rnor6.0
Rnor_5.0562,705,391 - 62,707,335 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4559,221,738 - 59,223,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera555,555,525 - 55,557,469 (-)NCBICelera
RGSC_v3.1559,221,917 - 59,223,865 (-)NCBI
Cytogenetic Map5q22NCBI
CCL19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,689,570 - 34,691,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,689,570 - 34,691,276 (-)Ensemblhg38GRCh38
GRCh37934,689,567 - 34,691,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,679,567 - 34,681,274 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34934,679,566 - 34,681,274NCBI
Celera934,621,038 - 34,622,745 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,643,820 - 34,645,529 (-)NCBIHuRef
CHM1_1934,689,356 - 34,691,063 (-)NCBICHM1_1
T2T-CHM13v2.0934,708,593 - 34,710,301 (-)NCBIT2T-CHM13v2.0
Ccl19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39442,754,525 - 42,756,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl442,754,525 - 42,756,577 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38442,754,525 - 42,756,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,754,525 - 42,756,577 (-)Ensemblmm10GRCm38
MGSCv37442,768,057 - 42,770,050 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36442,776,285 - 42,778,278 (-)NCBIMGSCv36mm8
Cytogenetic Map4A5NCBI
cM Map422.44NCBI
Ccl19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,444,316 - 1,446,490 (+)Ensembl
ChiLan1.0NW_0049554721,444,598 - 1,446,488 (+)NCBIChiLan1.0ChiLan1.0
CCL19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,912,711 - 89,915,161 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,918,652 - 89,921,102 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,525,820 - 34,527,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,334,353 - 35,336,108 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,334,353 - 35,336,108 (-)EnsemblpanPan2panpan1.1
CCL19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,357,706 - 51,359,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,340,530 - 51,359,365 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1149,985,833 - 49,987,334 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01152,298,251 - 52,299,753 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,281,068 - 52,299,911 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,960,957 - 50,962,456 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,829,100 - 50,830,599 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,593,870 - 51,595,370 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccl19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,217,691 - 166,219,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,765,267 - 2,767,385 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,765,271 - 2,767,259 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,110,065 - 32,112,734 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,250,009 - 36,252,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,928,212 - 45,930,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,929,071 - 45,930,904 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603843,045,463 - 43,047,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,088,921 - 39,090,394 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473639,088,741 - 39,090,745 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ccl19
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v113,760,442 - 3,762,403 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ccl19
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:110
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000020982
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 50 112 67 66 35 27 35 6 216 103 7 87 60 84 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000020982   ⟹   ENSRNOP00000020982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,759,220 - 61,768,953 (-)Ensembl
mRatBN7.2 Ensembl556,963,364 - 56,965,308 (-)Ensembl
Rnor_6.0 Ensembl558,181,026 - 58,183,017 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101776   ⟹   ENSRNOP00000086421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,759,490 - 61,761,164 (-)Ensembl
mRatBN7.2 Ensembl556,963,634 - 56,965,308 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140435   ⟹   ENSRNOP00000106570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,759,220 - 61,772,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146177   ⟹   ENSRNOP00000104179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,759,220 - 61,770,597 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153957   ⟹   ENSRNOP00000110206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,759,220 - 61,768,953 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167842   ⟹   ENSRNOP00000099773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,759,220 - 61,760,406 (-)Ensembl
RefSeq Acc Id: NM_001108661   ⟹   NP_001102131
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8561,759,220 - 61,761,164 (-)NCBI
mRatBN7.2556,963,364 - 56,965,308 (-)NCBI
Dahl_SR_JrHsd561,884,310 - 61,886,254 (-)NCBI
Lyon_Normotensive563,463,236 - 63,465,180 (-)NCBI
Lyon_Hypertensive562,781,481 - 62,783,425 (-)NCBI
F344_StmMcwi556,655,936 - 56,657,882 (-)NCBI
Rnor_6.0558,181,025 - 58,182,969 (-)NCBI
Rnor_5.0562,705,391 - 62,707,335 (-)NCBI
RGSC_v3.4559,221,738 - 59,223,682 (-)RGD
Celera555,555,525 - 55,557,469 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102131 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98706 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020982.5
  ENSRNOP00000086421.1
  ENSRNOP00000099773.1
  ENSRNOP00000104179.1
  ENSRNOP00000106570.1
  ENSRNOP00000110206.1
RefSeq Acc Id: NP_001102131   ⟸   NM_001108661
- Peptide Label: precursor
- UniProtKB: D3ZI84 (UniProtKB/TrEMBL),   A6IIY6 (UniProtKB/TrEMBL),   A0A8I6A271 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020982   ⟸   ENSRNOT00000020982
Ensembl Acc Id: ENSRNOP00000086421   ⟸   ENSRNOT00000101776
Ensembl Acc Id: ENSRNOP00000099773   ⟸   ENSRNOT00000167842
Ensembl Acc Id: ENSRNOP00000110206   ⟸   ENSRNOT00000153957
Ensembl Acc Id: ENSRNOP00000104179   ⟸   ENSRNOT00000146177
Ensembl Acc Id: ENSRNOP00000106570   ⟸   ENSRNOT00000140435
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZI84-F1-model_v2 AlphaFold D3ZI84 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693662
Promoter ID:EPDNEW_R4186
Type:single initiation site
Name:Ccl19_1
Description:C-C motif chemokine ligand 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0558,182,972 - 58,183,032EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310336 AgrOrtholog
BioCyc Gene G2FUF-41535 BioCyc
Ensembl Genes ENSRNOG00000015668 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020982.7 UniProtKB/TrEMBL
  ENSRNOT00000101776.2 UniProtKB/TrEMBL
  ENSRNOT00000140435.1 UniProtKB/TrEMBL
  ENSRNOT00000146177.1 UniProtKB/TrEMBL
  ENSRNOT00000153957.1 UniProtKB/TrEMBL
  ENSRNOT00000167842.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro CC_chemkine_sml_CS UniProtKB/TrEMBL
  Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_CC_DCCL UniProtKB/TrEMBL
  Chemokine_IL8 UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report rno:362506 UniProtKB/TrEMBL
NCBI Gene 362506 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 19 UniProtKB/TrEMBL
  PTHR12015 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PhenoGen Ccl19 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015668 RatGTEx
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP Chemokine_IL8 UniProtKB/TrEMBL
UniProt A0A8I6A271 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L416_RAT UniProtKB/TrEMBL
  A0ABK0L706_RAT UniProtKB/TrEMBL
  A0ABK0L8G2_RAT UniProtKB/TrEMBL
  A0ABK0M7B5_RAT UniProtKB/TrEMBL
  A6IIY6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZI84 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl19  C-C motif chemokine ligand 19  Ccl19  chemokine (C-C motif) ligand 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ccl19  chemokine (C-C motif) ligand 19   Ccl19_predicted  chemokine (C-C motif) ligand 19 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ccl19_predicted  chemokine (C-C motif) ligand 19 (predicted)      Symbol and Name status set to approved 70820 APPROVED